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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ECE1-WNT4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ECE1-WNT4
	FusionPDB ID: 24864
	FusionGDB2.0 ID: 24864
		Hgene	Tgene
	Gene symbol	ECE1	WNT4
	Gene ID	1889	54361
	Gene name	endothelin converting enzyme 1	Wnt family member 4
	Synonyms	ECE	SERKAL\|WNT-4
	Cytomap	1p36.12	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	endothelin-converting enzyme 1ECE-1	protein Wnt-4wingless-type MMTV integration site family, member 4
	Modification date	20200313	20200313
	UniProtAcc	P42892	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264205, ENST00000357071, ENST00000374893, ENST00000415912, ENST00000436918, ENST00000528294,	ENST00000290167, ENST00000542383,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 15 X 9=2160	4 X 4 X 4=64
	# samples	18	7
	** MAII score	log2(18/2160*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/64*10)=0.129283016944966 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ECE1 [Title/Abstract] AND WNT4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ECE1(21599192)-WNT4(22448069), # samples:3
Anticipated loss of major functional domain due to fusion event.	ECE1-WNT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ECE1-WNT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ECE1	GO:0010814	substance P catabolic process	18039931
Hgene	ECE1	GO:0010815	bradykinin catabolic process	18039931
Hgene	ECE1	GO:0010816	calcitonin catabolic process	18039931
Hgene	ECE1	GO:0016485	protein processing	7805846
Hgene	ECE1	GO:0016486	peptide hormone processing	7864876
Hgene	ECE1	GO:0034959	endothelin maturation	7805846
Hgene	ECE1	GO:0042447	hormone catabolic process	7864876
Tgene	WNT4	GO:0010629	negative regulation of gene expression	15317892
Tgene	WNT4	GO:0010894	negative regulation of steroid biosynthetic process	15317892\|18182450
Tgene	WNT4	GO:0030501	positive regulation of bone mineralization	17720811
Tgene	WNT4	GO:0032349	positive regulation of aldosterone biosynthetic process	16981135
Tgene	WNT4	GO:0032967	positive regulation of collagen biosynthetic process	17720811
Tgene	WNT4	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade	17720811
Tgene	WNT4	GO:0045669	positive regulation of osteoblast differentiation	17720811
Tgene	WNT4	GO:0045893	positive regulation of transcription, DNA-templated	16959810\|16981135\|18182450
Tgene	WNT4	GO:0060070	canonical Wnt signaling pathway	15317892\|16959810\|18182450
Tgene	WNT4	GO:0061184	positive regulation of dermatome development	10654605
Tgene	WNT4	GO:2000066	positive regulation of cortisol biosynthetic process	16981135
Tgene	WNT4	GO:2000180	negative regulation of androgen biosynthetic process	16959810

Fusion gene breakpoints across ECE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AJ-A3BF-01A	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-
ChimerDB4	UCEC	TCGA-AJ-A3BF-01A	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-
ChimerDB4	UCEC	TCGA-AJ-A3BF	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415912	ECE1	chr1	21599192	-	ENST00000290167	WNT4	chr1	22448069	-	4059	571	126	1313	395
ENST00000415912	ECE1	chr1	21599192	-	ENST00000542383	WNT4	chr1	22448069	-	1336	571	126	1313	395
ENST00000357071	ECE1	chr1	21599192	-	ENST00000290167	WNT4	chr1	22448069	-	4060	572	46	1314	422
ENST00000357071	ECE1	chr1	21599192	-	ENST00000542383	WNT4	chr1	22448069	-	1337	572	46	1314	422
ENST00000374893	ECE1	chr1	21599192	-	ENST00000290167	WNT4	chr1	22448069	-	4056	568	63	1310	415
ENST00000374893	ECE1	chr1	21599192	-	ENST00000542383	WNT4	chr1	22448069	-	1333	568	63	1310	415
ENST00000436918	ECE1	chr1	21599192	-	ENST00000290167	WNT4	chr1	22448069	-	4031	543	38	1285	415
ENST00000436918	ECE1	chr1	21599192	-	ENST00000542383	WNT4	chr1	22448069	-	1308	543	38	1285	415
ENST00000264205	ECE1	chr1	21599192	-	ENST00000290167	WNT4	chr1	22448069	-	4031	543	59	1285	408
ENST00000264205	ECE1	chr1	21599192	-	ENST00000542383	WNT4	chr1	22448069	-	1308	543	59	1285	408
ENST00000415912	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448069	-	4059	571	126	1313	395
ENST00000415912	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448069	-	1336	571	126	1313	395
ENST00000357071	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448069	-	4060	572	46	1314	422
ENST00000357071	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448069	-	1337	572	46	1314	422
ENST00000374893	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448069	-	4056	568	63	1310	415
ENST00000374893	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448069	-	1333	568	63	1310	415
ENST00000436918	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448069	-	4031	543	38	1285	415
ENST00000436918	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448069	-	1308	543	38	1285	415
ENST00000264205	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448069	-	4031	543	59	1285	408
ENST00000264205	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448069	-	1308	543	59	1285	408
ENST00000415912	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448068	-	4059	571	126	1313	395
ENST00000415912	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448068	-	1336	571	126	1313	395
ENST00000357071	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448068	-	4060	572	46	1314	422
ENST00000357071	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448068	-	1337	572	46	1314	422
ENST00000374893	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448068	-	4056	568	63	1310	415
ENST00000374893	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448068	-	1333	568	63	1310	415
ENST00000436918	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448068	-	4031	543	38	1285	415
ENST00000436918	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448068	-	1308	543	38	1285	415
ENST00000264205	ECE1	chr1	21599191	-	ENST00000290167	WNT4	chr1	22448068	-	4031	543	59	1285	408
ENST00000264205	ECE1	chr1	21599191	-	ENST00000542383	WNT4	chr1	22448068	-	1308	543	59	1285	408

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415912	ENST00000290167	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.08619073	0.91380924
ENST00000415912	ENST00000542383	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.09400291	0.9059971
ENST00000357071	ENST00000290167	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.15267023	0.8473298
ENST00000357071	ENST00000542383	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.11273663	0.8872633
ENST00000374893	ENST00000290167	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.06613036	0.9338696
ENST00000374893	ENST00000542383	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.07491036	0.9250896
ENST00000436918	ENST00000290167	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.06722	0.93277997
ENST00000436918	ENST00000542383	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.07458464	0.92541534
ENST00000264205	ENST00000290167	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.03312105	0.96687895
ENST00000264205	ENST00000542383	ECE1	chr1	21599192	-	WNT4	chr1	22448069	-	0.04901524	0.9509848
ENST00000415912	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.08619073	0.91380924
ENST00000415912	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.09400291	0.9059971
ENST00000357071	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.15267023	0.8473298
ENST00000357071	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.11273663	0.8872633
ENST00000374893	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.06613036	0.9338696
ENST00000374893	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.07491036	0.9250896
ENST00000436918	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.06722	0.93277997
ENST00000436918	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.07458464	0.92541534
ENST00000264205	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.03312105	0.96687895
ENST00000264205	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448069	-	0.04901524	0.9509848
ENST00000415912	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.08619073	0.91380924
ENST00000415912	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.09400291	0.9059971
ENST00000357071	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.15267023	0.8473298
ENST00000357071	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.11273663	0.8872633
ENST00000374893	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.06613036	0.9338696
ENST00000374893	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.07491036	0.9250896
ENST00000436918	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.06722	0.93277997
ENST00000436918	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.07458464	0.92541534
ENST00000264205	ENST00000290167	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.03312105	0.96687895
ENST00000264205	ENST00000542383	ECE1	chr1	21599191	-	WNT4	chr1	22448068	-	0.04901524	0.9509848

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24864_24864_1_ECE1-WNT4_ECE1_chr1_21599191_ENST00000264205_WNT4_chr1_22448068_ENST00000290167_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_2_ECE1-WNT4_ECE1_chr1_21599191_ENST00000264205_WNT4_chr1_22448068_ENST00000542383_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_3_ECE1-WNT4_ECE1_chr1_21599191_ENST00000264205_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_4_ECE1-WNT4_ECE1_chr1_21599191_ENST00000264205_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_5_ECE1-WNT4_ECE1_chr1_21599191_ENST00000357071_WNT4_chr1_22448068_ENST00000290167_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

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>24864_24864_6_ECE1-WNT4_ECE1_chr1_21599191_ENST00000357071_WNT4_chr1_22448068_ENST00000542383_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

--------------------------------------------------------------

>24864_24864_7_ECE1-WNT4_ECE1_chr1_21599191_ENST00000357071_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

--------------------------------------------------------------

>24864_24864_8_ECE1-WNT4_ECE1_chr1_21599191_ENST00000357071_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

--------------------------------------------------------------

>24864_24864_9_ECE1-WNT4_ECE1_chr1_21599191_ENST00000374893_WNT4_chr1_22448068_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_10_ECE1-WNT4_ECE1_chr1_21599191_ENST00000374893_WNT4_chr1_22448068_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

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>24864_24864_11_ECE1-WNT4_ECE1_chr1_21599191_ENST00000374893_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_12_ECE1-WNT4_ECE1_chr1_21599191_ENST00000374893_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_13_ECE1-WNT4_ECE1_chr1_21599191_ENST00000415912_WNT4_chr1_22448068_ENST00000290167_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_14_ECE1-WNT4_ECE1_chr1_21599191_ENST00000415912_WNT4_chr1_22448068_ENST00000542383_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_15_ECE1-WNT4_ECE1_chr1_21599191_ENST00000415912_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_16_ECE1-WNT4_ECE1_chr1_21599191_ENST00000415912_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_17_ECE1-WNT4_ECE1_chr1_21599191_ENST00000436918_WNT4_chr1_22448068_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_18_ECE1-WNT4_ECE1_chr1_21599191_ENST00000436918_WNT4_chr1_22448068_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_19_ECE1-WNT4_ECE1_chr1_21599191_ENST00000436918_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_20_ECE1-WNT4_ECE1_chr1_21599191_ENST00000436918_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_21_ECE1-WNT4_ECE1_chr1_21599192_ENST00000264205_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_22_ECE1-WNT4_ECE1_chr1_21599192_ENST00000264205_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=408AA_BP=161
MEALRESVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQT
RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFA
VTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSG
SCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAI

--------------------------------------------------------------

>24864_24864_23_ECE1-WNT4_ECE1_chr1_21599192_ENST00000357071_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

--------------------------------------------------------------

>24864_24864_24_ECE1-WNT4_ECE1_chr1_21599192_ENST00000357071_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=422AA_BP=175
MFLSWIRAESVGTRPPLRQEAALMPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAG
LVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREA
AFVYAISSAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAIL
THMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVL

--------------------------------------------------------------

>24864_24864_25_ECE1-WNT4_ECE1_chr1_21599192_ENST00000374893_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_26_ECE1-WNT4_ECE1_chr1_21599192_ENST00000374893_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_27_ECE1-WNT4_ECE1_chr1_21599192_ENST00000415912_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_28_ECE1-WNT4_ECE1_chr1_21599192_ENST00000415912_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=395AA_BP=148
MMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS
VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAISSAGVAFAVTRACSSGELEKC
GCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPP
FRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFH

--------------------------------------------------------------

>24864_24864_29_ECE1-WNT4_ECE1_chr1_21599192_ENST00000436918_WNT4_chr1_22448069_ENST00000290167_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

>24864_24864_30_ECE1-WNT4_ECE1_chr1_21599192_ENST00000436918_WNT4_chr1_22448069_ENST00000542383_length(amino acids)=415AA_BP=168
MGHSMRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA
LGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLGTREAAFVYAIS
SAGVAFAVTRACSSGELEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVEC
KCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21599192/chr1:22448069)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ECE1 P42892	.
FUNCTION: Converts big endothelin-1 to endothelin-1. {ECO:0000269\|PubMed:9396733}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000264205

1_68

161.33333333333334

768.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000357071

1_68

152.33333333333334

759.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000374893

1_68

164.33333333333334

771.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000415912

1_68

148.33333333333334

755.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000264205

1_68

161.33333333333334

768.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000357071

1_68

152.33333333333334

759.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000374893

1_68

164.33333333333334

771.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000415912

1_68

148.33333333333334

755.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000264205

1_68

161.33333333333334

768.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000357071

1_68

152.33333333333334

759.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000374893

1_68

164.33333333333334

771.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000415912

1_68

148.33333333333334

755.0

Topological domain

Cytoplasmic

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000264205

69_89

161.33333333333334

768.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000357071

69_89

152.33333333333334

759.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000374893

69_89

164.33333333333334

771.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000415912

69_89

148.33333333333334

755.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000264205

69_89

161.33333333333334

768.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000357071

69_89

152.33333333333334

759.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000374893

69_89

164.33333333333334

771.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000415912

69_89

148.33333333333334

755.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000264205

69_89

161.33333333333334

768.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000357071

69_89

152.33333333333334

759.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000374893

69_89

164.33333333333334

771.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000415912

69_89

148.33333333333334

755.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000264205

98_770

161.33333333333334

768.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000357071

98_770

152.33333333333334

759.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000374893

98_770

164.33333333333334

771.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000415912

98_770

148.33333333333334

755.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000264205

98_770

161.33333333333334

768.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000357071

98_770

152.33333333333334

759.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000374893

98_770

164.33333333333334

771.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000415912

98_770

148.33333333333334

755.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000264205

98_770

161.33333333333334

768.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000357071

98_770

152.33333333333334

759.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000374893

98_770

164.33333333333334

771.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000415912

98_770

148.33333333333334

755.0

Domain

Peptidase M13

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000264205

90_770

161.33333333333334

768.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000357071

90_770

152.33333333333334

759.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000374893

90_770

164.33333333333334

771.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448068

ENST00000415912

90_770

148.33333333333334

755.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000264205

90_770

161.33333333333334

768.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000357071

90_770

152.33333333333334

759.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000374893

90_770

164.33333333333334

771.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599191

chr1:22448069

ENST00000415912

90_770

148.33333333333334

755.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000264205

90_770

161.33333333333334

768.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000357071

90_770

152.33333333333334

759.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000374893

90_770

164.33333333333334

771.0

Topological domain

Extracellular

Hgene

ECE1

chr1:21599192

chr1:22448069

ENST00000415912

90_770

148.33333333333334

755.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ECE1
WNT4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ECE1-WNT4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ECE1-WNT4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source