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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DSG1-DSP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DSG1-DSP
FusionPDB ID: 24240
FusionGDB2.0 ID: 24240
HgeneTgene
Gene symbol

DSG1

DSP

Gene ID

1828

1834

Gene namedesmoglein 1dentin sialophosphoprotein
SynonymsCDHF4|DG1|DSG|EPKHE|EPKHIA|PPKS1|SPPK1DFNA39|DGI1|DMP3|DPP|DSP
Cytomap

18q12.1

4q22.1

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-1cadherin family member 4desmosomal glycoprotein 1pemphigus foliaceus antigendentin sialophosphoproteindeafness, autosomal dominant 39dentin phosphophoryndentin phosphoproteindentin phosphoryndentin sialoprotein
Modification date2020031320200313
UniProtAcc

Q02413

P15924

Ensembl transtripts involved in fusion geneENST idsENST00000257192, ENST00000462981, 
ENST00000379802, ENST00000418664, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=4822 X 19 X 10=4180
# samples 426
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DSG1 [Title/Abstract] AND DSP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DSG1(28911830)-DSP(7568014), # samples:1
Anticipated loss of major functional domain due to fusion event.DSG1-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSG1-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSG1

GO:0050821

protein stabilization

7983064


check buttonFusion gene breakpoints across DSG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4726-01ADSG1chr18

28911830

+DSPchr6

7568014

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257192DSG1chr1828911830+ENST00000379802DSPchr67568014+921189621283712719
ENST00000257192DSG1chr1828911830+ENST00000418664DSPchr67568014+726989621265742120

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257192ENST00000379802DSG1chr1828911830+DSPchr67568014+0.0033348820.99666506
ENST00000257192ENST00000418664DSG1chr1828911830+DSPchr67568014+0.0017682560.9982318

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24240_24240_1_DSG1-DSP_DSG1_chr18_28911830_ENST00000257192_DSP_chr6_7568014_ENST00000379802_length(amino acids)=2719AA_BP=228
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGV
GIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELE
KEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLII
PPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGD
DDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLP
LADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTED
MLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDK
QIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYE
LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC
NKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL
QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS
KNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQD
KNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRL
KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLED
ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRK
KLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRN
EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLIND
LQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN
DLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE
TQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISP
ESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASG
GVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTEL
VDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPV
EEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELS
EILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYET
FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVF
SSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ
DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQ
RLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDA

--------------------------------------------------------------

>24240_24240_2_DSG1-DSP_DSG1_chr18_28911830_ENST00000257192_DSP_chr6_7568014_ENST00000418664_length(amino acids)=2120AA_BP=228
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGV
GIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILN
ATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELE
KEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLII
PPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGD
DDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLP
LADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTED
MLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDK
QIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYE
LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC
NKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL
QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR
LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST
RETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPF
LRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFS
GKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCR
IEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIG
LVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ
IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTL
RKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS
LSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGI
VDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY
LTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:28911830/chr6:7568014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSG1

Q02413

DSP

P15924

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.FUNCTION: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+61550_158228.01050.0DomainCadherin 1
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241018_1945380.02872.0Coiled coilOntology_term=ECO:0000255
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241018_1945380.02273.0Coiled coilOntology_term=ECO:0000255
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824458_515380.02872.0DomainSH3
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824458_515380.02273.0DomainSH3
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241057_1945380.02872.0RegionNote=Central fibrous rod domain
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241946_2871380.02872.0RegionNote=Globular 2
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241960_2208380.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242244_2446380.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242609_2822380.02872.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242824_2847380.02872.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241057_1945380.02273.0RegionNote=Central fibrous rod domain
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241946_2871380.02273.0RegionNote=Globular 2
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241960_2208380.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242244_2446380.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242609_2822380.02273.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242824_2847380.02273.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242009_2045380.02872.0RepeatNote=Plectin 1
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242046_2083380.02872.0RepeatNote=Plectin 2
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242084_2121380.02872.0RepeatNote=Plectin 3
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242122_2159380.02872.0RepeatNote=Plectin 4
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242163_2197380.02872.0RepeatNote=Plectin 5
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242198_2233380.02872.0RepeatNote=Plectin 6
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242251_2288380.02872.0RepeatNote=Plectin 7
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242289_2326380.02872.0RepeatNote=Plectin 8
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242327_2364380.02872.0RepeatNote=Plectin 9
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242365_2402380.02872.0RepeatNote=Plectin 10
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242406_2440380.02872.0RepeatNote=Plectin 11
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242456_2493380.02872.0RepeatNote=Plectin 12
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242507_2544380.02872.0RepeatNote=Plectin 13
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242610_2647380.02872.0RepeatNote=Plectin 14
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242648_2685380.02872.0RepeatNote=Plectin 15
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242724_2761380.02872.0RepeatNote=Plectin 16
TgeneDSPchr18:28911830chr6:7568014ENST000003798028242762_2799380.02872.0RepeatNote=Plectin 17
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824516_545380.02872.0RepeatNote=Spectrin 3b
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824546_627380.02872.0RepeatNote=Spectrin 4
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824654_769380.02872.0RepeatNote=Spectrin 5
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824770_883380.02872.0RepeatNote=Spectrin 6
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242009_2045380.02273.0RepeatNote=Plectin 1
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242046_2083380.02273.0RepeatNote=Plectin 2
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242084_2121380.02273.0RepeatNote=Plectin 3
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242122_2159380.02273.0RepeatNote=Plectin 4
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242163_2197380.02273.0RepeatNote=Plectin 5
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242198_2233380.02273.0RepeatNote=Plectin 6
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242251_2288380.02273.0RepeatNote=Plectin 7
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242289_2326380.02273.0RepeatNote=Plectin 8
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242327_2364380.02273.0RepeatNote=Plectin 9
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242365_2402380.02273.0RepeatNote=Plectin 10
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242406_2440380.02273.0RepeatNote=Plectin 11
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242456_2493380.02273.0RepeatNote=Plectin 12
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242507_2544380.02273.0RepeatNote=Plectin 13
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242610_2647380.02273.0RepeatNote=Plectin 14
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242648_2685380.02273.0RepeatNote=Plectin 15
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242724_2761380.02273.0RepeatNote=Plectin 16
TgeneDSPchr18:28911830chr6:7568014ENST000004186648242762_2799380.02273.0RepeatNote=Plectin 17
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824516_545380.02273.0RepeatNote=Spectrin 3b
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824546_627380.02273.0RepeatNote=Spectrin 4
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824654_769380.02273.0RepeatNote=Spectrin 5
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824770_883380.02273.0RepeatNote=Spectrin 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615969_1019228.01050.0Compositional biasNote=Gly/Ser-rich
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615159_270228.01050.0DomainCadherin 2
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615271_385228.01050.0DomainCadherin 3
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615386_497228.01050.0DomainCadherin 4
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615813_839228.01050.0RepeatNote=Desmoglein repeat 1
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615840_869228.01050.0RepeatNote=Desmoglein repeat 2
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615870_899228.01050.0RepeatNote=Desmoglein repeat 3
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615900_927228.01050.0RepeatNote=Desmoglein repeat 4
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615928_956228.01050.0RepeatNote=Desmoglein repeat 5
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+61550_548228.01050.0Topological domainExtracellular
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615570_1049228.01050.0Topological domainCytoplasmic
HgeneDSG1chr18:28911830chr6:7568014ENST00000257192+615549_569228.01050.0TransmembraneHelical
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241_1056380.02872.0RegionNote=Globular 1
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241_1056380.02273.0RegionNote=Globular 1
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824178_271380.02872.0RepeatNote=Spectrin 1
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824272_375380.02872.0RepeatNote=Spectrin 2
TgeneDSPchr18:28911830chr6:7568014ENST00000379802824376_446380.02872.0RepeatNote=Spectrin 3a
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824178_271380.02273.0RepeatNote=Spectrin 1
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824272_375380.02273.0RepeatNote=Spectrin 2
TgeneDSPchr18:28911830chr6:7568014ENST00000418664824376_446380.02273.0RepeatNote=Spectrin 3a


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DSG1
DSP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDSPchr18:28911830chr6:7568014ENST000003798028241_584380.02872.0plakophilin 1 and junction plakoglobin
TgeneDSPchr18:28911830chr6:7568014ENST000004186648241_584380.02273.0plakophilin 1 and junction plakoglobin


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Related Drugs to DSG1-DSP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DSG1-DSP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource