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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DNAJB6-PICALM

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DNAJB6-PICALM
	FusionPDB ID: 23435
	FusionGDB2.0 ID: 23435
		Hgene	Tgene
	Gene symbol	DNAJB6	PICALM
	Gene ID	10049	8301
	Gene name	DnaJ heat shock protein family (Hsp40) member B6	phosphatidylinositol binding clathrin assembly protein
	Synonyms	DJ4\|DnaJ\|HHDJ1\|HSJ-2\|HSJ2\|LGMD1D\|LGMD1E\|LGMDD1\|MRJ\|MSJ-1	CALM\|CLTH\|LAP
	Cytomap	7q36.3	11q14.2
	Type of gene	protein-coding	protein-coding
	Description	dnaJ homolog subfamily B member 6DnaJ (Hsp40) homolog, subfamily B, member 6DnaJ-like 2 proteinheat shock protein J2	phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
	Modification date	20200328	20200322
	UniProtAcc	O75190	Q13492
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262177, ENST00000429029, ENST00000443280, ENST00000452797, ENST00000494267,	ENST00000356360, ENST00000528398, ENST00000528411, ENST00000393346, ENST00000526033, ENST00000532317,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 5 X 7=245	35 X 26 X 12=10920
	# samples	9	44
	** MAII score	log2(9/245*10)=-1.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(44/10920*10)=-4.63332552228256 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DNAJB6 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DNAJB6(157160177)-PICALM(85742653), # samples:1
Anticipated loss of major functional domain due to fusion event.	DNAJB6-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DNAJB6-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DNAJB6-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DNAJB6-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DNAJB6	GO:0006457	protein folding	11896048
Hgene	DNAJB6	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	11896048
Hgene	DNAJB6	GO:0045109	intermediate filament organization	10954706
Hgene	DNAJB6	GO:0090084	negative regulation of inclusion body assembly	21231916
Tgene	PICALM	GO:0006897	endocytosis	22118466
Tgene	PICALM	GO:0006898	receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:0032880	regulation of protein localization	10436022
Tgene	PICALM	GO:0045893	positive regulation of transcription, DNA-templated	11425879
Tgene	PICALM	GO:0048261	negative regulation of receptor-mediated endocytosis	10436022
Tgene	PICALM	GO:1905224	clathrin-coated pit assembly	16262731

Fusion gene breakpoints across DNAJB6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315374	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000429029	DNAJB6	chr7	157160177	+	ENST00000532317	PICALM	chr11	85742653	-	3616	551	205	2253	682
ENST00000429029	DNAJB6	chr7	157160177	+	ENST00000526033	PICALM	chr11	85742653	-	3717	551	205	2358	717
ENST00000429029	DNAJB6	chr7	157160177	+	ENST00000393346	PICALM	chr11	85742653	-	2612	551	205	2379	724
ENST00000262177	DNAJB6	chr7	157160177	+	ENST00000532317	PICALM	chr11	85742653	-	3616	551	205	2253	682
ENST00000262177	DNAJB6	chr7	157160177	+	ENST00000526033	PICALM	chr11	85742653	-	3717	551	205	2358	717
ENST00000262177	DNAJB6	chr7	157160177	+	ENST00000393346	PICALM	chr11	85742653	-	2612	551	205	2379	724
ENST00000452797	DNAJB6	chr7	157160177	+	ENST00000532317	PICALM	chr11	85742653	-	3456	391	192	2093	633
ENST00000452797	DNAJB6	chr7	157160177	+	ENST00000526033	PICALM	chr11	85742653	-	3557	391	192	2198	668
ENST00000452797	DNAJB6	chr7	157160177	+	ENST00000393346	PICALM	chr11	85742653	-	2452	391	192	2219	675
ENST00000443280	DNAJB6	chr7	157160177	+	ENST00000532317	PICALM	chr11	85742653	-	3557	492	146	2194	682
ENST00000443280	DNAJB6	chr7	157160177	+	ENST00000526033	PICALM	chr11	85742653	-	3658	492	146	2299	717
ENST00000443280	DNAJB6	chr7	157160177	+	ENST00000393346	PICALM	chr11	85742653	-	2553	492	146	2320	724

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000429029	ENST00000532317	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000409167	0.9995908
ENST00000429029	ENST00000526033	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.00039947	0.9996006
ENST00000429029	ENST00000393346	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000940641	0.9990594
ENST00000262177	ENST00000532317	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000409167	0.9995908
ENST00000262177	ENST00000526033	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.00039947	0.9996006
ENST00000262177	ENST00000393346	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000940641	0.9990594
ENST00000452797	ENST00000532317	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000512121	0.9994879
ENST00000452797	ENST00000526033	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000688637	0.9993113
ENST00000452797	ENST00000393346	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.001496901	0.9985031
ENST00000443280	ENST00000532317	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000427579	0.99957246
ENST00000443280	ENST00000526033	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.000418182	0.9995819
ENST00000443280	ENST00000393346	DNAJB6	chr7	157160177	+	PICALM	chr11	85742653	-	0.00101799	0.998982

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23435_23435_1_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000262177_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=724AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMF
VGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTT
KNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQ

--------------------------------------------------------------

>23435_23435_2_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000262177_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=717AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSP
VAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWS

--------------------------------------------------------------

>23435_23435_3_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000262177_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=682AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTV
ASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAY

--------------------------------------------------------------

>23435_23435_4_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000429029_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=724AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMF
VGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTT
KNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQ

--------------------------------------------------------------

>23435_23435_5_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000429029_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=717AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSP
VAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWS

--------------------------------------------------------------

>23435_23435_6_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000429029_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=682AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTV
ASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAY

--------------------------------------------------------------

>23435_23435_7_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000443280_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=724AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMF
VGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTT
KNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQ

--------------------------------------------------------------

>23435_23435_8_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000443280_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=717AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSP
VAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWS

--------------------------------------------------------------

>23435_23435_9_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000443280_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=682AA_BP=115
MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFG
FTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSN
FLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFM
LLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGK
KIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFS
TPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTV
ASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAY

--------------------------------------------------------------

>23435_23435_10_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000452797_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=675AA_BP=66
MPHPRILKRPKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERT
TNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMR
TMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRI
SEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKA
LKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVD
AVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPT
VASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTG

--------------------------------------------------------------

>23435_23435_11_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000452797_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=668AA_BP=66
MPHPRILKRPKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERT
TNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMR
TMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRI
SEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKA
LKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIP
SLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQN
LPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIP

--------------------------------------------------------------

>23435_23435_12_DNAJB6-PICALM_DNAJB6_chr7_157160177_ENST00000452797_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=633AA_BP=66
MPHPRILKRPKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFDLIQCTNEMNVNIPQLADSLFERT
TNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMR
TMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRI
SEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKA
LKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVA
QPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQP
GEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQI

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:157160177/chr11:85742653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DNAJB6 O75190	PICALM Q13492
FUNCTION: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. {ECO:0000269\|PubMed:10954706, ECO:0000269\|PubMed:11896048, ECO:0000269\|PubMed:20159555, ECO:0000269\|PubMed:22366786, ECO:0000269\|PubMed:28233300}.	FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269\|PubMed:10436022, ECO:0000269\|PubMed:16262731, ECO:0000269\|PubMed:21808019, ECO:0000269\|PubMed:22118466, ECO:0000269\|PubMed:23741335, ECO:0000269\|PubMed:24067654, ECO:0000269\|PubMed:25241929, ECO:0000269\|PubMed:25898166, ECO:0000269\|PubMed:27574975}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000262177

2_69

115.33333333333333

327.0

Domain

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000429029

2_69

115.33333333333333

242.0

Domain

Tgene

PICALM

chr7:157160177

chr11:85742653

ENST00000528398

14_145

552.0

Domain

ENTH

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000262177

155_194

115.33333333333333

327.0

Compositional bias

Note=Ser-rich

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000262177

83_172

115.33333333333333

327.0

Compositional bias

Note=Gly/Phe-rich

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000429029

155_194

115.33333333333333

242.0

Compositional bias

Note=Ser-rich

Hgene

DNAJB6

chr7:157160177

chr11:85742653

ENST00000429029

83_172

115.33333333333333

242.0

Compositional bias

Note=Gly/Phe-rich

Tgene

PICALM

chr7:157160177

chr11:85742653

ENST00000356360

14_145

43.333333333333336

633.0

Domain

ENTH

Tgene

PICALM

chr7:157160177

chr11:85742653

ENST00000393346

14_145

43.333333333333336

653.0

Domain

ENTH

Tgene

PICALM

chr7:157160177

chr11:85742653

ENST00000526033

14_145

43.333333333333336

646.0

Domain

ENTH

Tgene

PICALM

chr7:157160177

chr11:85742653

ENST00000532317

14_145

43.333333333333336

611.0

Domain

ENTH

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

PICALM

PLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DNAJB6
PICALM

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	DNAJB6	chr7:157160177	chr11:85742653	ENST00000262177	+	5	10	2_146	115.33333333333333	327.0	HSP70
Hgene	DNAJB6	chr7:157160177	chr11:85742653	ENST00000429029	+	5	8	2_146	115.33333333333333	242.0	HSP70
Hgene	DNAJB6	chr7:157160177	chr11:85742653	ENST00000262177	+	5	10	119_242	115.33333333333333	327.0	KRT18
Hgene	DNAJB6	chr7:157160177	chr11:85742653	ENST00000429029	+	5	8	119_242	115.33333333333333	242.0	KRT18

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Related Drugs to DNAJB6-PICALM

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DNAJB6-PICALM

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PICALM	C0002395	Alzheimer's Disease	2	CTD_human
Tgene	PICALM	C0011265	Presenile dementia	2	CTD_human
Tgene	PICALM	C0276496	Familial Alzheimer Disease (FAD)	2	CTD_human
Tgene	PICALM	C0494463	Alzheimer Disease, Late Onset	2	CTD_human
Tgene	PICALM	C0546126	Acute Confusional Senile Dementia	2	CTD_human
Tgene	PICALM	C0750900	Alzheimer's Disease, Focal Onset	2	CTD_human
Tgene	PICALM	C0750901	Alzheimer Disease, Early Onset	2	CTD_human
Tgene	PICALM	C0234985	Mental deterioration	1	CTD_human
Tgene	PICALM	C0338656	Impaired cognition	1	CTD_human
Tgene	PICALM	C1270972	Mild cognitive disorder	1	CTD_human