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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EFTUD2-SIN3A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EFTUD2-SIN3A
	FusionPDB ID: 25427
	FusionGDB2.0 ID: 25427
		Hgene	Tgene
	Gene symbol	EFTUD2	SIN3A
	Gene ID	9343	25942
	Gene name	elongation factor Tu GTP binding domain containing 2	SIN3 transcription regulator family member A
	Synonyms	MFDGA\|MFDM\|SNRNP116\|Snrp116\|Snu114\|U5-116KD	WITKOS
	Cytomap	17q21.31	15q24.2
	Type of gene	protein-coding	protein-coding
	Description	116 kDa U5 small nuclear ribonucleoprotein componentSNU114 homologU5 snRNP-specific protein, 116 kDaelongation factor Tu GTP-binding domain-containing protein 2hSNU114	paired amphipathic helix protein Sin3aSIN3 homolog A, transcription regulatorhistone deacetylase complex subunit Sin3atranscriptional co-repressor Sin3Atranscriptional corepressor Sin3atranscriptional regulator, SIN3A
	Modification date	20200313	20200328
	UniProtAcc	Q15029	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000402521, ENST00000426333, ENST00000591382, ENST00000592576, ENST00000589211,	ENST00000567289, ENST00000360439, ENST00000394947, ENST00000394949,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 12 X 10=1680	10 X 11 X 6=660
	# samples	15	11
	** MAII score	log2(15/1680*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/660*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EFTUD2 [Title/Abstract] AND SIN3A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EFTUD2(42931637)-SIN3A(75664550), # samples:3
Anticipated loss of major functional domain due to fusion event.	EFTUD2-SIN3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. EFTUD2-SIN3A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EFTUD2	GO:0000398	mRNA splicing, via spliceosome	28076346

Fusion gene breakpoints across EFTUD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SIN3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-J4-A67M-01A	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-
ChimerDB4	PRAD	TCGA-J4-A67M	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000426333	EFTUD2	chr17	42931637	-	ENST00000360439	SIN3A	chr15	75664550	-	3922	2645	298	2652	784
ENST00000592576	EFTUD2	chr17	42931637	-	ENST00000360439	SIN3A	chr15	75664550	-	3661	2384	67	2391	774
ENST00000591382	EFTUD2	chr17	42931637	-	ENST00000394949	SIN3A	chr15	75664550	-	3825	2745	398	2752	784
ENST00000402521	EFTUD2	chr17	42931637	-	ENST00000394949	SIN3A	chr15	75664550	-	3399	2319	62	2326	754

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000426333	ENST00000360439	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-	0.001147523	0.9988525
ENST00000592576	ENST00000360439	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-	0.001060227	0.9989398
ENST00000591382	ENST00000394949	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-	0.001259114	0.99874085
ENST00000402521	ENST00000394949	EFTUD2	chr17	42931637	-	SIN3A	chr15	75664550	-	0.001493063	0.99850696

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25427_25427_1_EFTUD2-SIN3A_EFTUD2_chr17_42931637_ENST00000402521_SIN3A_chr15_75664550_ENST00000394949_length(amino acids)=754AA_BP=
MSRREMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVN
FSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLIL
SPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDT
SLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTK
MYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRG
NEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVV
TFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTL

--------------------------------------------------------------

>25427_25427_2_EFTUD2-SIN3A_EFTUD2_chr17_42931637_ENST00000426333_SIN3A_chr15_75664550_ENST00000360439_length(amino acids)=784AA_BP=
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT
EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLP
PTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIE
HTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVIL
GTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT

--------------------------------------------------------------

>25427_25427_3_EFTUD2-SIN3A_EFTUD2_chr17_42931637_ENST00000591382_SIN3A_chr15_75664550_ENST00000394949_length(amino acids)=784AA_BP=
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT
EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLP
PTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA
PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIE
HTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE
VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVIL
GTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT

--------------------------------------------------------------

>25427_25427_4_EFTUD2-SIN3A_EFTUD2_chr17_42931637_ENST00000592576_SIN3A_chr15_75664550_ENST00000360439_length(amino acids)=774AA_BP=
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT
EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVL
PDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRH
IVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFV
EFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSD
LGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWV
LIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCV
MHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAAR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:42931637/chr15:75664550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EFTUD2 Q15029	.
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). {ECO:0000269\|PubMed:16723661, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:28781166, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30315277, ECO:0000269\|PubMed:30705154}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000402521

127_409

747.3333333333334

938.0

Domain

tr-type G

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000426333

127_409

782.3333333333334

973.0

Domain

tr-type G

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000591382

127_409

782.3333333333334

973.0

Domain

tr-type G

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000402521

136_143

747.3333333333334

938.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000402521

204_208

747.3333333333334

938.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000402521

258_261

747.3333333333334

938.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000426333

136_143

782.3333333333334

973.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000426333

204_208

782.3333333333334

973.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000426333

258_261

782.3333333333334

973.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000591382

136_143

782.3333333333334

973.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000591382

204_208

782.3333333333334

973.0

Nucleotide binding

GTP

Hgene

EFTUD2

chr17:42931637

chr15:75664550

ENST00000591382

258_261

782.3333333333334

973.0

Nucleotide binding

GTP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

903_932

1197.0

1274.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

903_932

1197.0

1274.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

903_932

1197.0

1274.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

218_285

1197.0

1274.0

Compositional bias

Note=Pro-rich

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

835_841

1197.0

1274.0

Compositional bias

Note=Poly-Glu

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

218_285

1197.0

1274.0

Compositional bias

Note=Pro-rich

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

835_841

1197.0

1274.0

Compositional bias

Note=Poly-Glu

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

218_285

1197.0

1274.0

Compositional bias

Note=Pro-rich

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

835_841

1197.0

1274.0

Compositional bias

Note=Poly-Glu

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

119_189

1197.0

1274.0

Domain

PAH 1

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

300_383

1197.0

1274.0

Domain

PAH 2

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000360439

456_525

1197.0

1274.0

Domain

PAH 3

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

119_189

1197.0

1274.0

Domain

PAH 1

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

300_383

1197.0

1274.0

Domain

PAH 2

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394947

456_525

1197.0

1274.0

Domain

PAH 3

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

119_189

1197.0

1274.0

Domain

PAH 1

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

300_383

1197.0

1274.0

Domain

PAH 2

Tgene

SIN3A

chr17:42931637

chr15:75664550

ENST00000394949

456_525

1197.0

1274.0

Domain

PAH 3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1568_EFTUD2_42931637_SIN3A_75664550_ranked_0.pdb	EFTUD2	42931637	42931637	ENST00000394949	SIN3A	chr15	75664550	-	MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLP PTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKA PTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIE HTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIE VNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVIL GTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQT	784

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EFTUD2_pLDDT.png

SIN3A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EFTUD2
SIN3A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	119_196	1197.0	1274.0	HCFC1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	119_196	1197.0	1274.0	HCFC1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	119_196	1197.0	1274.0	HCFC1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	687_829	1197.0	1274.0	HDAC1 and ARID4B
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	687_829	1197.0	1274.0	HDAC1 and ARID4B
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	687_829	1197.0	1274.0	HDAC1 and ARID4B
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	523_850	1197.0	1274.0	NCOR1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	523_850	1197.0	1274.0	NCOR1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	523_850	1197.0	1274.0	NCOR1
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	888_967	1197.0	1274.0	OGT
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	888_967	1197.0	1274.0	OGT
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	888_967	1197.0	1274.0	OGT
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	205_480	1197.0	1274.0	REST
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	205_480	1197.0	1274.0	REST
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	205_480	1197.0	1274.0	REST
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	458_525	1197.0	1274.0	SAP30
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	458_525	1197.0	1274.0	SAP30
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	458_525	1197.0	1274.0	SAP30
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000360439		19	21	524_659	1197.0	1274.0	SUDS3 and SAP130
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394947		19	21	524_659	1197.0	1274.0	SUDS3 and SAP130
Tgene	SIN3A	chr17:42931637	chr15:75664550	ENST00000394949		19	21	524_659	1197.0	1274.0	SUDS3 and SAP130

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Related Drugs to EFTUD2-SIN3A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EFTUD2-SIN3A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source