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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DNM3-RFWD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNM3-RFWD2
FusionPDB ID: 23675
FusionGDB2.0 ID: 23675
HgeneTgene
Gene symbol

DNM3

RFWD2

Gene ID

26052

64326

Gene namedynamin 3COP1 E3 ubiquitin ligase
SynonymsDyna IIICFAP78|FAP78|RFWD2|RNF200
Cytomap

1q24.3

1q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptiondynamin-3T-dynamindynamin family memberdynamin, testicularE3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri
Modification date2020031320200313
UniProtAcc

Q9UQ16

.
Ensembl transtripts involved in fusion geneENST idsENST00000355305, ENST00000358155, 
ENST00000367731, ENST00000367733, 
ENST00000520906, 		ENST00000308769, 
ENST00000367669, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 7 X 5=31528 X 17 X 12=5712
# samples 927
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/5712*10)=-4.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DNM3 [Title/Abstract] AND RFWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNM3(171810957)-RFWD2(176015460), # samples:2
Anticipated loss of major functional domain due to fusion event.DNM3-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM3-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM3-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNM3-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFWD2

GO:0010212

response to ionizing radiation

19805145


check buttonFusion gene breakpoints across DNM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RFWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-A4CIDNM3chr1

171810957

+RFWD2chr1

176015460

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358155DNM3chr1171810957+ENST00000367669RFWD2chr1176015460-15783371521255367
ENST00000358155DNM3chr1171810957+ENST00000308769RFWD2chr1176015460-12563371521255368
ENST00000367733DNM3chr1171810957+ENST00000367669RFWD2chr1176015460-15613201351238367
ENST00000367733DNM3chr1171810957+ENST00000308769RFWD2chr1176015460-12393201351238367
ENST00000355305DNM3chr1171810957+ENST00000367669RFWD2chr1176015460-15593181331236367
ENST00000355305DNM3chr1171810957+ENST00000308769RFWD2chr1176015460-12373181331236368
ENST00000367731DNM3chr1171810957+ENST00000367669RFWD2chr1176015460-15593181331236367
ENST00000367731DNM3chr1171810957+ENST00000308769RFWD2chr1176015460-12373181331236368
ENST00000520906DNM3chr1171810957+ENST00000367669RFWD2chr1176015460-15302891041207367
ENST00000520906DNM3chr1171810957+ENST00000308769RFWD2chr1176015460-12082891041207368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358155ENST00000367669DNM3chr1171810957+RFWD2chr1176015460-0.0012978730.99870217
ENST00000358155ENST00000308769DNM3chr1171810957+RFWD2chr1176015460-0.0031018530.9968982
ENST00000367733ENST00000367669DNM3chr1171810957+RFWD2chr1176015460-0.0013684470.99863154
ENST00000367733ENST00000308769DNM3chr1171810957+RFWD2chr1176015460-0.0033459480.99665403
ENST00000355305ENST00000367669DNM3chr1171810957+RFWD2chr1176015460-0.0013596910.99864036
ENST00000355305ENST00000308769DNM3chr1171810957+RFWD2chr1176015460-0.0033085160.99669147
ENST00000367731ENST00000367669DNM3chr1171810957+RFWD2chr1176015460-0.0013596910.99864036
ENST00000367731ENST00000308769DNM3chr1171810957+RFWD2chr1176015460-0.0033085160.99669147
ENST00000520906ENST00000367669DNM3chr1171810957+RFWD2chr1176015460-0.001131790.9988682
ENST00000520906ENST00000308769DNM3chr1171810957+RFWD2chr1176015460-0.0028393560.9971607

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>23675_23675_1_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000355305_RFWD2_chr1_176015460_ENST00000308769_length(amino acids)=368AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_2_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000355305_RFWD2_chr1_176015460_ENST00000367669_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_3_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000358155_RFWD2_chr1_176015460_ENST00000308769_length(amino acids)=368AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_4_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000358155_RFWD2_chr1_176015460_ENST00000367669_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_5_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000367731_RFWD2_chr1_176015460_ENST00000308769_length(amino acids)=368AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_6_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000367731_RFWD2_chr1_176015460_ENST00000367669_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_7_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000367733_RFWD2_chr1_176015460_ENST00000308769_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_8_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000367733_RFWD2_chr1_176015460_ENST00000367669_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_9_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000520906_RFWD2_chr1_176015460_ENST00000308769_length(amino acids)=368AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

>23675_23675_10_DNM3-RFWD2_DNM3_chr1_171810957_ENST00000520906_RFWD2_chr1_176015460_ENST00000367669_length(amino acids)=367AA_BP=61
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGSIEFDRDCDYFAIAGVTKKIKVYEYDTVI
QDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLR
SFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:171810957/chr1:176015460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM3

Q9UQ16

.
FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+12138_4653.666666666666664870.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+12138_4653.666666666666664864.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+12038_4653.666666666666664860.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+12138_4553.666666666666664870.0RegionG1 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+12138_4553.666666666666664864.0RegionG1 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+12038_4553.666666666666664860.0RegionG1 motif
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919419_458401.6666666666667708.0RepeatNote=WD 1
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919468_508401.6666666666667708.0RepeatNote=WD 2
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919511_551401.6666666666667708.0RepeatNote=WD 3
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919553_593401.6666666666667708.0RepeatNote=WD 4
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919597_635401.6666666666667708.0RepeatNote=WD 5
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919638_677401.6666666666667708.0RepeatNote=WD 6
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919691_729401.6666666666667708.0RepeatNote=WD 7
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020468_508425.6666666666667732.0RepeatNote=WD 2
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020511_551425.6666666666667732.0RepeatNote=WD 3
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020553_593425.6666666666667732.0RepeatNote=WD 4
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020597_635425.6666666666667732.0RepeatNote=WD 5
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020638_677425.6666666666667732.0RepeatNote=WD 6
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020691_729425.6666666666667732.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+12128_29453.666666666666664870.0DomainDynamin-type G
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121515_62153.666666666666664870.0DomainPH
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121659_75053.666666666666664870.0DomainGED
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+12128_29453.666666666666664864.0DomainDynamin-type G
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121515_62153.666666666666664864.0DomainPH
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121659_75053.666666666666664864.0DomainGED
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+12028_29453.666666666666664860.0DomainDynamin-type G
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120515_62153.666666666666664860.0DomainPH
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120659_75053.666666666666664860.0DomainGED
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121205_21153.666666666666664870.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121236_23953.666666666666664870.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121205_21153.666666666666664864.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121236_23953.666666666666664864.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120205_21153.666666666666664860.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120236_23953.666666666666664860.0Nucleotide bindingGTP
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121136_13953.666666666666664870.0RegionG3 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121205_20853.666666666666664870.0RegionG4 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+121235_23853.666666666666664870.0RegionG5 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000355305+12164_6653.666666666666664870.0RegionG2 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121136_13953.666666666666664864.0RegionG3 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121205_20853.666666666666664864.0RegionG4 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+121235_23853.666666666666664864.0RegionG5 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000358155+12164_6653.666666666666664864.0RegionG2 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120136_13953.666666666666664860.0RegionG3 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120205_20853.666666666666664860.0RegionG4 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+120235_23853.666666666666664860.0RegionG5 motif
HgeneDNM3chr1:171810957chr1:176015460ENST00000367731+12064_6653.666666666666664860.0RegionG2 motif
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919233_301401.6666666666667708.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020233_301425.6666666666667732.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:171810957chr1:176015460ENST000003087699192_110401.6666666666667708.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:171810957chr1:176015460ENST0000036766910202_110425.6666666666667732.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919109_113401.6666666666667708.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919195_206401.6666666666667708.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919235_245401.6666666666667708.0MotifNuclear export signal
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020109_113425.6666666666667732.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020195_206425.6666666666667732.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020235_245425.6666666666667732.0MotifNuclear export signal
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020419_458425.6666666666667732.0RepeatNote=WD 1
TgeneRFWD2chr1:171810957chr1:176015460ENST00000308769919136_174401.6666666666667708.0Zinc fingerRING-type
TgeneRFWD2chr1:171810957chr1:176015460ENST000003676691020136_174425.6666666666667732.0Zinc fingerRING-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DNM3
RFWD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DNM3-RFWD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNM3-RFWD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource