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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPB41L2-PTPRK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPB41L2-PTPRK
FusionPDB ID: 26837
FusionGDB2.0 ID: 26837
HgeneTgene
Gene symbol

EPB41L2

PTPRK

Gene ID

2037

5796

Gene nameerythrocyte membrane protein band 4.1 like 2protein tyrosine phosphatase receptor type K
Synonyms4.1-G|4.1GR-PTP-kappa
Cytomap

6q23.1-q23.2

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionband 4.1-like protein 2erythrocyte membrane protein band 4.1 like-protein 2generally expressed protein 4.1receptor-type tyrosine-protein phosphatase kappadJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappaprotein-tyrosine phosphatase kappaprotein-tyrosine phospha
Modification date2020031320200322
UniProtAcc

O43491

.
Ensembl transtripts involved in fusion geneENST idsENST00000337057, ENST00000368128, 
ENST00000392427, ENST00000445890, 
ENST00000525193, ENST00000525271, 
ENST00000527411, ENST00000527659, 
ENST00000528282, ENST00000529208, 
ENST00000530481, ENST00000524581, 
ENST00000530148, ENST00000530757, 
ENST00000531410, 		ENST00000524481, 
ENST00000525459, ENST00000368207, 
ENST00000368210, ENST00000368213, 
ENST00000368215, ENST00000368226, 
ENST00000368227, ENST00000532331, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 11 X 7=92417 X 12 X 9=1836
# samples 1321
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1836*10)=-3.12810482574769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPB41L2 [Title/Abstract] AND PTPRK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPB41L2(131276245)-PTPRK(128330413), # samples:2
PTPRK(128841404)-EPB41L2(131184858), # samples:2
Anticipated loss of major functional domain due to fusion event.PTPRK-EPB41L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRK-EPB41L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EPB41L2-PTPRK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRK

GO:0006470

protein dephosphorylation

16263724

TgenePTPRK

GO:0007165

signal transduction

16849327

TgenePTPRK

GO:0007179

transforming growth factor beta receptor signaling pathway

15899872

TgenePTPRK

GO:0008285

negative regulation of cell proliferation

15899872|18276111

TgenePTPRK

GO:0010839

negative regulation of keratinocyte proliferation

16263724

TgenePTPRK

GO:0030336

negative regulation of cell migration

18276111

TgenePTPRK

GO:0034394

protein localization to cell surface

18276111

TgenePTPRK

GO:0034614

cellular response to reactive oxygen species

16849327

TgenePTPRK

GO:0034644

cellular response to UV

16849327

TgenePTPRK

GO:0045786

negative regulation of cell cycle

15899872

TgenePTPRK

GO:0045892

negative regulation of transcription, DNA-templated

18276111


check buttonFusion gene breakpoints across EPB41L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IF-A3RQ-01AEPB41L2chr6

131276245

-PTPRKchr6

128330413

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000528282EPB41L2chr6131276245-ENST00000368226PTPRKchr6128330413-44448679562995679
ENST00000528282EPB41L2chr6131276245-ENST00000368227PTPRKchr6128330413-44948679563046696
ENST00000528282EPB41L2chr6131276245-ENST00000532331PTPRKchr6128330413-43128679563061701
ENST00000528282EPB41L2chr6131276245-ENST00000368213PTPRKchr6128330413-42648679563013685
ENST00000528282EPB41L2chr6131276245-ENST00000368210PTPRKchr6128330413-34408679563049697
ENST00000528282EPB41L2chr6131276245-ENST00000368215PTPRKchr6128330413-33248679532992679
ENST00000528282EPB41L2chr6131276245-ENST00000368207PTPRKchr6128330413-32068679563091711
ENST00000337057EPB41L2chr6131276245-ENST00000368226PTPRKchr6128330413-44648879763015679
ENST00000337057EPB41L2chr6131276245-ENST00000368227PTPRKchr6128330413-45148879763066696
ENST00000337057EPB41L2chr6131276245-ENST00000532331PTPRKchr6128330413-43328879763081701
ENST00000337057EPB41L2chr6131276245-ENST00000368213PTPRKchr6128330413-42848879763033685
ENST00000337057EPB41L2chr6131276245-ENST00000368210PTPRKchr6128330413-34608879763069697
ENST00000337057EPB41L2chr6131276245-ENST00000368215PTPRKchr6128330413-33448879733012679
ENST00000337057EPB41L2chr6131276245-ENST00000368207PTPRKchr6128330413-32268879763111711
ENST00000392427EPB41L2chr6131276245-ENST00000368226PTPRKchr6128330413-43757988872926679
ENST00000392427EPB41L2chr6131276245-ENST00000368227PTPRKchr6128330413-44257988872977696
ENST00000392427EPB41L2chr6131276245-ENST00000532331PTPRKchr6128330413-42437988872992701
ENST00000392427EPB41L2chr6131276245-ENST00000368213PTPRKchr6128330413-41957988872944685
ENST00000392427EPB41L2chr6131276245-ENST00000368210PTPRKchr6128330413-33717988872980697
ENST00000392427EPB41L2chr6131276245-ENST00000368215PTPRKchr6128330413-32557988842923679
ENST00000392427EPB41L2chr6131276245-ENST00000368207PTPRKchr6128330413-31377988873022711

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000528282ENST00000368226EPB41L2chr6131276245-PTPRKchr6128330413-0.0012768470.9987231
ENST00000528282ENST00000368227EPB41L2chr6131276245-PTPRKchr6128330413-0.0012132310.99878675
ENST00000528282ENST00000532331EPB41L2chr6131276245-PTPRKchr6128330413-0.0009466920.9990533
ENST00000528282ENST00000368213EPB41L2chr6131276245-PTPRKchr6128330413-0.0013129630.9986871
ENST00000528282ENST00000368210EPB41L2chr6131276245-PTPRKchr6128330413-0.0029798580.99702007
ENST00000528282ENST00000368215EPB41L2chr6131276245-PTPRKchr6128330413-0.0027227750.9972772
ENST00000528282ENST00000368207EPB41L2chr6131276245-PTPRKchr6128330413-0.0021036950.9978963
ENST00000337057ENST00000368226EPB41L2chr6131276245-PTPRKchr6128330413-0.0013985370.9986015
ENST00000337057ENST00000368227EPB41L2chr6131276245-PTPRKchr6128330413-0.001336230.9986638
ENST00000337057ENST00000532331EPB41L2chr6131276245-PTPRKchr6128330413-0.0010777710.9989222
ENST00000337057ENST00000368213EPB41L2chr6131276245-PTPRKchr6128330413-0.0014738250.9985261
ENST00000337057ENST00000368210EPB41L2chr6131276245-PTPRKchr6128330413-0.0036009070.99639904
ENST00000337057ENST00000368215EPB41L2chr6131276245-PTPRKchr6128330413-0.0033419680.9966581
ENST00000337057ENST00000368207EPB41L2chr6131276245-PTPRKchr6128330413-0.002660380.99733967
ENST00000392427ENST00000368226EPB41L2chr6131276245-PTPRKchr6128330413-0.0014181470.9985819
ENST00000392427ENST00000368227EPB41L2chr6131276245-PTPRKchr6128330413-0.0013524970.9986475
ENST00000392427ENST00000532331EPB41L2chr6131276245-PTPRKchr6128330413-0.0010818140.9989182
ENST00000392427ENST00000368213EPB41L2chr6131276245-PTPRKchr6128330413-0.0014838520.99851614
ENST00000392427ENST00000368210EPB41L2chr6131276245-PTPRKchr6128330413-0.0037003080.9962997
ENST00000392427ENST00000368215EPB41L2chr6131276245-PTPRKchr6128330413-0.0034474730.99655247
ENST00000392427ENST00000368207EPB41L2chr6131276245-PTPRKchr6128330413-0.0027343330.9972657

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26837_26837_1_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368207_length(amino acids)=711AA_BP=
MVFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTA
VLVPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN
RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKY
WPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR
TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQ
TLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT
SIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQV

--------------------------------------------------------------

>26837_26837_2_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368210_length(amino acids)=697AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVT
CVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA
EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDC
SIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGC
PQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRT

--------------------------------------------------------------

>26837_26837_3_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368213_length(amino acids)=685AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVV
RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCV
KALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN
RFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRY
GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG

--------------------------------------------------------------

>26837_26837_4_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368215_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_5_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368226_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_6_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000368227_length(amino acids)=696AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDVSIFIGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE
REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP
QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI

--------------------------------------------------------------

>26837_26837_7_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000337057_PTPRK_chr6_128330413_ENST00000532331_length(amino acids)=701AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENH
SATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDH
SRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGD
FKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIM
LDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQ
AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL
SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEG

--------------------------------------------------------------

>26837_26837_8_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368207_length(amino acids)=711AA_BP=
MVFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTA
VLVPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN
RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKY
WPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR
TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQ
TLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT
SIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQV

--------------------------------------------------------------

>26837_26837_9_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368210_length(amino acids)=697AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVT
CVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA
EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDC
SIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGC
PQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRT

--------------------------------------------------------------

>26837_26837_10_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368213_length(amino acids)=685AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVV
RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCV
KALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN
RFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRY
GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG

--------------------------------------------------------------

>26837_26837_11_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368215_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_12_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368226_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_13_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000368227_length(amino acids)=696AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDVSIFIGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE
REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP
QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI

--------------------------------------------------------------

>26837_26837_14_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000392427_PTPRK_chr6_128330413_ENST00000532331_length(amino acids)=701AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENH
SATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDH
SRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGD
FKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIM
LDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQ
AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL
SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEG

--------------------------------------------------------------

>26837_26837_15_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368207_length(amino acids)=711AA_BP=
MVFILLLLVVILIVKKRRSYYSYSYYLKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTA
VLVPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKN
RYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKY
WPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGR
TGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQ
TLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT
SIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQV

--------------------------------------------------------------

>26837_26837_16_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368210_length(amino acids)=697AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVT
CVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA
EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDC
SIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGC
PQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRT

--------------------------------------------------------------

>26837_26837_17_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368213_length(amino acids)=685AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVV
RTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCV
KALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKN
RFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRY
GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSG

--------------------------------------------------------------

>26837_26837_18_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368215_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_19_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368226_length(amino acids)=679AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYL
CEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDY
INANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLE
RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSR
RINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDML
PPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVE
CMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIG

--------------------------------------------------------------

>26837_26837_20_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000368227_length(amino acids)=696AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLDENHSATA
ESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVI
LQPVEDDPSSDYINANYIDVSIFIGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTC
VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE
REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCS
IACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCP
QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTI

--------------------------------------------------------------

>26837_26837_21_EPB41L2-PTPRK_EPB41L2_chr6_131276245_ENST00000528282_PTPRK_chr6_128330413_ENST00000532331_length(amino acids)=701AA_BP=
MVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENH
SATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDH
SRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGD
FKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIM
LDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQ
AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL
SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:131276245/chr6:128330413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPB41L2

O43491

.
FUNCTION: Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRKchr6:131276245chr6:128330413ENST0000036821312311173_1435731.33333333333341447.0DomainTyrosine-protein phosphatase 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231887_1141731.33333333333341447.0DomainTyrosine-protein phosphatase 1
TgenePTPRKchr6:131276245chr6:128330413ENST0000036821512301173_1435731.33333333333341440.0DomainTyrosine-protein phosphatase 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230887_1141731.33333333333341440.0DomainTyrosine-protein phosphatase 1
TgenePTPRKchr6:131276245chr6:128330413ENST0000036822612301173_1435731.33333333333341441.0DomainTyrosine-protein phosphatase 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230887_1141731.33333333333341441.0DomainTyrosine-protein phosphatase 1
TgenePTPRKchr6:131276245chr6:128330413ENST0000036821312311082_1088731.33333333333341447.0RegionSubstrate binding
TgenePTPRKchr6:131276245chr6:128330413ENST0000036821512301082_1088731.33333333333341440.0RegionSubstrate binding
TgenePTPRKchr6:131276245chr6:128330413ENST0000036822612301082_1088731.33333333333341441.0RegionSubstrate binding
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231775_1439731.33333333333341447.0Topological domainCytoplasmic
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230775_1439731.33333333333341440.0Topological domainCytoplasmic
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230775_1439731.33333333333341441.0Topological domainCytoplasmic
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231753_774731.33333333333341447.0TransmembraneHelical
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230753_774731.33333333333341440.0TransmembraneHelical
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230753_774731.33333333333341441.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000337057-320218_499235.01236.3333333333333DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000368128-320218_499235.01230.0DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000392427-315218_499235.0933.0DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000445890-317218_499235.0980.3333333333334DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000525271-315218_499235.0645.3333333333334DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000528282-317218_499235.0985.0DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000530481-318218_499235.01111.3333333333333DomainFERM
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000337057-320502_610235.01236.3333333333333RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000337057-320611_676235.01236.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000337057-320855_1005235.01236.3333333333333RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000368128-320502_610235.01230.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000368128-320611_676235.01230.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000368128-320855_1005235.01230.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000392427-315502_610235.0933.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000392427-315611_676235.0933.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000392427-315855_1005235.0933.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000445890-317502_610235.0980.3333333333334RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000445890-317611_676235.0980.3333333333334RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000445890-317855_1005235.0980.3333333333334RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000525271-315502_610235.0645.3333333333334RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000525271-315611_676235.0645.3333333333334RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000525271-315855_1005235.0645.3333333333334RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000528282-317502_610235.0985.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000528282-317611_676235.0985.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000528282-317855_1005235.0985.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000530481-318502_610235.01111.3333333333333RegionNote=Hydrophilic
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000530481-318611_676235.01111.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131276245chr6:128330413ENST00000530481-318855_1005235.01111.3333333333333RegionNote=C-terminal (CTD)
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231196_281731.33333333333341447.0DomainNote=Ig-like C2-type
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231294_389731.33333333333341447.0DomainFibronectin type-III 1
TgenePTPRKchr6:131276245chr6:128330413ENST00000368213123131_194731.33333333333341447.0DomainMAM
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231392_488731.33333333333341447.0DomainFibronectin type-III 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231491_595731.33333333333341447.0DomainFibronectin type-III 3
TgenePTPRKchr6:131276245chr6:128330413ENST000003682131231597_680731.33333333333341447.0DomainFibronectin type-III 4
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230196_281731.33333333333341440.0DomainNote=Ig-like C2-type
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230294_389731.33333333333341440.0DomainFibronectin type-III 1
TgenePTPRKchr6:131276245chr6:128330413ENST00000368215123031_194731.33333333333341440.0DomainMAM
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230392_488731.33333333333341440.0DomainFibronectin type-III 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230491_595731.33333333333341440.0DomainFibronectin type-III 3
TgenePTPRKchr6:131276245chr6:128330413ENST000003682151230597_680731.33333333333341440.0DomainFibronectin type-III 4
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230196_281731.33333333333341441.0DomainNote=Ig-like C2-type
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230294_389731.33333333333341441.0DomainFibronectin type-III 1
TgenePTPRKchr6:131276245chr6:128330413ENST00000368226123031_194731.33333333333341441.0DomainMAM
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230392_488731.33333333333341441.0DomainFibronectin type-III 2
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230491_595731.33333333333341441.0DomainFibronectin type-III 3
TgenePTPRKchr6:131276245chr6:128330413ENST000003682261230597_680731.33333333333341441.0DomainFibronectin type-III 4
TgenePTPRKchr6:131276245chr6:128330413ENST00000368213123127_752731.33333333333341447.0Topological domainExtracellular
TgenePTPRKchr6:131276245chr6:128330413ENST00000368215123027_752731.33333333333341440.0Topological domainExtracellular
TgenePTPRKchr6:131276245chr6:128330413ENST00000368226123027_752731.33333333333341441.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPB41L2
PTPRK


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EPB41L2-PTPRK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPB41L2-PTPRK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource