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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DMD-HNRNPD

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DMD-HNRNPD
FusionPDB ID: 23226
FusionGDB2.0 ID: 23226
HgeneTgene
Gene symbol

DMD

HNRNPD

Gene ID

1756

3184

Gene namedystrophinheterogeneous nuclear ribonucleoprotein D
SynonymsBMD|CMD3B|DXS142|DXS164|DXS206|DXS230|DXS239|DXS268|DXS269|DXS270|DXS272|MRX85AUF1|AUF1A|HNRPD|P37|hnRNPD0
Cytomap

Xp21.2-p21.1

4q21.22

Type of geneprotein-codingprotein-coding
Descriptiondystrophinheterogeneous nuclear ribonucleoprotein D0ARE-binding protein AUFI, type AAU-rich element RNA binding protein 1, 37kDahnRNP D0
Modification date2020032920200329
UniProtAcc

P11532

O14979

Ensembl transtripts involved in fusion geneENST idsENST00000357033, ENST00000378677, 
ENST00000288447, ENST00000343523, 
ENST00000359836, ENST00000361471, 
ENST00000378680, ENST00000378702, 
ENST00000378707, ENST00000378723, 
ENST00000445312, ENST00000474231, 
ENST00000541735, 		ENST00000508119, 
ENST00000541060, ENST00000352301, 
ENST00000313899, ENST00000353341, 
ENST00000543098, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score32 X 35 X 5=560019 X 13 X 8=1976
# samples 3619
** MAII scorelog2(36/5600*10)=-3.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1976*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DMD [Title/Abstract] AND HNRNPD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DMD(32305646)-HNRNPD(83280792), # samples:1
Anticipated loss of major functional domain due to fusion event.DMD-HNRNPD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DMD-HNRNPD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DMD-HNRNPD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DMD-HNRNPD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DMD-HNRNPD seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DMD-HNRNPD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DMD-HNRNPD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDMD

GO:0043043

peptide biosynthetic process

16000376


check buttonFusion gene breakpoints across DMD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HNRNPD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A0E0-11ADMDchrX

32305646

-HNRNPDchr4

83280792

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378677DMDchrX32305646-ENST00000313899HNRNPDchr483280792-8938647319572502351
ENST00000378677DMDchrX32305646-ENST00000353341HNRNPDchr483280792-7460647319571032302
ENST00000378677DMDchrX32305646-ENST00000543098HNRNPDchr483280792-7602647319572502351
ENST00000357033DMDchrX32305646-ENST00000313899HNRNPDchr483280792-8962649720772742355
ENST00000357033DMDchrX32305646-ENST00000353341HNRNPDchr483280792-7484649720771272306
ENST00000357033DMDchrX32305646-ENST00000543098HNRNPDchr483280792-7626649720772742355

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378677ENST00000313899DMDchrX32305646-HNRNPDchr483280792-0.0004637320.9995363
ENST00000378677ENST00000353341DMDchrX32305646-HNRNPDchr483280792-0.0020598770.9979401
ENST00000378677ENST00000543098DMDchrX32305646-HNRNPDchr483280792-0.001484520.9985154
ENST00000357033ENST00000313899DMDchrX32305646-HNRNPDchr483280792-0.0004632270.99953675
ENST00000357033ENST00000353341DMDchrX32305646-HNRNPDchr483280792-0.0020248130.9979752
ENST00000357033ENST00000543098DMDchrX32305646-HNRNPDchr483280792-0.0014631970.9985368

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23226_23226_1_DMD-HNRNPD_DMD_chrX_32305646_ENST00000357033_HNRNPD_chr4_83280792_ENST00000313899_length(amino acids)=2355AA_BP=2097
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS
RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEK
GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQ
EQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD
SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH
EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT
LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSR
WRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV
LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV
QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE
IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP
QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE
IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLL
KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE
TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE
RVKLQEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEH
KLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLS
KCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYG

--------------------------------------------------------------

>23226_23226_2_DMD-HNRNPD_DMD_chrX_32305646_ENST00000357033_HNRNPD_chr4_83280792_ENST00000353341_length(amino acids)=2306AA_BP=2097
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS
RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEK
GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQ
EQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD
SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH
EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT
LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSR
WRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV
LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV
QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE
IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP
QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE
IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLL
KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE
TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE
RVKLQEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEH
KLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLS

--------------------------------------------------------------

>23226_23226_3_DMD-HNRNPD_DMD_chrX_32305646_ENST00000357033_HNRNPD_chr4_83280792_ENST00000543098_length(amino acids)=2355AA_BP=2097
MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVD
LVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDL
FDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHH
QMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAED
TLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRW
ANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST
LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEI
RKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNS
RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEK
GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQ
EQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD
SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH
EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKT
LEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSR
WRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV
LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV
QKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKE
IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP
QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE
IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLL
KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE
TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE
RVKLQEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEH
KLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLS
KCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYG

--------------------------------------------------------------

>23226_23226_4_DMD-HNRNPD_DMD_chrX_32305646_ENST00000378677_HNRNPD_chr4_83280792_ENST00000313899_length(amino acids)=2351AA_BP=2093
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE
FCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGP
MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS
GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL
KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT
QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV
WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWREL
HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI
DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ
KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG
VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV
MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
QEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNG
KVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEI
KVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSR

--------------------------------------------------------------

>23226_23226_5_DMD-HNRNPD_DMD_chrX_32305646_ENST00000378677_HNRNPD_chr4_83280792_ENST00000353341_length(amino acids)=2302AA_BP=2093
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE
FCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGP
MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS
GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL
KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT
QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV
WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWREL
HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI
DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ
KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG
VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV
MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
QEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNG
KVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEI

--------------------------------------------------------------

>23226_23226_6_DMD-HNRNPD_DMD_chrX_32305646_ENST00000378677_HNRNPD_chr4_83280792_ENST00000543098_length(amino acids)=2351AA_BP=2093
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNI
GSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHY
SQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN
QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNK
SVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE
FCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGP
MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS
GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL
KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT
QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV
WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWREL
HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI
DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ
KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG
VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV
MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
QEALSQLDFQWEKVNKMYKDRQGKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNG
KVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEI
KVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:32305646/chr4:83280792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMD

P11532

HNRNPD

O14979

FUNCTION: Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. {ECO:0000250|UniProtKB:P11531, ECO:0000269|PubMed:16710609}.FUNCTION: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269|PubMed:9538234}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000031389919270_34796.66666666666667751.6666666666666Compositional biasNote=Gly-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000031389919294_33296.66666666666667751.6666666666666Compositional biasNote=Tyr-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035230108270_34777.66666666666667241.0Compositional biasNote=Gly-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035230108294_33277.66666666666667241.0Compositional biasNote=Tyr-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035334118270_34796.66666666666667249.0Compositional biasNote=Gly-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035334118294_33296.66666666666667249.0Compositional biasNote=Tyr-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000031389919182_26196.66666666666667751.6666666666666DomainRRM 2
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003138991997_17996.66666666666667751.6666666666666DomainRRM 1
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035230108182_26177.66666666666667241.0DomainRRM 2
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003523010897_17977.66666666666667241.0DomainRRM 1
TgeneHNRNPDchrX:32305646chr4:83280792ENST0000035334118182_26196.66666666666667249.0DomainRRM 2
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003533411897_17996.66666666666667249.0DomainRRM 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116134_2400623.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-11615_1190623.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1163055_30880623.0DomainWW
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113134_2400526.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-11315_1190526.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1133055_30880526.0DomainWW
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118134_2400618.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-11815_1190618.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1183055_30880618.0DomainWW
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117134_2400636.0DomainCalponin-homology (CH) 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-11715_1190636.0DomainCalponin-homology (CH) 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1173055_30880636.0DomainWW
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161_2400623.0RegionNote=Actin-binding
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1163466_35180623.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-11663_720623.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131_2400526.0RegionNote=Actin-binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1133466_35180526.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-11363_720526.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181_2400618.0RegionNote=Actin-binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1183466_35180618.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-11863_720618.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171_2400636.0RegionNote=Actin-binding
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1173466_35180636.0RegionNote=Binds to SNTB1
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-11763_720636.0RegionANK2- and ANK-3 binding
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161048_11540623.0RepeatNote=Spectrin 7
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161157_12630623.0RepeatNote=Spectrin 8
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161266_13670623.0RepeatNote=Spectrin 9
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161368_14630623.0RepeatNote=Spectrin 10
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161468_15680623.0RepeatNote=Spectrin 11
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161571_16760623.0RepeatNote=Spectrin 12
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161679_17780623.0RepeatNote=Spectrin 13
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161779_18740623.0RepeatNote=Spectrin 14
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161877_19790623.0RepeatNote=Spectrin 15
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161992_21010623.0RepeatNote=Spectrin 16
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162104_22080623.0RepeatNote=Spectrin 17
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162211_23180623.0RepeatNote=Spectrin 18
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162319_24230623.0RepeatNote=Spectrin 19
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162475_25770623.0RepeatNote=Spectrin 20
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162580_26860623.0RepeatNote=Spectrin 21
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162689_28020623.0RepeatNote=Spectrin 22
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162808_29300623.0RepeatNote=Spectrin 23
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1162935_30400623.0RepeatNote=Spectrin 24
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116339_4470623.0RepeatNote=Spectrin 1
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116448_5560623.0RepeatNote=Spectrin 2
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116559_6670623.0RepeatNote=Spectrin 3
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116719_8280623.0RepeatNote=Spectrin 4
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116830_9340623.0RepeatNote=Spectrin 5
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-116943_10450623.0RepeatNote=Spectrin 6
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131048_11540526.0RepeatNote=Spectrin 7
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131157_12630526.0RepeatNote=Spectrin 8
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131266_13670526.0RepeatNote=Spectrin 9
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131368_14630526.0RepeatNote=Spectrin 10
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131468_15680526.0RepeatNote=Spectrin 11
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131571_16760526.0RepeatNote=Spectrin 12
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131679_17780526.0RepeatNote=Spectrin 13
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131779_18740526.0RepeatNote=Spectrin 14
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131877_19790526.0RepeatNote=Spectrin 15
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131992_21010526.0RepeatNote=Spectrin 16
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132104_22080526.0RepeatNote=Spectrin 17
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132211_23180526.0RepeatNote=Spectrin 18
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132319_24230526.0RepeatNote=Spectrin 19
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132475_25770526.0RepeatNote=Spectrin 20
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132580_26860526.0RepeatNote=Spectrin 21
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132689_28020526.0RepeatNote=Spectrin 22
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132808_29300526.0RepeatNote=Spectrin 23
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1132935_30400526.0RepeatNote=Spectrin 24
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113339_4470526.0RepeatNote=Spectrin 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113448_5560526.0RepeatNote=Spectrin 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113559_6670526.0RepeatNote=Spectrin 3
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113719_8280526.0RepeatNote=Spectrin 4
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113830_9340526.0RepeatNote=Spectrin 5
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-113943_10450526.0RepeatNote=Spectrin 6
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181048_11540618.0RepeatNote=Spectrin 7
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181157_12630618.0RepeatNote=Spectrin 8
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181266_13670618.0RepeatNote=Spectrin 9
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181368_14630618.0RepeatNote=Spectrin 10
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181468_15680618.0RepeatNote=Spectrin 11
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181571_16760618.0RepeatNote=Spectrin 12
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181679_17780618.0RepeatNote=Spectrin 13
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181779_18740618.0RepeatNote=Spectrin 14
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181877_19790618.0RepeatNote=Spectrin 15
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181992_21010618.0RepeatNote=Spectrin 16
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182104_22080618.0RepeatNote=Spectrin 17
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182211_23180618.0RepeatNote=Spectrin 18
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182319_24230618.0RepeatNote=Spectrin 19
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182475_25770618.0RepeatNote=Spectrin 20
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182580_26860618.0RepeatNote=Spectrin 21
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182689_28020618.0RepeatNote=Spectrin 22
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182808_29300618.0RepeatNote=Spectrin 23
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1182935_30400618.0RepeatNote=Spectrin 24
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118339_4470618.0RepeatNote=Spectrin 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118448_5560618.0RepeatNote=Spectrin 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118559_6670618.0RepeatNote=Spectrin 3
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118719_8280618.0RepeatNote=Spectrin 4
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118830_9340618.0RepeatNote=Spectrin 5
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-118943_10450618.0RepeatNote=Spectrin 6
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171048_11540636.0RepeatNote=Spectrin 7
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171157_12630636.0RepeatNote=Spectrin 8
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171266_13670636.0RepeatNote=Spectrin 9
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171368_14630636.0RepeatNote=Spectrin 10
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171468_15680636.0RepeatNote=Spectrin 11
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171571_16760636.0RepeatNote=Spectrin 12
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171679_17780636.0RepeatNote=Spectrin 13
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171779_18740636.0RepeatNote=Spectrin 14
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171877_19790636.0RepeatNote=Spectrin 15
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171992_21010636.0RepeatNote=Spectrin 16
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172104_22080636.0RepeatNote=Spectrin 17
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172211_23180636.0RepeatNote=Spectrin 18
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172319_24230636.0RepeatNote=Spectrin 19
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172475_25770636.0RepeatNote=Spectrin 20
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172580_26860636.0RepeatNote=Spectrin 21
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172689_28020636.0RepeatNote=Spectrin 22
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172808_29300636.0RepeatNote=Spectrin 23
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1172935_30400636.0RepeatNote=Spectrin 24
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117339_4470636.0RepeatNote=Spectrin 1
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117448_5560636.0RepeatNote=Spectrin 2
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117559_6670636.0RepeatNote=Spectrin 3
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117719_8280636.0RepeatNote=Spectrin 4
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117830_9340636.0RepeatNote=Spectrin 5
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-117943_10450636.0RepeatNote=Spectrin 6
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1163307_33540623.0Zinc fingerZZ-type
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1133307_33540526.0Zinc fingerZZ-type
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1183307_33540618.0Zinc fingerZZ-type
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1173307_33540636.0Zinc fingerZZ-type
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003138991911_4596.66666666666667751.6666666666666Compositional biasNote=Ala-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003523010811_4577.66666666666667241.0Compositional biasNote=Ala-rich
TgeneHNRNPDchrX:32305646chr4:83280792ENST000003533411811_4596.66666666666667249.0Compositional biasNote=Ala-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DMD
HNRNPD


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1161415_19130623.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000361471-1163058_34080623.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1131415_19130526.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378680-1133058_34080526.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1181415_19130618.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378702-1183058_34080618.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1171415_19130636.0SYNM
HgeneDMDchrX:32305646chr4:83280792ENST00000378723-1173058_34080636.0SYNM


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Related Drugs to DMD-HNRNPD


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DMD-HNRNPD


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource