UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:DDX58-KDM4C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DDX58-KDM4C
FusionPDB ID: 22058
FusionGDB2.0 ID: 22058
HgeneTgene
Gene symbol

DDX58

KDM4C

Gene ID

23586

23081

Gene nameDExD/H-box helicase 58lysine demethylase 4C
SynonymsRIG-I|RIG1|RIGI|RLR-1|SGMRT2GASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

9p21.1

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionprobable ATP-dependent RNA helicase DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 58DEAD box protein 58DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptideRNA helicase RIG-Iretinoic acid-inducible gene 1 proteinretinoic acid-inducible gene I proteinlysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2020032920200329
UniProtAcc

O95786

Q9H3R0

Ensembl transtripts involved in fusion geneENST idsENST00000379868, ENST00000379882, 
ENST00000379883, ENST00000542096, 
ENST00000545044, 		ENST00000401787, 
ENST00000428870, ENST00000489243, 
ENST00000536108, ENST00000381306, 
ENST00000381309, ENST00000442236, 
ENST00000535193, ENST00000543771, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 6=29422 X 22 X 7=3388
# samples 926
** MAII scorelog2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3388*10)=-3.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DDX58 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DDX58(32491298)-KDM4C(7011697), # samples:1
Anticipated loss of major functional domain due to fusion event.DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DDX58-KDM4C seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DDX58-KDM4C seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
DDX58-KDM4C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DDX58-KDM4C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDDX58

GO:0009597

detection of virus

17079289

HgeneDDX58

GO:0010628

positive regulation of gene expression

24409285

HgeneDDX58

GO:0030334

regulation of cell migration

19122199

HgeneDDX58

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

24409285

HgeneDDX58

GO:0032727

positive regulation of interferon-alpha production

19576794

HgeneDDX58

GO:0032728

positive regulation of interferon-beta production

17079289

HgeneDDX58

GO:0032755

positive regulation of interleukin-6 production

24409285

HgeneDDX58

GO:0032757

positive regulation of interleukin-8 production

24409285

HgeneDDX58

GO:0039529

RIG-I signaling pathway

28469175

HgeneDDX58

GO:0045944

positive regulation of transcription by RNA polymerase II

17079289

HgeneDDX58

GO:0051091

positive regulation of DNA-binding transcription factor activity

17079289

HgeneDDX58

GO:0051607

defense response to virus

21478870

TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across DDX58 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5381NDDX58chr9

32491298

-KDM4Cchr9

7011697

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379882DDX58chr932491298-ENST00000535193KDM4Cchr97011697+21817141401369409
ENST00000379882DDX58chr932491298-ENST00000543771KDM4Cchr97011697+21817141401369409
ENST00000379882DDX58chr932491298-ENST00000381306KDM4Cchr97011697+29647141402071643
ENST00000379882DDX58chr932491298-ENST00000381309KDM4Cchr97011697+30187141402098652
ENST00000379882DDX58chr932491298-ENST00000442236KDM4Cchr97011697+21947141402098652
ENST00000379868DDX58chr932491298-ENST00000535193KDM4Cchr97011697+20525855031240245
ENST00000379868DDX58chr932491298-ENST00000543771KDM4Cchr97011697+20525855031240245
ENST00000379868DDX58chr932491298-ENST00000381306KDM4Cchr97011697+28355855031942479
ENST00000379868DDX58chr932491298-ENST00000381309KDM4Cchr97011697+28895855031969488
ENST00000379868DDX58chr932491298-ENST00000442236KDM4Cchr97011697+20655855031969488
ENST00000379883DDX58chr932491298-ENST00000535193KDM4Cchr97011697+23168491401504454
ENST00000379883DDX58chr932491298-ENST00000543771KDM4Cchr97011697+23168491401504454
ENST00000379883DDX58chr932491298-ENST00000381306KDM4Cchr97011697+30998491402206688
ENST00000379883DDX58chr932491298-ENST00000381309KDM4Cchr97011697+31538491402233697
ENST00000379883DDX58chr932491298-ENST00000442236KDM4Cchr97011697+23298491402233697
ENST00000545044DDX58chr932491298-ENST00000535193KDM4Cchr97011697+20395724901227245
ENST00000545044DDX58chr932491298-ENST00000543771KDM4Cchr97011697+20395724901227245
ENST00000545044DDX58chr932491298-ENST00000381306KDM4Cchr97011697+28225724901929479
ENST00000545044DDX58chr932491298-ENST00000381309KDM4Cchr97011697+28765724901956488
ENST00000545044DDX58chr932491298-ENST00000442236KDM4Cchr97011697+20525724901956488

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379882ENST00000535193DDX58chr932491298-KDM4Cchr97011697+0.0007288930.9992711
ENST00000379882ENST00000543771DDX58chr932491298-KDM4Cchr97011697+0.0007288930.9992711
ENST00000379882ENST00000381306DDX58chr932491298-KDM4Cchr97011697+0.0007075390.9992925
ENST00000379882ENST00000381309DDX58chr932491298-KDM4Cchr97011697+0.0006358520.9993642
ENST00000379882ENST00000442236DDX58chr932491298-KDM4Cchr97011697+0.002011760.9979882
ENST00000379868ENST00000535193DDX58chr932491298-KDM4Cchr97011697+0.0024677730.99753225
ENST00000379868ENST00000543771DDX58chr932491298-KDM4Cchr97011697+0.0024677730.99753225
ENST00000379868ENST00000381306DDX58chr932491298-KDM4Cchr97011697+0.0004403040.9995597
ENST00000379868ENST00000381309DDX58chr932491298-KDM4Cchr97011697+0.0004272950.9995727
ENST00000379868ENST00000442236DDX58chr932491298-KDM4Cchr97011697+0.0016294330.9983706
ENST00000379883ENST00000535193DDX58chr932491298-KDM4Cchr97011697+0.0006381310.99936193
ENST00000379883ENST00000543771DDX58chr932491298-KDM4Cchr97011697+0.0006381310.99936193
ENST00000379883ENST00000381306DDX58chr932491298-KDM4Cchr97011697+0.0006983570.9993017
ENST00000379883ENST00000381309DDX58chr932491298-KDM4Cchr97011697+0.0006060960.99939394
ENST00000379883ENST00000442236DDX58chr932491298-KDM4Cchr97011697+0.0021555030.99784446
ENST00000545044ENST00000535193DDX58chr932491298-KDM4Cchr97011697+0.0024745410.9975255
ENST00000545044ENST00000543771DDX58chr932491298-KDM4Cchr97011697+0.0024745410.9975255
ENST00000545044ENST00000381306DDX58chr932491298-KDM4Cchr97011697+0.0004321250.9995679
ENST00000545044ENST00000381309DDX58chr932491298-KDM4Cchr97011697+0.000418170.9995819
ENST00000545044ENST00000442236DDX58chr932491298-KDM4Cchr97011697+0.001567530.99843246

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22058_22058_1_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379868_KDM4C_chr9_7011697_ENST00000381306_length(amino acids)=479AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSSPH

--------------------------------------------------------------

>22058_22058_2_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379868_KDM4C_chr9_7011697_ENST00000381309_length(amino acids)=488AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQG

--------------------------------------------------------------

>22058_22058_3_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379868_KDM4C_chr9_7011697_ENST00000442236_length(amino acids)=488AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQG

--------------------------------------------------------------

>22058_22058_4_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379868_KDM4C_chr9_7011697_ENST00000535193_length(amino acids)=245AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR

--------------------------------------------------------------

>22058_22058_5_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379868_KDM4C_chr9_7011697_ENST00000543771_length(amino acids)=245AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR

--------------------------------------------------------------

>22058_22058_6_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379882_KDM4C_chr9_7011697_ENST00000381306_length(amino acids)=643AA_BP=189
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSE
CLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPEC
QNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDE
VVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGA
LKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWP
YVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQ
VKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSSPHVSQAQQETYLGFWINS

--------------------------------------------------------------

>22058_22058_7_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379882_KDM4C_chr9_7011697_ENST00000381309_length(amino acids)=652AA_BP=189
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSE
CLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPEC
QNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDE
VVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGA
LKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWP
YVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQ
VKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEY

--------------------------------------------------------------

>22058_22058_8_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379882_KDM4C_chr9_7011697_ENST00000442236_length(amino acids)=652AA_BP=189
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSE
CLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPEC
QNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDE
VVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGA
LKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWP
YVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQ
VKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGERKRQRVLSSRFKNEY

--------------------------------------------------------------

>22058_22058_9_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379882_KDM4C_chr9_7011697_ENST00000535193_length(amino acids)=409AA_BP=189
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSE
CLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPEC
QNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDE
VVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGA

--------------------------------------------------------------

>22058_22058_10_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379882_KDM4C_chr9_7011697_ENST00000543771_length(amino acids)=409AA_BP=189
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSE
CLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPEC
QNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDE
VVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGA

--------------------------------------------------------------

>22058_22058_11_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379883_KDM4C_chr9_7011697_ENST00000381306_length(amino acids)=688AA_BP=234
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSG
LYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLA
LEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFA
AEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCA
KCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLK
CIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRV
MAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEE

--------------------------------------------------------------

>22058_22058_12_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379883_KDM4C_chr9_7011697_ENST00000381309_length(amino acids)=697AA_BP=234
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSG
LYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLA
LEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFA
AEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCA
KCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLK
CIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRV
MAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEE

--------------------------------------------------------------

>22058_22058_13_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379883_KDM4C_chr9_7011697_ENST00000442236_length(amino acids)=697AA_BP=234
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSG
LYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLA
LEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFA
AEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCA
KCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLK
CIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRV
MAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEE

--------------------------------------------------------------

>22058_22058_14_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379883_KDM4C_chr9_7011697_ENST00000535193_length(amino acids)=454AA_BP=234
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSG
LYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLA
LEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFA
AEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCA
KCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLG

--------------------------------------------------------------

>22058_22058_15_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000379883_KDM4C_chr9_7011697_ENST00000543771_length(amino acids)=454AA_BP=234
MQAEAGMTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSG
LYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLA
LEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFA
AEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCA
KCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLG

--------------------------------------------------------------

>22058_22058_16_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000545044_KDM4C_chr9_7011697_ENST00000381306_length(amino acids)=479AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFVSAGRCHLGTCQVNSLSSPH

--------------------------------------------------------------

>22058_22058_17_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000545044_KDM4C_chr9_7011697_ENST00000381309_length(amino acids)=488AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQG

--------------------------------------------------------------

>22058_22058_18_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000545044_KDM4C_chr9_7011697_ENST00000442236_length(amino acids)=488AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR
NAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHV
TCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVS
RDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQG

--------------------------------------------------------------

>22058_22058_19_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000545044_KDM4C_chr9_7011697_ENST00000535193_length(amino acids)=245AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR

--------------------------------------------------------------

>22058_22058_20_DDX58-KDM4C_DDX58_chr9_32491298_ENST00000545044_KDM4C_chr9_7011697_ENST00000543771_length(amino acids)=245AA_BP=25
METSDIQIFYQEDPECQNLSENSCPPSELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPD
SSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32491298/chr9:7011697)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DDX58

O95786

KDM4C

Q9H3R0

FUNCTION: Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotaviruses and reoviruses. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. {ECO:0000269|PubMed:15208624, ECO:0000269|PubMed:15708988, ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:17190814, ECO:0000269|PubMed:18636086, ECO:0000269|PubMed:19122199, ECO:0000269|PubMed:19211564, ECO:0000269|PubMed:19576794, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:21742966, ECO:0000269|PubMed:28469175, ECO:0000269|PubMed:29117565, ECO:0000269|PubMed:31006531}.FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-4171_87185.33333333333334881.0DomainNote=CARD 1
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-41792_172185.33333333333334881.0DomainNote=CARD 2
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-5181_87230.33333333333334926.0DomainNote=CARD 1
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-51892_172230.33333333333334926.0DomainNote=CARD 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121877_934595.33333333333341048.0DomainNote=Tudor 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121935_991595.33333333333341048.0DomainNote=Tudor 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122877_934595.33333333333341057.0DomainNote=Tudor 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122935_991595.33333333333341057.0DomainNote=Tudor 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118877_934617.3333333333334836.0DomainNote=Tudor 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118935_991617.3333333333334836.0DomainNote=Tudor 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118877_934595.3333333333334814.0DomainNote=Tudor 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118935_991595.3333333333334814.0DomainNote=Tudor 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121689_747595.33333333333341048.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121752_785595.33333333333341048.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121808_865595.33333333333341048.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122689_747595.33333333333341057.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122752_785595.33333333333341057.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122808_865595.33333333333341057.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118689_747617.3333333333334836.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118752_785617.3333333333334836.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118808_865617.3333333333334836.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118689_747595.3333333333334814.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118752_785595.3333333333334814.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118808_865595.3333333333334814.0Zinc fingerPHD-type 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417251_430185.33333333333334881.0DomainHelicase ATP-binding
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417610_776185.33333333333334881.0DomainHelicase C-terminal
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417794_925185.33333333333334881.0DomainRLR CTR
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518251_430230.33333333333334926.0DomainHelicase ATP-binding
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518610_776230.33333333333334926.0DomainHelicase C-terminal
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518794_925230.33333333333334926.0DomainRLR CTR
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417372_375185.33333333333334881.0MotifNote=DECH box
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518372_375230.33333333333334926.0MotifNote=DECH box
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417264_271185.33333333333334881.0Nucleotide bindingATP
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518264_271230.33333333333334926.0Nucleotide bindingATP
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813061121144_310595.33333333333341048.0DomainJmjC
TgeneKDM4Cchr9:32491298chr9:7011697ENST00000381306112116_58595.33333333333341048.0DomainJmjN
TgeneKDM4Cchr9:32491298chr9:7011697ENST000003813091122144_310595.33333333333341057.0DomainJmjC
TgeneKDM4Cchr9:32491298chr9:7011697ENST00000381309112216_58595.33333333333341057.0DomainJmjN
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005351931118144_310617.3333333333334836.0DomainJmjC
TgeneKDM4Cchr9:32491298chr9:7011697ENST00000535193111816_58617.3333333333334836.0DomainJmjN
TgeneKDM4Cchr9:32491298chr9:7011697ENST000005437711118144_310595.3333333333334814.0DomainJmjC
TgeneKDM4Cchr9:32491298chr9:7011697ENST00000543771111816_58595.3333333333334814.0DomainJmjN


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DDX58
KDM4C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDDX58chr9:32491298chr9:7011697ENST00000379882-417218_925185.33333333333334881.0ZC3HAV1
HgeneDDX58chr9:32491298chr9:7011697ENST00000379883-518218_925230.33333333333334926.0ZC3HAV1


Top

Related Drugs to DDX58-KDM4C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to DDX58-KDM4C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource