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Fusion Protein:ENSA-CTSS |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: ENSA-CTSS | FusionPDB ID: 26663 | FusionGDB2.0 ID: 26663 | Hgene | Tgene | Gene symbol | ENSA | CTSS | Gene ID | 2029 | 1520 |
Gene name | endosulfine alpha | cathepsin S | |
Synonyms | ARPP-19e | - | |
Cytomap | 1q21.3 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-endosulfine | cathepsin S | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | O43768 | P25774 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000271690, ENST00000339643, ENST00000361532, ENST00000361631, ENST00000369009, ENST00000369014, ENST00000369016, ENST00000503241, ENST00000513281, ENST00000354702, ENST00000356527, ENST00000362052, ENST00000503345, | ENST00000480760, ENST00000368985, ENST00000448301, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 11 X 6=858 | 14 X 15 X 9=1890 |
# samples | 17 | 19 | |
** MAII score | log2(17/858*10)=-2.33544290136184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/1890*10)=-3.31431491077749 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: ENSA [Title/Abstract] AND CTSS [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ENSA(150599943)-CTSS(150727626), # samples:1 ENSA(150599942)-CTSS(150727626), # samples:1 ENSA(150598117)-CTSS(150737240), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ENSA | GO:0050796 | regulation of insulin secretion | 9653196 |
Tgene | CTSS | GO:0006508 | proteolysis | 12788072|22864553 |
Tgene | CTSS | GO:0010447 | response to acidic pH | 22864553 |
Tgene | CTSS | GO:0016485 | protein processing | 22864553 |
Tgene | CTSS | GO:0030574 | collagen catabolic process | 22952693 |
Tgene | CTSS | GO:0034769 | basement membrane disassembly | 22952693 |
Tgene | CTSS | GO:0048002 | antigen processing and presentation of peptide antigen | 8612130 |
Tgene | CTSS | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
Tgene | CTSS | GO:2001259 | positive regulation of cation channel activity | 22864553 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-D7-A6F0-01A | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - |
ChimerDB4 | STAD | TCGA-D7-A6F0 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - |
ChimerDB4 | STAD | TCGA-FP-8631 | ENSA | chr1 | 150598117 | - | CTSS | chr1 | 150737240 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000369016 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3876 | 279 | 18 | 1025 | 335 |
ENST00000369014 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3906 | 309 | 48 | 1055 | 335 |
ENST00000339643 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3886 | 289 | 28 | 1035 | 335 |
ENST00000271690 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3887 | 290 | 29 | 1036 | 335 |
ENST00000503241 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3869 | 272 | 11 | 1018 | 335 |
ENST00000361532 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3803 | 206 | 35 | 952 | 305 |
ENST00000361631 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3791 | 194 | 23 | 940 | 305 |
ENST00000513281 | ENSA | chr1 | 150599943 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3779 | 182 | 11 | 928 | 305 |
ENST00000369016 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3876 | 279 | 18 | 1025 | 335 |
ENST00000369014 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3906 | 309 | 48 | 1055 | 335 |
ENST00000339643 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3886 | 289 | 28 | 1035 | 335 |
ENST00000271690 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3887 | 290 | 29 | 1036 | 335 |
ENST00000503241 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3869 | 272 | 11 | 1018 | 335 |
ENST00000361532 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3803 | 206 | 35 | 952 | 305 |
ENST00000361631 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3791 | 194 | 23 | 940 | 305 |
ENST00000513281 | ENSA | chr1 | 150599942 | - | ENST00000368985 | CTSS | chr1 | 150727626 | - | 3779 | 182 | 11 | 928 | 305 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000369016 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000363631 | 0.9996364 |
ENST00000369014 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000381922 | 0.99961805 |
ENST00000339643 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000370269 | 0.99962974 |
ENST00000271690 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000370586 | 0.9996294 |
ENST00000503241 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000356004 | 0.99964404 |
ENST00000361532 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.00055552 | 0.9994444 |
ENST00000361631 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.000568119 | 0.9994319 |
ENST00000513281 | ENST00000368985 | ENSA | chr1 | 150599943 | - | CTSS | chr1 | 150727626 | - | 0.00056484 | 0.9994351 |
ENST00000369016 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000363631 | 0.9996364 |
ENST00000369014 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000381922 | 0.99961805 |
ENST00000339643 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000370269 | 0.99962974 |
ENST00000271690 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000370586 | 0.9996294 |
ENST00000503241 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000356004 | 0.99964404 |
ENST00000361532 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.00055552 | 0.9994444 |
ENST00000361631 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.000568119 | 0.9994319 |
ENST00000513281 | ENST00000368985 | ENSA | chr1 | 150599942 | - | CTSS | chr1 | 150727626 | - | 0.00056484 | 0.9994351 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >26663_26663_1_ENSA-CTSS_ENSA_chr1_150599942_ENST00000271690_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_2_ENSA-CTSS_ENSA_chr1_150599942_ENST00000339643_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_3_ENSA-CTSS_ENSA_chr1_150599942_ENST00000361532_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- >26663_26663_4_ENSA-CTSS_ENSA_chr1_150599942_ENST00000361631_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- >26663_26663_5_ENSA-CTSS_ENSA_chr1_150599942_ENST00000369014_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_6_ENSA-CTSS_ENSA_chr1_150599942_ENST00000369016_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_7_ENSA-CTSS_ENSA_chr1_150599942_ENST00000503241_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_8_ENSA-CTSS_ENSA_chr1_150599942_ENST00000513281_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- >26663_26663_9_ENSA-CTSS_ENSA_chr1_150599943_ENST00000271690_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_10_ENSA-CTSS_ENSA_chr1_150599943_ENST00000339643_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_11_ENSA-CTSS_ENSA_chr1_150599943_ENST00000361532_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- >26663_26663_12_ENSA-CTSS_ENSA_chr1_150599943_ENST00000361631_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- >26663_26663_13_ENSA-CTSS_ENSA_chr1_150599943_ENST00000369014_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_14_ENSA-CTSS_ENSA_chr1_150599943_ENST00000369016_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_15_ENSA-CTSS_ENSA_chr1_150599943_ENST00000503241_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=335AA_BP=87 MSPFPLPLPFSGCLPGPLTLHSPGPAMSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSE EVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGV -------------------------------------------------------------- >26663_26663_16_ENSA-CTSS_ENSA_chr1_150599943_ENST00000513281_CTSS_chr1_150727626_ENST00000368985_length(amino acids)=305AA_BP=57 MAGGLGCDVCYWFVEDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILP DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPY KAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLV -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150599943/chr1:150727626) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ENSA | CTSS |
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. {ECO:0000250, ECO:0000269|PubMed:9653196}. | FUNCTION: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. {ECO:0000269|PubMed:30612035}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
ENSA | |
CTSS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ENSA-CTSS |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ENSA-CTSS |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |