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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPHB2-ZBTB40

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPHB2-ZBTB40
FusionPDB ID: 26998
FusionGDB2.0 ID: 26998
HgeneTgene
Gene symbol

EPHB2

ZBTB40

Gene ID

2048

9923

Gene nameEPH receptor B2zinc finger and BTB domain containing 40
SynonymsBDPLT22|CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5ZNF923
Cytomap

1p36.12

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionephrin type-B receptor 2EPH-like kinase 5developmentally-regulated Eph-related tyrosine kinaseelk-related tyrosine kinaseeph tyrosine kinase 3protein-tyrosine kinase HEK5renal carcinoma antigen NY-REN-47tyrosine-protein kinase TYRO5tyrosine-proteizinc finger and BTB domain-containing protein 40
Modification date2020031320200313
UniProtAcc

P29323

.
Ensembl transtripts involved in fusion geneENST idsENST00000374630, ENST00000374632, 
ENST00000400191, ENST00000544305, 
ENST00000374627, ENST00000465676, 
ENST00000374651, ENST00000375647, 
ENST00000404138, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 7=3783 X 5 X 4=60
# samples 135
** MAII scorelog2(13/378*10)=-1.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPHB2 [Title/Abstract] AND ZBTB40 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPHB2(23111569)-ZBTB40(22843792), # samples:2
Anticipated loss of major functional domain due to fusion event.EPHB2-ZBTB40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHB2-ZBTB40 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHB2-ZBTB40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHB2-ZBTB40 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZBTB40

GO:0006974

cellular response to DNA damage stimulus

17525332


check buttonFusion gene breakpoints across EPHB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZBTB40 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01AEPHB2chr1

23111569

+ZBTB40chr1

22843793

+
ChimerDB4ESCATCGA-L5-A4OQEPHB2chr1

23111569

+ZBTB40chr1

22843792

+
ChimerDB4STADTCGA-VQ-A922EPHB2chr1

23037536

+ZBTB40chr1

22816372

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544305EPHB2chr123111569+ENST00000404138ZBTB40chr122843793+676895532006667
ENST00000544305EPHB2chr123111569+ENST00000375647ZBTB40chr122843793+676595532006667
ENST00000544305EPHB2chr123111569+ENST00000374651ZBTB40chr122843793+297395532006667
ENST00000374630EPHB2chr123111569+ENST00000404138ZBTB40chr122843793+6642829181880620
ENST00000374630EPHB2chr123111569+ENST00000375647ZBTB40chr122843793+6639829181880620
ENST00000374630EPHB2chr123111569+ENST00000374651ZBTB40chr122843793+2847829181880620
ENST00000400191EPHB2chr123111569+ENST00000404138ZBTB40chr122843793+6642829181880620
ENST00000400191EPHB2chr123111569+ENST00000375647ZBTB40chr122843793+6639829181880620
ENST00000400191EPHB2chr123111569+ENST00000374651ZBTB40chr122843793+2847829181880620
ENST00000374632EPHB2chr123111569+ENST00000404138ZBTB40chr122843793+6637824131875620
ENST00000374632EPHB2chr123111569+ENST00000375647ZBTB40chr122843793+6634824131875620
ENST00000374632EPHB2chr123111569+ENST00000374651ZBTB40chr122843793+2842824131875620
ENST00000374627EPHB2chr123111569+ENST00000404138ZBTB40chr122843793+6630817241868614
ENST00000374627EPHB2chr123111569+ENST00000375647ZBTB40chr122843793+6627817241868614
ENST00000374627EPHB2chr123111569+ENST00000374651ZBTB40chr122843793+2835817241868614
ENST00000544305EPHB2chr123111569+ENST00000404138ZBTB40chr122843792+676895532006667
ENST00000544305EPHB2chr123111569+ENST00000375647ZBTB40chr122843792+676595532006667
ENST00000544305EPHB2chr123111569+ENST00000374651ZBTB40chr122843792+297395532006667
ENST00000374630EPHB2chr123111569+ENST00000404138ZBTB40chr122843792+6642829181880620
ENST00000374630EPHB2chr123111569+ENST00000375647ZBTB40chr122843792+6639829181880620
ENST00000374630EPHB2chr123111569+ENST00000374651ZBTB40chr122843792+2847829181880620
ENST00000400191EPHB2chr123111569+ENST00000404138ZBTB40chr122843792+6642829181880620
ENST00000400191EPHB2chr123111569+ENST00000375647ZBTB40chr122843792+6639829181880620
ENST00000400191EPHB2chr123111569+ENST00000374651ZBTB40chr122843792+2847829181880620
ENST00000374632EPHB2chr123111569+ENST00000404138ZBTB40chr122843792+6637824131875620
ENST00000374632EPHB2chr123111569+ENST00000375647ZBTB40chr122843792+6634824131875620
ENST00000374632EPHB2chr123111569+ENST00000374651ZBTB40chr122843792+2842824131875620
ENST00000374627EPHB2chr123111569+ENST00000404138ZBTB40chr122843792+6630817241868614
ENST00000374627EPHB2chr123111569+ENST00000375647ZBTB40chr122843792+6627817241868614
ENST00000374627EPHB2chr123111569+ENST00000374651ZBTB40chr122843792+2835817241868614

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544305ENST00000404138EPHB2chr123111569+ZBTB40chr122843793+0.0017565610.99824345
ENST00000544305ENST00000375647EPHB2chr123111569+ZBTB40chr122843793+0.0017670730.99823284
ENST00000544305ENST00000374651EPHB2chr123111569+ZBTB40chr122843793+0.0118292240.98817074
ENST00000374630ENST00000404138EPHB2chr123111569+ZBTB40chr122843793+0.0017867370.9982133
ENST00000374630ENST00000375647EPHB2chr123111569+ZBTB40chr122843793+0.0017968710.99820316
ENST00000374630ENST00000374651EPHB2chr123111569+ZBTB40chr122843793+0.012739670.98726034
ENST00000400191ENST00000404138EPHB2chr123111569+ZBTB40chr122843793+0.0017867370.9982133
ENST00000400191ENST00000375647EPHB2chr123111569+ZBTB40chr122843793+0.0017968710.99820316
ENST00000400191ENST00000374651EPHB2chr123111569+ZBTB40chr122843793+0.012739670.98726034
ENST00000374632ENST00000404138EPHB2chr123111569+ZBTB40chr122843793+0.0017884620.9982115
ENST00000374632ENST00000375647EPHB2chr123111569+ZBTB40chr122843793+0.0017989480.998201
ENST00000374632ENST00000374651EPHB2chr123111569+ZBTB40chr122843793+0.0128048510.9871952
ENST00000374627ENST00000404138EPHB2chr123111569+ZBTB40chr122843793+0.0010658240.9989342
ENST00000374627ENST00000375647EPHB2chr123111569+ZBTB40chr122843793+0.0010719570.998928
ENST00000374627ENST00000374651EPHB2chr123111569+ZBTB40chr122843793+0.0069254190.99307454
ENST00000544305ENST00000404138EPHB2chr123111569+ZBTB40chr122843792+0.0017565610.99824345
ENST00000544305ENST00000375647EPHB2chr123111569+ZBTB40chr122843792+0.0017670730.99823284
ENST00000544305ENST00000374651EPHB2chr123111569+ZBTB40chr122843792+0.0118292240.98817074
ENST00000374630ENST00000404138EPHB2chr123111569+ZBTB40chr122843792+0.0017867370.9982133
ENST00000374630ENST00000375647EPHB2chr123111569+ZBTB40chr122843792+0.0017968710.99820316
ENST00000374630ENST00000374651EPHB2chr123111569+ZBTB40chr122843792+0.012739670.98726034
ENST00000400191ENST00000404138EPHB2chr123111569+ZBTB40chr122843792+0.0017867370.9982133
ENST00000400191ENST00000375647EPHB2chr123111569+ZBTB40chr122843792+0.0017968710.99820316
ENST00000400191ENST00000374651EPHB2chr123111569+ZBTB40chr122843792+0.012739670.98726034
ENST00000374632ENST00000404138EPHB2chr123111569+ZBTB40chr122843792+0.0017884620.9982115
ENST00000374632ENST00000375647EPHB2chr123111569+ZBTB40chr122843792+0.0017989480.998201
ENST00000374632ENST00000374651EPHB2chr123111569+ZBTB40chr122843792+0.0128048510.9871952
ENST00000374627ENST00000404138EPHB2chr123111569+ZBTB40chr122843792+0.0010658240.9989342
ENST00000374627ENST00000375647EPHB2chr123111569+ZBTB40chr122843792+0.0010719570.998928
ENST00000374627ENST00000374651EPHB2chr123111569+ZBTB40chr122843792+0.0069254190.99307454

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26998_26998_1_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843792_ENST00000374651_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

--------------------------------------------------------------

>26998_26998_2_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843792_ENST00000375647_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

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>26998_26998_3_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843792_ENST00000404138_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

--------------------------------------------------------------

>26998_26998_4_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843793_ENST00000374651_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

--------------------------------------------------------------

>26998_26998_5_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843793_ENST00000375647_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

--------------------------------------------------------------

>26998_26998_6_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374627_ZBTB40_chr1_22843793_ENST00000404138_length(amino acids)=614AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYAC
QYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGK
IFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFH
ECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTE

--------------------------------------------------------------

>26998_26998_7_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843792_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

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>26998_26998_8_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843792_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

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>26998_26998_9_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843792_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

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>26998_26998_10_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843793_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_11_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843793_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_12_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374630_ZBTB40_chr1_22843793_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_13_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843792_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_14_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843792_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_15_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843792_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_16_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843793_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_17_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843793_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_18_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000374632_ZBTB40_chr1_22843793_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_19_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843792_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_20_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843792_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_21_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843792_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_22_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843793_ENST00000374651_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_23_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843793_ENST00000375647_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_24_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000400191_ZBTB40_chr1_22843793_ENST00000404138_length(amino acids)=620AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
GKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHP
CPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLWYHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEH
ADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAATFRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHP

--------------------------------------------------------------

>26998_26998_25_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843792_ENST00000374651_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

>26998_26998_26_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843792_ENST00000375647_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

>26998_26998_27_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843792_ENST00000404138_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

>26998_26998_28_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843793_ENST00000374651_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

>26998_26998_29_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843793_ENST00000375647_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

>26998_26998_30_EPHB2-ZBTB40_EPHB2_chr1_23111569_ENST00000544305_ZBTB40_chr1_22843793_ENST00000404138_length(amino acids)=667AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGKMYACQYCDAVFAQSIELSRHVRTHTGDKPYVCRDCGKGFRQ
ANGLSIHLHTFHNIEDPYDCKKCRMSFPTLQDHRKHIHEVHSKEYHPCPTCGKIFSAPSMLERHVVTHVGGKPFSCGICNKAYQQLSGLW
YHNRTHHPDVFAAQNHRSSKFSSLQCSSCDKTFPNTIEHKKHIKAEHADMKFHECDQCKELFPTPALLQVHVKCQHSGSQPFRCLYCAAT
FRFPGALQHHVTTEHFKQSETTFPCELCGELFTSQAQLDSHLESEHPKVMSTETQAAASQMAQVIQTPEPVAPTEQVITLEETQLAGSQV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:23111569/chr1:22843792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPHB2

P29323

.
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269|PubMed:15300251, ECO:0000269|PubMed:30213874}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+31620_202270.3333333333333987.0DomainEph LBD
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+31620_202270.3333333333333988.0DomainEph LBD
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+31720_202270.33333333333331056.0DomainEph LBD
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+31620_202270.3333333333333987.0DomainEph LBD
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+31620_202270.3333333333333988.0DomainEph LBD
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+31720_202270.33333333333331056.0DomainEph LBD
TgeneZBTB40chr1:23111569chr1:22843792ENST0000037564711181006_1029889.33333333333341240.0Zinc fingerC2H2-type 8
TgeneZBTB40chr1:23111569chr1:22843792ENST0000037564711181046_1069889.33333333333341240.0Zinc fingerC2H2-type 9
TgeneZBTB40chr1:23111569chr1:22843792ENST0000037564711181075_1098889.33333333333341240.0Zinc fingerC2H2-type 10
TgeneZBTB40chr1:23111569chr1:22843792ENST0000037564711181104_1127889.33333333333341240.0Zinc fingerC2H2-type 11%3B atypical
TgeneZBTB40chr1:23111569chr1:22843792ENST0000037564711181135_1158889.33333333333341240.0Zinc fingerC2H2-type 12
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118893_915889.33333333333341240.0Zinc fingerC2H2-type 4
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118921_944889.33333333333341240.0Zinc fingerC2H2-type 5
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118950_973889.33333333333341240.0Zinc fingerC2H2-type 6
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118978_1000889.33333333333341240.0Zinc fingerC2H2-type 7
TgeneZBTB40chr1:23111569chr1:22843792ENST0000040413812191006_1029889.33333333333341240.0Zinc fingerC2H2-type 8
TgeneZBTB40chr1:23111569chr1:22843792ENST0000040413812191046_1069889.33333333333341240.0Zinc fingerC2H2-type 9
TgeneZBTB40chr1:23111569chr1:22843792ENST0000040413812191075_1098889.33333333333341240.0Zinc fingerC2H2-type 10
TgeneZBTB40chr1:23111569chr1:22843792ENST0000040413812191104_1127889.33333333333341240.0Zinc fingerC2H2-type 11%3B atypical
TgeneZBTB40chr1:23111569chr1:22843792ENST0000040413812191135_1158889.33333333333341240.0Zinc fingerC2H2-type 12
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219893_915889.33333333333341240.0Zinc fingerC2H2-type 4
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219921_944889.33333333333341240.0Zinc fingerC2H2-type 5
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219950_973889.33333333333341240.0Zinc fingerC2H2-type 6
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219978_1000889.33333333333341240.0Zinc fingerC2H2-type 7
TgeneZBTB40chr1:23111569chr1:22843793ENST0000037564711181006_1029889.33333333333341240.0Zinc fingerC2H2-type 8
TgeneZBTB40chr1:23111569chr1:22843793ENST0000037564711181046_1069889.33333333333341240.0Zinc fingerC2H2-type 9
TgeneZBTB40chr1:23111569chr1:22843793ENST0000037564711181075_1098889.33333333333341240.0Zinc fingerC2H2-type 10
TgeneZBTB40chr1:23111569chr1:22843793ENST0000037564711181104_1127889.33333333333341240.0Zinc fingerC2H2-type 11%3B atypical
TgeneZBTB40chr1:23111569chr1:22843793ENST0000037564711181135_1158889.33333333333341240.0Zinc fingerC2H2-type 12
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118893_915889.33333333333341240.0Zinc fingerC2H2-type 4
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118921_944889.33333333333341240.0Zinc fingerC2H2-type 5
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118950_973889.33333333333341240.0Zinc fingerC2H2-type 6
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118978_1000889.33333333333341240.0Zinc fingerC2H2-type 7
TgeneZBTB40chr1:23111569chr1:22843793ENST0000040413812191006_1029889.33333333333341240.0Zinc fingerC2H2-type 8
TgeneZBTB40chr1:23111569chr1:22843793ENST0000040413812191046_1069889.33333333333341240.0Zinc fingerC2H2-type 9
TgeneZBTB40chr1:23111569chr1:22843793ENST0000040413812191075_1098889.33333333333341240.0Zinc fingerC2H2-type 10
TgeneZBTB40chr1:23111569chr1:22843793ENST0000040413812191104_1127889.33333333333341240.0Zinc fingerC2H2-type 11%3B atypical
TgeneZBTB40chr1:23111569chr1:22843793ENST0000040413812191135_1158889.33333333333341240.0Zinc fingerC2H2-type 12
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219893_915889.33333333333341240.0Zinc fingerC2H2-type 4
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219921_944889.33333333333341240.0Zinc fingerC2H2-type 5
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219950_973889.33333333333341240.0Zinc fingerC2H2-type 6
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219978_1000889.33333333333341240.0Zinc fingerC2H2-type 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316184_324270.3333333333333987.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316184_324270.3333333333333988.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317184_324270.33333333333331056.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316184_324270.3333333333333987.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316184_324270.3333333333333988.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317184_324270.33333333333331056.0Compositional biasNote=Cys-rich
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316324_434270.3333333333333987.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316435_530270.3333333333333987.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316621_884270.3333333333333987.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316913_977270.3333333333333987.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316324_434270.3333333333333988.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316435_530270.3333333333333988.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316621_884270.3333333333333988.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316913_977270.3333333333333988.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317324_434270.33333333333331056.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317435_530270.33333333333331056.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317621_884270.33333333333331056.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317913_977270.33333333333331056.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316324_434270.3333333333333987.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316435_530270.3333333333333987.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316621_884270.3333333333333987.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316913_977270.3333333333333987.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316324_434270.3333333333333988.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316435_530270.3333333333333988.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316621_884270.3333333333333988.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316913_977270.3333333333333988.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317324_434270.33333333333331056.0DomainFibronectin type-III 1
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317435_530270.33333333333331056.0DomainFibronectin type-III 2
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317621_884270.33333333333331056.0DomainProtein kinase
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317913_977270.33333333333331056.0DomainSAM
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316984_986270.3333333333333987.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316984_986270.3333333333333988.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317984_986270.33333333333331056.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316984_986270.3333333333333987.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316984_986270.3333333333333988.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317984_986270.33333333333331056.0MotifPDZ-binding (in isoform 2)
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316627_635270.3333333333333987.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316627_635270.3333333333333988.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317627_635270.33333333333331056.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316627_635270.3333333333333987.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316627_635270.3333333333333988.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317627_635270.33333333333331056.0Nucleotide bindingATP
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+31619_543270.3333333333333987.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316565_1055270.3333333333333987.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+31619_543270.3333333333333988.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316565_1055270.3333333333333988.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+31719_543270.33333333333331056.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317565_1055270.33333333333331056.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+31619_543270.3333333333333987.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316565_1055270.3333333333333987.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+31619_543270.3333333333333988.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316565_1055270.3333333333333988.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+31719_543270.33333333333331056.0Topological domainExtracellular
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317565_1055270.33333333333331056.0Topological domainCytoplasmic
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374630+316544_564270.3333333333333987.0TransmembraneHelical
HgeneEPHB2chr1:23111569chr1:22843792ENST00000374632+316544_564270.3333333333333988.0TransmembraneHelical
HgeneEPHB2chr1:23111569chr1:22843792ENST00000400191+317544_564270.33333333333331056.0TransmembraneHelical
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374630+316544_564270.3333333333333987.0TransmembraneHelical
HgeneEPHB2chr1:23111569chr1:22843793ENST00000374632+316544_564270.3333333333333988.0TransmembraneHelical
HgeneEPHB2chr1:23111569chr1:22843793ENST00000400191+317544_564270.33333333333331056.0TransmembraneHelical
TgeneZBTB40chr1:23111569chr1:22843792ENST00000375647111824_87889.33333333333341240.0DomainBTB
TgeneZBTB40chr1:23111569chr1:22843792ENST00000404138121924_87889.33333333333341240.0DomainBTB
TgeneZBTB40chr1:23111569chr1:22843793ENST00000375647111824_87889.33333333333341240.0DomainBTB
TgeneZBTB40chr1:23111569chr1:22843793ENST00000404138121924_87889.33333333333341240.0DomainBTB
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118807_830889.33333333333341240.0Zinc fingerC2H2-type 1
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118836_858889.33333333333341240.0Zinc fingerC2H2-type 2
TgeneZBTB40chr1:23111569chr1:22843792ENST000003756471118864_887889.33333333333341240.0Zinc fingerC2H2-type 3
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219807_830889.33333333333341240.0Zinc fingerC2H2-type 1
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219836_858889.33333333333341240.0Zinc fingerC2H2-type 2
TgeneZBTB40chr1:23111569chr1:22843792ENST000004041381219864_887889.33333333333341240.0Zinc fingerC2H2-type 3
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118807_830889.33333333333341240.0Zinc fingerC2H2-type 1
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118836_858889.33333333333341240.0Zinc fingerC2H2-type 2
TgeneZBTB40chr1:23111569chr1:22843793ENST000003756471118864_887889.33333333333341240.0Zinc fingerC2H2-type 3
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219807_830889.33333333333341240.0Zinc fingerC2H2-type 1
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219836_858889.33333333333341240.0Zinc fingerC2H2-type 2
TgeneZBTB40chr1:23111569chr1:22843793ENST000004041381219864_887889.33333333333341240.0Zinc fingerC2H2-type 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPHB2
ZBTB40


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EPHB2-ZBTB40


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPHB2-ZBTB40


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource