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Fusion Protein:DDX5-ATP6V0C |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: DDX5-ATP6V0C | FusionPDB ID: 22071 | FusionGDB2.0 ID: 22071 | Hgene | Tgene | Gene symbol | DDX5 | ATP6V0C | Gene ID | 1655 | 527 |
Gene name | DEAD-box helicase 5 | ATPase H+ transporting V0 subunit c | |
Synonyms | G17P1|HLR1|HUMP68|p68 | ATP6C|ATP6L|ATPL|VATL|VPPC|Vma3 | |
Cytomap | 17q23.3 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | probable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h | V-type proton ATPase 16 kDa proteolipid subunitATPase, H+ transporting, lysosomal 16kDa, V0 subunit cH(+)-transporting two-sector ATPase, 16 kDa subunitV-ATPase 16 kDa proteolipid subunitvacuolar ATP synthase 16 kDa proteolipid subunitvacuolar H+ ATP | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q5T1V6 | P27449 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000225792, ENST00000450599, ENST00000578804, ENST00000580026, | ENST00000564973, ENST00000565223, ENST00000330398, ENST00000568562, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 33 X 25 X 10=8250 | 8 X 8 X 3=192 |
# samples | 27 | 9 | |
** MAII score | log2(27/8250*10)=-4.93336280696971 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: DDX5 [Title/Abstract] AND ATP6V0C [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DDX5(62502194)-ATP6V0C(2569219), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | DDX5-ATP6V0C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-ATP6V0C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DDX5-ATP6V0C seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. DDX5-ATP6V0C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DDX5-ATP6V0C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DDX5-ATP6V0C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDX5 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15298701 |
Hgene | DDX5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21343338 |
Hgene | DDX5 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 23788676 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315404 | DDX5 | chr17 | 62502194 | - | ATP6V0C | chr16 | 2569219 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000225792 | DDX5 | chr17 | 62502194 | - | ENST00000568562 | ATP6V0C | chr16 | 2569219 | + | 769 | 446 | 738 | 235 | 167 |
ENST00000450599 | DDX5 | chr17 | 62502194 | - | ENST00000568562 | ATP6V0C | chr16 | 2569219 | + | 535 | 212 | 504 | 1 | 167 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000225792 | ENST00000568562 | DDX5 | chr17 | 62502194 | - | ATP6V0C | chr16 | 2569219 | + | 0.6253918 | 0.37460816 |
ENST00000450599 | ENST00000568562 | DDX5 | chr17 | 62502194 | - | ATP6V0C | chr16 | 2569219 | + | 0.3010942 | 0.69890577 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >22071_22071_1_DDX5-ATP6V0C_DDX5_chr17_62502194_ENST00000225792_ATP6V0C_chr16_2569219_ENST00000568562_length(amino acids)=167AA_BP=1 MLGGAPHASVPHDADGKAGCQAAQAHAQAGAQLEEALVEADVVIQGVGDEDCHHQAVDGDDASHDHWDDGLHDLLRPHDRHGRNAGTALG -------------------------------------------------------------- >22071_22071_2_DDX5-ATP6V0C_DDX5_chr17_62502194_ENST00000450599_ATP6V0C_chr16_2569219_ENST00000568562_length(amino acids)=167AA_BP=1 MLGGAPHASVPHDADGKAGCQAAQAHAQAGAQLEEALVEADVVIQGVGDEDCHHQAVDGDDASHDHWDDGLHDLLRPHDRHGRNAGTALG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:62502194/chr16:2569219) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
DDX5 | ATP6V0C |
FUNCTION: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 115_131 | 26.333333333333332 | 156.0 | Topological domain | Cytoplasmic | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 153_155 | 26.333333333333332 | 156.0 | Topological domain | Lumenal | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 34_55 | 26.333333333333332 | 156.0 | Topological domain | Cytoplasmic | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 77_92 | 26.333333333333332 | 156.0 | Topological domain | Lumenal | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 132_152 | 26.333333333333332 | 156.0 | Transmembrane | Helical | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 56_76 | 26.333333333333332 | 156.0 | Transmembrane | Helical | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 93_114 | 26.333333333333332 | 156.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 125_300 | 14.666666666666666 | 615.0 | Domain | Helicase ATP-binding |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 328_475 | 14.666666666666666 | 615.0 | Domain | Helicase C-terminal |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 248_251 | 14.666666666666666 | 615.0 | Motif | Note=DEAD box |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 94_122 | 14.666666666666666 | 615.0 | Motif | Note=Q motif |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 114_116 | 14.666666666666666 | 615.0 | Nucleotide binding | Note=ATP |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 138_145 | 14.666666666666666 | 615.0 | Nucleotide binding | Note=ATP |
Hgene | DDX5 | chr17:62502194 | chr16:2569219 | ENST00000225792 | - | 1 | 13 | 477_614 | 14.666666666666666 | 615.0 | Region | Note=Transactivation domain |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 1_10 | 26.333333333333332 | 156.0 | Topological domain | Lumenal | |
Tgene | ATP6V0C | chr17:62502194 | chr16:2569219 | ENST00000330398 | 0 | 3 | 11_33 | 26.333333333333332 | 156.0 | Transmembrane | Helical |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
DDX5 | STK24, HDAC1, CREBBP, EP300, AKAP8, FBL, OTUB1, MEPCE, CDK9, HNRNPA1, HNRNPH1, KHDRBS2, IPO11, TCEA1, AIRE, MYOD1, SMARCA4, TBP, POLR2A, MGMT, SRRM1, SRRM2, tat, PIAS1, MBD3, CHD3, ESR1, TADA2A, SMN1, CD4, DGCR8, ZWINT, Cdk1, AI837181, Ybx1, CALM1, EBNA-LP, PIK3CA, PSMA3, TNNT1, VHL, SMARCAD1, YY1, NDRG1, HDGF, CENPA, MBNL1, SF3A2, ARRB2, ERG, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, DDX5, DDX17, HDAC2, HDAC3, BBLF2-BBLF3, INPPL1, SHC1, CRK, AKT1, DHX15, SRSF1, SF3B3, U2AF2, DHX38, SNRPA1, EIF4A3, PRKDC, SF3A1, HNRNPM, HNRNPF, SNRPD1, RBMX, SYNCRIP, U2AF1, SART1, PRPF40A, IGF2BP3, SNW1, PRPF19, SNRPD2, VTN, MCM7, SYN1, RPS20, XRCC4, RPS16, HNRNPA0, EEF2, PRSS1, THRAP3, GOLIM4, EPRS, RPL19, SRP14, SMURF1, FN1, VCAM1, RBM10, WBP11, HNRNPK, DHX9, RBM4, HNRNPH2, HNRNPH3, KHDRBS1, RBFOX2, IL7R, MAP1LC3A, ITGA4, CTNNB1, CD81, IGSF8, FBXW4, FBXO46, SP1, MAPK10, FBXO6, TARDBP, PARK2, PIN1, DBNL, ERO1L, FKBP10, LRSAM1, PABPC4, PRPSAP1, WDR4, rev, RPA1, RPA2, RPA3, STAU1, MDM2, SPRTN, AURKA, AURKB, CEP250, TP53, TUBGCP3, FUS, MAPKAPK2, DROSHA, NXF1, CUL7, OBSL1, CCDC8, UBE2I, EZH2, SUZ12, EED, RNF2, SMAD3, ABL1, ARAF, CDK2, DAPK1, ILK, MAST3, SGK2, SRPK1, TNK1, TYK2, LUZP4, RPS6KB2, UNK, NTRK1, ATXN2, ATXN2L, C14orf166, CPSF6, DDX18, DNAJC2, ELAC2, GTPBP4, HNRNPR, IMPDH1, SBDS, SKIV2L2, TRMT6, DHX36, EDC4, EIF2A, GMPS, LUC7L2, NACA, UPF1, SFN, SCARNA22, FRS3, gag, XPO1, HNRNPU, RPL10, MATR3, Bcas2, Bag2, Fus, SKI, MCM2, MCM5, Ksr1, CDC5L, CDC37, CRBN, CBX7, RYBP, WWP2, DERL1, EGFR, YPEL5, RMND5A, MAEA, RANBP9, ARMC8, NR2E1, CYLD, CD2BP2, INO80B, TRIM25, HOTAIR, HEY1, BRCA1, LMNA, MTF1, FBXO7, IQGAP1, TMPO, WDR77, MTCH2, PCBP1, PPIE, CCNT1, GSK3A, MAP2K3, MED12, POLD1, TGFB1, TRIP4, ZNF217, PRPF8, EFTUD2, AAR2, PIH1D1, TNIP2, CHD4, LARP7, RNF4, TNF, RIOK1, SQSTM1, HEXIM1, RUNX1, DPF2, RNF123, NBN, SNAI1, AGR2, RECQL4, ZFP36L2, CNTNAP1, MYC, Prkaa1, Prkab1, CDK5RAP2, METTL3, METTL14, WTAP, KIAA1429, PSME3, PHF1, PHB, FAF1, RBX1, KIN, USP14, NR2C2, UCHL3, PPP1CC, SETD1A, ZFYVE21, XRCC6, CTCF, AGRN, VRK1, HIST1H4A, PSMD14, APEX1, SNRNP70, EWSR1, TAF15, SNRPC, ITFG1, GSK3B, CDC6, BIRC3, BRD7, ERCC6, SOX2, TRIM28, CMTR1, PLEKHA4, MAGEA3, KCTD10, PINK1, YAP1, TFCP2, FANCD2, ORF50, ZC3H18, PTK6, STAG2, MAU2, HSCB, CELF1, ELAVL1, DUX4L9, DUX4, CIT, ANLN, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, ACACA, C12orf49, INS, SUMO2, NDN, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, nsp13ab, LGALS9, IFI16, EIF3F, DDX58, OGT, SPOP, UFL1, DDRGK1, NR4A1, DDX23, NIFK, RPL31, SLC26A4-AS1, E2F1, FZR1, WDR5, PAGE4, NAA40, BTF3, AGO2, AGO1, RCHY1, NBR1, nsp14, RB1CC1, DDX3X, ZEB1, |
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Gene | STRING network |
DDX5 | ![]() |
ATP6V0C |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to DDX5-ATP6V0C |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to DDX5-ATP6V0C |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DDX5 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | DDX5 | C0269102 | Endometrioma | 1 | CTD_human |