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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EPS15-CCDC18

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EPS15-CCDC18
	FusionPDB ID: 27054
	FusionGDB2.0 ID: 27054
		Hgene	Tgene
	Gene symbol	EPS15	CCDC18
	Gene ID	2060	343099
	Gene name	epidermal growth factor receptor pathway substrate 15	coiled-coil domain containing 18
	Synonyms	AF-1P\|AF1P\|MLLT5	NY-SAR-41
	Cytomap	1p32.3	1p22.1
	Type of gene	protein-coding	protein-coding
	Description	epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p	coiled-coil domain-containing protein 18sarcoma antigen NY-SAR-24sarcoma antigen NY-SAR-41
	Modification date	20200313	20200313
	UniProtAcc	Q9UBC2	A1A4V9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793,	ENST00000334652, ENST00000557479, ENST00000421014, ENST00000338949, ENST00000343253, ENST00000401026,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 13 X 11=2431	7 X 12 X 5=420
	# samples	17	11
	** MAII score	log2(17/2431*10)=-3.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/420*10)=-1.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EPS15 [Title/Abstract] AND CCDC18 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EPS15(51934145)-CCDC18(93680303), # samples:1 EPS15(51934145)-CCDC18(93676359), # samples:1
Anticipated loss of major functional domain due to fusion event.	EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EPS15-CCDC18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EPS15	GO:0048268	clathrin coat assembly	12807910

Fusion gene breakpoints across EPS15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-UY-A78N-01A	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+
ChimerDB4	BLCA	TCGA-UY-A78N-01A	EPS15	chr1	51934145	-	CCDC18	chr1	93680303	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371730	EPS15	chr1	51934145	-	ENST00000343253	CCDC18	chr1	93676359	+	3475	319	10	3474	1155
ENST00000371730	EPS15	chr1	51934145	-	ENST00000401026	CCDC18	chr1	93676359	+	3140	319	10	3009	999
ENST00000371730	EPS15	chr1	51934145	-	ENST00000338949	CCDC18	chr1	93676359	+	3114	319	10	2877	955
ENST00000371733	EPS15	chr1	51934145	-	ENST00000343253	CCDC18	chr1	93676359	+	3562	406	13	3561	1183
ENST00000371733	EPS15	chr1	51934145	-	ENST00000401026	CCDC18	chr1	93676359	+	3227	406	13	3096	1027
ENST00000371733	EPS15	chr1	51934145	-	ENST00000338949	CCDC18	chr1	93676359	+	3201	406	13	2964	983

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371730	ENST00000343253	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.003513289	0.99648666
ENST00000371730	ENST00000401026	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.004617968	0.995382
ENST00000371730	ENST00000338949	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.00471856	0.9952814
ENST00000371733	ENST00000343253	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.003420083	0.99657995
ENST00000371733	ENST00000401026	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.004395743	0.9956043
ENST00000371733	ENST00000338949	EPS15	chr1	51934145	-	CCDC18	chr1	93676359	+	0.004188365	0.9958117

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27054_27054_1_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371730_CCDC18_chr1_93676359_ENST00000338949_length(amino acids)=955AA_BP=103
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL
ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE
NMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQ
QQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKM
EKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQK
AQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECN
KQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEA
RHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISAD

--------------------------------------------------------------

>27054_27054_2_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371730_CCDC18_chr1_93676359_ENST00000343253_length(amino acids)=1155AA_BP=103
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE
SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK
KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNK
EKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK
MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH
STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL
KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE
MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREA
HLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEA
LLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKM

--------------------------------------------------------------

>27054_27054_3_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371730_CCDC18_chr1_93676359_ENST00000401026_length(amino acids)=999AA_BP=103
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES
SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKL
ESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE
KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN
KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLR
KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQ
HSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE
LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK
EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVRE
AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANE

--------------------------------------------------------------

>27054_27054_4_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371733_CCDC18_chr1_93676359_ENST00000338949_length(amino acids)=983AA_BP=131
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL
KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMLEAQLEKKDQQFKEQEKTMSML
QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY
CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK
RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREV
LETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIR
EHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ
YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSA

--------------------------------------------------------------

>27054_27054_5_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371733_CCDC18_chr1_93676359_ENST00000343253_length(amino acids)=1183AA_BP=131
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK
VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLA
FEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET
IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDT
QTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS
QLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAEL
RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE
KEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELE
DMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLE
LEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRR
SISASDLTFKIHGDEDLSEELLQDLKKMQLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVRLLKKSSM

--------------------------------------------------------------

>27054_27054_6_EPS15-CCDC18_EPS15_chr1_51934145_ENST00000371733_CCDC18_chr1_93676359_ENST00000401026_length(amino acids)=1027AA_BP=131
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE
AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL
KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL
AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEE
TIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED
TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL
SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAE
LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR
EKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSEL
EDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:51934145/chr1:93680303)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPS15 Q9UBC2	CCDC18 A1A4V9
FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

15_104

103.0

897.0

Domain

EH 1

Tgene

CCDC18

chr1:51934145

chr1:93676359

ENST00000343253

438_464

403.0

1455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC18

chr1:51934145

chr1:93676359

ENST00000343253

508_1309

403.0

1455.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

173_184

103.0

897.0

Calcium binding

Note=1

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

236_247

103.0

897.0

Calcium binding

Note=2

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

768_850

103.0

897.0

Compositional bias

Note=Pro-rich

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

128_216

103.0

897.0

Domain

EH 2

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

160_195

103.0

897.0

Domain

EF-hand 1

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

223_258

103.0

897.0

Domain

EF-hand 2

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

224_314

103.0

897.0

Domain

EH 3

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

851_870

103.0

897.0

Domain

UIM 1

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

877_896

103.0

897.0

Domain

UIM 2

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

768_774

103.0

897.0

Motif

Note=SH3-binding

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

599_827

103.0

897.0

Region

Note=15 X 3 AA repeats of D-P-F

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

599_601

103.0

897.0

Repeat

Note=1

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

623_625

103.0

897.0

Repeat

Note=2

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

629_631

103.0

897.0

Repeat

Note=3

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

634_636

103.0

897.0

Repeat

Note=4

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

640_642

103.0

897.0

Repeat

Note=5

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

645_647

103.0

897.0

Repeat

Note=6

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

651_653

103.0

897.0

Repeat

Note=7

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

664_666

103.0

897.0

Repeat

Note=8

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

672_674

103.0

897.0

Repeat

Note=9

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

692_694

103.0

897.0

Repeat

Note=10

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

709_711

103.0

897.0

Repeat

Note=11

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

737_739

103.0

897.0

Repeat

Note=12

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

798_800

103.0

897.0

Repeat

Note=13

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

804_806

103.0

897.0

Repeat

Note=14

Hgene

EPS15

chr1:51934145

chr1:93676359

ENST00000371733

825_827

103.0

897.0

Repeat

Note=15

Tgene

CCDC18

chr1:51934145

chr1:93676359

ENST00000343253

107_138

403.0

1455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CCDC18

chr1:51934145

chr1:93676359

ENST00000343253

170_402

403.0

1455.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

EPS15

RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, Synj1, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, Zwint, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, Dab2, FN1, VCAM1, Fcho2, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, UBI4, AGFG2, SLC25A41, AURKA, SPC25, Numb, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, Actb, Flot1, Myh9, Myo1c, Tpm1, Lima1, Calml3, Myh10, Sec24c, Flnb, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26, fcho1, HNRNPL, STK40, DYRK1A, PLK1, DVL2, MIB1, ORF7a, ESR1, TRIM56, KIF14, Rnf183, DNAJC5, DDX58, ACBD5, CLTA, VASP, NAA40, RNPS1, MACC1, SYCE1, RARRES1, POLR2J3, EPS15L1, C15orf59, ZCCHC10, SYNC, INO80E, DNAJC6, RUFY4,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EPS15
CCDC18

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EPS15	chr1:51934145	chr1:93676359	ENST00000371733	-	5	25	2_330	103.0	897.0	DAB2

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Related Drugs to EPS15-CCDC18

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EPS15-CCDC18

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source