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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ECE1-CAPZB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ECE1-CAPZB
FusionPDB ID: 24848
FusionGDB2.0 ID: 24848
HgeneTgene
Gene symbol

ECE1

CAPZB

Gene ID

1889

832

Gene nameendothelin converting enzyme 1capping actin protein of muscle Z-line subunit beta
SynonymsECECAPB|CAPPB|CAPZ
Cytomap

1p36.12

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionendothelin-converting enzyme 1ECE-1F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020031320200320
UniProtAcc

P42892

P47756

Ensembl transtripts involved in fusion geneENST idsENST00000264205, ENST00000357071, 
ENST00000374893, ENST00000415912, 
ENST00000436918, ENST00000528294, 
ENST00000375144, ENST00000482808, 
ENST00000264202, ENST00000264203, 
ENST00000375142, ENST00000401084, 
ENST00000433834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 15 X 9=216023 X 15 X 8=2760
# samples 1827
** MAII scorelog2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ECE1 [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ECE1(21582440)-CAPZB(19746244), # samples:1
Anticipated loss of major functional domain due to fusion event.ECE1-CAPZB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ECE1-CAPZB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneECE1

GO:0010814

substance P catabolic process

18039931

HgeneECE1

GO:0010815

bradykinin catabolic process

18039931

HgeneECE1

GO:0010816

calcitonin catabolic process

18039931

HgeneECE1

GO:0016485

protein processing

7805846

HgeneECE1

GO:0016486

peptide hormone processing

7864876

HgeneECE1

GO:0034959

endothelin maturation

7805846

HgeneECE1

GO:0042447

hormone catabolic process

7864876


check buttonFusion gene breakpoints across ECE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AECE1chr1

21582440

-CAPZBchr1

19746244

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415912ECE1chr121582440-ENST00000401084CAPZBchr119746244-267110981261913595
ENST00000415912ECE1chr121582440-ENST00000264203CAPZBchr119746244-259110981261799557
ENST00000415912ECE1chr121582440-ENST00000375142CAPZBchr119746244-273410981261928600
ENST00000415912ECE1chr121582440-ENST00000433834CAPZBchr119746244-208510981261913595
ENST00000415912ECE1chr121582440-ENST00000264202CAPZBchr119746244-192910981261928600
ENST00000357071ECE1chr121582440-ENST00000401084CAPZBchr119746244-26721099461914622
ENST00000357071ECE1chr121582440-ENST00000264203CAPZBchr119746244-25921099461800584
ENST00000357071ECE1chr121582440-ENST00000375142CAPZBchr119746244-27351099461929627
ENST00000357071ECE1chr121582440-ENST00000433834CAPZBchr119746244-20861099461914622
ENST00000357071ECE1chr121582440-ENST00000264202CAPZBchr119746244-19301099461929628
ENST00000374893ECE1chr121582440-ENST00000401084CAPZBchr119746244-26681095631910615
ENST00000374893ECE1chr121582440-ENST00000264203CAPZBchr119746244-25881095631796577
ENST00000374893ECE1chr121582440-ENST00000375142CAPZBchr119746244-27311095631925620
ENST00000374893ECE1chr121582440-ENST00000433834CAPZBchr119746244-20821095631910615
ENST00000374893ECE1chr121582440-ENST00000264202CAPZBchr119746244-19261095631925620
ENST00000436918ECE1chr121582440-ENST00000401084CAPZBchr119746244-26431070381885615
ENST00000436918ECE1chr121582440-ENST00000264203CAPZBchr119746244-25631070381771577
ENST00000436918ECE1chr121582440-ENST00000375142CAPZBchr119746244-27061070381900620
ENST00000436918ECE1chr121582440-ENST00000433834CAPZBchr119746244-20571070381885615
ENST00000436918ECE1chr121582440-ENST00000264202CAPZBchr119746244-19011070381900621
ENST00000264205ECE1chr121582440-ENST00000401084CAPZBchr119746244-26431070591885608
ENST00000264205ECE1chr121582440-ENST00000264203CAPZBchr119746244-25631070591771570
ENST00000264205ECE1chr121582440-ENST00000375142CAPZBchr119746244-27061070591900613
ENST00000264205ECE1chr121582440-ENST00000433834CAPZBchr119746244-20571070591885608
ENST00000264205ECE1chr121582440-ENST00000264202CAPZBchr119746244-19011070591900614

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415912ENST00000401084ECE1chr121582440-CAPZBchr119746244-0.0061650110.993835
ENST00000415912ENST00000264203ECE1chr121582440-CAPZBchr119746244-0.0075666060.9924334
ENST00000415912ENST00000375142ECE1chr121582440-CAPZBchr119746244-0.0069371730.9930628
ENST00000415912ENST00000433834ECE1chr121582440-CAPZBchr119746244-0.0172559620.98274404
ENST00000415912ENST00000264202ECE1chr121582440-CAPZBchr119746244-0.0178513270.98214865
ENST00000357071ENST00000401084ECE1chr121582440-CAPZBchr119746244-0.0037485550.9962515
ENST00000357071ENST00000264203ECE1chr121582440-CAPZBchr119746244-0.0051149670.994885
ENST00000357071ENST00000375142ECE1chr121582440-CAPZBchr119746244-0.0044238370.99557614
ENST00000357071ENST00000433834ECE1chr121582440-CAPZBchr119746244-0.0136135730.9863864
ENST00000357071ENST00000264202ECE1chr121582440-CAPZBchr119746244-0.0140145020.9859855
ENST00000374893ENST00000401084ECE1chr121582440-CAPZBchr119746244-0.0021177720.9978822
ENST00000374893ENST00000264203ECE1chr121582440-CAPZBchr119746244-0.0028700920.99713
ENST00000374893ENST00000375142ECE1chr121582440-CAPZBchr119746244-0.0027137910.9972862
ENST00000374893ENST00000433834ECE1chr121582440-CAPZBchr119746244-0.0067549320.99324507
ENST00000374893ENST00000264202ECE1chr121582440-CAPZBchr119746244-0.0072269150.9927731
ENST00000436918ENST00000401084ECE1chr121582440-CAPZBchr119746244-0.0021560290.997844
ENST00000436918ENST00000264203ECE1chr121582440-CAPZBchr119746244-0.0029216790.9970783
ENST00000436918ENST00000375142ECE1chr121582440-CAPZBchr119746244-0.002773640.9972263
ENST00000436918ENST00000433834ECE1chr121582440-CAPZBchr119746244-0.0072041850.99279577
ENST00000436918ENST00000264202ECE1chr121582440-CAPZBchr119746244-0.0079524640.99204755
ENST00000264205ENST00000401084ECE1chr121582440-CAPZBchr119746244-0.0034409840.99655896
ENST00000264205ENST00000264203ECE1chr121582440-CAPZBchr119746244-0.0034260080.99657404
ENST00000264205ENST00000375142ECE1chr121582440-CAPZBchr119746244-0.0041913260.9958087
ENST00000264205ENST00000433834ECE1chr121582440-CAPZBchr119746244-0.0107964670.9892035
ENST00000264205ENST00000264202ECE1chr121582440-CAPZBchr119746244-0.0113374980.98866254

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24848_24848_1_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000264205_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=614AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKN
LSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEG
GVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVS

--------------------------------------------------------------

>24848_24848_2_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000264205_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=570AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKN
LSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEG
GVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVS

--------------------------------------------------------------

>24848_24848_3_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000264205_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=613AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKN
LSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEG
GVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVS

--------------------------------------------------------------

>24848_24848_4_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000264205_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=608AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKN
LSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEG
GVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVS

--------------------------------------------------------------

>24848_24848_5_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000264205_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=608AA_BP=0
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYR
ACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE
NEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKN
LSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEG
GVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVS

--------------------------------------------------------------

>24848_24848_6_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000357071_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=628AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCAL
DLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------

>24848_24848_7_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000357071_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=584AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCAL
DLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------

>24848_24848_8_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000357071_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=627AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCAL
DLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------

>24848_24848_9_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000357071_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=622AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCAL
DLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------

>24848_24848_10_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000357071_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=622AA_BP=1
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA
SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG
LGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCAL
DLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEA
NNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLG

--------------------------------------------------------------

>24848_24848_11_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000374893_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=620AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_12_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000374893_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=577AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_13_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000374893_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=620AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_14_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000374893_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=615AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_15_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000374893_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=615AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_16_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000415912_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=600AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCE
DLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHG
FAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLV

--------------------------------------------------------------

>24848_24848_17_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000415912_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=557AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCE
DLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHG
FAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLV

--------------------------------------------------------------

>24848_24848_18_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000415912_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=600AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCE
DLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHG
FAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLV

--------------------------------------------------------------

>24848_24848_19_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000415912_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=595AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCE
DLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHG
FAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLV

--------------------------------------------------------------

>24848_24848_20_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000415912_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=595AA_BP=1
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRA
KPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV
QLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCE
DLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHG
FAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLV

--------------------------------------------------------------

>24848_24848_21_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000436918_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=621AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_22_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000436918_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=577AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_23_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000436918_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=620AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_24_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000436918_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=615AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

>24848_24848_25_ECE1-CAPZB_ECE1_chr1_21582440_ENST00000436918_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=615AA_BP=1
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAER
KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD
YYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQSDQQLDCALDLMRRLP
PQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQY
RDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQM

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21582440/chr1:19746244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECE1

P42892

CAPZB

P47756

FUNCTION: Converts big endothelin-1 to endothelin-1. {ECO:0000269|PubMed:9396733}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneECE1chr1:21582440chr1:19746244ENST00000264205-7181_68337.0768.0Topological domainCytoplasmic
HgeneECE1chr1:21582440chr1:19746244ENST00000357071-6171_68328.0759.0Topological domainCytoplasmic
HgeneECE1chr1:21582440chr1:19746244ENST00000374893-8191_68340.0771.0Topological domainCytoplasmic
HgeneECE1chr1:21582440chr1:19746244ENST00000415912-8191_68324.0755.0Topological domainCytoplasmic
HgeneECE1chr1:21582440chr1:19746244ENST00000264205-71869_89337.0768.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21582440chr1:19746244ENST00000357071-61769_89328.0759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21582440chr1:19746244ENST00000374893-81969_89340.0771.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21582440chr1:19746244ENST00000415912-81969_89324.0755.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneECE1chr1:21582440chr1:19746244ENST00000264205-71898_770337.0768.0DomainPeptidase M13
HgeneECE1chr1:21582440chr1:19746244ENST00000357071-61798_770328.0759.0DomainPeptidase M13
HgeneECE1chr1:21582440chr1:19746244ENST00000374893-81998_770340.0771.0DomainPeptidase M13
HgeneECE1chr1:21582440chr1:19746244ENST00000415912-81998_770324.0755.0DomainPeptidase M13
HgeneECE1chr1:21582440chr1:19746244ENST00000264205-71890_770337.0768.0Topological domainExtracellular
HgeneECE1chr1:21582440chr1:19746244ENST00000357071-61790_770328.0759.0Topological domainExtracellular
HgeneECE1chr1:21582440chr1:19746244ENST00000374893-81990_770340.0771.0Topological domainExtracellular
HgeneECE1chr1:21582440chr1:19746244ENST00000415912-81990_770324.0755.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ECE1
CAPZB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ECE1-CAPZB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ECE1-CAPZB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource