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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:DUSP16-FAT1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DUSP16-FAT1
FusionPDB ID: 24475
FusionGDB2.0 ID: 24475
HgeneTgene
Gene symbol

DUSP16

FAT1

Gene ID

80824

2195

Gene namedual specificity phosphatase 16FAT atypical cadherin 1
SynonymsMKP-7|MKP7CDHF7|CDHR8|FAT|ME5|hFat1
Cytomap

12p13.2

4q35.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 16MAP kinase phosphatase 7MAPK phosphatase-7mitogen-activated protein kinase phosphatase 7protocadherin Fat 1FAT tumor suppressor 1cadherin ME5cadherin family member 7cadherin-related family member 8cadherin-related tumor suppressor homologprotein fat homolog
Modification date2020031320200313
UniProtAcc

Q9BY84

Q14517

Ensembl transtripts involved in fusion geneENST idsENST00000228862, ENST00000298573, 
ENST00000545864, 		ENST00000512347, 
ENST00000441802, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 6=3248 X 12 X 3=288
# samples 911
** MAII scorelog2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: DUSP16 [Title/Abstract] AND FAT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DUSP16(12672796)-FAT1(187584767), # samples:1
Anticipated loss of major functional domain due to fusion event.DUSP16-FAT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
DUSP16-FAT1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUSP16

GO:0016311

dephosphorylation

24531476


check buttonFusion gene breakpoints across DUSP16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5803-01ADUSP16chr12

12672796

-FAT1chr4

187584767

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228862DUSP16chr1212672796-ENST00000441802FAT1chr4187584767-12310999632115003622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228862ENST00000441802DUSP16chr1212672796-FAT1chr4187584767-0.0007222220.9992778

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24475_24475_1_DUSP16-FAT1_DUSP16_chr12_12672796_ENST00000228862_FAT1_chr4_187584767_ENST00000441802_length(amino acids)=3622AA_BP=122
MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQ
SSQDVASLSSDCFLTVLLGKLEKSFNSVHLLAGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYP
EIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKIL
DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIK
AVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP
LDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFR
LDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAE
VLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFV
GMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE
SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVT
VHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASD
GRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEA
FDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEIS
LKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQ
FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNR
GISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHG
HFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNE
YEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVIL
TDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV
DNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSL
DHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEV
IESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDAD
SEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDV
LPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLEDVNDNAPEFS
ADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTV
IVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVE
ATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK
LLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDE
KAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVIGKIHATDQDVYD
TLTYSLDPQMDNLFSVSSTGGKLIAHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANLTPEEFVGDYWRNFQRA
LRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEKPGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDCPWKFCDEKVSVDE
SVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKYRLTE
NENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGT
APGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCFLTATEDCASNPCQNGG
VCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCD
SGFRGERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFVLCRKMI
SRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVPVRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHR
KAVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESCDDNGYHWDTS
DWMPSVPLPDIQEFPNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGS
SSRNRQRFNLNQYLPNFYPLDMSEPQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVSACCEVESEVMMSDYES

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12672796/chr4:187584767)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP16

Q9BY84

FAT1

Q14517

FUNCTION: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}.FUNCTION: [Protocadherin Fat 1]: Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271140_12451088.33333333333334589.0DomainCadherin 10
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271246_13571088.33333333333334589.0DomainCadherin 11
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271359_14561088.33333333333334589.0DomainCadherin 12
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271457_15621088.33333333333334589.0DomainCadherin 13
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271563_16671088.33333333333334589.0DomainCadherin 14
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271668_17651088.33333333333334589.0DomainCadherin 15
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271766_18791088.33333333333334589.0DomainCadherin 16
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271880_19791088.33333333333334589.0DomainCadherin 17
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271980_20811088.33333333333334589.0DomainCadherin 18
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272082_21821088.33333333333334589.0DomainCadherin 19
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272183_22831088.33333333333334589.0DomainCadherin 20
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272284_23901088.33333333333334589.0DomainCadherin 21
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272391_24921088.33333333333334589.0DomainCadherin 22
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272493_25961088.33333333333334589.0DomainCadherin 23
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272597_27031088.33333333333334589.0DomainCadherin 24
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272704_28091088.33333333333334589.0DomainCadherin 25
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272810_29181088.33333333333334589.0DomainCadherin 26
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021272919_30231088.33333333333334589.0DomainCadherin 27
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273024_31251088.33333333333334589.0DomainCadherin 28
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273126_32301088.33333333333334589.0DomainCadherin 29
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273231_33351088.33333333333334589.0DomainCadherin 30
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273336_34401088.33333333333334589.0DomainCadherin 31
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273441_35451088.33333333333334589.0DomainCadherin 32
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273546_36471088.33333333333334589.0DomainCadherin 33
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273790_38271088.33333333333334589.0DomainEGF-like 1
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021273829_40091088.33333333333334589.0DomainLaminin G-like
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274013_40501088.33333333333334589.0DomainEGF-like 2
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274052_40881088.33333333333334589.0DomainEGF-like 3
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274089_41251088.33333333333334589.0DomainEGF-like 4
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274127_41631088.33333333333334589.0DomainEGF-like 5%3B calcium-binding
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274204_42141088.33333333333334589.0MotifNuclear localization signal
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274378_43821088.33333333333334589.0MotifPTB-like motif
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274203_45881088.33333333333334589.0Topological domainCytoplasmic
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021274182_42021088.33333333333334589.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP16chr12:12672796chr4:187584767ENST00000228862-37158_300122.33333333333333666.0DomainTyrosine-protein phosphatase
HgeneDUSP16chr12:12672796chr4:187584767ENST00000228862-3722_137122.33333333333333666.0DomainRhodanese
TgeneFAT1chr12:12672796chr4:187584767ENST000004418021271035_11391088.33333333333334589.0DomainCadherin 9
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127150_2571088.33333333333334589.0DomainCadherin 2
TgeneFAT1chr12:12672796chr4:187584767ENST0000044180212735_1491088.33333333333334589.0DomainCadherin 1
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127368_4631088.33333333333334589.0DomainCadherin 3
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127464_5691088.33333333333334589.0DomainCadherin 4
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127570_6731088.33333333333334589.0DomainCadherin 5
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127718_8221088.33333333333334589.0DomainCadherin 6
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127823_9271088.33333333333334589.0DomainCadherin 7
TgeneFAT1chr12:12672796chr4:187584767ENST00000441802127928_10341088.33333333333334589.0DomainCadherin 8
TgeneFAT1chr12:12672796chr4:187584767ENST0000044180212722_41811088.33333333333334589.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
DUSP16
FAT1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to DUSP16-FAT1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DUSP16-FAT1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource