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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DISP2-CREBBP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DISP2-CREBBP
FusionPDB ID: 22945
FusionGDB2.0 ID: 22945
HgeneTgene
Gene symbol

DISP2

CREBBP

Gene ID

85455

1387

Gene namedispatched RND transporter family member 2CREB binding protein
SynonymsC15orf36|DISPB|HsT16908|LINC00594CBP|KAT3A|MKHK1|RSTS|RSTS1
Cytomap

15q15.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein dispatched homolog 2dispatched Blong intergenic non-protein coding RNA 594CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP
Modification date2020031320200329
UniProtAcc

A7MBM2

Q92793

Ensembl transtripts involved in fusion geneENST idsENST00000267889, ENST00000262367, 
ENST00000382070, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=4818 X 30 X 8=4320
# samples 428
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/4320*10)=-3.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DISP2 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DISP2(40657926)-CREBBP(3860780), # samples:1
Anticipated loss of major functional domain due to fusion event.DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DISP2-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across DISP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CREBBP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H5DISP2chr15

40657926

+CREBBPchr16

3860780

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267889DISP2chr1540657926+ENST00000262367CREBBPchr163860780-1022710328775622491
ENST00000267889DISP2chr1540657926+ENST00000382070CREBBPchr163860780-762810328774482453

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267889ENST00000262367DISP2chr1540657926+CREBBPchr163860780-0.0029797930.9970202
ENST00000267889ENST00000382070DISP2chr1540657926+CREBBPchr163860780-0.0101855970.9898144

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22945_22945_1_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000262367_length(amino acids)=2491AA_BP=314
MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAP
AHFTYPRALQEYQGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVI
FLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLE
DRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFP
TDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAG
KACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLP
YMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAA
PPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRS
RLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPG
MAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQS
PLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVAT
PQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQ
VKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLG
IPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTL
CCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDII
WPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPY
RTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDD
YIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAA
SETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLM
DGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDD
EGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVP
FCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPT
TVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQW
QQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVAN
QPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQ
QQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQAL
QQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTG

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>22945_22945_2_DISP2-CREBBP_DISP2_chr15_40657926_ENST00000267889_CREBBP_chr16_3860780_ENST00000382070_length(amino acids)=2453AA_BP=314
MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTKAVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAP
AHFTYPRALQEYQGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVI
FLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLE
DRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFP
TDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAG
KACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPM
NIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPA
ALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLS
LPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQF
PSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPS
TPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVA
SAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNG
TASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWL
MFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENV
TLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLE
DRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRV
YISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDY
KDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPS
MPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQG
QDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNAN
CSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQ
QSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQ
QHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPP
RSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGV
PRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGG
YPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASH
LPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:40657926/chr16:3860780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DISP2

A7MBM2

CREBBP

Q92793

FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78170_190315.01402.0TransmembraneHelical
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311061_1064266.02443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311199_1487266.02443.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311555_1562266.02443.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311943_1948266.02443.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311967_1970266.02443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312081_2085266.02443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312199_2216266.02443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312245_2248266.02443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671312297_2300266.02443.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301061_1064266.02405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301199_1487266.02405.0Compositional biasNote=Cys/His-rich
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301555_1562266.02405.0Compositional biasNote=Poly-Glu
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301943_1948266.02405.0Compositional biasNote=Poly-Pro
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301967_1970266.02405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302081_2085266.02405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302199_2216266.02405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302245_2248266.02405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701302297_2300266.02405.0Compositional biasNote=Poly-Gln
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311103_1175266.02443.0DomainBromo
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311323_1700266.02443.0DomainCBP/p300-type HAT
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131587_666266.02443.0DomainKIX
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301103_1175266.02405.0DomainBromo
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301323_1700266.02405.0DomainCBP/p300-type HAT
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130587_666266.02405.0DomainKIX
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311434_1436266.02443.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311446_1447266.02443.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301434_1436266.02405.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301446_1447266.02405.0RegionAcetyl-CoA binding
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311701_1744266.02443.0Zinc fingerZZ-type
TgeneCREBBPchr15:40657926chr16:3860780ENST000002623671311765_1846266.02443.0Zinc fingerTAZ-type 2
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131347_433266.02443.0Zinc fingerTAZ-type 1
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301701_1744266.02405.0Zinc fingerZZ-type
TgeneCREBBPchr15:40657926chr16:3860780ENST000003820701301765_1846266.02405.0Zinc fingerTAZ-type 2
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130347_433266.02405.0Zinc fingerTAZ-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78471_643315.01402.0DomainSSD
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781019_1039315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781064_1084315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+781088_1108315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78484_504315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78510_530315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78542_562315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78589_609315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78617_637315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78704_724315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78964_984315.01402.0TransmembraneHelical
HgeneDISP2chr15:40657926chr16:3860780ENST00000267889+78990_1010315.01402.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CREBBPEGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DISP2
CREBBPall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCREBBPchr15:40657926chr16:3860780ENST00000262367131227_410266.02443.0SRCAP
TgeneCREBBPchr15:40657926chr16:3860780ENST00000382070130227_410266.02405.0SRCAP


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Related Drugs to DISP2-CREBBP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DISP2-CREBBP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
TgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
TgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
TgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
TgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
TgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneCREBBPC0005695Bladder Neoplasm1CTD_human
TgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
TgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
TgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneCREBBPC0011573Endogenous depression1PSYGENET
TgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
TgeneCREBBPC0036920Sezary Syndrome1CTD_human
TgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
TgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
TgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
TgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
TgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
TgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
TgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
TgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human