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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EHMT1-PPP1R37

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EHMT1-PPP1R37
	FusionPDB ID: 25586
	FusionGDB2.0 ID: 25586
		Hgene	Tgene
	Gene symbol	EHMT1	PPP1R37
	Gene ID	79813	284352
	Gene name	euchromatic histone lysine methyltransferase 1	protein phosphatase 1 regulatory subunit 37
	Synonyms	EHMT1-IT1\|EUHMTASE1\|Eu-HMTase1\|FP13812\|GLP\|GLP1\|KLEFS1\|KMT1D	LRRC68
	Cytomap	9q34.3	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-m	protein phosphatase 1 regulatory subunit 37leucine rich repeat containing 68leucine-rich repeat-containing protein 68
	Modification date	20200313	20200313
	UniProtAcc	Q9H9B1	O75864
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371394, ENST00000334856, ENST00000460843, ENST00000462484,	ENST00000221462, ENST00000421905, ENST00000496125,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 9 X 8=1080	6 X 4 X 4=96
	# samples	20	7
	** MAII score	log2(20/1080*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EHMT1 [Title/Abstract] AND PPP1R37 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EHMT1(140622981)-PPP1R37(45641772), # samples:2
Anticipated loss of major functional domain due to fusion event.	EHMT1-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EHMT1-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EHMT1-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EHMT1-PPP1R37 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EHMT1	GO:0006325	chromatin organization	12004135
Hgene	EHMT1	GO:0016571	histone methylation	12004135
Hgene	EHMT1	GO:0018027	peptidyl-lysine dimethylation	20118233
Tgene	PPP1R37	GO:0010923	negative regulation of phosphatase activity	19389623

Fusion gene breakpoints across EHMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-H4-A2HO-01A	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+
ChimerDB4	BLCA	TCGA-H4-A2HO	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000462484	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641772	+	2722	860	22	2721	900
ENST00000462484	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641772	+	3457	860	22	2733	903
ENST00000334856	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641772	+	2722	860	22	2721	900
ENST00000334856	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641772	+	3457	860	22	2733	903
ENST00000460843	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641772	+	2712	850	12	2711	899
ENST00000460843	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641772	+	3447	850	12	2723	903
ENST00000462484	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641771	+	2722	860	22	2721	900
ENST00000462484	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641771	+	3457	860	22	2733	903
ENST00000334856	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641771	+	2722	860	22	2721	900
ENST00000334856	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641771	+	3457	860	22	2733	903
ENST00000460843	EHMT1	chr9	140622981	+	ENST00000421905	PPP1R37	chr19	45641771	+	2712	850	12	2711	899
ENST00000460843	EHMT1	chr9	140622981	+	ENST00000221462	PPP1R37	chr19	45641771	+	3447	850	12	2723	903

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000462484	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.02111652	0.9788835
ENST00000462484	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.012730869	0.98726916
ENST00000334856	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.02111652	0.9788835
ENST00000334856	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.012730869	0.98726916
ENST00000460843	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.021749785	0.9782502
ENST00000460843	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641772	+	0.013181808	0.9868182
ENST00000462484	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.02111652	0.9788835
ENST00000462484	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.012730869	0.98726916
ENST00000334856	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.02111652	0.9788835
ENST00000334856	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.012730869	0.98726916
ENST00000460843	ENST00000421905	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.021749785	0.9782502
ENST00000460843	ENST00000221462	EHMT1	chr9	140622981	+	PPP1R37	chr19	45641771	+	0.013181808	0.9868182

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25586_25586_1_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000334856_PPP1R37_chr19_45641771_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_2_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000334856_PPP1R37_chr19_45641771_ENST00000421905_length(amino acids)=900AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP
SLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETLX

--------------------------------------------------------------

>25586_25586_3_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000334856_PPP1R37_chr19_45641772_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_4_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000334856_PPP1R37_chr19_45641772_ENST00000421905_length(amino acids)=900AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP
SLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETLX

--------------------------------------------------------------

>25586_25586_5_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000460843_PPP1R37_chr19_45641771_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_6_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000460843_PPP1R37_chr19_45641771_ENST00000421905_length(amino acids)=899AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP

--------------------------------------------------------------

>25586_25586_7_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000460843_PPP1R37_chr19_45641772_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_8_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000460843_PPP1R37_chr19_45641772_ENST00000421905_length(amino acids)=899AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP

--------------------------------------------------------------

>25586_25586_9_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000462484_PPP1R37_chr19_45641771_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_10_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000462484_PPP1R37_chr19_45641771_ENST00000421905_length(amino acids)=900AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP
SLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETLX

--------------------------------------------------------------

>25586_25586_11_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000462484_PPP1R37_chr19_45641772_ENST00000221462_length(amino acids)=903AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS
LLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSD
SDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSP
PASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQ

--------------------------------------------------------------

>25586_25586_12_EHMT1-PPP1R37_EHMT1_chr9_140622981_ENST00000462484_PPP1R37_chr19_45641772_ENST00000421905_length(amino acids)=900AA_BP=279
MRARAMAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGT
NTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAP
PATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQC
YMATTKSQTAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDE
DGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLML
LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT
LSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL
DLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSD
GEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASP
SLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETLX

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140622981/chr19:45641772)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EHMT1 Q9H9B1	PPP1R37 O75864
FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250\|UniProtKB:Q5DW34, ECO:0000269\|PubMed:12004135, ECO:0000269\|PubMed:20118233}.	FUNCTION: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. {ECO:0000269\|PubMed:19389623}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

514_522

67.33333333333333

741.6666666666666

Compositional bias

Note=Poly-Glu

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

527_653

67.33333333333333

741.6666666666666

Compositional bias

Note=Pro-rich

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

514_522

67.33333333333333

741.6666666666666

Compositional bias

Note=Poly-Glu

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

527_653

67.33333333333333

741.6666666666666

Compositional bias

Note=Pro-rich

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

220_240

67.33333333333333

741.6666666666666

Repeat

Note=LRR 1

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

248_269

67.33333333333333

741.6666666666666

Repeat

Note=LRR 2

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

277_297

67.33333333333333

741.6666666666666

Repeat

Note=LRR 3

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

306_326

67.33333333333333

741.6666666666666

Repeat

Note=LRR 4

Tgene

PPP1R37

chr9:140622981

chr19:45641771

ENST00000221462

334_354

67.33333333333333

741.6666666666666

Repeat

Note=LRR 5

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

220_240

67.33333333333333

741.6666666666666

Repeat

Note=LRR 1

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

248_269

67.33333333333333

741.6666666666666

Repeat

Note=LRR 2

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

277_297

67.33333333333333

741.6666666666666

Repeat

Note=LRR 3

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

306_326

67.33333333333333

741.6666666666666

Repeat

Note=LRR 4

Tgene

PPP1R37

chr9:140622981

chr19:45641772

ENST00000221462

334_354

67.33333333333333

741.6666666666666

Repeat

Note=LRR 5

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

1292_1295

243.33333333333334

826.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

406_409

243.33333333333334

826.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

442_449

243.33333333333334

826.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

1292_1295

274.3333333333333

1299.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

406_409

274.3333333333333

1299.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

442_449

274.3333333333333

1299.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

1292_1295

274.3333333333333

809.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

406_409

274.3333333333333

809.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

442_449

274.3333333333333

809.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

1292_1295

243.33333333333334

826.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

406_409

243.33333333333334

826.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

442_449

243.33333333333334

826.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

1292_1295

274.3333333333333

1299.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

406_409

274.3333333333333

1299.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

442_449

274.3333333333333

1299.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

1292_1295

274.3333333333333

809.0

Compositional bias

Note=Poly-Ala

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

406_409

274.3333333333333

809.0

Compositional bias

Note=Poly-Glu

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

442_449

274.3333333333333

809.0

Compositional bias

Note=Poly-Arg

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

1060_1123

243.33333333333334

826.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

1126_1243

243.33333333333334

826.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

1060_1123

274.3333333333333

1299.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

1126_1243

274.3333333333333

1299.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

1060_1123

274.3333333333333

809.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

1126_1243

274.3333333333333

809.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

1060_1123

243.33333333333334

826.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

1126_1243

243.33333333333334

826.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

1060_1123

274.3333333333333

1299.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

1126_1243

274.3333333333333

1299.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

1060_1123

274.3333333333333

809.0

Domain

Pre-SET

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

1126_1243

274.3333333333333

809.0

Domain

SET

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

1136_1138

243.33333333333334

826.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

1200_1201

243.33333333333334

826.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

905_907

243.33333333333334

826.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

1136_1138

274.3333333333333

1299.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

1200_1201

274.3333333333333

1299.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

905_907

274.3333333333333

1299.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

1136_1138

274.3333333333333

809.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

1200_1201

274.3333333333333

809.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

905_907

274.3333333333333

809.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

1136_1138

243.33333333333334

826.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

1200_1201

243.33333333333334

826.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

905_907

243.33333333333334

826.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

1136_1138

274.3333333333333

1299.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

1200_1201

274.3333333333333

1299.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

905_907

274.3333333333333

1299.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

1136_1138

274.3333333333333

809.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

1200_1201

274.3333333333333

809.0

Region

Note=S-adenosyl-L-methionine binding

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

905_907

274.3333333333333

809.0

Region

Note=Histone H3K9me binding

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

737_766

243.33333333333334

826.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

772_801

243.33333333333334

826.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

805_834

243.33333333333334

826.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

838_868

243.33333333333334

826.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

872_901

243.33333333333334

826.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

905_934

243.33333333333334

826.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

938_967

243.33333333333334

826.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000334856

971_1004

243.33333333333334

826.0

Repeat

Note=ANK 8

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

737_766

274.3333333333333

1299.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

772_801

274.3333333333333

1299.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

805_834

274.3333333333333

1299.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

838_868

274.3333333333333

1299.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

872_901

274.3333333333333

1299.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

905_934

274.3333333333333

1299.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

938_967

274.3333333333333

1299.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000460843

971_1004

274.3333333333333

1299.0

Repeat

Note=ANK 8

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

737_766

274.3333333333333

809.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

772_801

274.3333333333333

809.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

805_834

274.3333333333333

809.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

838_868

274.3333333333333

809.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

872_901

274.3333333333333

809.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

905_934

274.3333333333333

809.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

938_967

274.3333333333333

809.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641771

ENST00000462484

971_1004

274.3333333333333

809.0

Repeat

Note=ANK 8

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

737_766

243.33333333333334

826.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

772_801

243.33333333333334

826.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

805_834

243.33333333333334

826.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

838_868

243.33333333333334

826.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

872_901

243.33333333333334

826.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

905_934

243.33333333333334

826.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

938_967

243.33333333333334

826.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000334856

971_1004

243.33333333333334

826.0

Repeat

Note=ANK 8

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

737_766

274.3333333333333

1299.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

772_801

274.3333333333333

1299.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

805_834

274.3333333333333

1299.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

838_868

274.3333333333333

1299.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

872_901

274.3333333333333

1299.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

905_934

274.3333333333333

1299.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

938_967

274.3333333333333

1299.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000460843

971_1004

274.3333333333333

1299.0

Repeat

Note=ANK 8

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

737_766

274.3333333333333

809.0

Repeat

Note=ANK 1

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

772_801

274.3333333333333

809.0

Repeat

Note=ANK 2

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

805_834

274.3333333333333

809.0

Repeat

Note=ANK 3

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

838_868

274.3333333333333

809.0

Repeat

Note=ANK 4

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

872_901

274.3333333333333

809.0

Repeat

Note=ANK 5

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

905_934

274.3333333333333

809.0

Repeat

Note=ANK 6

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

938_967

274.3333333333333

809.0

Repeat

Note=ANK 7

Hgene

EHMT1

chr9:140622981

chr19:45641772

ENST00000462484

971_1004

274.3333333333333

809.0

Repeat

Note=ANK 8

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EHMT1
PPP1R37

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000334856	+	4	17	1162_1181	243.33333333333334	826.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000334856	+	4	17	1242_1245	243.33333333333334	826.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000460843	+	4	27	1162_1181	274.3333333333333	1299.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000460843	+	4	27	1242_1245	274.3333333333333	1299.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000462484	+	4	16	1162_1181	274.3333333333333	809.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641771	ENST00000462484	+	4	16	1242_1245	274.3333333333333	809.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000334856	+	4	17	1162_1181	243.33333333333334	826.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000334856	+	4	17	1242_1245	243.33333333333334	826.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000460843	+	4	27	1162_1181	274.3333333333333	1299.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000460843	+	4	27	1242_1245	274.3333333333333	1299.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000462484	+	4	16	1162_1181	274.3333333333333	809.0	histone H3
Hgene	EHMT1	chr9:140622981	chr19:45641772	ENST00000462484	+	4	16	1242_1245	274.3333333333333	809.0	histone H3

Top

Related Drugs to EHMT1-PPP1R37

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EHMT1-PPP1R37

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source