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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DSTYK-INTS3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DSTYK-INTS3
	FusionPDB ID: 24328
	FusionGDB2.0 ID: 24328
		Hgene	Tgene
	Gene symbol	DSTYK	INTS3
	Gene ID	25778	65123
	Gene name	dual serine/threonine and tyrosine protein kinase	integrator complex subunit 3
	Synonyms	CAKUT1\|DustyPK\|HDCMD38P\|RIP5\|RIPK5\|SPG23	C1orf193\|C1orf60\|INT3\|SOSS-A\|SOSSA
	Cytomap	1q32.1	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	dual serine/threonine and tyrosine protein kinaseRIP-homologous kinasedusty PKdusty protein kinasereceptor-interacting serine/threonine-protein kinase 5sgK496spastic paraplegia 23 (autosomal recessive)sugen kinase 496	integrator complex subunit 3SOSS complex subunit Asensor of single-strand DNA complex subunit Asensor of ssDNA subunit A
	Modification date	20200313	20200313
	UniProtAcc	Q6XUX3	Q68E01
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367160, ENST00000367161, ENST00000367162,	ENST00000476843, ENST00000318967, ENST00000435409, ENST00000456435, ENST00000512605,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 5 X 7=280	7 X 5 X 2=70
	# samples	11	7
	** MAII score	log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/70*10)=0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DSTYK [Title/Abstract] AND INTS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DSTYK(205180399)-INTS3(153730048), # samples:3
Anticipated loss of major functional domain due to fusion event.	DSTYK-INTS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-INTS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-INTS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-INTS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DSTYK	GO:0044344	cellular response to fibroblast growth factor stimulus	23862974
Tgene	INTS3	GO:0016180	snRNA processing	16239144

Fusion gene breakpoints across DSTYK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across INTS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-A5FT-01A	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000456435	INTS3	chr1	153730048	+	3508	329	293	2698	801
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000318967	INTS3	chr1	153730048	+	3310	329	293	2500	735
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000435409	INTS3	chr1	153730048	+	2766	329	293	2500	735
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000512605	INTS3	chr1	153730048	+	3157	329	293	2698	801
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000456435	INTS3	chr1	153730048	+	3475	296	260	2665	801
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000318967	INTS3	chr1	153730048	+	3277	296	260	2467	735
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000435409	INTS3	chr1	153730048	+	2733	296	260	2467	735
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000512605	INTS3	chr1	153730048	+	3124	296	260	2665	801
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000456435	INTS3	chr1	153730048	+	3475	296	260	2665	801
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000318967	INTS3	chr1	153730048	+	3277	296	260	2467	735
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000435409	INTS3	chr1	153730048	+	2733	296	260	2467	735
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000512605	INTS3	chr1	153730048	+	3124	296	260	2665	801

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367160	ENST00000456435	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.011662599	0.98833746
ENST00000367160	ENST00000318967	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.015788125	0.98421186
ENST00000367160	ENST00000435409	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.019909479	0.98009056
ENST00000367160	ENST00000512605	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.016852623	0.98314744
ENST00000367161	ENST00000456435	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.011660559	0.9883394
ENST00000367161	ENST00000318967	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.01596178	0.98403823
ENST00000367161	ENST00000435409	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.020168355	0.97983164
ENST00000367161	ENST00000512605	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.016922122	0.9830778
ENST00000367162	ENST00000456435	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.011660559	0.9883394
ENST00000367162	ENST00000318967	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.01596178	0.98403823
ENST00000367162	ENST00000435409	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.020168355	0.97983164
ENST00000367162	ENST00000512605	DSTYK	chr1	205180399	-	INTS3	chr1	153730048	+	0.016922122	0.9830778

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24328_24328_1_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367160_INTS3_chr1_153730048_ENST00000318967_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_2_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367160_INTS3_chr1_153730048_ENST00000435409_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_3_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367160_INTS3_chr1_153730048_ENST00000456435_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

>24328_24328_4_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367160_INTS3_chr1_153730048_ENST00000512605_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

>24328_24328_5_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367161_INTS3_chr1_153730048_ENST00000318967_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_6_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367161_INTS3_chr1_153730048_ENST00000435409_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_7_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367161_INTS3_chr1_153730048_ENST00000456435_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

>24328_24328_8_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367161_INTS3_chr1_153730048_ENST00000512605_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

>24328_24328_9_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367162_INTS3_chr1_153730048_ENST00000318967_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_10_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367162_INTS3_chr1_153730048_ENST00000435409_length(amino acids)=735AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAALSSPRSRKNATQPPNAEEESGSSSASEEEDTKPKPT

--------------------------------------------------------------

>24328_24328_11_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367162_INTS3_chr1_153730048_ENST00000456435_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

>24328_24328_12_DSTYK-INTS3_DSTYK_chr1_205180399_ENST00000367162_INTS3_chr1_153730048_ENST00000512605_length(amino acids)=801AA_BP=12
MQAMSPKPGCRRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHPSNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFY
DWLFFSPDKDSIMNIEPAILVMHHSMKPHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRA
MLREKFPEFCSSPSPPVEVKIEEPVSMEMDNHMSDKDESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDES
LRDKVLQLQKGSDTEAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKAHFRGEVLPEEITEESLEESVGKPLYLIFRNLCQMQEDNS
SFSLLLDLLSELYQKQPKIGYHLLYYLRASKAAAGKMNLYESFAQATQLGDLHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPDETLRSG
ELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLAHNIPLETIIPILQHLKYKEHPEALSCLLLQL
RREKPSEEMVKMVLSRPCHPDDQFTTSILRHWCMKHDELLAEHIKSLLIKNNSLPRKRQSLRSSSSKLAQLTLEQILEHLDNLRLNLTNT
KQNCMPSTLGVQCRRCCPGPDYAWSQAGGRGRTPGATTHTRDKTTCACCLISSQTSDCFSFPALPFLPLVFSQTPILQALQHVQASCDEA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:205180399/chr1:153730048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSTYK Q6XUX3	INTS3 Q68E01
FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269\|PubMed:15178406, ECO:0000269\|PubMed:23862974, ECO:0000269\|PubMed:28157540}.	FUNCTION: Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269\|PubMed:23904267, ECO:0000305\|PubMed:16239144}.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. {ECO:0000269\|PubMed:19605351, ECO:0000269\|PubMed:19683501}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

15_22

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

69_72

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

15_22

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

69_72

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

189_215

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

395_431

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

189_215

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

395_431

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

652_906

88.33333333333333

885.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

652_906

88.33333333333333

930.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367161

658_666

88.33333333333333

885.0

Nucleotide binding

ATP

Hgene

DSTYK

chr1:205180399

chr1:153730048

ENST00000367162

658_666

88.33333333333333

930.0

Nucleotide binding

ATP

Tgene

INTS3

chr1:205180399

chr1:153730048

ENST00000318967

9_34

319.0

1043.0

Compositional bias

Note=Ala/Gly-rich

Tgene

INTS3

chr1:205180399

chr1:153730048

ENST00000435409

9_34

319.0

1043.0

Compositional bias

Note=Ala/Gly-rich

Tgene

INTS3

chr1:205180399

chr1:153730048

ENST00000456435

9_34

113.0

903.0

Compositional bias

Note=Ala/Gly-rich

Tgene

INTS3

chr1:205180399

chr1:153730048

ENST00000512605

9_34

113.0

903.0

Compositional bias

Note=Ala/Gly-rich

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DSTYK
INTS3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to DSTYK-INTS3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DSTYK-INTS3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source