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Fusion Protein:DNAJA3-CREBBP |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: DNAJA3-CREBBP | FusionPDB ID: 23389 | FusionGDB2.0 ID: 23389 | Hgene | Tgene | Gene symbol | DNAJA3 | CREBBP | Gene ID | 9093 | 1387 |
| Gene name | DnaJ heat shock protein family (Hsp40) member A3 | CREB binding protein | |
| Synonyms | HCA57|TID1|hTID-1 | CBP|KAT3A|MKHK1|RSTS|RSTS1 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily A member 3, mitochondrialDnaJ (Hsp40) homolog, subfamily A, member 3dnaJ protein Tid-1hepatocellular carcinoma-associated antigen 57tumorous imaginal discs protein Tid56 homolog | CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | Q96EY1 | Q92793 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262375, ENST00000355296, ENST00000431375, ENST00000572139, | ENST00000262367, ENST00000382070, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 5 X 4=120 | 18 X 30 X 8=4320 |
| # samples | 6 | 28 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/4320*10)=-3.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: DNAJA3 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | |||
| Anticipated loss of major functional domain due to fusion event. | CREBBP-DNAJA3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CREBBP-DNAJA3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CREBBP-DNAJA3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. CREBBP-DNAJA3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CREBBP-DNAJA3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CREBBP-DNAJA3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJA3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21106534 |
| Hgene | DNAJA3 | GO:0008285 | negative regulation of cell proliferation | 11719219 |
| Tgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
| Tgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
| Tgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24207024|24939902|28790157|30540930 |
| Tgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
| Tgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Tgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
| Tgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
| Tgene | CREBBP | GO:1990258 | histone glutamine methylation | 30540930 |
| Fusion gene breakpoints across DNAJA3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CREBBP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | DNAJA3 | chr16 | 4500498 | + | CREBBP | chr16 | 3901011 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262375 | DNAJA3 | chr16 | 4500498 | + | ENST00000262367 | CREBBP | chr16 | 3901011 | - | 11324 | 1416 | 77 | 8659 | 2860 |
| ENST00000262375 | DNAJA3 | chr16 | 4500498 | + | ENST00000382070 | CREBBP | chr16 | 3901011 | - | 8725 | 1416 | 77 | 8545 | 2822 |
| ENST00000355296 | DNAJA3 | chr16 | 4500498 | + | ENST00000262367 | CREBBP | chr16 | 3901011 | - | 11269 | 1361 | 22 | 8604 | 2860 |
| ENST00000355296 | DNAJA3 | chr16 | 4500498 | + | ENST00000382070 | CREBBP | chr16 | 3901011 | - | 8670 | 1361 | 22 | 8490 | 2822 |
| ENST00000431375 | DNAJA3 | chr16 | 4500498 | + | ENST00000262367 | CREBBP | chr16 | 3901011 | - | 10915 | 1007 | 127 | 8250 | 2707 |
| ENST00000431375 | DNAJA3 | chr16 | 4500498 | + | ENST00000382070 | CREBBP | chr16 | 3901011 | - | 8316 | 1007 | 127 | 8136 | 2669 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >23389_23389_1_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000262375_CREBBP_chr16_3901011_ENST00000262367_length(amino acids)=2860AA_BP=441 MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLA KEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTV DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFV MRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSP LSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGS LGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQS MVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL NHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQ RAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIG TLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQ KELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQ MNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQ LPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQT PVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMM EEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFR QPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGR KYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQ ICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDS GEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIW ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEE RKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDP DPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKM VKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKH CQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFP SVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPV MPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIK QRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREM LRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGAD STPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPS -------------------------------------------------------------- >23389_23389_2_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000262375_CREBBP_chr16_3901011_ENST00000382070_length(amino acids)=2822AA_BP=441 MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLA KEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTV DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFV MRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSP LSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGS LGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQS MVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL NHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRT LNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQ AIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQP VRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQ SQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPP QPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDN RVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVK EEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEP WQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKC FTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQ TTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSD CPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKA FAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSI SRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLC MLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLV HACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMA TMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAAR QIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAG PRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQ NLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQ FQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHM LSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLP -------------------------------------------------------------- >23389_23389_3_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000355296_CREBBP_chr16_3901011_ENST00000262367_length(amino acids)=2860AA_BP=441 MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLA KEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTV DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFV MRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSP LSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGS LGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQS MVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL NHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQ RAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIG TLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQ KELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQ MNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQ LPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQT PVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMM EEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFR QPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGR KYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQ ICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDS GEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIW ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEE RKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDP DPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKM VKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKH CQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFP SVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPV MPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIK QRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREM LRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGAD STPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPS -------------------------------------------------------------- >23389_23389_4_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000355296_CREBBP_chr16_3901011_ENST00000382070_length(amino acids)=2822AA_BP=441 MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLA KEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTV DPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFV MRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSP LSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGS LGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASKQS MVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL NHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRT LNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQ AIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQP VRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQ SQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPP QPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDN RVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVK EEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEP WQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKC FTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQ TTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSD CPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKA FAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSI SRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLC MLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLV HACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMA TMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAAR QIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAG PRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQ NLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQ FQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHM LSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLP -------------------------------------------------------------- >23389_23389_5_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000431375_CREBBP_chr16_3901011_ENST00000262367_length(amino acids)=2707AA_BP=288 MAEPQAERPRLCVFPDLLRPPSAADIETWCQPYRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKG NEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRV QKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSL ILSYAEDETDVEGTVNGVTLTSSDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPV QQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTH PGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSP FGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAH KCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQN TIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNL ISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKK VEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFN PMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPA QTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGS VPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVL EMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIF KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVY KFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKD QFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAG EVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCL RTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAK ELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATM EKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVE TRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHT KGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQ QPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGR TGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLK SPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLN PQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLP LQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRS PAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTL -------------------------------------------------------------- >23389_23389_6_DNAJA3-CREBBP_DNAJA3_chr16_4500498_ENST00000431375_CREBBP_chr16_3901011_ENST00000382070_length(amino acids)=2669AA_BP=288 MAEPQAERPRLCVFPDLLRPPSAADIETWCQPYRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKG NEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRV QKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSL ILSYAEDETDVEGTVNGVTLTSSDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPV QQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTH PGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSP FGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAH KCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYM NQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPP SSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL HKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMA ISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPL HPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQ SSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVK EETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIP DYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCC YGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWP SGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRT KALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYI FHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASE TTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDG RDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEG SSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFC LNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTV STGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQ APLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQP GMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQ QQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQ RILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSP -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:/chr16:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJA3 | CREBBP |
| FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. | FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file (1181) | DNAJA3 | chr16 | 4500498 | + | CREBBP | chr16 | 3901011 | - | MAEPQAERPRLCVFPDLLRPPSAADIETWCQPYRKIFGEFSSSSFGDFQT VFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHC HYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKR VMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFIS IAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGD HYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGSLFD LENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPG IGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPK QAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTH PGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGAS SSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGG QPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIV PTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHC RTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNP NPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNP LGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGT LSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKD RRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRL HKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNS FNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPP NMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQ VPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTT PPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQ AQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVP TPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMME EDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQ STSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIP DYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSR VYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPR DAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKND TLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENK FSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKP GMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPP PNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWA CPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIF KQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASE TTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYA TMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARD KHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVC EDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQ RCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLI ALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMN TRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPS VARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLY RVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQ APLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRT LKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQS QPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNI MNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAG GMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQ MGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSG QPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSP HHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSE | 2669 |
| PDB file (1189) | DNAJA3 | chr16 | 4500498 | + | CREBBP | chr16 | 3901011 | - | MAEPQAERPRLCVFPDLLRPPSAADIETWCQPYRKIFGEFSSSSFGDFQT VFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHC HYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKR VMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFIS IAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGD HYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGSLFD LENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPG IGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPK QAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTH PGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGAS SSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGG QPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIV PTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHC RTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKN ASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAY AALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGG ITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSS TGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKK VEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPAL PAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLP QAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMA QAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNM LGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAP TQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQ PPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNS QQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEE TDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIF KPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDL STIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVF EQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYH FCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKE CGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLG NHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEM SESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLD SIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFH CHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAK ELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNA KKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVI HLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSK WSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNT KSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQC RNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQE NKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSP TSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVST GKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGR TGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGL PRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQ VLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQ QPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASM NPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQ GPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTP NIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQI ATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHP GLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTL | 2707 |
| PDB file (1207) >>>1207.pdbFusion protein BP residue: 441 CIF file (1207) >>>1207.cif | DNAJA3 | chr16 | 4500498 | + | CREBBP | chr16 | 3901011 | - | MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFAS SLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGV PRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVK RKQYDAYGSAGFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGD FQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKV QHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQ KKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDL FISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYG YGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQ AGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSV GIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSL SNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRT LNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGN IGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAA LKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRR SRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQG MNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMP QPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVS QGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQ HTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQA AAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDN RVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSE MMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGT ASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLL GIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRK TSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCT IPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKK KNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK ENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVE VKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSD CPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGH IWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYK DIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTA ASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQK LYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTL ARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHC TVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRL SIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCK QLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMA TMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAG FPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQ HLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQ WQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDL LRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPG LQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQA LNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAG MAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQ LGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHM LSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQ PSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSAL | 2822 |
| 3D view using mol* of 1207 (AA BP:441) | ||||||||||
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| PDB file (1217) >>>1217.pdbFusion protein BP residue: 441 CIF file (1217) >>>1217.cif | DNAJA3 | chr16 | 4500498 | + | CREBBP | chr16 | 3901011 | - | MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFAS SLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGV PRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVK RKQYDAYGSAGFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGD FQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKV QHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQ KKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDL FISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYG YGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSDFGS LFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSI NPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPS LPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFN QTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQ GASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQ AGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSV GIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLP LKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQ RAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIP AGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAP PSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAY AKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQ PALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNV QLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNN MMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNP LNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQP AAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQT PVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAE TNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQV KEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRK KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA EVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQN RYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVD CKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTT RLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDS GEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYIS YLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDY IFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLT SAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDS KNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVF FVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLR RSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINC YNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHA CQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKH CQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSL PSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTT VSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMP PGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPM PGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQ QQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPG MHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNM ASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQ QPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGAD STPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPG QQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGS PHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTG | 2860 |
| 3D view using mol* of 1217 (AA BP:441) | ||||||||||
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
DNAJA3_pLDDT.png  |
CREBBP_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
DNAJA3_CREBBP_1181_pLDDT_and_active_sites.png (AA BP:) |
DNAJA3_CREBBP_1181_violinplot.png (AA BP:) |
DNAJA3_CREBBP_1207_pLDDT.png (AA BP:441) |
DNAJA3_CREBBP_1207_pLDDT_and_active_sites.png (AA BP:441) |
DNAJA3_CREBBP_1207_violinplot.png (AA BP:441) |
DNAJA3_CREBBP_1217_pLDDT.png (AA BP:441) |
DNAJA3_CREBBP_1217_pLDDT_and_active_sites.png (AA BP:441) |
DNAJA3_CREBBP_1217_violinplot.png (AA BP:441) |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
| DNAJA3_CREBBP_1181.png |
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| DNAJA3_CREBBP_1207.png |
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| DNAJA3_CREBBP_1217.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
| 1181 | 1.045856 | 201 | 1.103301 | 742.938 | 0.63587 | 0.686372 | 0.838546 | 0.930373 | 0.76234 | 1.220418 | 1.314516 | Chain A: 200,201,202,204,205,228,257,258,259,260,2 62,263,267,268,270,271,272,274,278,281,282,284,285 ,286,605,606,607,608,609,610,611,612,615,616,870,8 72,873,875,876,879,880,883,887 |
| 1181 | 1.077 | 194 | 1.152 | 665.42 | 0.595 | 0.695 | 0.838 | 1.191 | 0.63 | 1.891 | 0.719 | Chain A: 1930,1931,1932,1940,1941,1942,1943,1944,1 946,1971,1972,1973,1974,1975,1991,1995,1996,1998,1 999,2000,2002,2003,2004,2024,2027,2028,2044,2045,2 047,2048,2049,2051,2052,2055,2056,2059,2060 |
| 1207 | 1.011 | 661 | 1.05 | 2142.721 | 0.64 | 0.676 | 0.849 | 0.513 | 0.906 | 0.566 | 0.899 | Chain A: 654,655,656,657,658,659,660,661,711,712,7 13,714,715,716,717,718,719,720,721,722,1185,1186,1 187,1188,1189,1190,1352,1353,1354,1355,1538,1542,1 545,1546,1547,1548,1549,1550,1555,1559,1562,1563,1 583,1585,1586,1587,1588,1589,1590,1591,1592,1593,1 594,1595,1596,1597,1598,1599,1600,1601,1602,1603,1 604,1605,1606,1607,1609,1610,1611,1612,1615,1617,1 618,1619,1620,1623,1624,1625,1626,1628,1629,1630,1 632,1634,1635,1637,1639,1648,1649,1650,1651,1652,1 653,1654,1655,1656,1852,1854,1855,1856,1857,1858,1 859,1860,1861,1865,1866,1867,1868,1869,1871,1872,1 873,1874,1875,1876,1878,1924,2008,2011,2044,2045,2 048,2049,2052,2053,2055,2057,2247 |
| 1217 | 1.02 | 272 | 1.06 | 862.988 | 0.61 | 0.685 | 0.914 | 0.741 | 0.894 | 0.829 | 0.8 | Chain A: 776,777,779,780,781,783,784,785,786,787,7 88,789,790,792,794,796,797,798,799,800,807,810,811 ,813,814,834,837,838,851,852,854,855,856,857,858,8 91,892,893,894,896,897,898,899,900,901,902,910,911 ,912,914,915,916,917,918 |
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Potentially Interacting Small Molecules through Virtual Screening |
| The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide. |
| Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
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| Drug information from DrugBank of the top 20 interacting small molecules. |
| ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
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Biochemical Features of Small Molecules |
| ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9) |
| ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
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Drug Toxicity Information |
| Toxicity information of individual drugs using eToxPred |
| ZINC ID | Smile | Surface Accessibility | Toxicity |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| CREBBP | EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2, |
| DNAJA3 | RNF34, FAM131C, ZBTB22, BRCA1, Jak2, JAK2, IFNGR2, HSPA8, RAD51, DMC1, RASA1, VHL, UBC, MYC, ICT1, GRB2, KRAS, STUB1, CUL3, CUL5, HSPA9, NFKBIA, NFKBIB, RELA, COIL, ATXN1, GFI1B, USP7, CRK, CLTC, RPS18, NDUFS7, MYO1C, SCFD1, UQCRQ, NOS2, SMAD9, KDM1A, CARM1, PRMT6, HDAC11, EGFR, HSP90AA1, HSPA1A, LATS2, IRS4, HUWE1, PCSK9, FOSL2, TCF19, STK16, INPP5J, OSGIN1, NOC4L, GCC1, MYO15B, FAM214B, FRMD6, ALS2CR11, AATK, ILK, IRAK1, CAD, PKM, RAB1A, RAB1B, SDHA, PRKACA, CEP162, SSX2IP, S100A4, Ppp4c, Hnrnpf, Ksr1, NANOG, POU5F1, PHF12, CTDSP2, MTMR11, PPM1E, CHRM3, THBS3, SMARCB1, MCPH1, ESR1, BIT61, TAE1, GCD7, ORC1, FBXO7, EGLN3, RIPK4, MAPK6, PPEF1, HIF1A, PRPF8, EFTUD2, RPTOR, SOCS6, HAVCR1, RUNX1, SNAI1, WWOX, RECQL4, TUBA1A, MRM1, HSPD1, TRMT61B, AURKAIP1, GRWD1, KIAA1429, AMBRA1, RC3H1, RC3H2, ATG16L1, CTDP1, PHB, MAD2L2, USP14, NR2C2, PPARG, PRDM16, MECOM, NIN, ATXN3, HIST1H4A, SNRNP70, ITFG1, CLUAP1, BIRC3, BRD7, Hsp22, CIDEB, CYSRT1, CUL7, PLEKHA4, MIB1, E7, PTEN, ZC3H18, MAP3K14, PTPRR, LAMTOR5, GRSF1, CIT, CHMP4C, BRD1, SP100, TRIM66, MCUR1, FASTKD5, MTG2, MTIF2, RPUSD4, TRUB2, TSFM, E5b, CIC, LGALS9, BKRF1, ASXL1, HNRNPA1, HSPA1L, CAPRIN1, RPS28, CLPP, HAX1, CLPX, POLDIP2, IARS2, TMEM231, GRPEL1, TUBB1, TUBB6, TUBB, NDUFA5, DARS2, RPS23, NDUFS3, EIF4H, ARGLU1, ABCB7, ACADVL, ACP1, SLC25A6, COX4I1, COX5B, DLST, ECH1, ECHS1, ETFA, GLS, LETM1, LGALS3BP, NDUFA2, NDUFA6, NDUFA7, NDUFA9, NDUFB10, NDUFS1, NDUFS2, NDUFV1, NDUFS4, NDUFS6, NDUFS8, NDUFV2, OXA1L, MRPL23, MRPL12, RPS25, SHMT2, SSBP1, TXN, COX5A, DGCR2, LRPPRC, SLC25A15, MRPS31, SLC30A9, TIMM44, AFG3L2, IMMT, PHB2, VWA8, MRPS27, PLD3, NDUFAF3, ERAL1, GHITM, COA3, MRPS18B, ACAD9, MRPL13, NDUFAF4, MRPL22, PYCR2, STOML2, PAM16, MRPL4, NDUFAF1, MRPL37, ECSIT, MRPS23, SARS2, PTCD3, NDUFA12, SLC25A40, SHROOM3, MRPS35, MRPS26, MRPS9, MRPL44, MRPS34, COQ5, MRPL43, RTN4IP1, NDUFAF2, PTPMT1, MRPL53, TMEM65, ATP5H, COX15, MTPN, ETFB, MRPL21, ABCB10, TMEM186, TIMM21, NDUFV3, MRPS7, ATP5O, MRPL50, VARS2, MRS2, SCO1, SDHB, MRPS14, ACOT1, MRPS24, MRPS5, MRPL49, DAP3, MRPS22, PMPCB, FKBP8, DDX58, TULP3, UFL1, DDRGK1, AARS2, COX8A, CS, PDHA1, TRAP1, FZR1, CACNA1C, FXR1, SHANK3, WDR5, TMCO3, HPN, PRSS50, TNFSF14, CTSG, MAP2K2, PRTN3, SPRTN, TMPRSS2, CTSL, FURIN, DPP4, BSG, IFITM3, TMPRSS11B, CLEC4E, M, nsp15, ORF3a, TFRC, APOBEC3B, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| DNAJA3 |  |
| CREBBP |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to DNAJA3-CREBBP |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to DNAJA3-CREBBP |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CREBBP | C4551859 | RUBINSTEIN-TAYBI SYNDROME 1 | 12 | CLINGEN;GENOMICS_ENGLAND;UNIPROT |
| Tgene | CREBBP | C0035934 | Rubinstein-Taybi Syndrome | 6 | CLINGEN;CTD_human |
| Tgene | CREBBP | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | CREBBP | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| Tgene | CREBBP | C4511003 | Acute myeloid leukemia with t(8;16)(p11;p13) translocation | 2 | ORPHANET |
| Tgene | CREBBP | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Tgene | CREBBP | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | CREBBP | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | CREBBP | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Tgene | CREBBP | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | CREBBP | C0079745 | Lymphoma, Large-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0079758 | Lymphoma, Mixed-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0079765 | Lymphoma, Small Cleaved-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | CREBBP | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | CREBBP | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | CREBBP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| Tgene | CREBBP | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human |
| Tgene | CREBBP | C1956130 | Lymphoma, Follicular, Grade 1 | 1 | CTD_human |
| Tgene | CREBBP | C1956131 | Lymphoma, Follicular, Grade 3 | 1 | CTD_human |
| Tgene | CREBBP | C1956132 | Lymphoma, Follicular, Grade 2 | 1 | CTD_human |
| Tgene | CREBBP | C4551993 | Amyotrophic Lateral Sclerosis, Familial | 1 | CTD_human |
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