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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ENPEP-SEC31A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ENPEP-SEC31A
FusionPDB ID: 26642
FusionGDB2.0 ID: 26642
HgeneTgene
Gene symbol

ENPEP

SEC31A

Gene ID

2028

22872

Gene nameglutamyl aminopeptidaseSEC31 homolog A, COPII coat complex component
SynonymsAPA|CD249|gp160ABP125|ABP130|HSPC275|HSPC334|NEDSOSB|SEC31L1
Cytomap

4q25

4q21.22

Type of geneprotein-codingprotein-coding
Descriptionglutamyl aminopeptidaseAP-AEAPaminopeptidase Adifferentiation antigen gp160protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2020031320200313
UniProtAcc

Q07075

O94979

Ensembl transtripts involved in fusion geneENST idsENST00000265162, ENST00000504100, 
ENST00000436790, ENST00000508479, 
ENST00000264405, ENST00000311785, 
ENST00000326950, ENST00000348405, 
ENST00000355196, ENST00000432794, 
ENST00000443462, ENST00000448323, 
ENST00000500777, ENST00000505472, 
ENST00000505984, ENST00000509142, 
ENST00000513858, ENST00000395310, 
ENST00000508502, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 3=2727 X 19 X 11=5643
# samples 328
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(28/5643*10)=-4.33296361729939
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ENPEP [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ENPEP(111441522)-SEC31A(83740406), # samples:1
Anticipated loss of major functional domain due to fusion event.ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ENPEP-SEC31A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENPEP

GO:0003081

regulation of systemic arterial blood pressure by renin-angiotensin

19608358

HgeneENPEP

GO:0008283

cell proliferation

14998491

HgeneENPEP

GO:0016477

cell migration

14998491

TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across ENPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SEC31A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4691-01AENPEPchr4

111441522

+SEC31Achr4

83740406

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265162ENPEPchr4111441522+ENST00000395310SEC31Achr483740406-266220693242144606
ENST00000265162ENPEPchr4111441522+ENST00000508502SEC31Achr483740406-231220693242144606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265162ENST00000395310ENPEPchr4111441522+SEC31Achr483740406-0.0007758520.9992242
ENST00000265162ENST00000508502ENPEPchr4111441522+SEC31Achr483740406-0.0009305680.9990695

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26642_26642_1_ENPEP-SEC31A_ENPEP_chr4_111441522_ENST00000265162_SEC31A_chr4_83740406_ENST00000395310_length(amino acids)=606AA_BP=573
MTLEAKMNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDE
SGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAE
EELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKE
ESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDF
GTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLED
VLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEV

--------------------------------------------------------------

>26642_26642_2_ENPEP-SEC31A_ENPEP_chr4_111441522_ENST00000265162_SEC31A_chr4_83740406_ENST00000508502_length(amino acids)=606AA_BP=573
MTLEAKMNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDE
SGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAE
EELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKE
ESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDF
GTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLED
VLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:111441522/chr4:83740406)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENPEP

Q07075

SEC31A

O94979

FUNCTION: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. {ECO:0000305|PubMed:23888046}.FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENPEPchr4:111441522chr4:83740406ENST00000265162+1020357_361575.6666666666666958.0RegionSubstrate binding
HgeneENPEPchr4:111441522chr4:83740406ENST00000265162+10201_18575.6666666666666958.0Topological domainCytoplasmic
HgeneENPEPchr4:111441522chr4:83740406ENST00000265162+102019_39575.6666666666666958.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENPEPchr4:111441522chr4:83740406ENST00000265162+102040_957575.6666666666666958.0Topological domainExtracellular
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426800_10911047.01107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325800_10911122.01182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325800_10911122.01182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729800_10911161.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527800_10911161.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628800_10911174.01234.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426800_10911141.01201.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527800_10911161.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123800_10911008.01068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527800_10911146.01206.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426800_10911047.01107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224800_10911008.01068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426842_8481047.01107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325842_8481122.01182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325842_8481122.01182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729842_8481161.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527842_8481161.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628842_8481174.01234.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426842_8481141.01201.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527842_8481161.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123842_8481008.01068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527842_8481146.01206.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426842_8481047.01107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224842_8481008.01068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426120_1601047.01107.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426166_2061047.01107.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426209_2541047.01107.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426258_2981047.01107.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426301_3421047.01107.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000031178524264_471047.01107.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000311785242668_1111047.01107.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325120_1601122.01182.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325166_2061122.01182.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325209_2541122.01182.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325258_2981122.01182.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325301_3421122.01182.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000032695023254_471122.01182.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000326950232568_1111122.01182.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325120_1601122.01182.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325166_2061122.01182.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325209_2541122.01182.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325258_2981122.01182.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325301_3421122.01182.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000034840523254_471122.01182.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000348405232568_1111122.01182.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729120_1601161.01221.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729166_2061161.01221.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729209_2541161.01221.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729258_2981161.01221.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729301_3421161.01221.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000035519627294_471161.01221.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000355196272968_1111161.01221.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527120_1601161.01221.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527166_2061161.01221.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527209_2541161.01221.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527258_2981161.01221.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527301_3421161.01221.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000039531025274_471161.01221.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000395310252768_1111161.01221.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628120_1601174.01234.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628166_2061174.01234.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628209_2541174.01234.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628258_2981174.01234.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628301_3421174.01234.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000043279426284_471174.01234.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000432794262868_1111174.01234.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426120_1601141.01201.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426166_2061141.01201.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426209_2541141.01201.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426258_2981141.01201.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426301_3421141.01201.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000044346224264_471141.01201.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000443462242668_1111141.01201.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527120_1601161.01221.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527166_2061161.01221.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527209_2541161.01221.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527258_2981161.01221.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527301_3421161.01221.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000044832325274_471161.01221.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000448323252768_1111161.01221.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123120_1601008.01068.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123166_2061008.01068.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123209_2541008.01068.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123258_2981008.01068.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123301_3421008.01068.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000050077721234_471008.01068.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000500777212368_1111008.01068.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527120_1601146.01206.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527166_2061146.01206.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527209_2541146.01206.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527258_2981146.01206.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527301_3421146.01206.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000050850225274_471146.01206.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000508502252768_1111146.01206.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426120_1601047.01107.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426166_2061047.01107.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426209_2541047.01107.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426258_2981047.01107.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426301_3421047.01107.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000050914224264_471047.01107.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000509142242668_1111047.01107.0RepeatNote=WD 2
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224120_1601008.01068.0RepeatNote=WD 3
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224166_2061008.01068.0RepeatNote=WD 4
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224209_2541008.01068.0RepeatNote=WD 5
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224258_2981008.01068.0RepeatNote=WD 6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224301_3421008.01068.0RepeatNote=WD 7
TgeneSEC31Achr4:111441522chr4:83740406ENST0000051385822244_471008.01068.0RepeatNote=WD 1
TgeneSEC31Achr4:111441522chr4:83740406ENST00000513858222468_1111008.01068.0RepeatNote=WD 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SEC31ASEC13, APC, TNNT1, PFDN1, ALG2, STAM, STAM2, CUL3, CDK9, HSPA8, VCAM1, ITGA4, REL, SHMT2, MOV10, NXF1, TFG, SCYL1, C6orf211, ATP6V1C1, ENO2, FDPS, NUDT13, SEC23A, SEC23B, SEC24B, ALDH5A1, ATP6V1D, CBS, CTH, CYB5B, DHX15, HNRNPA1, HSD17B10, NAPRT, NSF, SAR1A, TBCA, TPD52L2, TRIM25, TSTA3, TCEB2, NTRK1, TMEM17, XPO1, Sec24c, TSC22D2, NOP14, SEC23IP, NOC4L, GNPDA1, CCDC88A, BRCA1, KLHL12, PEF1, PDCD6, UBC, SEC24C, SEC24D, UBE2M, PIH1D1, ARIH1, USP8, ESR2, ARF1, POLE3, TBL1XR1, IGF2BP1, DEPDC5, BAZ1A, ARL5A, BMI1, RAB5C, MTF2, MAN1A1, NCOR1, MAN2A1, SLC39A9, TRAPPC12, TRAPPC10, TSC1, GCNT2, CARM1, HNRNPD, ARFGAP2, SLC30A5, UBE2J1, TRAPPC13, VPS51, HDAC8, DCAF7, EP300, SLC33A1, VPS45, IGF2R, RAB1B, TRAPPC11, VPS53, TRAPPC5, RABGEF1, HSP90AB1, TCF3, MAN1B1, B3GNT2, IGF1R, RICTOR, SEC24A, SLC39A7, MOGS, EZH2, EED, TRAPPC2, CTBP1, TRAPPC2L, MYC, TP53, BET1, VCP, KIAA1429, PRNP, APEX1, ABCC6, PPP1CA, BIRC3, LMBR1L, TRIM28, FHL5, PLEKHA4, N, LUZP1, ORF6, ORF7a, E, ORF14, ORF7b, MYOM2, CIT, CHMP4C, KIF14, KIF23, ACACA, Rnf183, LGALS9, RIN3, B3GAT1, CAV1, EBAG9, EMD, ERGIC2, GJA1, GJD3, HSD3B7, NUP155, ZFPL1, WDR5, GORASP1, TMPRSS2, FURIN, IFITM1, OPTN,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ENPEP
SEC31Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426800_11131047.01107.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325800_11131122.01182.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325800_11131122.01182.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729800_11131161.01221.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527800_11131161.01221.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628800_11131174.01234.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426800_11131141.01201.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527800_11131161.01221.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123800_11131008.01068.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527800_11131146.01206.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426800_11131047.01107.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224800_11131008.01068.0PDCD6
TgeneSEC31Achr4:111441522chr4:83740406ENST000003117852426161_4711047.01107.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000003269502325161_4711122.01182.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000003484052325161_4711122.01182.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000003551962729161_4711161.01221.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000003953102527161_4711161.01221.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000004327942628161_4711174.01234.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000004434622426161_4711141.01201.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000004483232527161_4711161.01221.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000005007772123161_4711008.01068.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000005085022527161_4711146.01206.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000005091422426161_4711047.01107.0SEC13
TgeneSEC31Achr4:111441522chr4:83740406ENST000005138582224161_4711008.01068.0SEC13


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Related Drugs to ENPEP-SEC31A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ENPEP-SEC31A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human