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Fusion Protein:AFF1-PTPN13 |
Fusion Protein Summary |
Fusion gene summary |
Fusion partner gene information | Fusion gene name: AFF1-PTPN13 | FusionPDB ID: 2666 | FusionGDB2.0 ID: 2666 | Hgene | Tgene | Gene symbol | AFF1 | PTPN13 | Gene ID | 4299 | 5783 |
Gene name | AF4/FMR2 family member 1 | protein tyrosine phosphatase non-receptor type 13 | |
Synonyms | AF4|MLLT2|PBM1 | FAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E | |
Cytomap | 4q21.3-q22.1 | 4q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P51825 | PRY,PRY2 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000511996, ENST00000395146, ENST00000307808, ENST00000544085, | ENST00000427191, ENST00000436978, ENST00000316707, ENST00000411767, ENST00000502971, ENST00000511467, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 27 X 51 X 13=17901 | 8 X 13 X 6=624 |
# samples | 68 | 15 | |
** MAII score | log2(68/17901*10)=-4.71836162613835 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/624*10)=-2.05658352836637 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: AFF1 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract] The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: 25500544) | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | AFF1(87869723)-PTPN13(87556405), # samples:3 PTPN13(87610343)-AFF1(88005272), # samples:2 PTPN13(87556524)-AFF1(87869649), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPN13-AFF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. AFF1-PTPN13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. AFF1-PTPN13 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTPN13 | GO:0006470 | protein dephosphorylation | 17657516|19307596 |
Tgene | PTPN13 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 23604317 |
Fusion gene breakpoints across AFF1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PTPN13 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
Fusion gene information from FusionGDB2.0. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-4Z-AA7Q-01A | AFF1 | chr4 | 87928576 | - | PTPN13 | chr4 | 87718027 | + |
ChimerDB4 | BLCA | TCGA-4Z-AA87-01A | AFF1 | chr4 | 87869723 | - | PTPN13 | chr4 | 87718027 | + |
ChimerDB4 | BLCA | TCGA-4Z-AA87 | AFF1 | chr4 | 87869723 | + | PTPN13 | chr4 | 87718026 | + |
ChimerDB4 | BLCA | TCGA-4Z-AA87 | AFF1 | chr4 | 87869723 | + | PTPN13 | chr4 | 87718027 | + |
ChimerDB4 | BLCA | TCGA-DK-A1AD-01A | AFF1 | chr4 | 87869723 | - | PTPN13 | chr4 | 87637683 | + |
ChimerDB4 | BLCA | TCGA-DK-A1AD-01A | AFF1 | chr4 | 87928576 | + | PTPN13 | chr4 | 87637683 | + |
ChimerDB4 | BLCA | TCGA-DK-A1AD | AFF1 | chr4 | 87928576 | + | PTPN13 | chr4 | 87637682 | + |
ChimerDB4 | BLCA | TCGA-E7-A6MD-01A | AFF1 | chr4 | 88046295 | - | PTPN13 | chr4 | 87720254 | + |
ChimerDB4 | BLCA | TCGA-E7-A6MD-01A | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + |
ChimerDB4 | BLCA | TCGA-GC-A3BM-01A | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + |
ChimerDB4 | CESC | TCGA-EA-A5ZD-01A | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87718027 | + |
ChimerDB4 | CESC | TCGA-EA-A5ZD | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + |
ChimerDB4 | LUAD | TCGA-05-4249-01A | AFF1 | chr4 | 87869723 | - | PTPN13 | chr4 | 87556405 | + |
ChimerDB4 | LUAD | TCGA-05-4249-01A | AFF1 | chr4 | 87869723 | + | PTPN13 | chr4 | 87556405 | + |
ChimerDB4 | LUSC | TCGA-60-2695-01A | AFF1 | chr4 | 87869723 | - | PTPN13 | chr4 | 87556405 | + |
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Fusion ORF Analysis |
Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000395146 | AFF1 | chr4 | 88046295 | + | ENST00000427191 | PTPN13 | chr4 | 87720254 | + | 4511 | 2848 | 266 | 3904 | 1212 |
ENST00000395146 | AFF1 | chr4 | 88046295 | + | ENST00000436978 | PTPN13 | chr4 | 87720254 | + | 4525 | 2848 | 266 | 3904 | 1212 |
ENST00000307808 | AFF1 | chr4 | 88046295 | + | ENST00000427191 | PTPN13 | chr4 | 87720254 | + | 4635 | 2972 | 420 | 4028 | 1202 |
ENST00000307808 | AFF1 | chr4 | 88046295 | + | ENST00000436978 | PTPN13 | chr4 | 87720254 | + | 4649 | 2972 | 420 | 4028 | 1202 |
ENST00000544085 | AFF1 | chr4 | 88046295 | + | ENST00000427191 | PTPN13 | chr4 | 87720254 | + | 3333 | 1670 | 132 | 2726 | 864 |
ENST00000544085 | AFF1 | chr4 | 88046295 | + | ENST00000436978 | PTPN13 | chr4 | 87720254 | + | 3347 | 1670 | 132 | 2726 | 864 |
ENST00000395146 | AFF1 | chr4 | 88048855 | + | ENST00000427191 | PTPN13 | chr4 | 87718027 | + | 4958 | 3239 | 266 | 4351 | 1361 |
ENST00000395146 | AFF1 | chr4 | 88048855 | + | ENST00000436978 | PTPN13 | chr4 | 87718027 | + | 4972 | 3239 | 266 | 4351 | 1361 |
ENST00000307808 | AFF1 | chr4 | 88048855 | + | ENST00000427191 | PTPN13 | chr4 | 87718027 | + | 5082 | 3363 | 420 | 4475 | 1351 |
ENST00000307808 | AFF1 | chr4 | 88048855 | + | ENST00000436978 | PTPN13 | chr4 | 87718027 | + | 5096 | 3363 | 420 | 4475 | 1351 |
ENST00000544085 | AFF1 | chr4 | 88048855 | + | ENST00000427191 | PTPN13 | chr4 | 87718027 | + | 3780 | 2061 | 132 | 3173 | 1013 |
ENST00000544085 | AFF1 | chr4 | 88048855 | + | ENST00000436978 | PTPN13 | chr4 | 87718027 | + | 3794 | 2061 | 132 | 3173 | 1013 |
ENST00000395146 | AFF1 | chr4 | 88048855 | - | ENST00000427191 | PTPN13 | chr4 | 87666119 | + | 8759 | 3239 | 266 | 8152 | 2628 |
ENST00000395146 | AFF1 | chr4 | 88048855 | - | ENST00000436978 | PTPN13 | chr4 | 87666119 | + | 8845 | 3239 | 266 | 8224 | 2652 |
ENST00000307808 | AFF1 | chr4 | 88048855 | - | ENST00000427191 | PTPN13 | chr4 | 87666119 | + | 8883 | 3363 | 420 | 8276 | 2618 |
ENST00000307808 | AFF1 | chr4 | 88048855 | - | ENST00000436978 | PTPN13 | chr4 | 87666119 | + | 8969 | 3363 | 420 | 8348 | 2642 |
ENST00000544085 | AFF1 | chr4 | 88048855 | - | ENST00000427191 | PTPN13 | chr4 | 87666119 | + | 7581 | 2061 | 132 | 6974 | 2280 |
ENST00000544085 | AFF1 | chr4 | 88048855 | - | ENST00000436978 | PTPN13 | chr4 | 87666119 | + | 7667 | 2061 | 132 | 7046 | 2304 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000395146 | ENST00000427191 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003343949 | 0.99665606 |
ENST00000395146 | ENST00000436978 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003301547 | 0.99669844 |
ENST00000307808 | ENST00000427191 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003481564 | 0.9965184 |
ENST00000307808 | ENST00000436978 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003453241 | 0.9965468 |
ENST00000544085 | ENST00000427191 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003110469 | 0.99688953 |
ENST00000544085 | ENST00000436978 | AFF1 | chr4 | 88046295 | + | PTPN13 | chr4 | 87720254 | + | 0.003051666 | 0.9969483 |
ENST00000395146 | ENST00000427191 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.003704681 | 0.9962953 |
ENST00000395146 | ENST00000436978 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.003659869 | 0.99634016 |
ENST00000307808 | ENST00000427191 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.00395229 | 0.9960477 |
ENST00000307808 | ENST00000436978 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.003904836 | 0.9960951 |
ENST00000544085 | ENST00000427191 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.00154445 | 0.9984555 |
ENST00000544085 | ENST00000436978 | AFF1 | chr4 | 88048855 | + | PTPN13 | chr4 | 87718027 | + | 0.001513006 | 0.998487 |
ENST00000395146 | ENST00000427191 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000802773 | 0.9991972 |
ENST00000395146 | ENST00000436978 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000762154 | 0.9992379 |
ENST00000307808 | ENST00000427191 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000874989 | 0.99912506 |
ENST00000307808 | ENST00000436978 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000836503 | 0.9991635 |
ENST00000544085 | ENST00000427191 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000579943 | 0.99942005 |
ENST00000544085 | ENST00000436978 | AFF1 | chr4 | 88048855 | - | PTPN13 | chr4 | 87666119 | + | 0.000550842 | 0.9994492 |
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Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >2666_2666_1_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000307808_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=1202AA_BP=851 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT -------------------------------------------------------------- >2666_2666_2_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000307808_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=1202AA_BP=851 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT -------------------------------------------------------------- >2666_2666_3_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000395146_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=1212AA_BP=861 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM -------------------------------------------------------------- >2666_2666_4_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000395146_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=1212AA_BP=861 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM -------------------------------------------------------------- >2666_2666_5_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000544085_PTPN13_chr4_87720254_ENST00000427191_length(amino acids)=864AA_BP=513 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERT NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD -------------------------------------------------------------- >2666_2666_6_AFF1-PTPN13_AFF1_chr4_88046295_ENST00000544085_PTPN13_chr4_87720254_ENST00000436978_length(amino acids)=864AA_BP=513 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTNLIQKPQEKKTDDDEITWGNDELPIERT NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD -------------------------------------------------------------- >2666_2666_7_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2618AA_BP=979 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMKKKITLQNT SDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQ AEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGV TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVA PGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKD HHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKP GISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYV KAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGT APEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAP ANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHH ISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH TDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV STQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTY QIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEAT KMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGL LDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMI WEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDD LLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQ -------------------------------------------------------------- >2666_2666_8_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2642AA_BP=979 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMKKKITLQNT SDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQ AEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGV TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQI IGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKN YMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVIS KATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSL GISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPV TPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV ILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQC KSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA PGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAK SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDI NPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPN DSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPV VKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTR EVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT -------------------------------------------------------------- >2666_2666_9_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1351AA_BP=979 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMATKMNGCEE YCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPS KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTV IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISY MRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLL -------------------------------------------------------------- >2666_2666_10_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000307808_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1351AA_BP=979 MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKP KYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRR ADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPP SQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEIL KEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAP PSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRR HPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL PYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSR TSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKL AKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSA SSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMATKMNGCEE YCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPS KELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTV IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISY MRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLL -------------------------------------------------------------- >2666_2666_11_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2628AA_BP=989 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL MKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLN KLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMS RSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRL DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFT DSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQ GPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQ QEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSG SGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASS SSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKV NDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL LDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEI SYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGS PLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANL KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLP TTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWP DHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV -------------------------------------------------------------- >2666_2666_12_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2652AA_BP=989 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL MKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLN KLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMS RSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKK DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPST PVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQ HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFE VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ SPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDEN EMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDS NPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCY VHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDS LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVG SCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSC GPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFL TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYI NASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVR AMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCM -------------------------------------------------------------- >2666_2666_13_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1361AA_BP=989 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL MATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVL RGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFW QMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQ PDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAE -------------------------------------------------------------- >2666_2666_14_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000395146_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1361AA_BP=989 METMAFTERVNSSGNSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRL DASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFG SSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQ DSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYS NEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQT PEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPE GPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTS LQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ GPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSE KRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREAD TCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAEL MATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVL RGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFW QMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQ PDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAE -------------------------------------------------------------- >2666_2666_15_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87666119_ENST00000427191_length(amino acids)=2280AA_BP=641 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM REAKKMKQKAELMKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRA ISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTV AELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLG FQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNE MKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPS VISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKND NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP QCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL KVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKS PSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPG QSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD GRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDS FSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLS EERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVK VLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKE EFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREV RHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTED -------------------------------------------------------------- >2666_2666_16_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87666119_ENST00000436978_length(amino acids)=2304AA_BP=641 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM REAKKMKQKAELMKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRA ISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTV AELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSS PEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVIS QPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFA SHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF SSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT GQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIV RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYP QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGF TVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKE ELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAP KSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQN LLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERT NHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDA TRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQD -------------------------------------------------------------- >2666_2666_17_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87718027_ENST00000427191_length(amino acids)=1013AA_BP=641 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM REAKKMKQKAELMATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKY TGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIAC QGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLN FTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ -------------------------------------------------------------- >2666_2666_18_AFF1-PTPN13_AFF1_chr4_88048855_ENST00000544085_PTPN13_chr4_87718027_ENST00000436978_length(amino acids)=1013AA_BP=641 MNYGSPVKQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQ LSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNW LTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKP VKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTP EHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAED KQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPA KPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHM REAKKMKQKAELMATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKY TGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIAC QGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLN FTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:87869723/chr4:87556405) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AFF1 | PTPN13 |
147 |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000307808 | + | 12 | 20 | 483_492 | 850.6666666666666 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000307808 | + | 12 | 20 | 835_843 | 850.6666666666666 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000395146 | + | 13 | 21 | 483_492 | 857.6666666666666 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000395146 | + | 13 | 21 | 835_843 | 857.6666666666666 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000307808 | - | 15 | 20 | 483_492 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000307808 | - | 15 | 20 | 835_843 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000307808 | - | 15 | 20 | 866_869 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000307808 | - | 15 | 20 | 871_874 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000395146 | - | 16 | 21 | 483_492 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000395146 | - | 16 | 21 | 835_843 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000395146 | - | 16 | 21 | 866_869 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88048855 | chr4:87666119 | ENST00000395146 | - | 16 | 21 | 871_874 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000307808 | + | 15 | 20 | 483_492 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000307808 | + | 15 | 20 | 835_843 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000307808 | + | 15 | 20 | 866_869 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000307808 | + | 15 | 20 | 871_874 | 981.0 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000395146 | + | 16 | 21 | 483_492 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000395146 | + | 16 | 21 | 835_843 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000395146 | + | 16 | 21 | 866_869 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88048855 | chr4:87718027 | ENST00000395146 | + | 16 | 21 | 871_874 | 988.0 | 1219.0 | Compositional bias | Note=Poly-Ser |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1742_1749 | 829.0 | 2295.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1742_1749 | 829.0 | 2486.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1742_1749 | 829.0 | 2467.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1742_1749 | 829.0 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1742_1749 | 829.0 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 2213_2467 | 1942.6666666666667 | 2295.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 2213_2467 | 2133.6666666666665 | 2486.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 2213_2467 | 2114.6666666666665 | 2467.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 2213_2467 | 2138.6666666666665 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 2213_2467 | 2138.6666666666665 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1093_1178 | 829.0 | 2295.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1368_1452 | 829.0 | 2295.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1501_1588 | 829.0 | 2295.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1788_1868 | 829.0 | 2295.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 1882_1965 | 829.0 | 2295.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 2213_2467 | 829.0 | 2295.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1093_1178 | 829.0 | 2486.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1368_1452 | 829.0 | 2486.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1501_1588 | 829.0 | 2486.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1788_1868 | 829.0 | 2486.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 1882_1965 | 829.0 | 2486.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 2213_2467 | 829.0 | 2486.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1093_1178 | 829.0 | 2467.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1368_1452 | 829.0 | 2467.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1501_1588 | 829.0 | 2467.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1788_1868 | 829.0 | 2467.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 1882_1965 | 829.0 | 2467.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 2213_2467 | 829.0 | 2467.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1093_1178 | 829.0 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1368_1452 | 829.0 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1501_1588 | 829.0 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1788_1868 | 829.0 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 1882_1965 | 829.0 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 2213_2467 | 829.0 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1093_1178 | 829.0 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1368_1452 | 829.0 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1501_1588 | 829.0 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1788_1868 | 829.0 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 1882_1965 | 829.0 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 2213_2467 | 829.0 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 2213_2467 | 1924.0 | 2295.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 2213_2467 | 2115.0 | 2486.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 2213_2467 | 2096.0 | 2467.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 2213_2467 | 2120.0 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 2213_2467 | 2120.0 | 2491.0 | Domain | Tyrosine-protein phosphatase | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 2408_2414 | 1942.6666666666667 | 2295.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 2408_2414 | 2133.6666666666665 | 2486.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 2408_2414 | 2114.6666666666665 | 2467.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 2408_2414 | 2138.6666666666665 | 2491.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 2408_2414 | 2138.6666666666665 | 2491.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 2408_2414 | 829.0 | 2295.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 2408_2414 | 829.0 | 2486.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 2408_2414 | 829.0 | 2467.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 2408_2414 | 829.0 | 2491.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 2408_2414 | 829.0 | 2491.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 2408_2414 | 1924.0 | 2295.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 2408_2414 | 2115.0 | 2486.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 2408_2414 | 2096.0 | 2467.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 2408_2414 | 2120.0 | 2491.0 | Region | Substrate binding | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 2408_2414 | 2120.0 | 2491.0 | Region | Substrate binding |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000307808 | + | 12 | 20 | 866_869 | 850.6666666666666 | 1211.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000307808 | + | 12 | 20 | 871_874 | 850.6666666666666 | 1211.0 | Compositional bias | Note=Poly-Ser |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000395146 | + | 13 | 21 | 866_869 | 857.6666666666666 | 1219.0 | Compositional bias | Note=Poly-Pro |
Hgene | AFF1 | chr4:88046295 | chr4:87720254 | ENST00000395146 | + | 13 | 21 | 871_874 | 857.6666666666666 | 1219.0 | Compositional bias | Note=Poly-Ser |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 469_504 | 1942.6666666666667 | 2295.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 469_504 | 2133.6666666666665 | 2486.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 469_504 | 2114.6666666666665 | 2467.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 469_504 | 2138.6666666666665 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 469_504 | 2138.6666666666665 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 469_504 | 829.0 | 2295.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 469_504 | 829.0 | 2486.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 469_504 | 829.0 | 2467.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 469_504 | 829.0 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 469_504 | 829.0 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 469_504 | 1924.0 | 2295.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 469_504 | 2115.0 | 2486.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 469_504 | 2096.0 | 2467.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 469_504 | 2120.0 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 469_504 | 2120.0 | 2491.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1742_1749 | 1942.6666666666667 | 2295.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 56_59 | 1942.6666666666667 | 2295.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1742_1749 | 2133.6666666666665 | 2486.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 56_59 | 2133.6666666666665 | 2486.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1742_1749 | 2114.6666666666665 | 2467.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 56_59 | 2114.6666666666665 | 2467.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1742_1749 | 2138.6666666666665 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 56_59 | 2138.6666666666665 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1742_1749 | 2138.6666666666665 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 56_59 | 2138.6666666666665 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 56_59 | 829.0 | 2295.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 56_59 | 829.0 | 2486.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 56_59 | 829.0 | 2467.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 56_59 | 829.0 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 56_59 | 829.0 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1742_1749 | 1924.0 | 2295.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 56_59 | 1924.0 | 2295.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1742_1749 | 2115.0 | 2486.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 56_59 | 2115.0 | 2486.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1742_1749 | 2096.0 | 2467.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 56_59 | 2096.0 | 2467.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1742_1749 | 2120.0 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 56_59 | 2120.0 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1742_1749 | 2120.0 | 2491.0 | Compositional bias | Note=Poly-Ser | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 56_59 | 2120.0 | 2491.0 | Compositional bias | Note=Poly-Leu | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1093_1178 | 1942.6666666666667 | 2295.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1368_1452 | 1942.6666666666667 | 2295.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1501_1588 | 1942.6666666666667 | 2295.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1788_1868 | 1942.6666666666667 | 2295.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 1882_1965 | 1942.6666666666667 | 2295.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 3_190 | 1942.6666666666667 | 2295.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000316707 | 37 | 45 | 572_872 | 1942.6666666666667 | 2295.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1093_1178 | 2133.6666666666665 | 2486.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1368_1452 | 2133.6666666666665 | 2486.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1501_1588 | 2133.6666666666665 | 2486.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1788_1868 | 2133.6666666666665 | 2486.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 1882_1965 | 2133.6666666666665 | 2486.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 3_190 | 2133.6666666666665 | 2486.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000411767 | 40 | 48 | 572_872 | 2133.6666666666665 | 2486.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1093_1178 | 2114.6666666666665 | 2467.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1368_1452 | 2114.6666666666665 | 2467.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1501_1588 | 2114.6666666666665 | 2467.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1788_1868 | 2114.6666666666665 | 2467.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 1882_1965 | 2114.6666666666665 | 2467.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 3_190 | 2114.6666666666665 | 2467.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000427191 | 39 | 47 | 572_872 | 2114.6666666666665 | 2467.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1093_1178 | 2138.6666666666665 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1368_1452 | 2138.6666666666665 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1501_1588 | 2138.6666666666665 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1788_1868 | 2138.6666666666665 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 1882_1965 | 2138.6666666666665 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 3_190 | 2138.6666666666665 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000436978 | 40 | 48 | 572_872 | 2138.6666666666665 | 2491.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1093_1178 | 2138.6666666666665 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1368_1452 | 2138.6666666666665 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1501_1588 | 2138.6666666666665 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1788_1868 | 2138.6666666666665 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 1882_1965 | 2138.6666666666665 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 3_190 | 2138.6666666666665 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88046295 | chr4:87720254 | ENST00000511467 | 39 | 47 | 572_872 | 2138.6666666666665 | 2491.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 3_190 | 829.0 | 2295.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000316707 | 15 | 45 | 572_872 | 829.0 | 2295.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 3_190 | 829.0 | 2486.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000411767 | 15 | 48 | 572_872 | 829.0 | 2486.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 3_190 | 829.0 | 2467.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000427191 | 15 | 47 | 572_872 | 829.0 | 2467.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 3_190 | 829.0 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000436978 | 15 | 48 | 572_872 | 829.0 | 2491.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 3_190 | 829.0 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87666119 | ENST00000511467 | 14 | 47 | 572_872 | 829.0 | 2491.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1093_1178 | 1924.0 | 2295.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1368_1452 | 1924.0 | 2295.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1501_1588 | 1924.0 | 2295.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1788_1868 | 1924.0 | 2295.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 1882_1965 | 1924.0 | 2295.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 3_190 | 1924.0 | 2295.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000316707 | 36 | 45 | 572_872 | 1924.0 | 2295.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1093_1178 | 2115.0 | 2486.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1368_1452 | 2115.0 | 2486.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1501_1588 | 2115.0 | 2486.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1788_1868 | 2115.0 | 2486.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 1882_1965 | 2115.0 | 2486.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 3_190 | 2115.0 | 2486.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000411767 | 39 | 48 | 572_872 | 2115.0 | 2486.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1093_1178 | 2096.0 | 2467.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1368_1452 | 2096.0 | 2467.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1501_1588 | 2096.0 | 2467.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1788_1868 | 2096.0 | 2467.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 1882_1965 | 2096.0 | 2467.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 3_190 | 2096.0 | 2467.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000427191 | 38 | 47 | 572_872 | 2096.0 | 2467.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1093_1178 | 2120.0 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1368_1452 | 2120.0 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1501_1588 | 2120.0 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1788_1868 | 2120.0 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 1882_1965 | 2120.0 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 3_190 | 2120.0 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000436978 | 39 | 48 | 572_872 | 2120.0 | 2491.0 | Domain | FERM | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1093_1178 | 2120.0 | 2491.0 | Domain | PDZ 1 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1368_1452 | 2120.0 | 2491.0 | Domain | PDZ 2 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1501_1588 | 2120.0 | 2491.0 | Domain | PDZ 3 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1788_1868 | 2120.0 | 2491.0 | Domain | PDZ 4 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 1882_1965 | 2120.0 | 2491.0 | Domain | PDZ 5 | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 3_190 | 2120.0 | 2491.0 | Domain | KIND | |
Tgene | PTPN13 | chr4:88048855 | chr4:87718027 | ENST00000511467 | 38 | 47 | 572_872 | 2120.0 | 2491.0 | Domain | FERM |
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Fusion Protein-Protein Interaction |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
Gene | PPI interactors |
AFF1 | MLLT1, CCNT1, NT5E, MLLT3, CDK9, AFF4, KMT2A, AFF1, BRD4, RELA, NPM1, PCSK1, MLLT10, DOT1L, POLR2A, DDX6, HEXIM1, HIST3H3, NSD1, CARM1, SIAH1, SIAH2, SMAD9, tat, MED26, EAF1, ELL2, LARP7, ELL3, HDAC1, MYH7, SLC16A6, ZNF526, Mllt1, Mad2l1bp, Rrbp1, Rcc1, VDR, PIP4K2A, CAMKV, TRIM25, HNRNPL, ESR2, KIAA1429, SASH1, DYRK1A, ARFIP1, MRPL12, KIF20A, CCAR2, FGF12, PLCD3, EPB41L1, EPB41L3, |
Protein-protein interactors based on sequence similarity (STRING) |
Gene | STRING network |
AFF1 | |
PTPN13 |
- Retained interactions in fusion protein (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost interactions due to fusion (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to AFF1-PTPN13 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to AFF1-PTPN13 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |