UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:AFF1-PTPN13

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AFF1-PTPN13
FusionPDB ID: 2666
FusionGDB2.0 ID: 2666
HgeneTgene
Gene symbol

AFF1

PTPN13

Gene ID

4299

5783

Gene nameAF4/FMR2 family member 1protein tyrosine phosphatase non-receptor type 13
SynonymsAF4|MLLT2|PBM1FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E
Cytomap

4q21.3-q22.1

4q21.3

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas
Modification date2020031320200313
UniProtAcc

P51825

PRY,PRY2

Ensembl transtripts involved in fusion geneENST idsENST00000511996, ENST00000395146, 
ENST00000307808, ENST00000544085, 
ENST00000427191, ENST00000436978, 
ENST00000316707, ENST00000411767, 
ENST00000502971, ENST00000511467, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 51 X 13=179018 X 13 X 6=624
# samples 6815
** MAII scorelog2(68/17901*10)=-4.71836162613835
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/624*10)=-2.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AFF1 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract]

The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: 25500544)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AFF1(87869723)-PTPN13(87556405), # samples:3
PTPN13(87610343)-AFF1(88005272), # samples:2
PTPN13(87556524)-AFF1(87869649), # samples:2
Anticipated loss of major functional domain due to fusion event.AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPN13

GO:0006470

protein dephosphorylation

17657516|19307596

TgenePTPN13

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317


check buttonFusion gene breakpoints across AFF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPN13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA7Q-01AAFF1chr4

87928576

-PTPN13chr4

87718027

+
ChimerDB4BLCATCGA-4Z-AA87-01AAFF1chr4

87869723

-PTPN13chr4

87718027

+
ChimerDB4BLCATCGA-4Z-AA87AFF1chr4

87869723

+PTPN13chr4

87718026

+
ChimerDB4BLCATCGA-4Z-AA87AFF1chr4

87869723

+PTPN13chr4

87718027

+
ChimerDB4BLCATCGA-DK-A1AD-01AAFF1chr4

87869723

-PTPN13chr4

87637683

+
ChimerDB4BLCATCGA-DK-A1AD-01AAFF1chr4

87928576

+PTPN13chr4

87637683

+
ChimerDB4BLCATCGA-DK-A1ADAFF1chr4

87928576

+PTPN13chr4

87637682

+
ChimerDB4BLCATCGA-E7-A6MD-01AAFF1chr4

88046295

-PTPN13chr4

87720254

+
ChimerDB4BLCATCGA-E7-A6MD-01AAFF1chr4

88046295

+PTPN13chr4

87720254

+
ChimerDB4BLCATCGA-GC-A3BM-01AAFF1chr4

88048855

-PTPN13chr4

87666119

+
ChimerDB4CESCTCGA-EA-A5ZD-01AAFF1chr4

88048855

-PTPN13chr4

87718027

+
ChimerDB4CESCTCGA-EA-A5ZDAFF1chr4

88048855

+PTPN13chr4

87718027

+
ChimerDB4LUADTCGA-05-4249-01AAFF1chr4

87869723

-PTPN13chr4

87556405

+
ChimerDB4LUADTCGA-05-4249-01AAFF1chr4

87869723

+PTPN13chr4

87556405

+
ChimerDB4LUSCTCGA-60-2695-01AAFF1chr4

87869723

-PTPN13chr4

87556405

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395146AFF1chr488046295+ENST00000427191PTPN13chr487720254+4511284826639041212
ENST00000395146AFF1chr488046295+ENST00000436978PTPN13chr487720254+4525284826639041212
ENST00000307808AFF1chr488046295+ENST00000427191PTPN13chr487720254+4635297242040281202
ENST00000307808AFF1chr488046295+ENST00000436978PTPN13chr487720254+4649297242040281202
ENST00000544085AFF1chr488046295+ENST00000427191PTPN13chr487720254+333316701322726864
ENST00000544085AFF1chr488046295+ENST00000436978PTPN13chr487720254+334716701322726864
ENST00000395146AFF1chr488048855+ENST00000427191PTPN13chr487718027+4958323926643511361
ENST00000395146AFF1chr488048855+ENST00000436978PTPN13chr487718027+4972323926643511361
ENST00000307808AFF1chr488048855+ENST00000427191PTPN13chr487718027+5082336342044751351
ENST00000307808AFF1chr488048855+ENST00000436978PTPN13chr487718027+5096336342044751351
ENST00000544085AFF1chr488048855+ENST00000427191PTPN13chr487718027+3780206113231731013
ENST00000544085AFF1chr488048855+ENST00000436978PTPN13chr487718027+3794206113231731013
ENST00000395146AFF1chr488048855-ENST00000427191PTPN13chr487666119+8759323926681522628
ENST00000395146AFF1chr488048855-ENST00000436978PTPN13chr487666119+8845323926682242652
ENST00000307808AFF1chr488048855-ENST00000427191PTPN13chr487666119+8883336342082762618
ENST00000307808AFF1chr488048855-ENST00000436978PTPN13chr487666119+8969336342083482642
ENST00000544085AFF1chr488048855-ENST00000427191PTPN13chr487666119+7581206113269742280
ENST00000544085AFF1chr488048855-ENST00000436978PTPN13chr487666119+7667206113270462304

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395146ENST00000427191AFF1chr488046295+PTPN13chr487720254+0.0033439490.99665606
ENST00000395146ENST00000436978AFF1chr488046295+PTPN13chr487720254+0.0033015470.99669844
ENST00000307808ENST00000427191AFF1chr488046295+PTPN13chr487720254+0.0034815640.9965184
ENST00000307808ENST00000436978AFF1chr488046295+PTPN13chr487720254+0.0034532410.9965468
ENST00000544085ENST00000427191AFF1chr488046295+PTPN13chr487720254+0.0031104690.99688953
ENST00000544085ENST00000436978AFF1chr488046295+PTPN13chr487720254+0.0030516660.9969483
ENST00000395146ENST00000427191AFF1chr488048855+PTPN13chr487718027+0.0037046810.9962953
ENST00000395146ENST00000436978AFF1chr488048855+PTPN13chr487718027+0.0036598690.99634016
ENST00000307808ENST00000427191AFF1chr488048855+PTPN13chr487718027+0.003952290.9960477
ENST00000307808ENST00000436978AFF1chr488048855+PTPN13chr487718027+0.0039048360.9960951
ENST00000544085ENST00000427191AFF1chr488048855+PTPN13chr487718027+0.001544450.9984555
ENST00000544085ENST00000436978AFF1chr488048855+PTPN13chr487718027+0.0015130060.998487
ENST00000395146ENST00000427191AFF1chr488048855-PTPN13chr487666119+0.0008027730.9991972
ENST00000395146ENST00000436978AFF1chr488048855-PTPN13chr487666119+0.0007621540.9992379
ENST00000307808ENST00000427191AFF1chr488048855-PTPN13chr487666119+0.0008749890.99912506
ENST00000307808ENST00000436978AFF1chr488048855-PTPN13chr487666119+0.0008365030.9991635
ENST00000544085ENST00000427191AFF1chr488048855-PTPN13chr487666119+0.0005799430.99942005
ENST00000544085ENST00000436978AFF1chr488048855-PTPN13chr487666119+0.0005508420.9994492

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2666_2666_1_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000307808_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=1202AA_BP=851
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV
VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG
KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR
EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT

--------------------------------------------------------------

>2666_2666_2_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000307808_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=1202AA_BP=851
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV
VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG
KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR
EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT

--------------------------------------------------------------

>2666_2666_3_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000395146_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=1212AA_BP=861
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL
TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI
NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR
AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM

--------------------------------------------------------------

>2666_2666_4_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000395146_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=1212AA_BP=861
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL
TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI
NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR
AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM

--------------------------------------------------------------

>2666_2666_5_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000544085_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=864AA_BP=513
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERT
NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA
TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL
VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD

--------------------------------------------------------------

>2666_2666_6_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000544085_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=864AA_BP=513
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERT
NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA
TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL
VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD

--------------------------------------------------------------

>2666_2666_7_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2618AA_BP=979
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA
SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMKKKITLQNT
SDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQ
AEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGV
TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVA
PGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKD
HHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKP
GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYV
KAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ
VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGT
APEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAP
ANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHH
ISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH
TDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV
STQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTY
QIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEAT
KMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGL
LDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMI
WEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDD
LLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQ

--------------------------------------------------------------

>2666_2666_8_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2642AA_BP=979
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA
SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMKKKITLQNT
SDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQ
AEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGV
TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQI
IGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKN
YMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVIS
KATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSL
GISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV
TPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV
ILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQC
KSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA
PGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAK
SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDI
NPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPN
DSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK
LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV
VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG
KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR
EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT

--------------------------------------------------------------

>2666_2666_9_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1351AA_BP=979
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA
SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMATKMNGCEE
YCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPS
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTV
IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISY
MRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLL

--------------------------------------------------------------

>2666_2666_10_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1351AA_BP=979
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP
KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR
ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP
SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL
KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP
PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR
HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL
PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR
TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL
AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA
SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMATKMNGCEE
YCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPS
KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTV
IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISY
MRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLL

--------------------------------------------------------------

>2666_2666_11_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2628AA_BP=989
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD
TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL
MKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLN
KLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMS
RSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRL
DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ
DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFT
DSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN
TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQ
GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQ
QEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSG
SGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASS
SSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKV
NDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL
LDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEI
SYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGS
PLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANL
KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLP
TTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWP
DHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV

--------------------------------------------------------------

>2666_2666_12_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2652AA_BP=989
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD
TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL
MKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLN
KLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMS
RSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKK
DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPST
PVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQ
HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE
VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ
SPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA
ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDEN
EMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDS
NPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCY
VHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS
LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVG
SCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSC
GPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL
TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI
NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR
AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM

--------------------------------------------------------------

>2666_2666_13_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1361AA_BP=989
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD
TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL
MATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVL
RGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFW
QMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQ
PDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAE

--------------------------------------------------------------

>2666_2666_14_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1361AA_BP=989
METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL
DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG
SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ
DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS
NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT
PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE
GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS
LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ
GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE
KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD
TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL
MATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVL
RGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFW
QMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQ
PDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAE

--------------------------------------------------------------

>2666_2666_15_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2280AA_BP=641
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA
KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM
REAKKMKQKAELMKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRA
ISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTV
AELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLG
FQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNE
MKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPS
VISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKND
NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP
QCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL
KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKS
PSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPG
QSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD
GRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP
RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDS
FSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLS
EERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVK
VLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKE
EFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREV
RHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTED

--------------------------------------------------------------

>2666_2666_16_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2304AA_BP=641
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA
KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM
REAKKMKQKAELMKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRA
ISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTV
AELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSS
PEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVIS
QPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFA
SHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF
SSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT
GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIV
RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP
SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYP
QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGF
TVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE
ELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAP
KSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQN
LLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERT
NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA
TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL
VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD

--------------------------------------------------------------

>2666_2666_17_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1013AA_BP=641
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA
KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM
REAKKMKQKAELMATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKY
TGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIAC
QGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLN
FTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ

--------------------------------------------------------------

>2666_2666_18_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1013AA_BP=641
MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ
LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW
LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP
VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP
EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED
KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA
KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM
REAKKMKQKAELMATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKY
TGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIAC
QGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLN
FTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:87869723/chr4:87556405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF1

P51825

PTPN13

PRY,PRY2

147

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF1chr4:88046295chr4:87720254ENST00000307808+1220483_492850.66666666666661211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88046295chr4:87720254ENST00000307808+1220835_843850.66666666666661211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88046295chr4:87720254ENST00000395146+1321483_492857.66666666666661219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88046295chr4:87720254ENST00000395146+1321835_843857.66666666666661219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000307808-1520483_492981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000307808-1520835_843981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000307808-1520866_869981.01211.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88048855chr4:87666119ENST00000307808-1520871_874981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000395146-1621483_492988.01219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000395146-1621835_843988.01219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87666119ENST00000395146-1621866_869988.01219.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88048855chr4:87666119ENST00000395146-1621871_874988.01219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000307808+1520483_492981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000307808+1520835_843981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000307808+1520866_869981.01211.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88048855chr4:87718027ENST00000307808+1520871_874981.01211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000395146+1621483_492988.01219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000395146+1621835_843988.01219.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88048855chr4:87718027ENST00000395146+1621866_869988.01219.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88048855chr4:87718027ENST00000395146+1621871_874988.01219.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451742_1749829.02295.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481742_1749829.02486.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471742_1749829.02467.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481742_1749829.02491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471742_1749829.02491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737452213_24671942.66666666666672295.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740482213_24672133.66666666666652486.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139472213_24672114.66666666666652467.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840482213_24672138.66666666666652491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739472213_24672138.66666666666652491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451093_1178829.02295.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451368_1452829.02295.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451501_1588829.02295.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451788_1868829.02295.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715451882_1965829.02295.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715452213_2467829.02295.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481093_1178829.02486.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481368_1452829.02486.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481501_1588829.02486.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481788_1868829.02486.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715481882_1965829.02486.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715482213_2467829.02486.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471093_1178829.02467.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471368_1452829.02467.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471501_1588829.02467.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471788_1868829.02467.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115471882_1965829.02467.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115472213_2467829.02467.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481093_1178829.02491.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481368_1452829.02491.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481501_1588829.02491.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481788_1868829.02491.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815481882_1965829.02491.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815482213_2467829.02491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471093_1178829.02491.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471368_1452829.02491.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471501_1588829.02491.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471788_1868829.02491.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714471882_1965829.02491.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714472213_2467829.02491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736452213_24671924.02295.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739482213_24672115.02486.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138472213_24672096.02467.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839482213_24672120.02491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738472213_24672120.02491.0DomainTyrosine-protein phosphatase
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737452408_24141942.66666666666672295.0RegionSubstrate binding
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740482408_24142133.66666666666652486.0RegionSubstrate binding
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139472408_24142114.66666666666652467.0RegionSubstrate binding
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840482408_24142138.66666666666652491.0RegionSubstrate binding
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739472408_24142138.66666666666652491.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715452408_2414829.02295.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715482408_2414829.02486.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115472408_2414829.02467.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815482408_2414829.02491.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714472408_2414829.02491.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736452408_24141924.02295.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739482408_24142115.02486.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138472408_24142096.02467.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839482408_24142120.02491.0RegionSubstrate binding
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738472408_24142120.02491.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAFF1chr4:88046295chr4:87720254ENST00000307808+1220866_869850.66666666666661211.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88046295chr4:87720254ENST00000307808+1220871_874850.66666666666661211.0Compositional biasNote=Poly-Ser
HgeneAFF1chr4:88046295chr4:87720254ENST00000395146+1321866_869857.66666666666661219.0Compositional biasNote=Poly-Pro
HgeneAFF1chr4:88046295chr4:87720254ENST00000395146+1321871_874857.66666666666661219.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST000003167073745469_5041942.66666666666672295.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88046295chr4:87720254ENST000004117674048469_5042133.66666666666652486.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88046295chr4:87720254ENST000004271913947469_5042114.66666666666652467.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88046295chr4:87720254ENST000004369784048469_5042138.66666666666652491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88046295chr4:87720254ENST000005114673947469_5042138.66666666666652491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87666119ENST000003167071545469_504829.02295.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87666119ENST000004117671548469_504829.02486.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87666119ENST000004271911547469_504829.02467.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87666119ENST000004369781548469_504829.02491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87666119ENST000005114671447469_504829.02491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87718027ENST000003167073645469_5041924.02295.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87718027ENST000004117673948469_5042115.02486.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87718027ENST000004271913847469_5042096.02467.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87718027ENST000004369783948469_5042120.02491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88048855chr4:87718027ENST000005114673847469_5042120.02491.0Coiled coilOntology_term=ECO:0000255
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451742_17491942.66666666666672295.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST00000316707374556_591942.66666666666672295.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481742_17492133.66666666666652486.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST00000411767404856_592133.66666666666652486.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471742_17492114.66666666666652467.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST00000427191394756_592114.66666666666652467.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481742_17492138.66666666666652491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST00000436978404856_592138.66666666666652491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471742_17492138.66666666666652491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88046295chr4:87720254ENST00000511467394756_592138.66666666666652491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87666119ENST00000316707154556_59829.02295.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87666119ENST00000411767154856_59829.02486.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87666119ENST00000427191154756_59829.02467.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87666119ENST00000436978154856_59829.02491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87666119ENST00000511467144756_59829.02491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451742_17491924.02295.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87718027ENST00000316707364556_591924.02295.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481742_17492115.02486.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87718027ENST00000411767394856_592115.02486.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471742_17492096.02467.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87718027ENST00000427191384756_592096.02467.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481742_17492120.02491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87718027ENST00000436978394856_592120.02491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471742_17492120.02491.0Compositional biasNote=Poly-Ser
TgenePTPN13chr4:88048855chr4:87718027ENST00000511467384756_592120.02491.0Compositional biasNote=Poly-Leu
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451093_11781942.66666666666672295.0DomainPDZ 1
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451368_14521942.66666666666672295.0DomainPDZ 2
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451501_15881942.66666666666672295.0DomainPDZ 3
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451788_18681942.66666666666672295.0DomainPDZ 4
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737451882_19651942.66666666666672295.0DomainPDZ 5
TgenePTPN13chr4:88046295chr4:87720254ENST0000031670737453_1901942.66666666666672295.0DomainKIND
TgenePTPN13chr4:88046295chr4:87720254ENST000003167073745572_8721942.66666666666672295.0DomainFERM
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481093_11782133.66666666666652486.0DomainPDZ 1
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481368_14522133.66666666666652486.0DomainPDZ 2
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481501_15882133.66666666666652486.0DomainPDZ 3
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481788_18682133.66666666666652486.0DomainPDZ 4
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740481882_19652133.66666666666652486.0DomainPDZ 5
TgenePTPN13chr4:88046295chr4:87720254ENST0000041176740483_1902133.66666666666652486.0DomainKIND
TgenePTPN13chr4:88046295chr4:87720254ENST000004117674048572_8722133.66666666666652486.0DomainFERM
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471093_11782114.66666666666652467.0DomainPDZ 1
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471368_14522114.66666666666652467.0DomainPDZ 2
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471501_15882114.66666666666652467.0DomainPDZ 3
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471788_18682114.66666666666652467.0DomainPDZ 4
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139471882_19652114.66666666666652467.0DomainPDZ 5
TgenePTPN13chr4:88046295chr4:87720254ENST0000042719139473_1902114.66666666666652467.0DomainKIND
TgenePTPN13chr4:88046295chr4:87720254ENST000004271913947572_8722114.66666666666652467.0DomainFERM
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481093_11782138.66666666666652491.0DomainPDZ 1
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481368_14522138.66666666666652491.0DomainPDZ 2
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481501_15882138.66666666666652491.0DomainPDZ 3
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481788_18682138.66666666666652491.0DomainPDZ 4
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840481882_19652138.66666666666652491.0DomainPDZ 5
TgenePTPN13chr4:88046295chr4:87720254ENST0000043697840483_1902138.66666666666652491.0DomainKIND
TgenePTPN13chr4:88046295chr4:87720254ENST000004369784048572_8722138.66666666666652491.0DomainFERM
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471093_11782138.66666666666652491.0DomainPDZ 1
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471368_14522138.66666666666652491.0DomainPDZ 2
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471501_15882138.66666666666652491.0DomainPDZ 3
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471788_18682138.66666666666652491.0DomainPDZ 4
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739471882_19652138.66666666666652491.0DomainPDZ 5
TgenePTPN13chr4:88046295chr4:87720254ENST0000051146739473_1902138.66666666666652491.0DomainKIND
TgenePTPN13chr4:88046295chr4:87720254ENST000005114673947572_8722138.66666666666652491.0DomainFERM
TgenePTPN13chr4:88048855chr4:87666119ENST0000031670715453_190829.02295.0DomainKIND
TgenePTPN13chr4:88048855chr4:87666119ENST000003167071545572_872829.02295.0DomainFERM
TgenePTPN13chr4:88048855chr4:87666119ENST0000041176715483_190829.02486.0DomainKIND
TgenePTPN13chr4:88048855chr4:87666119ENST000004117671548572_872829.02486.0DomainFERM
TgenePTPN13chr4:88048855chr4:87666119ENST0000042719115473_190829.02467.0DomainKIND
TgenePTPN13chr4:88048855chr4:87666119ENST000004271911547572_872829.02467.0DomainFERM
TgenePTPN13chr4:88048855chr4:87666119ENST0000043697815483_190829.02491.0DomainKIND
TgenePTPN13chr4:88048855chr4:87666119ENST000004369781548572_872829.02491.0DomainFERM
TgenePTPN13chr4:88048855chr4:87666119ENST0000051146714473_190829.02491.0DomainKIND
TgenePTPN13chr4:88048855chr4:87666119ENST000005114671447572_872829.02491.0DomainFERM
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451093_11781924.02295.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451368_14521924.02295.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451501_15881924.02295.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451788_18681924.02295.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736451882_19651924.02295.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87718027ENST0000031670736453_1901924.02295.0DomainKIND
TgenePTPN13chr4:88048855chr4:87718027ENST000003167073645572_8721924.02295.0DomainFERM
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481093_11782115.02486.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481368_14522115.02486.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481501_15882115.02486.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481788_18682115.02486.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739481882_19652115.02486.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87718027ENST0000041176739483_1902115.02486.0DomainKIND
TgenePTPN13chr4:88048855chr4:87718027ENST000004117673948572_8722115.02486.0DomainFERM
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471093_11782096.02467.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471368_14522096.02467.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471501_15882096.02467.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471788_18682096.02467.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138471882_19652096.02467.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87718027ENST0000042719138473_1902096.02467.0DomainKIND
TgenePTPN13chr4:88048855chr4:87718027ENST000004271913847572_8722096.02467.0DomainFERM
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481093_11782120.02491.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481368_14522120.02491.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481501_15882120.02491.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481788_18682120.02491.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839481882_19652120.02491.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87718027ENST0000043697839483_1902120.02491.0DomainKIND
TgenePTPN13chr4:88048855chr4:87718027ENST000004369783948572_8722120.02491.0DomainFERM
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471093_11782120.02491.0DomainPDZ 1
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471368_14522120.02491.0DomainPDZ 2
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471501_15882120.02491.0DomainPDZ 3
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471788_18682120.02491.0DomainPDZ 4
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738471882_19652120.02491.0DomainPDZ 5
TgenePTPN13chr4:88048855chr4:87718027ENST0000051146738473_1902120.02491.0DomainKIND
TgenePTPN13chr4:88048855chr4:87718027ENST000005114673847572_8722120.02491.0DomainFERM


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
AFF1MLLT1, CCNT1, NT5E, MLLT3, CDK9, AFF4, KMT2A, AFF1, BRD4, RELA, NPM1, PCSK1, MLLT10, DOT1L, POLR2A, DDX6, HEXIM1, HIST3H3, NSD1, CARM1, SIAH1, SIAH2, SMAD9, tat, MED26, EAF1, ELL2, LARP7, ELL3, HDAC1, MYH7, SLC16A6, ZNF526, Mllt1, Mad2l1bp, Rrbp1, Rcc1, VDR, PIP4K2A, CAMKV, TRIM25, HNRNPL, ESR2, KIAA1429, SASH1, DYRK1A, ARFIP1, MRPL12, KIF20A, CCAR2, FGF12, PLCD3, EPB41L1, EPB41L3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AFF1all structure
PTPN13


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to AFF1-PTPN13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to AFF1-PTPN13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource