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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DDX39B-C6orf10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DDX39B-C6orf10
FusionPDB ID: 21973
FusionGDB2.0 ID: 21973
HgeneTgene
Gene symbol

DDX39B

C6orf10

Gene ID

7919

10665

Gene nameDExD-box helicase 39Btestis expressed basic protein 1
SynonymsBAT1|D6S81E|UAP56C6orf10|TSBP
Cytomap

6p21.33

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionspliceosome RNA helicase DDX39B56 kDa U2AF65-associated proteinATP-dependent RNA helicase p47DEAD (Asp-Glu-Ala-Asp) box polypeptide 39BDEAD-box helicase 39BHLA-B-associated transcript 1 proteinnuclear RNA helicase (DEAD family)spliceosome RNA helictestis-expressed basic protein 1testis specific basic proteinuncharacterized protein C6orf10
Modification date2020031320200313
UniProtAcc

Q13838

.
Ensembl transtripts involved in fusion geneENST idsENST00000449074, ENST00000376177, 
ENST00000396172, ENST00000417556, 
ENST00000453105, ENST00000458640, 
ENST00000383508, ENST00000400293, 
ENST00000400295, ENST00000400296, 
ENST00000412106, ENST00000412330, 
ENST00000413678, ENST00000414440, 
ENST00000415382, ENST00000415689, 
ENST00000416863, ENST00000430703, 
ENST00000430784, ENST00000431360, 
ENST00000438578, ENST00000441425, 
ENST00000445218, ENST00000446341, 
ENST00000448296, ENST00000450987, 
ENST00000453138, ENST00000453488, 
ENST00000456476, ENST00000456666, 
ENST00000462421, ENST00000463430, 
ENST00000468089, ENST00000470514, 
ENST00000483957, ENST00000489325, 
ENST00000495391, ENST00000546633, 
ENST00000546637, ENST00000547039, 
ENST00000547489, ENST00000548331, 
ENST00000548340, ENST00000548614, 
ENST00000549374, ENST00000550217, 
ENST00000550435, ENST00000551031, 
ENST00000552288, ENST00000552820, 
ENST00000375007, ENST00000375015, 
ENST00000442822, ENST00000447241, 
ENST00000527965, ENST00000533191, 
ENST00000383130, ENST00000383262, 
ENST00000399749, ENST00000413045, 
ENST00000424621, ENST00000425722, 
ENST00000427082, ENST00000438312, 
ENST00000448986, ENST00000449847, 
ENST00000451857, ENST00000457429, 
ENST00000547550, ENST00000548927, 
ENST00000548975, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 6 X 6=2883 X 2 X 3=18
# samples 93
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DDX39B [Title/Abstract] AND C6orf10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DDX39B(31506540)-C6orf10(32337760), # samples:3
Anticipated loss of major functional domain due to fusion event.DDX39B-C6orf10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX39B-C6orf10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX39B-C6orf10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX39B-C6orf10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX39B-C6orf10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX39B

GO:0000245

spliceosomal complex assembly

18593880

HgeneDDX39B

GO:0006406

mRNA export from nucleus

17190602

HgeneDDX39B

GO:0008380

RNA splicing

18593880

HgeneDDX39B

GO:0010501

RNA secondary structure unwinding

18593880

HgeneDDX39B

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across DDX39B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C6orf10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-A5-A7WK-01ADDX39Bchr6

31506540

-C6orf10chr6

32337760

-
ChimerDB4UCECTCGA-A5-A7WKDDX39Bchr6

31506540

-C6orf10chr6

32337760

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458640DDX39Bchr631506540-ENST00000442822C6orf10chr632337760-24239339412326461
ENST00000458640DDX39Bchr631506540-ENST00000447241C6orf10chr632337760-28959339412611556
ENST00000458640DDX39Bchr631506540-ENST00000375015C6orf10chr632337760-28929339412608555
ENST00000458640DDX39Bchr631506540-ENST00000533191C6orf10chr632337760-28899339412605554
ENST00000458640DDX39Bchr631506540-ENST00000527965C6orf10chr632337760-28309339412563540
ENST00000458640DDX39Bchr631506540-ENST00000375007C6orf10chr632337760-28729339412605554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458640ENST00000442822DDX39Bchr631506540-C6orf10chr632337760-0.0027515260.9972485
ENST00000458640ENST00000447241DDX39Bchr631506540-C6orf10chr632337760-0.0021829410.99781704
ENST00000458640ENST00000375015DDX39Bchr631506540-C6orf10chr632337760-0.0012725520.9987274
ENST00000458640ENST00000533191DDX39Bchr631506540-C6orf10chr632337760-0.0014830210.998517
ENST00000458640ENST00000527965DDX39Bchr631506540-C6orf10chr632337760-0.0017010420.99829894
ENST00000458640ENST00000375007DDX39Bchr631506540-C6orf10chr632337760-0.0015017860.9984982

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>21973_21973_1_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000375007_length(amino acids)=554AA_BP=387
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSGNLCFQRSKRDYTPSTNSLVSMASKFSLGQTE
LILLLMCFILALSRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPIIIS
QRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGK
GTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVE
KSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVK
NTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRA

--------------------------------------------------------------

>21973_21973_2_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000375015_length(amino acids)=555AA_BP=388
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSDTSYDNRERSKRDYTPSTNSLALSRSSIALPQ
GSMSSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNVRSHPHTITGPPSAPRGPPMAPIIISQRTASQ
LAAPIRIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREG
KGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQV
EKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQV
KNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKR

--------------------------------------------------------------

>21973_21973_3_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000442822_length(amino acids)=461AA_BP=
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSERSKRDYTPSTNSLALSRSSIALPQGSMSSIK
CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPIIISQRTASQLAAPIIISQRTARIP
QVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKD
KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVP
RRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTECFRN

--------------------------------------------------------------

>21973_21973_4_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000447241_length(amino acids)=556AA_BP=389
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQ
TELILLLMCFILALSRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPII
ISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPERE
GKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQ
VEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQ
VKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSK

--------------------------------------------------------------

>21973_21973_5_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000527965_length(amino acids)=540AA_BP=373
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSERSKRDYTPSTNSLALSRSSIALPQGSMSSIK
CLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPIIISQRTASQLAAPIRIPQVHTMDS
SGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGKGTDLEKDKIGMEVK
VDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQV
KKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQV
KKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRAKANTGRKYNKKVEE

--------------------------------------------------------------

>21973_21973_6_DDX39B-C6orf10_DDX39B_chr6_31506540_ENST00000458640_C6orf10_chr6_32337760_ENST00000533191_length(amino acids)=554AA_BP=387
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSDTSYDNRERSKRDYTPSTNSLALSRSSIALPQ
GSMSSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPIIISQRTASQLAAPIIIS
QRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPEREGK
GTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVE
KSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVK
NTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSKRA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31506540/chr6:32337760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX39B

Q13838

.
FUNCTION: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000396172-41145_73144.0429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000458640-41145_73144.0429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000396172-41189_96144.0429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000458640-41189_96144.0429.0Nucleotide bindingNote=ATP
TgeneC6orf10chr6:31506540chr6:32337760ENST00000375015026474_5604.333333333333333563.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST00000383130023474_5600564.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST00000399749023474_5600564.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST00000447241023474_5604.333333333333333564.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST00000448986026474_5600563.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST00000457429023474_5600564.0Compositional biasNote=Lys-rich
TgeneC6orf10chr6:31506540chr6:32337760ENST000003750150263_234.333333333333333563.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000037501502699_1194.333333333333333563.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST000003831300233_230564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000038313002399_1190564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST000003997490233_230564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000039974902399_1190564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST000004472410233_234.333333333333333564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000044724102399_1194.333333333333333564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST000004489860263_230563.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000044898602699_1190563.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST000004574290233_230564.0TransmembraneHelical
TgeneC6orf10chr6:31506540chr6:32337760ENST0000045742902399_1190564.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000383508-113261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000383508-11376_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000396172-411261_422144.0429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000396172-41176_249144.0429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400295-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400295-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400296-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400296-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412106-113261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412106-11376_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412330-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412330-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000413678-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000413678-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000414440-113261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000414440-11376_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000415689-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000415689-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000416863-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000416863-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000430784-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000430784-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000431360-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000431360-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000441425-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000441425-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000445218-113261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000445218-11376_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000448296-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000448296-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000453138-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000453138-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456476-111261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456476-11176_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456666-113261_4220429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456666-11376_2490429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000458640-411261_422144.0429.0DomainHelicase C-terminal
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000458640-41176_249144.0429.0DomainHelicase ATP-binding
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000383508-113196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000383508-11345_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000396172-411196_199144.0429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400295-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400295-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400296-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400296-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412106-113196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412106-11345_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412330-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412330-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000413678-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000413678-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000414440-113196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000414440-11345_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000415689-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000415689-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000416863-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000416863-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000430784-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000430784-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000431360-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000431360-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000441425-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000441425-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000445218-113196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000445218-11345_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000448296-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000448296-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000453138-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000453138-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456476-111196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456476-11145_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456666-113196_1990429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456666-11345_730429.0MotifNote=Q motif
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000458640-411196_199144.0429.0MotifNote=DECD box
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000383508-11389_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400295-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000400296-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412106-11389_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000412330-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000413678-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000414440-11389_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000415689-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000416863-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000430784-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000431360-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000441425-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000445218-11389_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000448296-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000453138-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456476-11189_960429.0Nucleotide bindingNote=ATP
HgeneDDX39Bchr6:31506540chr6:32337760ENST00000456666-11389_960429.0Nucleotide bindingNote=ATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1190_DDX39B_31506540_C6orf10_32337760_1190_DDX39B_31506540_C6orf10_32337760_ranked_0.pdbDDX39B3150654031506540ENST00000375007C6orf10chr632337760-
MAVILTLLGLAILAILLTRWARCKQSEMYISRYSSEQSARLLDYEDGRGSRHAYSTQSDTSYDNRERSKRDYTPSTNSLVSMASKFSLGQ
TELILLLMCFILALSRSSIGSIKCLQTTEEPPSRTAGAMMQFTAPIPGATGPIKLSQKTIVQTPGPIVQYPGSNAGPPSAPRGPPMAPII
ISQRTARIPQVHTMDSSGKITLTPVVILTGYMDEELAKKSCSKIQILKCGGTARSQNSREENKEALKNDIIFTNSVESLKSAHIKEPERE
GKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQ
VEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQ
VKNTEVSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRESEINGEKSKGSK
556


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
DDX39B_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DDX39B
C6orf10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DDX39B-C6orf10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DDX39B-C6orf10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource