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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DSP-LY86

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DSP-LY86
FusionPDB ID: 24272
FusionGDB2.0 ID: 24272
HgeneTgene
Gene symbol

DSP

LY86

Gene ID

1834

9450

Gene namedentin sialophosphoproteinlymphocyte antigen 86
SynonymsDFNA39|DGI1|DMP3|DPP|DSPMD-1|MD1|MMD-1|dJ80N2.1
Cytomap

4q22.1

6p25.1

Type of geneprotein-codingprotein-coding
Descriptiondentin sialophosphoproteindeafness, autosomal dominant 39dentin phosphophoryndentin phosphoproteindentin phosphoryndentin sialoproteinlymphocyte antigen 86MD-1, RP105-associatedly-86protein MD-1
Modification date2020031320200313
UniProtAcc

P15924

O95711

Ensembl transtripts involved in fusion geneENST idsENST00000379802, ENST00000418664, 
ENST00000230568, ENST00000379953, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 19 X 11=33442 X 5 X 2=20
# samples 224
** MAII scorelog2(22/3344*10)=-3.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/20*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DSP [Title/Abstract] AND LY86 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DSP(7542318)-LY86(6649858), # samples:3
Anticipated loss of major functional domain due to fusion event.DSP-LY86 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DSP-LY86 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DSP-LY86 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DSP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LY86 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FD-01ADSPchr6

7542318

-LY86chr6

6649858

+
ChimerDB4ESCATCGA-JY-A6FD-01ADSPchr6

7542318

+LY86chr6

6649858

+
ChimerDB4ESCATCGA-JY-A6FDDSPchr6

7542318

+LY86chr6

6649857

+
ChimerDB4ESCATCGA-JY-A6FDDSPchr6

7542318

+LY86chr6

6649858

+
ChimerDB4ESCATCGA-JY-A6FDDSPchr6

7542318

+LY86chr6

6649863

+
ChimerDB4ESCATCGA-JY-A6FDDSPchr6

7542318

+LY86chr6

6654776

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379802DSPchr67542318+ENST00000230568LY86chr66654776+5995113901130
ENST00000418664DSPchr67542318+ENST00000230568LY86chr66654776+5574693481116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379802ENST00000230568DSPchr67542318+LY86chr66654776+0.218796570.78120345
ENST00000418664ENST00000230568DSPchr67542318+LY86chr66654776+0.38003720.6199628

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24272_24272_1_DSP-LY86_DSP_chr6_7542318_ENST00000379802_LY86_chr6_6654776_ENST00000230568_length(amino acids)=130AA_BP=
MRPRVLIRGWEPPLQLMSAGNRESGSAPRHKRGGPARRKRRGPRIGGRPGNRAGVRKAREVAARYLGPPEAAASAETATGRGQEREESCG

--------------------------------------------------------------

>24272_24272_2_DSP-LY86_DSP_chr6_7542318_ENST00000418664_LY86_chr6_6654776_ENST00000230568_length(amino acids)=116AA_BP=
MRPRVLIRGWEPPLQLMSAGNRESGSAPRHKRGGPARRKRRGPRIGGRPGNRAGVRKAREVAARYLGPPEAAASAETATGRGQEREESCG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:7542318/chr6:6649858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSP

P15924

LY86

O95711

FUNCTION: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.FUNCTION: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241018_194556.6666666666666642872.0Coiled coilOntology_term=ECO:0000255
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241018_194556.6666666666666642273.0Coiled coilOntology_term=ECO:0000255
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124458_51556.6666666666666642872.0DomainSH3
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124458_51556.6666666666666642273.0DomainSH3
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241057_194556.6666666666666642872.0RegionNote=Central fibrous rod domain
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241946_287156.6666666666666642872.0RegionNote=Globular 2
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241960_220856.6666666666666642872.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241_105656.6666666666666642872.0RegionNote=Globular 1
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242244_244656.6666666666666642872.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242609_282256.6666666666666642872.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242824_284756.6666666666666642872.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241057_194556.6666666666666642273.0RegionNote=Central fibrous rod domain
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241946_287156.6666666666666642273.0RegionNote=Globular 2
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241960_220856.6666666666666642273.0RegionNote=4.5 X 38 AA tandem repeats (Domain A)
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241_105656.6666666666666642273.0RegionNote=Globular 1
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242244_244656.6666666666666642273.0RegionNote=4.5 X 38 AA tandem repeats (Domain B)
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242609_282256.6666666666666642273.0RegionNote=4.5 X 38 AA tandem repeats (Domain C)
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242824_284756.6666666666666642273.0RegionNote=6 X 4 AA tandem repeats of G-S-R-[SR]
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124178_27156.6666666666666642872.0RepeatNote=Spectrin 1
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242009_204556.6666666666666642872.0RepeatNote=Plectin 1
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242046_208356.6666666666666642872.0RepeatNote=Plectin 2
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242084_212156.6666666666666642872.0RepeatNote=Plectin 3
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242122_215956.6666666666666642872.0RepeatNote=Plectin 4
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242163_219756.6666666666666642872.0RepeatNote=Plectin 5
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242198_223356.6666666666666642872.0RepeatNote=Plectin 6
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242251_228856.6666666666666642872.0RepeatNote=Plectin 7
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242289_232656.6666666666666642872.0RepeatNote=Plectin 8
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242327_236456.6666666666666642872.0RepeatNote=Plectin 9
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242365_240256.6666666666666642872.0RepeatNote=Plectin 10
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242406_244056.6666666666666642872.0RepeatNote=Plectin 11
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242456_249356.6666666666666642872.0RepeatNote=Plectin 12
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242507_254456.6666666666666642872.0RepeatNote=Plectin 13
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242610_264756.6666666666666642872.0RepeatNote=Plectin 14
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242648_268556.6666666666666642872.0RepeatNote=Plectin 15
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242724_276156.6666666666666642872.0RepeatNote=Plectin 16
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124272_37556.6666666666666642872.0RepeatNote=Spectrin 2
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1242762_279956.6666666666666642872.0RepeatNote=Plectin 17
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124376_44656.6666666666666642872.0RepeatNote=Spectrin 3a
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124516_54556.6666666666666642872.0RepeatNote=Spectrin 3b
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124546_62756.6666666666666642872.0RepeatNote=Spectrin 4
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124654_76956.6666666666666642872.0RepeatNote=Spectrin 5
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+124770_88356.6666666666666642872.0RepeatNote=Spectrin 6
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124178_27156.6666666666666642273.0RepeatNote=Spectrin 1
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242009_204556.6666666666666642273.0RepeatNote=Plectin 1
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242046_208356.6666666666666642273.0RepeatNote=Plectin 2
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242084_212156.6666666666666642273.0RepeatNote=Plectin 3
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242122_215956.6666666666666642273.0RepeatNote=Plectin 4
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242163_219756.6666666666666642273.0RepeatNote=Plectin 5
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242198_223356.6666666666666642273.0RepeatNote=Plectin 6
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242251_228856.6666666666666642273.0RepeatNote=Plectin 7
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242289_232656.6666666666666642273.0RepeatNote=Plectin 8
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242327_236456.6666666666666642273.0RepeatNote=Plectin 9
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242365_240256.6666666666666642273.0RepeatNote=Plectin 10
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242406_244056.6666666666666642273.0RepeatNote=Plectin 11
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242456_249356.6666666666666642273.0RepeatNote=Plectin 12
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242507_254456.6666666666666642273.0RepeatNote=Plectin 13
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242610_264756.6666666666666642273.0RepeatNote=Plectin 14
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242648_268556.6666666666666642273.0RepeatNote=Plectin 15
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242724_276156.6666666666666642273.0RepeatNote=Plectin 16
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124272_37556.6666666666666642273.0RepeatNote=Spectrin 2
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1242762_279956.6666666666666642273.0RepeatNote=Plectin 17
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124376_44656.6666666666666642273.0RepeatNote=Spectrin 3a
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124516_54556.6666666666666642273.0RepeatNote=Spectrin 3b
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124546_62756.6666666666666642273.0RepeatNote=Spectrin 4
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124654_76956.6666666666666642273.0RepeatNote=Spectrin 5
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+124770_88356.6666666666666642273.0RepeatNote=Spectrin 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DSP
LY86


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDSPchr6:7542318chr6:6654776ENST00000379802+1241_58456.6666666666666642872.0plakophilin 1 and junction plakoglobin
HgeneDSPchr6:7542318chr6:6654776ENST00000418664+1241_58456.6666666666666642273.0plakophilin 1 and junction plakoglobin


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Related Drugs to DSP-LY86


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DSP-LY86


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource