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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPB41L1-CNBD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPB41L1-CNBD2
FusionPDB ID: 26808
FusionGDB2.0 ID: 26808
HgeneTgene
Gene symbol

EPB41L1

CNBD2

Gene ID

2036

140894

Gene nameerythrocyte membrane protein band 4.1 like 1cyclic nucleotide binding domain containing 2
Synonyms4.1N|MRD11C20orf152|CNMPD1
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionband 4.1-like protein 1neuron-type nonerythroid protein 4.1neuronal protein 4.1cyclic nucleotide-binding domain-containing protein 2cyclic nucleotide (cNMP) binding domain containing 1
Modification date2020031320200313
UniProtAcc

Q9H4G0

Q96M20

Ensembl transtripts involved in fusion geneENST idsENST00000202028, ENST00000373950, 
ENST00000441639, ENST00000338074, 
ENST00000373941, ENST00000373946, 
ENST00000479336, 		ENST00000349339, 
ENST00000373973, ENST00000538900, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 23 X 12=662413 X 10 X 11=1430
# samples 3417
** MAII scorelog2(34/6624*10)=-4.28409602136162
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1430*10)=-3.07240849552805
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPB41L1 [Title/Abstract] AND CNBD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPB41L1(34800298)-CNBD2(34582960), # samples:2
EPB41L1(34700402)-CNBD2(34618279), # samples:2
Anticipated loss of major functional domain due to fusion event.EPB41L1-CNBD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L1-CNBD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L1-CNBD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L1-CNBD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EPB41L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-98-A538-01AEPB41L1chr20

34800298

+CNBD2chr20

34582960

+
ChimerDB4LUSCTCGA-98-A538EPB41L1chr20

34800298

+CNBD2chr20

34582960

+
ChimerDB4LUSCTCGA-98-A538EPB41L1chr20

34802362

+CNBD2chr20

34582960

+
ChimerDB4OVTCGA-23-1026-01BEPB41L1chr20

34680735

+CNBD2chr20

34618279

+
ChimerDB4OVTCGA-23-1026-01BEPB41L1chr20

34700402

+CNBD2chr20

34618279

+
ChimerDB4STADTCGA-HF-7132-01AEPB41L1chr20

34700402

+CNBD2chr20

34582960

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000202028EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+306321351133010965
ENST00000202028EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+305121351132998961
ENST00000202028EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+286221351132551812
ENST00000373950EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+311021822353057940
ENST00000373950EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+309821822353045936
ENST00000373950EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+290921822352598787
ENST00000441639EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+2954202642901965
ENST00000441639EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+2942202642889961
ENST00000441639EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+2753202642442812
ENST00000373946EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+2572164402519839
ENST00000373946EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+2560164402507835
ENST00000373946EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+2371164402060686
ENST00000338074EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+327323457732201047
ENST00000338074EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+326123457732081043
ENST00000338074EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+30722345772761894
ENST00000373941EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+31212193030681022
ENST00000373941EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+31092193030561018
ENST00000373941EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+2920219302609869
ENST00000479336EPB41L1chr2034800298+ENST00000373973CNBD2chr2034582960+1774846421721559
ENST00000479336EPB41L1chr2034800298+ENST00000349339CNBD2chr2034582960+1762846421709555
ENST00000479336EPB41L1chr2034800298+ENST00000538900CNBD2chr2034582960+1573846421262406
ENST00000373950EPB41L1chr2034802362+ENST00000373973CNBD2chr2034582960+319422662353141968
ENST00000373950EPB41L1chr2034802362+ENST00000349339CNBD2chr2034582960+318222662353129964
ENST00000373950EPB41L1chr2034802362+ENST00000538900CNBD2chr2034582960+299322662352682815
ENST00000373946EPB41L1chr2034802362+ENST00000373973CNBD2chr2034582960+2656172802603867
ENST00000373946EPB41L1chr2034802362+ENST00000349339CNBD2chr2034582960+2644172802591863
ENST00000373946EPB41L1chr2034802362+ENST00000538900CNBD2chr2034582960+2455172802144714
ENST00000338074EPB41L1chr2034802362+ENST00000373973CNBD2chr2034582960+335724297733041075
ENST00000338074EPB41L1chr2034802362+ENST00000349339CNBD2chr2034582960+334524297732921071
ENST00000338074EPB41L1chr2034802362+ENST00000538900CNBD2chr2034582960+31562429772845922
ENST00000373941EPB41L1chr2034802362+ENST00000373973CNBD2chr2034582960+32022274031491049
ENST00000373941EPB41L1chr2034802362+ENST00000349339CNBD2chr2034582960+31902274031371045
ENST00000373941EPB41L1chr2034802362+ENST00000538900CNBD2chr2034582960+3001227402690896

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000202028ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.0031896880.99681026
ENST00000202028ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0033705520.9966294
ENST00000202028ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0094639780.99053603
ENST00000373950ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.005259730.9947403
ENST00000373950ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0054577990.9945422
ENST00000373950ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0144064870.9855935
ENST00000441639ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.0033422040.99665785
ENST00000441639ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0035386610.99646133
ENST00000441639ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0100546410.98994535
ENST00000373946ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.0090545930.99094546
ENST00000373946ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0100826160.98991734
ENST00000373946ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0213341790.9786659
ENST00000338074ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.0029437810.99705625
ENST00000338074ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0046610090.99533904
ENST00000338074ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0167938430.9832062
ENST00000373941ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.002140950.99785906
ENST00000373941ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.0034713850.99652857
ENST00000373941ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0146889330.98531103
ENST00000479336ENST00000373973EPB41L1chr2034800298+CNBD2chr2034582960+0.0065510750.9934489
ENST00000479336ENST00000349339EPB41L1chr2034800298+CNBD2chr2034582960+0.007756910.9922431
ENST00000479336ENST00000538900EPB41L1chr2034800298+CNBD2chr2034582960+0.0110270150.98897296
ENST00000373950ENST00000373973EPB41L1chr2034802362+CNBD2chr2034582960+0.004172580.9958274
ENST00000373950ENST00000349339EPB41L1chr2034802362+CNBD2chr2034582960+0.0045764570.9954235
ENST00000373950ENST00000538900EPB41L1chr2034802362+CNBD2chr2034582960+0.0125073970.98749256
ENST00000373946ENST00000373973EPB41L1chr2034802362+CNBD2chr2034582960+0.0089561190.9910439
ENST00000373946ENST00000349339EPB41L1chr2034802362+CNBD2chr2034582960+0.0097791740.9902208
ENST00000373946ENST00000538900EPB41L1chr2034802362+CNBD2chr2034582960+0.0210008160.97899914
ENST00000338074ENST00000373973EPB41L1chr2034802362+CNBD2chr2034582960+0.0059477980.99405223
ENST00000338074ENST00000349339EPB41L1chr2034802362+CNBD2chr2034582960+0.0050752910.99492466
ENST00000338074ENST00000538900EPB41L1chr2034802362+CNBD2chr2034582960+0.0144247120.9855753
ENST00000373941ENST00000373973EPB41L1chr2034802362+CNBD2chr2034582960+0.005423280.9945767
ENST00000373941ENST00000349339EPB41L1chr2034802362+CNBD2chr2034582960+0.0029762120.99702376
ENST00000373941ENST00000538900EPB41L1chr2034802362+CNBD2chr2034582960+0.0123758860.98762417

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26808_26808_1_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000202028_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=961AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE
ILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFT

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>26808_26808_2_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000202028_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=965AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE
ILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQS

--------------------------------------------------------------

>26808_26808_3_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000202028_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=812AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE

--------------------------------------------------------------

>26808_26808_4_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000338074_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=1043AA_BP=755
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY
PLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEG
ECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKRE

--------------------------------------------------------------

>26808_26808_5_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000338074_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=1047AA_BP=755
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY
PLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAF
LPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRP

--------------------------------------------------------------

>26808_26808_6_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000338074_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=894AA_BP=755
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY

--------------------------------------------------------------

>26808_26808_7_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373941_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=1018AA_BP=730
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFS
RKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFY
ELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPRYPIF

--------------------------------------------------------------

>26808_26808_8_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373941_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=1022AA_BP=730
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFS
RKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRK
EIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPR

--------------------------------------------------------------

>26808_26808_9_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373941_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=869AA_BP=730
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFS

--------------------------------------------------------------

>26808_26808_10_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373946_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=835AA_BP=547
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKI
RTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELI
DNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPRYPIFMAP

--------------------------------------------------------------

>26808_26808_11_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373946_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=839AA_BP=547
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKI
RTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIF
YELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPRYPI

--------------------------------------------------------------

>26808_26808_12_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373946_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=686AA_BP=547
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKI

--------------------------------------------------------------

>26808_26808_13_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373950_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=936AA_BP=648
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAW
GLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLGNELI
RIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKT

--------------------------------------------------------------

>26808_26808_14_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373950_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=940AA_BP=648
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAW
GLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLG
NELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCS

--------------------------------------------------------------

>26808_26808_15_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000373950_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=787AA_BP=648
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAW

--------------------------------------------------------------

>26808_26808_16_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000441639_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=961AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE
ILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFT

--------------------------------------------------------------

>26808_26808_17_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000441639_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=965AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE
ILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQS

--------------------------------------------------------------

>26808_26808_18_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000441639_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=812AA_BP=673
MTDRSSCPRGAGVDRGGSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNL
LEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQA
ELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRD
RLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQ
TRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVL
LKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFL
KDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGAC
STPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERF
KEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGE

--------------------------------------------------------------

>26808_26808_19_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000479336_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=555AA_BP=267
MSEGEARSLPNDVSSEAPVGQAEQQRSTLSDLGFAQLQPPGDFASPKATHSTVIPLATRHFREDTSASYQEAHTELEPVSPNSGCETTLA
EATGTGRAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSL
PELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGS
CEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKM
LGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKL
LKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPRYPIFMAPQKYLPPLRIV

--------------------------------------------------------------

>26808_26808_20_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000479336_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=559AA_BP=267
MSEGEARSLPNDVSSEAPVGQAEQQRSTLSDLGFAQLQPPGDFASPKATHSTVIPLATRHFREDTSASYQEAHTELEPVSPNSGCETTLA
EATGTGRAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSL
PELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGS
CEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKM
LGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEM
IKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIYNPKSVVLDLCSINKTTKPRYPIFMAPQKYLPP

--------------------------------------------------------------

>26808_26808_21_EPB41L1-CNBD2_EPB41L1_chr20_34800298_ENST00000479336_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=406AA_BP=267
MSEGEARSLPNDVSSEAPVGQAEQQRSTLSDLGFAQLQPPGDFASPKATHSTVIPLATRHFREDTSASYQEAHTELEPVSPNSGCETTLA
EATGTGRAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSL
PELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGS
CEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKM

--------------------------------------------------------------

>26808_26808_22_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000338074_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=1071AA_BP=784
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLE
LIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGE
LPKEAAVGAYVKVHTVEQGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWN

--------------------------------------------------------------

>26808_26808_23_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000338074_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=1075AA_BP=784
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLE
LIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGE
LPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQ

--------------------------------------------------------------

>26808_26808_24_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000338074_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=922AA_BP=784
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLE
LIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGE

--------------------------------------------------------------

>26808_26808_25_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373941_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=1045AA_BP=758
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIK
SYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLP
EGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKK

--------------------------------------------------------------

>26808_26808_26_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373941_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=1049AA_BP=758
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIK
SYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQ
AFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPN

--------------------------------------------------------------

>26808_26808_27_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373941_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=896AA_BP=758
LVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSP
QKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYP
PDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG
EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNH
RSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHD
AGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERR
LPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGD
YHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVL
QTRVSAMDNTQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIK

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>26808_26808_28_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373946_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=863AA_BP=576
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY
PLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILAFLPEG
ECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKRE

--------------------------------------------------------------

>26808_26808_29_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373946_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=867AA_BP=576
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY
PLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAF
LPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRP

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>26808_26808_30_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373946_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=714AA_BP=576
MVFLGRINEVEPAKGLAESLAPTERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQV
LFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVT
HALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLG
VCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGS
KFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKE
LKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANEPVKTETMTVSSLAIRKKIEPEAVLQTR
VSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY

--------------------------------------------------------------

>26808_26808_31_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373950_CNBD2_chr20_34582960_ENST00000349339_length(amino acids)=964AA_BP=677
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE
QGEILAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQ

--------------------------------------------------------------

>26808_26808_32_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373950_CNBD2_chr20_34582960_ENST00000373973_length(amino acids)=968AA_BP=677
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE
QGEILGLHQAFLPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEP

--------------------------------------------------------------

>26808_26808_33_EPB41L1-CNBD2_EPB41L1_chr20_34802362_ENST00000373950_CNBD2_chr20_34582960_ENST00000538900_length(amino acids)=815AA_BP=677
MRADGTGSSKADPDTEARPVQQGPHTLSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVENWLDPSKE
IKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQT
RELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIK
IRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTM
SRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRD
RDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAE
VDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRK
KIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPM
ERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:34800298/chr20:34582960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41L1

Q9H4G0

CNBD2

Q96M20

FUNCTION: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.FUNCTION: Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm. {ECO:0000250|UniProtKB:Q9D5U8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000202028+152097_378654.0780.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000338074+162297_378728.0882.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373941+152197_378728.0881.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373946+131997_378548.0702.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373950+152197_378619.0773.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000441639+141997_378654.0780.0DomainFERM
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000338074+172297_378756.0882.0DomainFERM
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373941+162197_378755.0881.0DomainFERM
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373946+141997_378576.0702.0DomainFERM
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373950+162197_378647.0773.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000202028+1520483_541654.0780.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000338074+1622483_541728.0882.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373941+1521483_541728.0881.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373946+1319483_541548.0702.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373950+1521483_541619.0773.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000441639+1419483_541654.0780.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000338074+1722483_541756.0882.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373941+1621483_541755.0881.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373946+1419483_541576.0702.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373950+1621483_541647.0773.0RegionNote=Spectrin--actin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000202028+12097_3780780.0DomainFERM
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000441639+11997_3780780.0DomainFERM
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000202028+1520746_881654.0780.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000338074+1622746_881728.0882.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373941+1521746_881728.0881.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373946+1319746_881548.0702.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000373950+1521746_881619.0773.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34800298chr20:34582960ENST00000441639+1419746_881654.0780.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000202028+120483_5410780.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000202028+120746_8810780.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000338074+1722746_881756.0882.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373941+1621746_881755.0881.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373946+1419746_881576.0702.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000373950+1621746_881647.0773.0RegionNote=C-terminal (CTD)
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000441639+119483_5410780.0RegionNote=Spectrin--actin-binding
HgeneEPB41L1chr20:34802362chr20:34582960ENST00000441639+119746_8810780.0RegionNote=C-terminal (CTD)
TgeneCNBD2chr20:34800298chr20:34582960ENST00000349339612116_239285.0573.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:34800298chr20:34582960ENST00000373973612116_239285.0577.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:34800298chr20:34582960ENST00000538900611116_239285.0424.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:34802362chr20:34582960ENST00000349339612116_239285.0573.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:34802362chr20:34582960ENST00000373973612116_239285.0577.0Nucleotide bindingNote=cNMP
TgeneCNBD2chr20:34802362chr20:34582960ENST00000538900611116_239285.0424.0Nucleotide bindingNote=cNMP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1827_EPB41L1_34800298_CNBD2_34582960_ranked_0.pdbEPB41L13480236234800298ENST00000538900CNBD2chr2034582960+
MPARGAEGAAPRPTCPTWGTPGPGVLVTMTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLD
MEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWL
DPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF
APNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS
NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSS
KRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASIN
ELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIE
RKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQF
EPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQGSCEVLRLLDLGASPSYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSY
PLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLPKMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAF
LPEGECDTRPLILMSLGNELIRIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRP
1047


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EPB41L1_pLDDT.png
all structure
all structure
CNBD2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPB41L1
CNBD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EPB41L1-CNBD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPB41L1-CNBD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource