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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DCN-VIM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DCN-VIM
FusionPDB ID: 21638
FusionGDB2.0 ID: 21638
HgeneTgene
Gene symbol

DCN

VIM

Gene ID

1634

7431

Gene namedecorinvimentin
SynonymsCSCD|DSPG2|PG40|PGII|PGS2|SLRR1B-
Cytomap

12q21.33

10p13

Type of geneprotein-codingprotein-coding
Descriptiondecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1Bvimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc

P07585

VMAC

Ensembl transtripts involved in fusion geneENST idsENST00000052754, ENST00000228329, 
ENST00000393155, ENST00000420120, 
ENST00000425043, ENST00000547568, 
ENST00000552962, ENST00000303320, 
ENST00000441303, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000548768, ENST00000550099, 
ENST00000551354, 		ENST00000485947, 
ENST00000224237, ENST00000544301, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 2=9842 X 25 X 11=11550
# samples 741
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DCN [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DCN(91545431)-VIM(17278293), # samples:1
Anticipated loss of major functional domain due to fusion event.DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCN

GO:0010508

positive regulation of autophagy

23798385

HgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

HgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

HgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

HgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

HgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across DCN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A0DL-11ADCNchr12

91545431

-VIMchr10

17278293

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393155DCNchr1291545431-ENST00000544301VIMchr1017278293+158111392541195313
ENST00000393155DCNchr1291545431-ENST00000224237VIMchr1017278293+158911392541195313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393155ENST00000544301DCNchr1291545431-VIMchr1017278293+0.0015249080.99847513
ENST00000393155ENST00000224237DCNchr1291545431-VIMchr1017278293+0.0015300830.9984699

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21638_21638_1_DCN-VIM_DCN_chr12_91545431_ENST00000393155_VIM_chr10_17278293_ENST00000224237_length(amino acids)=313AA_BP=293
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQN
NKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH

--------------------------------------------------------------

>21638_21638_2_DCN-VIM_DCN_chr12_91545431_ENST00000393155_VIM_chr10_17278293_ENST00000544301_length(amino acids)=313AA_BP=293
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQN
NKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:91545431/chr10:17278293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCN

P07585

VIM

VMAC

FUNCTION: May affect the rate of fibrils formation.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7854_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5654_67186.0251.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7854_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4554_67186.0251.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3454_67148.0213.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4554_67148.0213.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8954_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7873_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7894_117295.0360.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56118_141186.0251.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56142_162186.0251.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56163_186186.0251.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5673_93186.0251.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5694_117186.0251.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7873_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7894_117295.0360.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45118_141186.0251.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45142_162186.0251.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45163_186186.0251.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4573_93186.0251.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4594_117186.0251.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34118_141148.0213.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3473_93148.0213.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3494_117148.0213.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45118_141148.0213.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4573_93148.0213.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4594_117148.0213.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8973_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8994_117295.0360.0RepeatNote=LRR 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1454_670173.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1354_670.0173.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1254_670.076.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78335_359295.0360.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56187_212186.0251.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56213_233186.0251.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56234_257186.0251.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56258_281186.0251.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56282_304186.0251.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56305_334186.0251.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56335_359186.0251.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14118_1410173.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14142_1620173.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14163_1860173.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14187_2120173.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14213_2330173.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14234_2570173.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14258_2810173.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14282_3040173.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14305_3340173.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14335_3590173.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1473_930173.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1494_1170173.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78335_359295.0360.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45187_212186.0251.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45213_233186.0251.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45234_257186.0251.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45258_281186.0251.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45282_304186.0251.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45305_334186.0251.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45335_359186.0251.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34142_162148.0213.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34163_186148.0213.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34187_212148.0213.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34213_233148.0213.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34234_257148.0213.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34258_281148.0213.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34282_304148.0213.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34305_334148.0213.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34335_359148.0213.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13118_1410.0173.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13142_1620.0173.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13163_1860.0173.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13187_2120.0173.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13213_2330.0173.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13234_2570.0173.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13258_2810.0173.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13282_3040.0173.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13305_3340.0173.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13335_3590.0173.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1373_930.0173.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1394_1170.0173.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12118_1410.076.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12142_1620.076.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12163_1860.076.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12187_2120.076.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12213_2330.076.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12234_2570.076.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12258_2810.076.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12282_3040.076.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12305_3340.076.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12335_3590.076.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1273_930.076.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1294_1170.076.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45142_162148.0213.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45163_186148.0213.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45187_212148.0213.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45213_233148.0213.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45234_257148.0213.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45258_281148.0213.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45282_304148.0213.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45305_334148.0213.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45335_359148.0213.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89335_359295.0360.0RepeatNote=LRR 12
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST000002242376996_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000054430171096_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr12:91545431chr10:17278293ENST00000224237692_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769408_466424.3333333333333467.0RegionNote=Tail
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr12:91545431chr10:17278293ENST000005443017102_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710408_466424.3333333333333467.0RegionNote=Tail


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DCN
VIM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DCN-VIM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DCN-VIM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource