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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABCC4-ABCB4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCC4-ABCB4
FusionPDB ID: 265
FusionGDB2.0 ID: 265
HgeneTgene
Gene symbol

ABCC4

ABCB4

Gene ID

10257

5244

Gene nameATP binding cassette subfamily C member 4ATP binding cassette subfamily B member 4
SynonymsMOAT-B|MOATB|MRP4ABC21|GBD1|ICP3|MDR2|MDR2/3|MDR3|PFIC-3|PGY3
Cytomap

13q32.1

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 4MRP/cMOAT-related ABC transporterbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)canalicular multispecific organic anion transporter (ABC superfamily)multi-specific organic anion transporter phosphatidylcholine translocator ABCB4ATP-binding cassette sub-family B member 4ATP-binding cassette, sub-family B (MDR/TAP), member 4P-glycoprotein 3P-glycoprotein-3/multiple drug resistance-3multidrug resistance protein 3multiple drug resistance 3
Modification date2020031320200315
UniProtAcc

O15439

P21439

Ensembl transtripts involved in fusion geneENST idsENST00000538287, ENST00000376887, 
ENST00000412704, ENST00000431522, 
ENST00000536256, ENST00000474158, 
ENST00000265723, ENST00000358400, 
ENST00000359206, ENST00000453593, 
ENST00000545634, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 11=53134 X 5 X 4=80
# samples 254
** MAII scorelog2(25/5313*10)=-4.40952671281098
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCC4 [Title/Abstract] AND ABCB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCC4(95829961)-ABCB4(87038708), # samples:2
Anticipated loss of major functional domain due to fusion event.ABCC4-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC4-ABCB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC4

GO:0032310

prostaglandin secretion

25173977

TgeneABCB4

GO:0032376

positive regulation of cholesterol transport

17523162

TgeneABCB4

GO:0045332

phospholipid translocation

8898203

TgeneABCB4

GO:0055088

lipid homeostasis

17523162

TgeneABCB4

GO:0061092

positive regulation of phospholipid translocation

17523162

TgeneABCB4

GO:0099040

ceramide translocation

8898203

TgeneABCB4

GO:1903413

cellular response to bile acid

17523162

TgeneABCB4

GO:2001140

positive regulation of phospholipid transport

8898203


check buttonFusion gene breakpoints across ABCC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CR-6467-01AABCC4chr13

95829961

-ABCB4chr7

87038708

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412704ABCC4chr1395829961-ENST00000359206ABCB4chr787038708-281318461192761880
ENST00000412704ABCC4chr1395829961-ENST00000358400ABCB4chr787038708-281318461192761880
ENST00000412704ABCC4chr1395829961-ENST00000265723ABCB4chr787038708-283018461192782887
ENST00000412704ABCC4chr1395829961-ENST00000545634ABCB4chr787038708-276218461192761881
ENST00000412704ABCC4chr1395829961-ENST00000453593ABCB4chr787038708-276218461192761881
ENST00000376887ABCC4chr1395829961-ENST00000359206ABCB4chr787038708-280918421152757880
ENST00000376887ABCC4chr1395829961-ENST00000358400ABCB4chr787038708-280918421152757880
ENST00000376887ABCC4chr1395829961-ENST00000265723ABCB4chr787038708-282618421152778887
ENST00000376887ABCC4chr1395829961-ENST00000545634ABCB4chr787038708-275818421152757881
ENST00000376887ABCC4chr1395829961-ENST00000453593ABCB4chr787038708-275818421152757881
ENST00000536256ABCC4chr1395829961-ENST00000359206ABCB4chr787038708-258816211192536805
ENST00000536256ABCC4chr1395829961-ENST00000358400ABCB4chr787038708-258816211192536805
ENST00000536256ABCC4chr1395829961-ENST00000265723ABCB4chr787038708-260516211192557812
ENST00000536256ABCC4chr1395829961-ENST00000545634ABCB4chr787038708-253716211192536806
ENST00000536256ABCC4chr1395829961-ENST00000453593ABCB4chr787038708-253716211192536806
ENST00000431522ABCC4chr1395829961-ENST00000359206ABCB4chr787038708-281318461192761880
ENST00000431522ABCC4chr1395829961-ENST00000358400ABCB4chr787038708-281318461192761880
ENST00000431522ABCC4chr1395829961-ENST00000265723ABCB4chr787038708-283018461192782887
ENST00000431522ABCC4chr1395829961-ENST00000545634ABCB4chr787038708-276218461192761881
ENST00000431522ABCC4chr1395829961-ENST00000453593ABCB4chr787038708-276218461192761881

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412704ENST00000359206ABCC4chr1395829961-ABCB4chr787038708-0.0024179710.99758196
ENST00000412704ENST00000358400ABCC4chr1395829961-ABCB4chr787038708-0.0024179710.99758196
ENST00000412704ENST00000265723ABCC4chr1395829961-ABCB4chr787038708-0.0022939210.99770606
ENST00000412704ENST00000545634ABCC4chr1395829961-ABCB4chr787038708-0.0026478880.9973521
ENST00000412704ENST00000453593ABCC4chr1395829961-ABCB4chr787038708-0.0026478880.9973521
ENST00000376887ENST00000359206ABCC4chr1395829961-ABCB4chr787038708-0.0024209510.99757904
ENST00000376887ENST00000358400ABCC4chr1395829961-ABCB4chr787038708-0.0024209510.99757904
ENST00000376887ENST00000265723ABCC4chr1395829961-ABCB4chr787038708-0.0022953230.9977047
ENST00000376887ENST00000545634ABCC4chr1395829961-ABCB4chr787038708-0.0026574170.99734265
ENST00000376887ENST00000453593ABCC4chr1395829961-ABCB4chr787038708-0.0026574170.99734265
ENST00000536256ENST00000359206ABCC4chr1395829961-ABCB4chr787038708-0.0027379780.997262
ENST00000536256ENST00000358400ABCC4chr1395829961-ABCB4chr787038708-0.0027379780.997262
ENST00000536256ENST00000265723ABCC4chr1395829961-ABCB4chr787038708-0.0023893380.9976107
ENST00000536256ENST00000545634ABCC4chr1395829961-ABCB4chr787038708-0.0030658470.9969342
ENST00000536256ENST00000453593ABCC4chr1395829961-ABCB4chr787038708-0.0030658470.9969342
ENST00000431522ENST00000359206ABCC4chr1395829961-ABCB4chr787038708-0.0024179710.99758196
ENST00000431522ENST00000358400ABCC4chr1395829961-ABCB4chr787038708-0.0024179710.99758196
ENST00000431522ENST00000265723ABCC4chr1395829961-ABCB4chr787038708-0.0022939210.99770606
ENST00000431522ENST00000545634ABCC4chr1395829961-ABCB4chr787038708-0.0026478880.9973521
ENST00000431522ENST00000453593ABCC4chr1395829961-ABCB4chr787038708-0.0026478880.9973521

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>265_265_1_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000376887_ABCB4_chr7_87038708_ENST00000265723_length(amino acids)=887AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQL
GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEAT

--------------------------------------------------------------

>265_265_2_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000376887_ABCB4_chr7_87038708_ENST00000358400_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_3_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000376887_ABCB4_chr7_87038708_ENST00000359206_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_4_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000376887_ABCB4_chr7_87038708_ENST00000453593_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_5_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000376887_ABCB4_chr7_87038708_ENST00000545634_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_6_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000412704_ABCB4_chr7_87038708_ENST00000265723_length(amino acids)=887AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQL
GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEAT

--------------------------------------------------------------

>265_265_7_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000412704_ABCB4_chr7_87038708_ENST00000358400_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_8_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000412704_ABCB4_chr7_87038708_ENST00000359206_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_9_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000412704_ABCB4_chr7_87038708_ENST00000453593_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_10_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000412704_ABCB4_chr7_87038708_ENST00000545634_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_11_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000431522_ABCB4_chr7_87038708_ENST00000265723_length(amino acids)=887AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQL
GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEAT

--------------------------------------------------------------

>265_265_12_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000431522_ABCB4_chr7_87038708_ENST00000358400_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_13_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000431522_ABCB4_chr7_87038708_ENST00000359206_length(amino acids)=880AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_14_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000431522_ABCB4_chr7_87038708_ENST00000453593_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_15_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000431522_ABCB4_chr7_87038708_ENST00000545634_length(amino acids)=881AA_BP=576
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTD
ARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG
KSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK
FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEP
ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES

--------------------------------------------------------------

>265_265_16_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000536256_ABCB4_chr7_87038708_ENST00000265723_length(amino acids)=812AA_BP=501
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV
RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL
TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ
PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDG
QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ

--------------------------------------------------------------

>265_265_17_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000536256_ABCB4_chr7_87038708_ENST00000358400_length(amino acids)=805AA_BP=501
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV
RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL
TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ
PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLN
VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQ

--------------------------------------------------------------

>265_265_18_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000536256_ABCB4_chr7_87038708_ENST00000359206_length(amino acids)=805AA_BP=501
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV
RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL
TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ
PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLN
VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQ

--------------------------------------------------------------

>265_265_19_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000536256_ABCB4_chr7_87038708_ENST00000453593_length(amino acids)=806AA_BP=501
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV
RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL
TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ
PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLN
VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQ

--------------------------------------------------------------

>265_265_20_ABCC4-ABCB4_ABCC4_chr13_95829961_ENST00000536256_ABCB4_chr7_87038708_ENST00000545634_length(amino acids)=806AA_BP=501
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWK
SYLVLGIFTLIEALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFG
KLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV
ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV
RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDL
TVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ
PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLN
VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:95829961/chr7:87038708)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCC4

O15439

ABCB4

P21439

FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). {ECO:0000269|PubMed:11106685, ECO:0000269|PubMed:11856762, ECO:0000269|PubMed:12105214, ECO:0000269|PubMed:12523936, ECO:0000269|PubMed:12835412, ECO:0000269|PubMed:12883481, ECO:0000269|PubMed:15364914, ECO:0000269|PubMed:15454390, ECO:0000269|PubMed:16282361, ECO:0000269|PubMed:17344354, ECO:0000269|PubMed:17959747, ECO:0000269|PubMed:18300232, ECO:0000269|PubMed:26721430}.FUNCTION: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity). {ECO:0000250|UniProtKB:P21440, ECO:0000269|PubMed:17523162, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:23468132, ECO:0000269|PubMed:24045840, ECO:0000269|PubMed:24594635, ECO:0000269|PubMed:24723470, ECO:0000269|PubMed:24806754, ECO:0000269|PubMed:28012258, ECO:0000269|PubMed:7957936, ECO:0000269|PubMed:8898203, ECO:0000269|PubMed:9366571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-133192_377575.66666666666661326.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-133092_377575.66666666666661279.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-132192_377575.6666666666666860.0DomainABC transmembrane type-1 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331445_452575.66666666666661326.0Nucleotide bindingATP 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330445_452575.66666666666661279.0Nucleotide bindingATP 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321445_452575.6666666666666860.0Nucleotide bindingATP 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331136_156575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331207_227575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331228_248575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331328_348575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331351_371575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331440_460575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-133193_113575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330136_156575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330207_227575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330228_248575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330328_348575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330351_371575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330440_460575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-133093_113575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321136_156575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321207_227575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321228_248575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321328_348575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321351_371575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321440_460575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-132193_113575.6666666666666860.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST0000026572322281034_1279974.66666666666661287.0DomainABC transporter 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000035840021271034_1279927.66666666666661233.0DomainABC transporter 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000035920622281034_1279974.66666666666661280.0DomainABC transporter 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000045359320261034_1279927.66666666666661233.0DomainABC transporter 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000054563421271034_1279974.66666666666661280.0DomainABC transporter 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000026572322281069_1076974.66666666666661287.0Nucleotide bindingATP 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000035840021271069_1076927.66666666666661233.0Nucleotide bindingATP 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000035920622281069_1076974.66666666666661280.0Nucleotide bindingATP 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000045359320261069_1076927.66666666666661233.0Nucleotide bindingATP 2
TgeneABCB4chr13:95829961chr7:87038708ENST0000054563421271069_1076974.66666666666661280.0Nucleotide bindingATP 2
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228995_1286974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127957_972927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127995_1286927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228995_1286974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026957_972927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026995_1286927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127995_1286974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228973_994974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127934_956927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127973_994927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228973_994974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026934_956927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026973_994927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127973_994974.66666666666661280.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-13311041_1274575.66666666666661326.0DomainABC transporter 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331410_633575.66666666666661326.0DomainABC transporter 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331714_1005575.66666666666661326.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-13301041_1274575.66666666666661279.0DomainABC transporter 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330410_633575.66666666666661279.0DomainABC transporter 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330714_1005575.66666666666661279.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-13211041_1274575.6666666666666860.0DomainABC transporter 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321410_633575.6666666666666860.0DomainABC transporter 1
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321714_1005575.6666666666666860.0DomainABC transmembrane type-1 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-13311322_1325575.66666666666661326.0MotifNote=PDZ-binding
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-13301322_1325575.66666666666661279.0MotifNote=PDZ-binding
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-13211322_1325575.6666666666666860.0MotifNote=PDZ-binding
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-13311075_1082575.66666666666661326.0Nucleotide bindingATP 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-13301075_1082575.66666666666661279.0Nucleotide bindingATP 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-13211075_1082575.6666666666666860.0Nucleotide bindingATP 2
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-13311038_1058575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331710_730575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331771_791575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331836_856575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331858_878575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331954_974575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000376887-1331977_997575.66666666666661326.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-13301038_1058575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330710_730575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330771_791575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330836_856575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330858_878575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330954_974575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000412704-1330977_997575.66666666666661279.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-13211038_1058575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321710_730575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321771_791575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321836_856575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321858_878575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321954_974575.6666666666666860.0TransmembraneHelical
HgeneABCC4chr13:95829961chr7:87038708ENST00000431522-1321977_997575.6666666666666860.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228394_630974.66666666666661287.0DomainABC transporter 1
TgeneABCB4chr13:95829961chr7:87038708ENST00000265723222857_359974.66666666666661287.0DomainABC transmembrane type-1 1
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228711_999974.66666666666661287.0DomainABC transmembrane type-1 2
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127394_630927.66666666666661233.0DomainABC transporter 1
TgeneABCB4chr13:95829961chr7:87038708ENST00000358400212757_359927.66666666666661233.0DomainABC transmembrane type-1 1
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127711_999927.66666666666661233.0DomainABC transmembrane type-1 2
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228394_630974.66666666666661280.0DomainABC transporter 1
TgeneABCB4chr13:95829961chr7:87038708ENST00000359206222857_359974.66666666666661280.0DomainABC transmembrane type-1 1
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228711_999974.66666666666661280.0DomainABC transmembrane type-1 2
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026394_630927.66666666666661233.0DomainABC transporter 1
TgeneABCB4chr13:95829961chr7:87038708ENST00000453593202657_359927.66666666666661233.0DomainABC transmembrane type-1 1
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026711_999927.66666666666661233.0DomainABC transmembrane type-1 2
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127394_630974.66666666666661280.0DomainABC transporter 1
TgeneABCB4chr13:95829961chr7:87038708ENST00000545634212757_359974.66666666666661280.0DomainABC transmembrane type-1 1
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127711_999974.66666666666661280.0DomainABC transmembrane type-1 2
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228429_436974.66666666666661287.0Nucleotide bindingATP 1
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127429_436927.66666666666661233.0Nucleotide bindingATP 1
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228429_436974.66666666666661280.0Nucleotide bindingATP 1
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026429_436927.66666666666661233.0Nucleotide bindingATP 1
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127429_436974.66666666666661280.0Nucleotide bindingATP 1
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228140_188974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST0000026572322281_50974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228211_217974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228239_296974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228319_332974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228355_711974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228733_755974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST00000265723222874_118974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228777_831974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228853_853974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228874_933974.66666666666661287.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228957_972974.66666666666661287.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127140_188927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST0000035840021271_50927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127211_217927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127239_296927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127319_332927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127355_711927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127733_755927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST00000358400212774_118927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127777_831927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127853_853927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127874_933927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228140_188974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST0000035920622281_50974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228211_217974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228239_296974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228319_332974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228355_711974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228733_755974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST00000359206222874_118974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228777_831974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228853_853974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228874_933974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228957_972974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026140_188927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST0000045359320261_50927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026211_217927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026239_296927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026319_332927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026355_711927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026733_755927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST00000453593202674_118927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026777_831927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026853_853927.66666666666661233.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026874_933927.66666666666661233.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127140_188974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST0000054563421271_50974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127211_217974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127239_296974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127319_332974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127355_711974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127733_755974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST00000545634212774_118974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127777_831974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127853_853974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127874_933974.66666666666661280.0Topological domainCytoplasmic
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127957_972974.66666666666661280.0Topological domainExtracellular
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228119_139974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228189_210974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228218_238974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228297_318974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228333_354974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST00000265723222851_73974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228712_732974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228756_776974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228832_852974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228854_873974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228934_956974.66666666666661287.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127119_139927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127189_210927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127218_238927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127297_318927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127333_354927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST00000358400212751_73927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127712_732927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127756_776927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127832_852927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127854_873927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228119_139974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228189_210974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228218_238974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228297_318974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228333_354974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST00000359206222851_73974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228712_732974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228756_776974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228832_852974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228854_873974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228934_956974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026119_139927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026189_210927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026218_238927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026297_318927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026333_354927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST00000453593202651_73927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026712_732927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026756_776927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026832_852927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026854_873927.66666666666661233.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127119_139974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127189_210974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127218_238974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127297_318974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127333_354974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST00000545634212751_73974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127712_732974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127756_776974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127832_852974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127854_873974.66666666666661280.0TransmembraneHelical
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127934_956974.66666666666661280.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCC4
ABCB4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneABCB4chr13:95829961chr7:87038708ENST000002657232228625_647974.66666666666661287.0HAX1
TgeneABCB4chr13:95829961chr7:87038708ENST000003584002127625_647927.66666666666661233.0HAX1
TgeneABCB4chr13:95829961chr7:87038708ENST000003592062228625_647974.66666666666661280.0HAX1
TgeneABCB4chr13:95829961chr7:87038708ENST000004535932026625_647927.66666666666661233.0HAX1
TgeneABCB4chr13:95829961chr7:87038708ENST000005456342127625_647974.66666666666661280.0HAX1


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Related Drugs to ABCC4-ABCB4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABCC4-ABCB4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource