UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EGFR-ACADM

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EGFR-ACADM
	FusionPDB ID: 25443
	FusionGDB2.0 ID: 25443
		Hgene	Tgene
	Gene symbol	EGFR	ACADM
	Gene ID	1956	34
	Gene name	epidermal growth factor receptor	acyl-CoA dehydrogenase medium chain
	Synonyms	ERBB\|ERBB1\|HER1\|NISBD2\|PIG61\|mENA	ACAD1\|MCAD\|MCADH
	Cytomap	7p11.2	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	epidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas	medium-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-CoA dehydrogenase, C-4 to C-12 straight chainacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chainmedium-chain acyl-CoA dehydrogenasetesticular tissue protein Li 7
	Modification date	20200329	20200313
	UniProtAcc	P00533	P11310
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000463948, ENST00000275493, ENST00000342916, ENST00000344576, ENST00000420316, ENST00000442591, ENST00000455089, ENST00000454757,	ENST00000370834, ENST00000370841, ENST00000541113, ENST00000420607, ENST00000543667, ENST00000481374,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	41 X 25 X 14=14350	3 X 4 X 3=36
	# samples	53	4
	** MAII score	log2(53/14350*10)=-4.75891456699985 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EGFR [Title/Abstract] AND ACADM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EGFR(55087058)-ACADM(76198329), # samples:3
Anticipated loss of major functional domain due to fusion event.	EGFR-ACADM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EGFR-ACADM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EGFR-ACADM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EGFR-ACADM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EGFR	GO:0001934	positive regulation of protein phosphorylation	20551055
Hgene	EGFR	GO:0007165	signal transduction	10572067
Hgene	EGFR	GO:0007166	cell surface receptor signaling pathway	7736574
Hgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	7736574\|12435727
Hgene	EGFR	GO:0008283	cell proliferation	17115032
Hgene	EGFR	GO:0008284	positive regulation of cell proliferation	7736574
Hgene	EGFR	GO:0010750	positive regulation of nitric oxide mediated signal transduction	12828935
Hgene	EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	22732145
Hgene	EGFR	GO:0030307	positive regulation of cell growth	15467833
Hgene	EGFR	GO:0042177	negative regulation of protein catabolic process	17115032
Hgene	EGFR	GO:0042327	positive regulation of phosphorylation	15082764
Hgene	EGFR	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	EGFR	GO:0045739	positive regulation of DNA repair	17115032
Hgene	EGFR	GO:0045740	positive regulation of DNA replication	17115032
Hgene	EGFR	GO:0045944	positive regulation of transcription by RNA polymerase II	20551055
Hgene	EGFR	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	EGFR	GO:0050999	regulation of nitric-oxide synthase activity	12828935
Hgene	EGFR	GO:0070141	response to UV-A	18483258
Hgene	EGFR	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20551055
Hgene	EGFR	GO:0071392	cellular response to estradiol stimulus	20551055
Hgene	EGFR	GO:1900020	positive regulation of protein kinase C activity	22732145
Hgene	EGFR	GO:1903078	positive regulation of protein localization to plasma membrane	22732145
Tgene	ACADM	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	1902818\|3597357\|19224950\|25416781
Tgene	ACADM	GO:0051791	medium-chain fatty acid metabolic process	1970566
Tgene	ACADM	GO:0051793	medium-chain fatty acid catabolic process	1970566
Tgene	ACADM	GO:0055114	oxidation-reduction process	1902818

Fusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACADM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-6941-01A	EGFR	chr7	55087058	-	ACADM	chr1	76198329	+
ChimerDB4	HNSC	TCGA-CV-6941-01A	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+
ChimerDB4	HNSC	TCGA-CV-6941	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+
ChimerDB4	HNSC	TCGA-CV-6941	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000455089	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2409	345	257	1492	411
ENST00000455089	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2320	345	257	1591	444
ENST00000455089	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1736	345	257	1492	411
ENST00000342916	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2398	334	246	1481	411
ENST00000342916	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2309	334	246	1580	444
ENST00000342916	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1725	334	246	1481	411
ENST00000344576	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2397	333	245	1480	411
ENST00000344576	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2308	333	245	1579	444
ENST00000344576	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1724	333	245	1480	411
ENST00000420316	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2396	332	244	1479	411
ENST00000420316	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2307	332	244	1578	444
ENST00000420316	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1723	332	244	1479	411
ENST00000275493	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2329	265	177	1412	411
ENST00000275493	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2240	265	177	1511	444
ENST00000275493	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1656	265	177	1412	411
ENST00000442591	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198329	+	2312	248	160	1395	411
ENST00000442591	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198329	+	2223	248	160	1494	444
ENST00000442591	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198329	+	1639	248	160	1395	411
ENST00000455089	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2409	345	257	1492	411
ENST00000455089	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2320	345	257	1591	444
ENST00000455089	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1736	345	257	1492	411
ENST00000342916	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2398	334	246	1481	411
ENST00000342916	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2309	334	246	1580	444
ENST00000342916	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1725	334	246	1481	411
ENST00000344576	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2397	333	245	1480	411
ENST00000344576	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2308	333	245	1579	444
ENST00000344576	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1724	333	245	1480	411
ENST00000420316	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2396	332	244	1479	411
ENST00000420316	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2307	332	244	1578	444
ENST00000420316	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1723	332	244	1479	411
ENST00000275493	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2329	265	177	1412	411
ENST00000275493	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2240	265	177	1511	444
ENST00000275493	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1656	265	177	1412	411
ENST00000442591	EGFR	chr7	55087058	+	ENST00000370841	ACADM	chr1	76198328	+	2312	248	160	1395	411
ENST00000442591	EGFR	chr7	55087058	+	ENST00000370834	ACADM	chr1	76198328	+	2223	248	160	1494	444
ENST00000442591	EGFR	chr7	55087058	+	ENST00000541113	ACADM	chr1	76198328	+	1639	248	160	1395	411

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000455089	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000148821	0.9998511
ENST00000455089	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000162726	0.9998373
ENST00000455089	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000628589	0.99937147
ENST00000342916	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000148362	0.9998516
ENST00000342916	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000160701	0.9998393
ENST00000342916	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000617347	0.9993826
ENST00000344576	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.00014763	0.9998523
ENST00000344576	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000160532	0.9998394
ENST00000344576	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000610732	0.9993893
ENST00000420316	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000147778	0.9998522
ENST00000420316	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000161347	0.9998386
ENST00000420316	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000612798	0.99938715
ENST00000275493	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000138044	0.99986196
ENST00000275493	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000148339	0.9998516
ENST00000275493	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000566793	0.9994332
ENST00000442591	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000133307	0.9998667
ENST00000442591	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000141968	0.999858
ENST00000442591	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198329	+	0.000520354	0.9994797
ENST00000455089	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000148821	0.9998511
ENST00000455089	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000162726	0.9998373
ENST00000455089	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000628589	0.99937147
ENST00000342916	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000148362	0.9998516
ENST00000342916	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000160701	0.9998393
ENST00000342916	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000617347	0.9993826
ENST00000344576	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.00014763	0.9998523
ENST00000344576	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000160532	0.9998394
ENST00000344576	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000610732	0.9993893
ENST00000420316	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000147778	0.9998522
ENST00000420316	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000161347	0.9998386
ENST00000420316	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000612798	0.99938715
ENST00000275493	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000138044	0.99986196
ENST00000275493	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000148339	0.9998516
ENST00000275493	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000566793	0.9994332
ENST00000442591	ENST00000370841	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000133307	0.9998667
ENST00000442591	ENST00000370834	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000141968	0.999858
ENST00000442591	ENST00000541113	EGFR	chr7	55087058	+	ACADM	chr1	76198328	+	0.000520354	0.9994797

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25443_25443_1_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_2_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_3_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_4_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_5_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_6_EGFR-ACADM_EGFR_chr7_55087058_ENST00000275493_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_7_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_8_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_9_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_10_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_11_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_12_EGFR-ACADM_EGFR_chr7_55087058_ENST00000342916_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_13_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_14_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_15_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_16_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_17_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_18_EGFR-ACADM_EGFR_chr7_55087058_ENST00000344576_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_19_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_20_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_21_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_22_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_23_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_24_EGFR-ACADM_EGFR_chr7_55087058_ENST00000420316_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_25_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_26_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_27_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_28_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_29_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_30_EGFR-ACADM_EGFR_chr7_55087058_ENST00000442591_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_31_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198328_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_32_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198328_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_33_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198328_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_34_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198329_ENST00000370834_length(amino acids)=444AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC
PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA
YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY

--------------------------------------------------------------

>25443_25443_35_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198329_ENST00000370841_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

>25443_25443_36_EGFR-ACADM_EGFR_chr7_55087058_ENST00000455089_ACADM_chr1_76198329_ENST00000541113_length(amino acids)=411AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGL
GTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM
WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKT
RPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55087058/chr1:76198329)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EGFR P00533	ACADM P11310
FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). {ECO:0000250\|UniProtKB:Q01279, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11116146, ECO:0000269\|PubMed:11483589, ECO:0000269\|PubMed:11602604, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15374980, ECO:0000269\|PubMed:15590694, ECO:0000269\|PubMed:15611079, ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:19560417, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:21258366, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960, ECO:0000269\|PubMed:7679104, ECO:0000269\|PubMed:8144591, ECO:0000269\|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.	FUNCTION: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:2251268). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:25416781, PubMed:15159392). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:1970566, PubMed:8823175, PubMed:21237683, PubMed:2251268). {ECO:0000269\|PubMed:15159392, ECO:0000269\|PubMed:1970566, ECO:0000269\|PubMed:21237683, ECO:0000269\|PubMed:2251268, ECO:0000269\|PubMed:25416781, ECO:0000269\|PubMed:8823175}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

158_167

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

191_193

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

306_308

39.333333333333336

422.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

316_317

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

374_378

39.333333333333336

422.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

401_405

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

158_167

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

191_193

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

306_308

43.333333333333336

426.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

316_317

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

374_378

43.333333333333336

426.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

401_405

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

158_167

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

191_193

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

306_308

39.333333333333336

422.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

316_317

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

374_378

39.333333333333336

422.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

401_405

39.333333333333336

422.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

158_167

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

191_193

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

306_308

43.333333333333336

426.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

316_317

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

374_378

43.333333333333336

426.0

Nucleotide binding

FAD%3B shared with dimeric partner

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

401_405

43.333333333333336

426.0

Nucleotide binding

FAD

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000370841

278_281

39.333333333333336

422.0

Region

Substrate binding

Tgene

ACADM

chr7:55087058

chr1:76198328

ENST00000420607

278_281

43.333333333333336

426.0

Region

Substrate binding

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000370841

278_281

39.333333333333336

422.0

Region

Substrate binding

Tgene

ACADM

chr7:55087058

chr1:76198329

ENST00000420607

278_281

43.333333333333336

426.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

712_979

29.333333333333332

1211.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

712_979

29.333333333333332

629.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

712_979

29.333333333333332

706.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

712_979

29.333333333333332

406.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

712_979

29.333333333333332

1211.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

712_979

29.333333333333332

629.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

712_979

29.333333333333332

706.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

712_979

29.333333333333332

406.0

Domain

Protein kinase

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

718_726

29.333333333333332

1211.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

790_791

29.333333333333332

1211.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

718_726

29.333333333333332

629.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

790_791

29.333333333333332

629.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

718_726

29.333333333333332

706.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

790_791

29.333333333333332

706.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

718_726

29.333333333333332

406.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

790_791

29.333333333333332

406.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

718_726

29.333333333333332

1211.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

790_791

29.333333333333332

1211.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

718_726

29.333333333333332

629.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

790_791

29.333333333333332

629.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

718_726

29.333333333333332

706.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

790_791

29.333333333333332

706.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

718_726

29.333333333333332

406.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

790_791

29.333333333333332

406.0

Nucleotide binding

ATP

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

688_704

29.333333333333332

1211.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

688_704

29.333333333333332

629.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

688_704

29.333333333333332

706.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

688_704

29.333333333333332

406.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

688_704

29.333333333333332

1211.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

688_704

29.333333333333332

629.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

688_704

29.333333333333332

706.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

688_704

29.333333333333332

406.0

Region

Note=Important for dimerization%2C phosphorylation and activation

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

390_600

29.333333333333332

1211.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

75_300

29.333333333333332

1211.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

390_600

29.333333333333332

629.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

75_300

29.333333333333332

629.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

390_600

29.333333333333332

706.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

75_300

29.333333333333332

706.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

390_600

29.333333333333332

406.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

75_300

29.333333333333332

406.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

390_600

29.333333333333332

1211.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

75_300

29.333333333333332

1211.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

390_600

29.333333333333332

629.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

75_300

29.333333333333332

629.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

390_600

29.333333333333332

706.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

75_300

29.333333333333332

706.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

390_600

29.333333333333332

406.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

75_300

29.333333333333332

406.0

Repeat

Note=Approximate

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

25_645

29.333333333333332

1211.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

669_1210

29.333333333333332

1211.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

25_645

29.333333333333332

629.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

669_1210

29.333333333333332

629.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

25_645

29.333333333333332

706.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

669_1210

29.333333333333332

706.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

25_645

29.333333333333332

406.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

669_1210

29.333333333333332

406.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

25_645

29.333333333333332

1211.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

669_1210

29.333333333333332

1211.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

25_645

29.333333333333332

629.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

669_1210

29.333333333333332

629.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

25_645

29.333333333333332

706.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

669_1210

29.333333333333332

706.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

25_645

29.333333333333332

406.0

Topological domain

Extracellular

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

669_1210

29.333333333333332

406.0

Topological domain

Cytoplasmic

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000275493

646_668

29.333333333333332

1211.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000342916

646_668

29.333333333333332

629.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000344576

646_668

29.333333333333332

706.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198328

ENST00000420316

646_668

29.333333333333332

406.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000275493

646_668

29.333333333333332

1211.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000342916

646_668

29.333333333333332

629.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000344576

646_668

29.333333333333332

706.0

Transmembrane

Helical

Hgene

EGFR

chr7:55087058

chr1:76198329

ENST00000420316

646_668

29.333333333333332

406.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>929_EGFR_55087058_ACADM_76198329_929_EGFR_55087058_ACADM_76198329_ranked_0.pdb	EGFR	55087058	55087058	ENST00000541113	ACADM	chr1	76198329	+	MRPSGTAGAALLALLAALCPASRALEEKKEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVC PLLEACTLYLDAFFLLLTGSNLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCA YCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSY	444

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EGFR_pLDDT.png

ACADM_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EGFR
ACADM

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to EGFR-ACADM

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EGFR-ACADM

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source