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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DLGAP4-ZNF668

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DLGAP4-ZNF668
FusionPDB ID: 23184
FusionGDB2.0 ID: 23184
HgeneTgene
Gene symbol

DLGAP4

ZNF668

Gene ID

22839

79759

Gene nameDLG associated protein 4zinc finger protein 668
SynonymsDAP-4|DAP4|DLP4|SAPAP-4|SAPAP4-
Cytomap

20q11.23

16p11.2

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 4PSD-95/SAP90-binding protein 4SAP90/PSD-95-associated protein 4discs large homolog associated protein 4zinc finger protein 668
Modification date2020031320200313
UniProtAcc

Q9Y2H0

.
Ensembl transtripts involved in fusion geneENST idsENST00000475894, ENST00000339266, 
ENST00000340491, ENST00000373907, 
ENST00000373913, ENST00000401952, 
ENST00000300849, ENST00000394983, 
ENST00000417110, ENST00000426488, 
ENST00000535577, ENST00000538906, 
ENST00000539836, ENST00000564456, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 16 X 9=25922 X 2 X 2=8
# samples 232
** MAII scorelog2(23/2592*10)=-3.49435995194025
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: DLGAP4 [Title/Abstract] AND ZNF668 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DLGAP4(35125171)-ZNF668(31073323), # samples:1
Anticipated loss of major functional domain due to fusion event.DLGAP4-ZNF668 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
DLGAP4-ZNF668 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DLGAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF668 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA524473DLGAP4chr20

35125171

+ZNF668chr16

31073323

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373913DLGAP4chr2035125171+ENST00000538906ZNF668chr1631073323-358124264802213577
ENST00000373913DLGAP4chr2035125171+ENST00000394983ZNF668chr1631073323-357924264802213577
ENST00000373913DLGAP4chr2035125171+ENST00000417110ZNF668chr1631073323-255424264802213577
ENST00000401952DLGAP4chr2035125171+ENST00000538906ZNF668chr1631073323-340822533072040577
ENST00000401952DLGAP4chr2035125171+ENST00000394983ZNF668chr1631073323-340622533072040577
ENST00000401952DLGAP4chr2035125171+ENST00000417110ZNF668chr1631073323-238122533072040577
ENST00000373907DLGAP4chr2035125171+ENST00000538906ZNF668chr1631073323-330021451991932577
ENST00000373907DLGAP4chr2035125171+ENST00000394983ZNF668chr1631073323-329821451991932577
ENST00000373907DLGAP4chr2035125171+ENST00000417110ZNF668chr1631073323-227321451991932577
ENST00000339266DLGAP4chr2035125171+ENST00000538906ZNF668chr1631073323-3101194601733577
ENST00000339266DLGAP4chr2035125171+ENST00000394983ZNF668chr1631073323-3099194601733577
ENST00000339266DLGAP4chr2035125171+ENST00000417110ZNF668chr1631073323-2074194601733577
ENST00000340491DLGAP4chr2035125171+ENST00000538906ZNF668chr1631073323-230611511913939324
ENST00000340491DLGAP4chr2035125171+ENST00000394983ZNF668chr1631073323-230411511913939324
ENST00000340491DLGAP4chr2035125171+ENST00000417110ZNF668chr1631073323-1279115135805256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373913ENST00000538906DLGAP4chr2035125171+ZNF668chr1631073323-0.142293560.8577064
ENST00000373913ENST00000394983DLGAP4chr2035125171+ZNF668chr1631073323-0.142323720.85767627
ENST00000373913ENST00000417110DLGAP4chr2035125171+ZNF668chr1631073323-0.153871420.84612864
ENST00000401952ENST00000538906DLGAP4chr2035125171+ZNF668chr1631073323-0.13788740.8621126
ENST00000401952ENST00000394983DLGAP4chr2035125171+ZNF668chr1631073323-0.137777160.8622228
ENST00000401952ENST00000417110DLGAP4chr2035125171+ZNF668chr1631073323-0.160411310.8395887
ENST00000373907ENST00000538906DLGAP4chr2035125171+ZNF668chr1631073323-0.141877670.8581223
ENST00000373907ENST00000394983DLGAP4chr2035125171+ZNF668chr1631073323-0.14184170.8581583
ENST00000373907ENST00000417110DLGAP4chr2035125171+ZNF668chr1631073323-0.160811890.8391881
ENST00000339266ENST00000538906DLGAP4chr2035125171+ZNF668chr1631073323-0.149662990.850337
ENST00000339266ENST00000394983DLGAP4chr2035125171+ZNF668chr1631073323-0.149696020.85030395
ENST00000339266ENST00000417110DLGAP4chr2035125171+ZNF668chr1631073323-0.176029220.8239708
ENST00000340491ENST00000538906DLGAP4chr2035125171+ZNF668chr1631073323-0.85622680.1437732
ENST00000340491ENST00000394983DLGAP4chr2035125171+ZNF668chr1631073323-0.85575410.14424588
ENST00000340491ENST00000417110DLGAP4chr2035125171+ZNF668chr1631073323-0.91117690.0888231

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23184_23184_1_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000339266_ZNF668_chr16_31073323_ENST00000394983_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_2_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000339266_ZNF668_chr16_31073323_ENST00000417110_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_3_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000339266_ZNF668_chr16_31073323_ENST00000538906_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_4_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000340491_ZNF668_chr16_31073323_ENST00000394983_length(amino acids)=324AA_BP=1
MCLRSPARSEKLLPHWVQGKGRSSGCERSCRRSSVIVEKVSLHSRHTNWGGFSSASSPPASPAPSKGPGASRTPASWHSTCSTVMPTTCH
CVAITPPDSGGSPSSPAGGSPSPAPAAGAAELSPATPTGSANPTTSSCAGGTPAASLLRWVRSCFLRLDDTTKDFPHALQWKGRSPECTR
LCFVRLARSAKARPHSSQRKGRWPECTSACRLRSQDATNVLSHCRHLNGRSPVCTRRCMARSAGCRKSLPHFSQFVFLSMTVSFWGRPRG

--------------------------------------------------------------

>23184_23184_5_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000340491_ZNF668_chr16_31073323_ENST00000417110_length(amino acids)=256AA_BP=
MSSRQSSSPCPRSARFVSPRLAVSLSLPSRSSAAPPSLPISGPLLRALFSPQSRPFWATPLFGTPPQSAPRSFGVPLENTFHSPQGLPVS
FLHILWGFCTPSRWGLASSEPPLPLGFPSSGCSPYPLGAPRSQVGVFLLGTPQYVLSSLTSGAPLCFPLVCPLSLSLLVLSQVSEHPHFS

--------------------------------------------------------------

>23184_23184_6_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000340491_ZNF668_chr16_31073323_ENST00000538906_length(amino acids)=324AA_BP=1
MCLRSPARSEKLLPHWVQGKGRSSGCERSCRRSSVIVEKVSLHSRHTNWGGFSSASSPPASPAPSKGPGASRTPASWHSTCSTVMPTTCH
CVAITPPDSGGSPSSPAGGSPSPAPAAGAAELSPATPTGSANPTTSSCAGGTPAASLLRWVRSCFLRLDDTTKDFPHALQWKGRSPECTR
LCFVRLARSAKARPHSSQRKGRWPECTSACRLRSQDATNVLSHCRHLNGRSPVCTRRCMARSAGCRKSLPHFSQFVFLSMTVSFWGRPRG

--------------------------------------------------------------

>23184_23184_7_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373907_ZNF668_chr16_31073323_ENST00000394983_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_8_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373907_ZNF668_chr16_31073323_ENST00000417110_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_9_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373907_ZNF668_chr16_31073323_ENST00000538906_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_10_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373913_ZNF668_chr16_31073323_ENST00000394983_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_11_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373913_ZNF668_chr16_31073323_ENST00000417110_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_12_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000373913_ZNF668_chr16_31073323_ENST00000538906_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_13_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000401952_ZNF668_chr16_31073323_ENST00000394983_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_14_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000401952_ZNF668_chr16_31073323_ENST00000417110_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

--------------------------------------------------------------

>23184_23184_15_DLGAP4-ZNF668_DLGAP4_chr20_35125171_ENST00000401952_ZNF668_chr16_31073323_ENST00000538906_length(amino acids)=577AA_BP=
MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPS
HAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGR
RAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPP
PAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIP
CRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:35125171/chr16:31073323)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLGAP4

Q9Y2H0

.
FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903112_1340620.0Zinc fingerC2H2-type 3
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903140_1620620.0Zinc fingerC2H2-type 4
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903168_1900620.0Zinc fingerC2H2-type 5
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903196_2180620.0Zinc fingerC2H2-type 6
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903224_2460620.0Zinc fingerC2H2-type 7
TgeneZNF668chr20:35125171chr16:31073323ENST000003008490322_440620.0Zinc fingerC2H2-type 1
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903252_2740620.0Zinc fingerC2H2-type 8
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903280_3020620.0Zinc fingerC2H2-type 9
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903308_3300620.0Zinc fingerC2H2-type 10
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903336_3580620.0Zinc fingerC2H2-type 11
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903364_3860620.0Zinc fingerC2H2-type 12
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903392_4140620.0Zinc fingerC2H2-type 13
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903516_5380620.0Zinc fingerC2H2-type 14
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903544_5660620.0Zinc fingerC2H2-type 15
TgeneZNF668chr20:35125171chr16:31073323ENST0000030084903572_5940620.0Zinc fingerC2H2-type 16
TgeneZNF668chr20:35125171chr16:31073323ENST000003008490384_1060620.0Zinc fingerC2H2-type 2
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303112_1340620.0Zinc fingerC2H2-type 3
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303140_1620620.0Zinc fingerC2H2-type 4
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303168_1900620.0Zinc fingerC2H2-type 5
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303196_2180620.0Zinc fingerC2H2-type 6
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303224_2460620.0Zinc fingerC2H2-type 7
TgeneZNF668chr20:35125171chr16:31073323ENST000003949830322_440620.0Zinc fingerC2H2-type 1
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303252_2740620.0Zinc fingerC2H2-type 8
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303280_3020620.0Zinc fingerC2H2-type 9
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303308_3300620.0Zinc fingerC2H2-type 10
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303336_3580620.0Zinc fingerC2H2-type 11
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303364_3860620.0Zinc fingerC2H2-type 12
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303392_4140620.0Zinc fingerC2H2-type 13
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303516_5380620.0Zinc fingerC2H2-type 14
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303544_5660620.0Zinc fingerC2H2-type 15
TgeneZNF668chr20:35125171chr16:31073323ENST0000039498303572_5940620.0Zinc fingerC2H2-type 16
TgeneZNF668chr20:35125171chr16:31073323ENST000003949830384_1060620.0Zinc fingerC2H2-type 2
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703112_1340620.0Zinc fingerC2H2-type 3
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703140_1620620.0Zinc fingerC2H2-type 4
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703168_1900620.0Zinc fingerC2H2-type 5
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703196_2180620.0Zinc fingerC2H2-type 6
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703224_2460620.0Zinc fingerC2H2-type 7
TgeneZNF668chr20:35125171chr16:31073323ENST000005355770322_440620.0Zinc fingerC2H2-type 1
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703252_2740620.0Zinc fingerC2H2-type 8
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703280_3020620.0Zinc fingerC2H2-type 9
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703308_3300620.0Zinc fingerC2H2-type 10
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703336_3580620.0Zinc fingerC2H2-type 11
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703364_3860620.0Zinc fingerC2H2-type 12
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703392_4140620.0Zinc fingerC2H2-type 13
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703516_5380620.0Zinc fingerC2H2-type 14
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703544_5660620.0Zinc fingerC2H2-type 15
TgeneZNF668chr20:35125171chr16:31073323ENST0000053557703572_5940620.0Zinc fingerC2H2-type 16
TgeneZNF668chr20:35125171chr16:31073323ENST000005355770384_1060620.0Zinc fingerC2H2-type 2
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603112_1340620.0Zinc fingerC2H2-type 3
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603140_1620620.0Zinc fingerC2H2-type 4
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603168_1900620.0Zinc fingerC2H2-type 5
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603196_2180620.0Zinc fingerC2H2-type 6
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603224_2460620.0Zinc fingerC2H2-type 7
TgeneZNF668chr20:35125171chr16:31073323ENST000005389060322_440620.0Zinc fingerC2H2-type 1
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603252_2740620.0Zinc fingerC2H2-type 8
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603280_3020620.0Zinc fingerC2H2-type 9
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603308_3300620.0Zinc fingerC2H2-type 10
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603336_3580620.0Zinc fingerC2H2-type 11
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603364_3860620.0Zinc fingerC2H2-type 12
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603392_4140620.0Zinc fingerC2H2-type 13
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603516_5380620.0Zinc fingerC2H2-type 14
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603544_5660620.0Zinc fingerC2H2-type 15
TgeneZNF668chr20:35125171chr16:31073323ENST0000053890603572_5940620.0Zinc fingerC2H2-type 16
TgeneZNF668chr20:35125171chr16:31073323ENST000005389060384_1060620.0Zinc fingerC2H2-type 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLGAP4chr20:35125171chr16:31073323ENST00000339266+111267_2740.0993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35125171chr16:31073323ENST00000340491+17267_2740454.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35125171chr16:31073323ENST00000373907+112267_2740993.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35125171chr16:31073323ENST00000373913+113267_2740990.0Compositional biasNote=Poly-Pro
HgeneDLGAP4chr20:35125171chr16:31073323ENST00000401952+112267_2740990.0Compositional biasNote=Poly-Pro


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DLGAP4
ZNF668


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DLGAP4-ZNF668


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DLGAP4-ZNF668


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource