UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DCAF5-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DCAF5-RAD51B
	FusionPDB ID: 21515
	FusionGDB2.0 ID: 21515
		Hgene	Tgene
	Gene symbol	DCAF5	RAD51B
	Gene ID	8816	5890
	Gene name	DDB1 and CUL4 associated factor 5	RAD51 paralog B
	Synonyms	BCRG2\|BCRP2\|D14S1461E\|WDR22	R51H2\|RAD51L1\|REC2
	Cytomap	14q24.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200313	20200313
	UniProtAcc	Q96JK2	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000341516, ENST00000389997, ENST00000554215, ENST00000556847, ENST00000557386, ENST00000553293,	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 13 X 8=1560	41 X 23 X 12=11316
	# samples	16	56
	** MAII score	log2(16/1560*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DCAF5 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DCAF5(69558391)-RAD51B(68934889), # samples:3 RAD51B(68353921)-DCAF5(69589077), # samples:3
Anticipated loss of major functional domain due to fusion event.	DCAF5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DCAF5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DCAF5-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DCAF5-RAD51B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. DCAF5-RAD51B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. RAD51B-DCAF5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. RAD51B-DCAF5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RAD51B-DCAF5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DCAF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-A5NZ-01A	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+
ChimerDB4	OV	TCGA-29-A5NZ	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341516	DCAF5	chr14	69558391	-	ENST00000487861	RAD51B	chr14	68934889	+	1666	1027	148	1347	399
ENST00000341516	DCAF5	chr14	69558391	-	ENST00000471583	RAD51B	chr14	68934889	+	1558	1027	148	1122	324
ENST00000341516	DCAF5	chr14	69558391	-	ENST00000487270	RAD51B	chr14	68934889	+	2618	1027	148	1224	358
ENST00000341516	DCAF5	chr14	69558391	-	ENST00000488612	RAD51B	chr14	68934889	+	1593	1027	148	1170	340
ENST00000341516	DCAF5	chr14	69558391	-	ENST00000390683	RAD51B	chr14	68934889	+	1171	1027	148	1170	341
ENST00000557386	DCAF5	chr14	69558391	-	ENST00000487861	RAD51B	chr14	68934889	+	1540	901	25	1221	398
ENST00000557386	DCAF5	chr14	69558391	-	ENST00000471583	RAD51B	chr14	68934889	+	1432	901	25	996	323
ENST00000557386	DCAF5	chr14	69558391	-	ENST00000487270	RAD51B	chr14	68934889	+	2492	901	25	1098	357
ENST00000557386	DCAF5	chr14	69558391	-	ENST00000488612	RAD51B	chr14	68934889	+	1467	901	25	1044	339
ENST00000557386	DCAF5	chr14	69558391	-	ENST00000390683	RAD51B	chr14	68934889	+	1045	901	25	1044	340
ENST00000389997	DCAF5	chr14	69558391	-	ENST00000487861	RAD51B	chr14	68934889	+	1523	884	5	1204	399
ENST00000389997	DCAF5	chr14	69558391	-	ENST00000471583	RAD51B	chr14	68934889	+	1415	884	5	979	324
ENST00000389997	DCAF5	chr14	69558391	-	ENST00000487270	RAD51B	chr14	68934889	+	2475	884	5	1081	358
ENST00000389997	DCAF5	chr14	69558391	-	ENST00000488612	RAD51B	chr14	68934889	+	1450	884	5	1027	340
ENST00000389997	DCAF5	chr14	69558391	-	ENST00000390683	RAD51B	chr14	68934889	+	1028	884	5	1027	341
ENST00000341516	DCAF5	chr14	69558390	-	ENST00000487861	RAD51B	chr14	68934888	+	1666	1027	148	1347	399
ENST00000341516	DCAF5	chr14	69558390	-	ENST00000471583	RAD51B	chr14	68934888	+	1558	1027	148	1122	324
ENST00000341516	DCAF5	chr14	69558390	-	ENST00000487270	RAD51B	chr14	68934888	+	2618	1027	148	1224	358
ENST00000341516	DCAF5	chr14	69558390	-	ENST00000488612	RAD51B	chr14	68934888	+	1593	1027	148	1170	340
ENST00000341516	DCAF5	chr14	69558390	-	ENST00000390683	RAD51B	chr14	68934888	+	1171	1027	148	1170	341
ENST00000557386	DCAF5	chr14	69558390	-	ENST00000487861	RAD51B	chr14	68934888	+	1540	901	25	1221	398
ENST00000557386	DCAF5	chr14	69558390	-	ENST00000471583	RAD51B	chr14	68934888	+	1432	901	25	996	323
ENST00000557386	DCAF5	chr14	69558390	-	ENST00000487270	RAD51B	chr14	68934888	+	2492	901	25	1098	357
ENST00000557386	DCAF5	chr14	69558390	-	ENST00000488612	RAD51B	chr14	68934888	+	1467	901	25	1044	339
ENST00000557386	DCAF5	chr14	69558390	-	ENST00000390683	RAD51B	chr14	68934888	+	1045	901	25	1044	340
ENST00000389997	DCAF5	chr14	69558390	-	ENST00000487861	RAD51B	chr14	68934888	+	1523	884	5	1204	399
ENST00000389997	DCAF5	chr14	69558390	-	ENST00000471583	RAD51B	chr14	68934888	+	1415	884	5	979	324
ENST00000389997	DCAF5	chr14	69558390	-	ENST00000487270	RAD51B	chr14	68934888	+	2475	884	5	1081	358
ENST00000389997	DCAF5	chr14	69558390	-	ENST00000488612	RAD51B	chr14	68934888	+	1450	884	5	1027	340
ENST00000389997	DCAF5	chr14	69558390	-	ENST00000390683	RAD51B	chr14	68934888	+	1028	884	5	1027	341

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341516	ENST00000487861	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.016921757	0.9830783
ENST00000341516	ENST00000471583	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001331316	0.9986687
ENST00000341516	ENST00000487270	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.00235667	0.9976433
ENST00000341516	ENST00000488612	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001362433	0.9986375
ENST00000341516	ENST00000390683	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001463863	0.9985361
ENST00000557386	ENST00000487861	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.021938441	0.97806156
ENST00000557386	ENST00000471583	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001486727	0.9985133
ENST00000557386	ENST00000487270	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.002546083	0.99745387
ENST00000557386	ENST00000488612	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001360854	0.99863917
ENST00000557386	ENST00000390683	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001590476	0.99840957
ENST00000389997	ENST00000487861	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.019873435	0.98012656
ENST00000389997	ENST00000471583	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001298255	0.9987017
ENST00000389997	ENST00000487270	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.002387866	0.9976121
ENST00000389997	ENST00000488612	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001234742	0.99876523
ENST00000389997	ENST00000390683	DCAF5	chr14	69558391	-	RAD51B	chr14	68934889	+	0.001425814	0.99857414
ENST00000341516	ENST00000487861	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.016921757	0.9830783
ENST00000341516	ENST00000471583	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001331316	0.9986687
ENST00000341516	ENST00000487270	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.00235667	0.9976433
ENST00000341516	ENST00000488612	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001362433	0.9986375
ENST00000341516	ENST00000390683	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001463863	0.9985361
ENST00000557386	ENST00000487861	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.021938441	0.97806156
ENST00000557386	ENST00000471583	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001486727	0.9985133
ENST00000557386	ENST00000487270	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.002546083	0.99745387
ENST00000557386	ENST00000488612	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001360854	0.99863917
ENST00000557386	ENST00000390683	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001590476	0.99840957
ENST00000389997	ENST00000487861	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.019873435	0.98012656
ENST00000389997	ENST00000471583	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001298255	0.9987017
ENST00000389997	ENST00000487270	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.002387866	0.9976121
ENST00000389997	ENST00000488612	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001234742	0.99876523
ENST00000389997	ENST00000390683	DCAF5	chr14	69558390	-	RAD51B	chr14	68934888	+	0.001425814	0.99857414

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21515_21515_1_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000341516_RAD51B_chr14_68934888_ENST00000390683_length(amino acids)=341AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_2_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000341516_RAD51B_chr14_68934888_ENST00000471583_length(amino acids)=324AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_3_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000341516_RAD51B_chr14_68934888_ENST00000487270_length(amino acids)=358AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_4_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000341516_RAD51B_chr14_68934888_ENST00000487861_length(amino acids)=399AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ
FDNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRL

--------------------------------------------------------------

>21515_21515_5_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000341516_RAD51B_chr14_68934888_ENST00000488612_length(amino acids)=340AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_6_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000389997_RAD51B_chr14_68934888_ENST00000390683_length(amino acids)=341AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_7_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000389997_RAD51B_chr14_68934888_ENST00000471583_length(amino acids)=324AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_8_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000389997_RAD51B_chr14_68934888_ENST00000487270_length(amino acids)=358AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_9_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000389997_RAD51B_chr14_68934888_ENST00000487861_length(amino acids)=399AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ
FDNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRL

--------------------------------------------------------------

>21515_21515_10_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000389997_RAD51B_chr14_68934888_ENST00000488612_length(amino acids)=340AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_11_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000557386_RAD51B_chr14_68934888_ENST00000390683_length(amino acids)=340AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_12_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000557386_RAD51B_chr14_68934888_ENST00000471583_length(amino acids)=323AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_13_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000557386_RAD51B_chr14_68934888_ENST00000487270_length(amino acids)=357AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_14_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000557386_RAD51B_chr14_68934888_ENST00000487861_length(amino acids)=398AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF
DNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLL

--------------------------------------------------------------

>21515_21515_15_DCAF5-RAD51B_DCAF5_chr14_69558390_ENST00000557386_RAD51B_chr14_68934888_ENST00000488612_length(amino acids)=339AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_16_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000341516_RAD51B_chr14_68934889_ENST00000390683_length(amino acids)=341AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_17_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000341516_RAD51B_chr14_68934889_ENST00000471583_length(amino acids)=324AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_18_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000341516_RAD51B_chr14_68934889_ENST00000487270_length(amino acids)=358AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_19_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000341516_RAD51B_chr14_68934889_ENST00000487861_length(amino acids)=399AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ
FDNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRL

--------------------------------------------------------------

>21515_21515_20_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000341516_RAD51B_chr14_68934889_ENST00000488612_length(amino acids)=340AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_21_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000389997_RAD51B_chr14_68934889_ENST00000390683_length(amino acids)=341AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_22_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000389997_RAD51B_chr14_68934889_ENST00000471583_length(amino acids)=324AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_23_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000389997_RAD51B_chr14_68934889_ENST00000487270_length(amino acids)=358AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_24_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000389997_RAD51B_chr14_68934889_ENST00000487861_length(amino acids)=399AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ
FDNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRL

--------------------------------------------------------------

>21515_21515_25_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000389997_RAD51B_chr14_68934889_ENST00000488612_length(amino acids)=340AA_BP=292
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQ

--------------------------------------------------------------

>21515_21515_26_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000557386_RAD51B_chr14_68934889_ENST00000390683_length(amino acids)=340AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_27_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000557386_RAD51B_chr14_68934889_ENST00000471583_length(amino acids)=323AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_28_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000557386_RAD51B_chr14_68934889_ENST00000487270_length(amino acids)=357AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

>21515_21515_29_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000557386_RAD51B_chr14_68934889_ENST00000487861_length(amino acids)=398AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF
DNQGYFNSCTMKSCCFAGDRDQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLL

--------------------------------------------------------------

>21515_21515_30_DCAF5-RAD51B_DCAF5_chr14_69558391_ENST00000557386_RAD51B_chr14_68934889_ENST00000488612_length(amino acids)=339AA_BP=291
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:69558391/chr14:68934889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF5 Q96JK2	RAD51B O15315
FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

140_180

293.0

943.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

185_225

293.0

943.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

51_91

293.0

943.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

99_139

293.0

943.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

140_180

211.0

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

51_91

211.0

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

99_139

211.0

861.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

140_180

211.0

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

51_91

211.0

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

99_139

211.0

861.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

140_180

293.0

943.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

185_225

293.0

943.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

51_91

293.0

943.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

99_139

293.0

943.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

140_180

211.0

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

51_91

211.0

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

99_139

211.0

861.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

140_180

211.0

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

51_91

211.0

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

99_139

211.0

861.0

Repeat

Note=WD 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

277_317

293.0

943.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000341516

331_370

293.0

943.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

185_225

211.0

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

277_317

211.0

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000554215

331_370

211.0

861.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

185_225

211.0

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

277_317

211.0

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558390

chr14:68934888

ENST00000556847

331_370

211.0

861.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

277_317

293.0

943.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000341516

331_370

293.0

943.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

185_225

211.0

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

277_317

211.0

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000554215

331_370

211.0

861.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

185_225

211.0

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

277_317

211.0

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69558391

chr14:68934889

ENST00000556847

331_370

211.0

861.0

Repeat

Note=WD 6

Tgene

RAD51B

chr14:69558390

chr14:68934888

ENST00000390683

108_115

319.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558390

chr14:68934888

ENST00000471583

108_115

319.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558390

chr14:68934888

ENST00000487270

108_115

319.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558390

chr14:68934888

ENST00000488612

108_115

319.0

495.6666666666667

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558391

chr14:68934889

ENST00000390683

108_115

319.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558391

chr14:68934889

ENST00000471583

108_115

319.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558391

chr14:68934889

ENST00000487270

108_115

319.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:69558391

chr14:68934889

ENST00000488612

108_115

319.0

495.6666666666667

Nucleotide binding

ATP

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DCAF5
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RAD51B	chr14:69558390	chr14:68934888	ENST00000390683		7	10	1_75	319.0	367.0	RAD51C
Tgene	RAD51B	chr14:69558390	chr14:68934888	ENST00000471583		8	11	1_75	319.0	351.0	RAD51C
Tgene	RAD51B	chr14:69558390	chr14:68934888	ENST00000487270		8	11	1_75	319.0	385.0	RAD51C
Tgene	RAD51B	chr14:69558390	chr14:68934888	ENST00000488612		8	12	1_75	319.0	495.6666666666667	RAD51C
Tgene	RAD51B	chr14:69558391	chr14:68934889	ENST00000390683		7	10	1_75	319.0	367.0	RAD51C
Tgene	RAD51B	chr14:69558391	chr14:68934889	ENST00000471583		8	11	1_75	319.0	351.0	RAD51C
Tgene	RAD51B	chr14:69558391	chr14:68934889	ENST00000487270		8	11	1_75	319.0	385.0	RAD51C
Tgene	RAD51B	chr14:69558391	chr14:68934889	ENST00000488612		8	12	1_75	319.0	495.6666666666667	RAD51C

Top

Related Drugs to DCAF5-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DCAF5-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human