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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DCAF5-RDH11

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DCAF5-RDH11
	FusionPDB ID: 21516
	FusionGDB2.0 ID: 21516
		Hgene	Tgene
	Gene symbol	DCAF5	RDH11
	Gene ID	8816	51109
	Gene name	DDB1 and CUL4 associated factor 5	retinol dehydrogenase 11
	Synonyms	BCRG2\|BCRP2\|D14S1461E\|WDR22	ARSDR1\|CGI82\|HCBP12\|MDT1\|PSDR1\|RALR1\|RDJCSS\|SCALD\|SDR7C1
	Cytomap	14q24.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	DDB1- and CUL4-associated factor 5WD repeat-containing protein 22breakpoint cluster region protein, uterine leiomyoma, 2	retinol dehydrogenase 11HCV core-binding protein HCBP12androgen-regulated short-chain dehydrogenase/reductase 1prostate short-chain dehydrogenase reductase 1retinal reductase 1retinol dehydrogenase 11 (all-trans/9-cis/11-cis)short chain dehydrogenas
	Modification date	20200313	20200313
	UniProtAcc	Q96JK2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000553293, ENST00000554215, ENST00000556847, ENST00000341516, ENST00000389997, ENST00000557386,	ENST00000381346, ENST00000428130, ENST00000553384,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 13 X 8=1560	9 X 7 X 5=315
	# samples	16	9
	** MAII score	log2(16/1560*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DCAF5 [Title/Abstract] AND RDH11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DCAF5(69583083)-RDH11(68159769), # samples:2
Anticipated loss of major functional domain due to fusion event.	DCAF5-RDH11 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DCAF5-RDH11 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RDH11	GO:0001523	retinoid metabolic process	12226107
Tgene	RDH11	GO:0042574	retinal metabolic process	12807874
Tgene	RDH11	GO:0110095	cellular detoxification of aldehyde	12807874

Fusion gene breakpoints across DCAF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RDH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5744-01A	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-
ChimerDB4	PRAD	TCGA-CH-5744	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341516	DCAF5	chr14	69583083	-	ENST00000381346	RDH11	chr14	68159769	-	3216	813	148	1695	515
ENST00000341516	DCAF5	chr14	69583083	-	ENST00000553384	RDH11	chr14	68159769	-	2614	813	148	1656	502
ENST00000341516	DCAF5	chr14	69583083	-	ENST00000428130	RDH11	chr14	68159769	-	1773	813	148	1485	445
ENST00000557386	DCAF5	chr14	69583083	-	ENST00000381346	RDH11	chr14	68159769	-	3090	687	25	1569	514
ENST00000557386	DCAF5	chr14	69583083	-	ENST00000553384	RDH11	chr14	68159769	-	2488	687	25	1530	501
ENST00000557386	DCAF5	chr14	69583083	-	ENST00000428130	RDH11	chr14	68159769	-	1647	687	25	1359	444
ENST00000389997	DCAF5	chr14	69583083	-	ENST00000381346	RDH11	chr14	68159769	-	3073	670	5	1552	515
ENST00000389997	DCAF5	chr14	69583083	-	ENST00000553384	RDH11	chr14	68159769	-	2471	670	5	1513	502
ENST00000389997	DCAF5	chr14	69583083	-	ENST00000428130	RDH11	chr14	68159769	-	1630	670	5	1342	445

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341516	ENST00000381346	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.001367569	0.9986324
ENST00000341516	ENST00000553384	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.006079434	0.99392056
ENST00000341516	ENST00000428130	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.008327008	0.99167293
ENST00000557386	ENST00000381346	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.001292317	0.99870765
ENST00000557386	ENST00000553384	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.004700747	0.9952992
ENST00000557386	ENST00000428130	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.007100219	0.9928998
ENST00000389997	ENST00000381346	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.001262483	0.9987375
ENST00000389997	ENST00000553384	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.005591152	0.9944088
ENST00000389997	ENST00000428130	DCAF5	chr14	69583083	-	RDH11	chr14	68159769	-	0.008002775	0.9919972

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21516_21516_1_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000341516_RDH11_chr14_68159769_ENST00000381346_length(amino acids)=515AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACR
DVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEK
LKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLF

--------------------------------------------------------------

>21516_21516_2_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000341516_RDH11_chr14_68159769_ENST00000428130_length(amino acids)=445AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACR
DVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGSGVTTYSVHPG

--------------------------------------------------------------

>21516_21516_3_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000341516_RDH11_chr14_68159769_ENST00000553384_length(amino acids)=502AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGARVYLACRDVEKGELVAKEIQ
TTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVS
SLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQT

--------------------------------------------------------------

>21516_21516_4_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000389997_RDH11_chr14_68159769_ENST00000381346_length(amino acids)=515AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACR
DVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEK
LKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLF

--------------------------------------------------------------

>21516_21516_5_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000389997_RDH11_chr14_68159769_ENST00000428130_length(amino acids)=445AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACR
DVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGSGVTTYSVHPG

--------------------------------------------------------------

>21516_21516_6_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000389997_RDH11_chr14_68159769_ENST00000553384_length(amino acids)=502AA_BP=221
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGARVYLACRDVEKGELVAKEIQ
TTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVS
SLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQT

--------------------------------------------------------------

>21516_21516_7_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000557386_RDH11_chr14_68159769_ENST00000381346_length(amino acids)=514AA_BP=220
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRD
VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKL
KESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFS

--------------------------------------------------------------

>21516_21516_8_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000557386_RDH11_chr14_68159769_ENST00000428130_length(amino acids)=444AA_BP=220
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRD
VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGSGVTTYSVHPGT

--------------------------------------------------------------

>21516_21516_9_DCAF5-RDH11_DCAF5_chr14_69583083_ENST00000557386_RDH11_chr14_68159769_ENST00000553384_length(amino acids)=501AA_BP=220
MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR
VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPF
CLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGARVYLACRDVEKGELVAKEIQT
TTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSS
LAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSFFIKTPQQGAQTS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:69583083/chr14:68159769)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DCAF5 Q96JK2	.
FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269\|PubMed:16949367, ECO:0000269\|PubMed:16964240}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

140_180

221.66666666666666

943.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

51_91

221.66666666666666

943.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

99_139

221.66666666666666

943.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

51_91

139.66666666666666

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

99_139

139.66666666666666

861.0

Repeat

Note=WD 2

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

51_91

139.66666666666666

861.0

Repeat

Note=WD 1

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

99_139

139.66666666666666

861.0

Repeat

Note=WD 2

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000381346

48_54

24.666666666666668

319.0

Nucleotide binding

NADP

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000428130

48_54

24.666666666666668

249.0

Nucleotide binding

NADP

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000553384

48_54

24.666666666666668

306.0

Nucleotide binding

NADP

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000381346

22_318

24.666666666666668

319.0

Topological domain

Cytoplasmic

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000428130

22_318

24.666666666666668

249.0

Topological domain

Cytoplasmic

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000553384

22_318

24.666666666666668

306.0

Topological domain

Cytoplasmic

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

185_225

221.66666666666666

943.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

277_317

221.66666666666666

943.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000341516

331_370

221.66666666666666

943.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

140_180

139.66666666666666

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

185_225

139.66666666666666

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

277_317

139.66666666666666

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000554215

331_370

139.66666666666666

861.0

Repeat

Note=WD 6

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

140_180

139.66666666666666

861.0

Repeat

Note=WD 3

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

185_225

139.66666666666666

861.0

Repeat

Note=WD 4

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

277_317

139.66666666666666

861.0

Repeat

Note=WD 5

Hgene

DCAF5

chr14:69583083

chr14:68159769

ENST00000556847

331_370

139.66666666666666

861.0

Repeat

Note=WD 6

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000381346

1_21

24.666666666666668

319.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000428130

1_21

24.666666666666668

249.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RDH11

chr14:69583083

chr14:68159769

ENST00000553384

1_21

24.666666666666668

306.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1093_DCAF5_69583083_RDH11_68159769_1093_DCAF5_69583083_RDH11_68159769_ranked_0.pdb	DCAF5	69583083	69583083	ENST00000428130	RDH11	chr14	68159769	-	MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACR DVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEK LKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLF	515

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DCAF5_pLDDT.png

RDH11_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DCAF5
RDH11

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DCAF5-RDH11

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DCAF5-RDH11

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source