UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EPS15-KMT2A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EPS15-KMT2A
	FusionPDB ID: 27061
	FusionGDB2.0 ID: 27061
		Hgene	Tgene
	Gene symbol	EPS15	KMT2A
	Gene ID	2060	4297
	Gene name	epidermal growth factor receptor pathway substrate 15	lysine methyltransferase 2A
	Synonyms	AF-1P\|AF1P\|MLLT5	ALL-1\|CXXC7\|HRX\|HTRX1\|MLL\|MLL1\|MLL1A\|TRX1\|WDSTS
	Cytomap	1p32.3	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	epidermal growth factor receptor substrate 15ALL1 fused gene from chromosome 1protein AF-1p	histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
	Modification date	20200313	20200319
	UniProtAcc	Q9UBC2	Q03164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000371730, ENST00000371733, ENST00000396122, ENST00000493793,	ENST00000420751, ENST00000354520, ENST00000389506, ENST00000534358,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 13 X 11=2431	31 X 72 X 3=6696
	# samples	17	79
	** MAII score	log2(17/2431*10)=-3.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(79/6696*10)=-3.08337496948588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EPS15 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KMT2A(118355690)-EPS15(51946988), # samples:1
Anticipated loss of major functional domain due to fusion event.	EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a transcription factor by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. EPS15-KMT2A seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KMT2A-EPS15 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EPS15	GO:0048268	clathrin coat assembly	12807910
Tgene	KMT2A	GO:0044648	histone H3-K4 dimethylation	25561738
Tgene	KMT2A	GO:0045944	positive regulation of transcription by RNA polymerase II	20861184
Tgene	KMT2A	GO:0051568	histone H3-K4 methylation	19556245
Tgene	KMT2A	GO:0065003	protein-containing complex assembly	15199122
Tgene	KMT2A	GO:0080182	histone H3-K4 trimethylation	20861184
Tgene	KMT2A	GO:0097692	histone H3-K4 monomethylation	25561738\|26324722

Fusion gene breakpoints across EPS15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	EPS15	chr1	51912631	-	KMT2A	chr11	118353136
ChimerKB3	.	.	EPS15	chr1	51913717	-	KMT2A	chr11	118354897
ChimerKB3	.	.	EPS15	chr1	51984870	-	KMT2A	chr11	118354897
ChimerKB3	.	.	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371730	EPS15	chr1	51984870	-	ENST00000534358	KMT2A	chr11	118354897	+	12528	43	10	7875	2621
ENST00000371730	EPS15	chr1	51984870	-	ENST00000389506	KMT2A	chr11	118354897	+	9612	43	10	7866	2618
ENST00000371730	EPS15	chr1	51984870	-	ENST00000354520	KMT2A	chr11	118354897	+	10277	43	10	7752	2580
ENST00000371733	EPS15	chr1	51984870	-	ENST00000534358	KMT2A	chr11	118354897	+	12615	130	13	7962	2649
ENST00000371733	EPS15	chr1	51984870	-	ENST00000389506	KMT2A	chr11	118354897	+	9699	130	13	7953	2646
ENST00000371733	EPS15	chr1	51984870	-	ENST00000354520	KMT2A	chr11	118354897	+	10364	130	13	7839	2608
ENST00000371730	EPS15	chr1	51913717	-	ENST00000534358	KMT2A	chr11	118354897		13146	661	10	8493	2827
ENST00000371730	EPS15	chr1	51913717	-	ENST00000389506	KMT2A	chr11	118354897		10230	661	10	8484	2824
ENST00000371730	EPS15	chr1	51913717	-	ENST00000354520	KMT2A	chr11	118354897		10895	661	10	8370	2786
ENST00000371733	EPS15	chr1	51913717	-	ENST00000534358	KMT2A	chr11	118354897		13233	748	13	8580	2855
ENST00000371733	EPS15	chr1	51913717	-	ENST00000389506	KMT2A	chr11	118354897		10317	748	13	8571	2852
ENST00000371733	EPS15	chr1	51913717	-	ENST00000354520	KMT2A	chr11	118354897		10982	748	13	8457	2814

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27061_27061_1_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371730_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2786AA_BP=217
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCE
PFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGK
GWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWR
LALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSV
LEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSH
TEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNC
ALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEV
FRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDI
NSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTH
EIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTS
SNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAE
PSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSS
KSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES
QSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARA
RSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPK
ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSS
LESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGL
FEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDP
TPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKP
ATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLH
SFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMT
LINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNV
VSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQ
TTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQ
RSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAV
LPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSN
ARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNP
NDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCY

--------------------------------------------------------------

>27061_27061_2_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371730_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2824AA_BP=217
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVW
EMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSY
HPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWV
HSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSS
PEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSR
FWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPP
GIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYH
FMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLF
PIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCY
YHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVS
SVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKS
SEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLS
GMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMP
GVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQS
NNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSD
EDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKE
HVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLK
NTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQN
PSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPV
SPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPM
GGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPS
SGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQS
VGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQ
PVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQ
TVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETT
SLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKP
KKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANE
PPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFC
KRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIY

--------------------------------------------------------------

>27061_27061_3_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371730_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2827AA_BP=217
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS
LSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVW
EMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSY
HPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWV
HSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPS
RSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVK
KSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELN
PPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTS
NYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCED
KLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSG
SCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRN
NVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLS
SKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTL
KLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGL
SMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQD
SQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLS
TSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAG
EKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDF
VLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVP
SQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQ
VPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVL
GPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVA
TPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLL
PQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGI
QDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSN
FTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQ
ETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITE
KKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEE
ANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRG
LFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMR

--------------------------------------------------------------

>27061_27061_4_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371733_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2814AA_BP=245
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVK
PVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGN
SSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYP
TKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDE
MYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLT
EVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSN
SGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCAL
CLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCV
FLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVY
WSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRI
RTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATD
LESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAY
PGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIIN
EHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQV
EGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQD
RNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFT
RTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHK
NEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGE
SPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDS
GEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQK
YVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGL
NPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISR
LQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAG
TSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGM
FPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGL
EQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPG
AEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISS
DDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSAR
AEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMV
IEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYK

--------------------------------------------------------------

>27061_27061_5_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371733_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2852AA_BP=245
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVK
PVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGN
SSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCR
RCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGN
FCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTT
SHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEI
KKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDS
PTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIR
GKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPE
NIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSS
KESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHST
SSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSE
MKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRN
DRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDE
VLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTE
PISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPF
YSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKS
SQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTE
LLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISA
EEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSP
PCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNG
VTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIG
VQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTS
SHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNP
RLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQ
LLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPL
DKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEE
EESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAV
VFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMP
MRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINH

--------------------------------------------------------------

>27061_27061_6_EPS15-KMT2A_EPS15_chr1_51913717_ENST00000371733_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2855AA_BP=245
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADT
DGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVK
PVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGN
SSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCR
RCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGN
FCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNS
RTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQ
PEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGE
PDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMA
VIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGL
EPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTE
SSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRR
HSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSS
SSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRG
QRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEF
MDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTS
PTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEED
IPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATT
RKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTY
NTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSS
ISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHI
SSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTL
PNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGL
LIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSL
NTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTL
TNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQH
VNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQ
LPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKT
VEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILH
DAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDL
PMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARF

--------------------------------------------------------------

>27061_27061_7_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371730_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2580AA_BP=11
MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRC
KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFC
PLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSH
LLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKK
ANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPT
PLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGK
QLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENI
HMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKE
SQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSS
LSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMK
QSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDR
DQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVL
TPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPI
SASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYS
SSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQ
IPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELL
KSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEE
QFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPC
GSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVT
QKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQ
PPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSH
RTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRL
LGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLL
ASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDK
GNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEE
SNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVF
LIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR
FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSC

--------------------------------------------------------------

>27061_27061_8_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371730_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2618AA_BP=11
MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSG
HVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCV
RCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTC
VNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGV
KRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHN
YAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLL
YIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLI
KGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKI
VECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRP
LPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLN
SSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSR
ELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKK
SCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVK
VTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGS
FKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHN
LFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKT
QGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGL
GLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSE
SDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISN
AAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASK
GLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPS
NIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSV
SGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAIT
AASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTS
PGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQ
KECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWK
SLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFL
ASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKR
EKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA

--------------------------------------------------------------

>27061_27061_9_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371730_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2621AA_BP=11
MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSG
HVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCV
RCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVA
YTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDL
EGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSL
DHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAG
RLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHR
DLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYT
CKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPG
CRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLG
PLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNT
TSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQK
GKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKR
TVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQE
DGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLA
SHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSR
VKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLG
EGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVA
SSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQ
ISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPS
ASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSS
TPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTS
GSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTA
AITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQAS
PTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQ
SSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIED
AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMF
NFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQT
DKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCN

--------------------------------------------------------------

>27061_27061_10_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371733_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2608AA_BP=39
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVC
CEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTP
GKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAE
WRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYT
SVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREEN
SHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHV
NCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGF
EVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEP
DINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPT
THEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTS
TSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSF
AEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKH
SSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMEN
ESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSA
RARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDL
PKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQL
SSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDM
GLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGV
DPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHL
KPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQH
LHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSN
MTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVL
NVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPS
TQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSS
GQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQV
AVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEAR
SNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEY
NPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIG

--------------------------------------------------------------

>27061_27061_11_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371733_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2646AA_BP=39
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAEN
VWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRN
SYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDR
WVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSR
SSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKK
SRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNP
PPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSN
YHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDK
LFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGS
CYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNN
VSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSS
KSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLK
LSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLS
MPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS
QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLST
SDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGE
KEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFV
LKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPS
QNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV
PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLG
PMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVAT
PSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLP
QSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQ
DQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNF
TQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQE
TTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEK
KPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEA
NEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGL
FCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRK

--------------------------------------------------------------

>27061_27061_12_EPS15-KMT2A_EPS15_chr1_51984870_ENST00000371733_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2649AA_BP=39
MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAEN
VWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRN
SYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDR
WVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI
PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFS
VKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE
LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSC
TSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDC
EDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQT
SGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS
RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKV
LSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK
TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDK
GLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC
QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADD
LSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED
AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIM
DFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPT
VPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPG
LQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS
VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTT
VATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP
LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSL
GIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV
SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIP
DQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI
TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKP
EEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG
RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:118355690/chr11:51946988)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPS15 Q9UBC2	KMT2A Q03164
FUNCTION: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269\|PubMed:22648170, ECO:0000269\|PubMed:9407958}.	FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

173_184

217.0

897.0

Calcium binding

Note=1

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

128_216

217.0

897.0

Domain

EH 2

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

15_104

217.0

897.0

Domain

EH 1

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

160_195

217.0

897.0

Domain

EF-hand 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1822_1847

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2096_2118

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2146_2174

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2189_2232

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2275_2320

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2402_2418

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2419_2445

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2526_2594

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2721_2746

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2747_2784

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2785_2821

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3011_3064

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3166_3183

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3195_3222

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3230_3244

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3464_3530

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3563_3606

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1822_1847

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2096_2118

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2146_2174

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2189_2232

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2275_2320

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2402_2418

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2419_2445

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2526_2594

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2721_2746

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2747_2784

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2785_2821

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3011_3064

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3166_3183

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3195_3222

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3230_3244

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3464_3530

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3563_3606

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1822_1847

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2096_2118

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2146_2174

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2189_2232

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2275_2320

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2402_2418

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2419_2445

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2526_2594

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2721_2746

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2747_2784

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2785_2821

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3011_3064

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3166_3183

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3195_3222

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3230_3244

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3464_3530

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3563_3606

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1703_1748

1362.0

3932.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2018_2074

1362.0

3932.0

Domain

FYR N-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3666_3747

1362.0

3932.0

Domain

FYR C-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3829_3945

1362.0

3932.0

Domain

SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3953_3969

1362.0

3932.0

Domain

Post-SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1703_1748

1362.0

3970.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2018_2074

1362.0

3970.0

Domain

FYR N-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3666_3747

1362.0

3970.0

Domain

FYR C-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3829_3945

1362.0

3970.0

Domain

SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3953_3969

1362.0

3970.0

Domain

Post-SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1703_1748

1362.0

3973.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2018_2074

1362.0

3973.0

Domain

FYR N-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3666_3747

1362.0

3973.0

Domain

FYR C-terminal

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3829_3945

1362.0

3973.0

Domain

SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3953_3969

1362.0

3973.0

Domain

Post-SET

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1663_1713

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1806_1869

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2081_2133

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2145_2232

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2275_2333

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2373_2460

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2475_2618

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2647_2675

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2713_2821

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

2961_3064

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3166_3244

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3464_3608

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3620_3643

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3785_3808

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

3906_3907

1362.0

3932.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1663_1713

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1806_1869

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2081_2133

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2145_2232

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2275_2333

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2373_2460

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2475_2618

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2647_2675

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2713_2821

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

2961_3064

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3166_3244

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3464_3608

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3620_3643

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3785_3808

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

3906_3907

1362.0

3970.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1663_1713

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1806_1869

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2081_2133

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2145_2232

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2275_2333

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2373_2460

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2475_2618

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2647_2675

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2713_2821

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

2961_3064

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3166_3244

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3464_3608

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3620_3643

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3785_3808

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

3906_3907

1362.0

3973.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1431_1482

1362.0

3932.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1479_1533

1362.0

3932.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1566_1627

1362.0

3932.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1870_1910

1362.0

3932.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1931_1978

1362.0

3932.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1431_1482

1362.0

3970.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1479_1533

1362.0

3970.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1566_1627

1362.0

3970.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1870_1910

1362.0

3970.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1931_1978

1362.0

3970.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1431_1482

1362.0

3973.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1479_1533

1362.0

3973.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1566_1627

1362.0

3973.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1870_1910

1362.0

3973.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1931_1978

1362.0

3973.0

Zinc finger

PHD-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

236_247

217.0

897.0

Calcium binding

Note=2

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

542_586

217.0

897.0

Compositional bias

Polar residues

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

587_601

217.0

897.0

Compositional bias

Basic and acidic residues

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

771_785

217.0

897.0

Compositional bias

Pro residues

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

826_848

217.0

897.0

Compositional bias

Polar residues

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

223_258

217.0

897.0

Domain

EF-hand 2

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

224_314

217.0

897.0

Domain

EH 3

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

851_870

217.0

897.0

Domain

UIM 1

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

877_896

217.0

897.0

Domain

UIM 2

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

768_774

217.0

897.0

Motif

Note=SH3-binding

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

542_606

217.0

897.0

Region

Disordered

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

599_827

217.0

897.0

Region

Note=15 X 3 AA repeats of D-P-F

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

760_848

217.0

897.0

Region

Disordered

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

599_601

217.0

897.0

Repeat

Note=1

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

623_625

217.0

897.0

Repeat

Note=2

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

629_631

217.0

897.0

Repeat

Note=3

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

634_636

217.0

897.0

Repeat

Note=4

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

640_642

217.0

897.0

Repeat

Note=5

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

645_647

217.0

897.0

Repeat

Note=6

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

651_653

217.0

897.0

Repeat

Note=7

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

664_666

217.0

897.0

Repeat

Note=8

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

672_674

217.0

897.0

Repeat

Note=9

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

692_694

217.0

897.0

Repeat

Note=10

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

709_711

217.0

897.0

Repeat

Note=11

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

737_739

217.0

897.0

Repeat

Note=12

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

798_800

217.0

897.0

Repeat

Note=13

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

804_806

217.0

897.0

Repeat

Note=14

Hgene

EPS15

chr1:51913717

chr11:118354897

ENST00000371733

825_827

217.0

897.0

Repeat

Note=15

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1046_1061

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1249_1272

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1278_1302

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1303_1317

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

184_203

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

204_226

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

236_253

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

325_351

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

37_58

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

445_495

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

535_556

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

557_576

1362.0

3932.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

713_731

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

747_780

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

798_845

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

81_103

1362.0

3932.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

846_898

1362.0

3932.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1046_1061

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1249_1272

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1278_1302

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1303_1317

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

184_203

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

204_226

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

236_253

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

325_351

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

37_58

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

445_495

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

535_556

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

557_576

1362.0

3970.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

713_731

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

747_780

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

798_845

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

81_103

1362.0

3970.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

846_898

1362.0

3970.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1046_1061

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1249_1272

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1278_1302

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1303_1317

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

184_203

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

204_226

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

236_253

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

325_351

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

37_58

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

445_495

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

535_556

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

557_576

1362.0

3973.0

Compositional bias

Pro residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

713_731

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

747_780

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

798_845

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

81_103

1362.0

3973.0

Compositional bias

Polar residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

846_898

1362.0

3973.0

Compositional bias

Basic and acidic residues

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

169_180

1362.0

3932.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

217_227

1362.0

3932.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

301_309

1362.0

3932.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

169_180

1362.0

3970.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

217_227

1362.0

3970.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

301_309

1362.0

3970.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

169_180

1362.0

3973.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

217_227

1362.0

3973.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

301_309

1362.0

3973.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

123_134

1362.0

3932.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

147_152

1362.0

3932.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

6_25

1362.0

3932.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

123_134

1362.0

3970.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

147_152

1362.0

3970.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

6_25

1362.0

3970.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

123_134

1362.0

3973.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

147_152

1362.0

3973.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

6_25

1362.0

3973.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1038_1066

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1106_1166

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1200_1375

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

132_253

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1_108

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

301_352

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

445_585

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

713_780

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

798_949

1362.0

3932.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1038_1066

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1106_1166

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1200_1375

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

132_253

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1_108

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

301_352

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

445_585

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

713_780

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

798_949

1362.0

3970.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1038_1066

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1106_1166

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1200_1375

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

132_253

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1_108

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

301_352

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

445_585

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

713_780

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

798_949

1362.0

3973.0

Region

Disordered

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000354520

1147_1195

1362.0

3932.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000389506

1147_1195

1362.0

3970.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr1:51913717

chr11:118354897

ENST00000534358

1147_1195

1362.0

3973.0

Zinc finger

CXXC-type

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (1149) >>>1149.pdbFusion protein BP residue: 11 CIF file (1149) >>>1149.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRI RVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQH QATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGST TPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCG KCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKE LQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGP DPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAIN SDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGML PNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPT PLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGR LLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKP GATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPEN GFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD CEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEH DENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVI SKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRS IGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESS AKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMK QSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTT SRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSA NSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKE KHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGD KGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNAL KESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQ NLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRS YGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVI SSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQ IPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRV KTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSD DCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREK DMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSP TVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHM TPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTV PIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLY VLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSL PTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQ PPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSST PSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRS KSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSS VLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQS LGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITA ASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDA PNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPK TKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAE QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEE SNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDA WKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKH CRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPP EYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIH GRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDD SEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEE	2580
3D view using mol* of 1149 (AA BP:11)


PDB file (1155) >>>1155.pdbFusion protein BP residue: 39 CIF file (1155) >>>1155.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQEN AGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLE ENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLG PNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAK LFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILS NLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLL RYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGV KRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQ MERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREEN SHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPEL NPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVF EDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRA KNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFL NGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDA RKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQ NTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRP LPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMS PMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTS TSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVL SSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSS KEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRS SIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLK PEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKE LQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISA SENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGS FKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSA EGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDL PKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDA GEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVH TSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQ ALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSV SSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVT ITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGS VEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISN AAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSST PSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQH LHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTV ATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQ LPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAA TAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGH VTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGT SQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLAS KTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTS PGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLR TSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQV AVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESIT EKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSF AGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPH GSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATS MDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGN VIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEP NCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGA	2608
3D view using mol* of 1155 (AA BP:39)


PDB file (1160) >>>1160.pdbFusion protein BP residue: 11 CIF file (1160) >>>1160.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRI RVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVC CEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKC RNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSH DFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCEN LSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTAL LNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQD DQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKAN SMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHN YAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILST DRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHV NCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCT SNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDF EGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQC SRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTS FTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYS PTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLS PQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLN SSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSS SLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSF AEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKT LKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQ VTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAP PMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIE STSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLP DGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSS TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHN LFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTE NLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQL SSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMD FVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQL PTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAV ISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDA DHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNST DSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQK IQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASK GLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSES SQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSN MTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPL LPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTT PTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPP SSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQ LQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKAL SSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGN GKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQ KECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQ QEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEAR SNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE EANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEV QLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDA GEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNA ARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDA	2618
3D view using mol* of 1160 (AA BP:11)


PDB file (1161) >>>1161.pdbFusion protein BP residue: 11 CIF file (1161) >>>1161.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MAAAAQLSLTQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRI RVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVC CEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKC RNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSH DFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCEN LSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVL TALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVS KQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIK KANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSL DHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPI LSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEW THVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLT SCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVF VDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIG YQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHS PTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTP SYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTS SLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLG PLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVS KSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKI GSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTE VKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLE PGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVP KAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPL QIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNL MLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFY SSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLA SHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKEN GTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLE AQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSD IMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFS QQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSR LAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGH MDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVP NSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGV TQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPS ASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLV SESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDV VSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEP APLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQT TTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVA LPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADE HYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQN KALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLD KGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQ SSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLML WLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQ EARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFH KPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEE EEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRN IDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMH GNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPI	2621
3D view using mol* of 1161 (AA BP:11)


PDB file (1170) >>>1170.pdbFusion protein BP residue: 39 CIF file (1170) >>>1170.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQEN AGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGIL TSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLEN WCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCD KCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVN CTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLN PETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSV LEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKK SRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKI IPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQC ALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHM AVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVY CQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMI GSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVE CRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPD RPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTH EIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNN VSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTV GNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNV AYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLR GQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSR DRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEY MGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVT LTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQP SPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARA RSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLST SDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDG TESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVG HKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDT YNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSE LLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFEL PLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESD PALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLT RNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKP ATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLG PMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSF PPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPI SRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGS LNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDT SHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTP DIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAA SSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLD SASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQ RSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQE TTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNP ANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEI SSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGIL HDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKS AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHL KKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREK YYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQ	2646
3D view using mol* of 1170 (AA BP:39)


PDB file (1171) >>>1171.pdbFusion protein BP residue: 39 CIF file (1171) >>>1171.cif	EPS15	chr1	51984870	-	KMT2A	chr11	118354897	+	MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQEKPPPVNKQEN AGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGIL TSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLEN WCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCD KCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYT CVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPP DLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNY TSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFS VKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLM KKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDN RQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDK KVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIH MMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCK IVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPP SPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTP TTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTV VTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSA HNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHL HLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGS SSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLT PEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTV KVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPV AQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRS ARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADD LSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGV DDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKS SVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESS SSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQ FELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASS ESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQ DLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPH LKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQ SSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKK RPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLD LGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTIS QDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLL GTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAI TAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQR DLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPS SGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIP DQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVT QNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLV FEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHL RKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRF RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDK REKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINI	2649
3D view using mol* of 1171 (AA BP:39)


PDB file (1202) >>>1202.pdbFusion protein BP residue: 217 CIF file (1202) >>>1202.cif	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPD LILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPP PRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDK VKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP VPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPA DGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCH VCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRC KSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYES KMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWR LALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSR SSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKI IQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVS SNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPG EPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDS ANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRC EFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKG EVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGI LNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDI NSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGS CYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLL SSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTA TDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGS SSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAP QVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHT DSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSC KETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVS SDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENES QSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDS QSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTP LYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYN FTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTAT TRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNC HSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDS DNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGL DSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSV LTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDP TPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQ NMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTT GLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSG LLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKK LAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVP NIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSG LASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLI KASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQ TTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNF TQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGP TKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGT PGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPK TVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICA ESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQ LSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLAS KHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGV YRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCY MFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRK	2786
3D view using mol* of 1202 (AA BP:217)


PDB file (1206) >>>1206.pdbFusion protein BP residue: 245 CIF file (1206) >>>1206.cif	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKY YRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQE FFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPW AVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELS DIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPP VNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPF HKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSY HPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSL CHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDE MYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSR TTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQP LDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVK SFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQW QEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSR EDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCAL WSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYH FMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGIS LRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVY WSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTES SSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQR SPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRS KLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTS LGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKG EKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPS SVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLS GMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTG EEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQV EGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSP TEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPK PQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKK RGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFRE EEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKI DRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLE SSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLK NTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTE PVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDS GEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHIS SPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPG PSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLT SSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLP MSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRT DLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLI NFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQS VGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSS ASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGM FPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHV NQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAV QASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKH KVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECG QPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQK RKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNAR LKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANE PPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKS ARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMV IEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFI NHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKL	2814
3D view using mol* of 1206 (AA BP:245)


PDB file (1208) >>>1208.pdbFusion protein BP residue: 217 CIF file (1208) >>>1208.cif	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPD LILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPP PRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDK VKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP VPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPA DGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEF VYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQL LECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGW DAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWV HSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLK QVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLT EVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQP EIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLP PSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPT PPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQ NEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC CLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFR RVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLF PIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTI AHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRI RTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRH STSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDH VLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASD LVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNV SKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDE DTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKS FLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMP GVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPA SPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQD RNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDI PFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEE RLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNG KENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQD SLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNIL PSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFE VFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQN PSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFI QGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQK YVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLP NGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSL FPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQ LLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAP SDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMY FEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVS MQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQ PVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGE ADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGL EQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQL PLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTAS VEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSP LMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTD KVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKF RFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPND EEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFC KRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDA TMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYK	2824
3D view using mol* of 1208 (AA BP:217)


PDB file (1209) >>>1209.pdbFusion protein BP residue: 217 CIF file (1209) >>>1209.cif	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPD LILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPP PRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDK VKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP VPMSLPPALVPPSKRKTEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPA DGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEF VYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQL LECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGW DAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWV HSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQI SLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPP VLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDG GQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNA VLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLH PPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLY IGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGAT VGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFE VFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCED KLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDEN RTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKV PRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGS RRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKV VDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSS ASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRE LNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSS PDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHS SKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGL SMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKES SPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLP VQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGE EDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSG GEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPK RNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQ GQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCG NILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMG LFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVP SQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPD HFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQ NQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQ TLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTS QSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPP DPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSN IAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSS IMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLN VVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGI QDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASP SGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNS MGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKR FQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQD TASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNF SSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKS LTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRN YKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYN PNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRG LFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEV VDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTY	2827
3D view using mol* of 1209 (AA BP:217)


PDB file (1213) >>>1213.pdbFusion protein BP residue: 245 CIF file (1213) >>>1213.cif	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKY YRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQE FFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPW AVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELS DIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPP VNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEM GGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPL EDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTK PTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGN FCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESV AYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAA KPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQ GNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFP WFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQP PLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGI EDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGS LKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFL DDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPE NIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVY TCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEII SPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGS PTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGN TYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQ RTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSE GSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSF PHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEH MGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDE VLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRK RTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGD GPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYP RRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDG ADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQL DGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHV TKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSD KNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESP ESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISA EEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSV ASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHG NNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTT PPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMET NTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPA ATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSG LKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPS LLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTS TISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNP RLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPST AAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHS SQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPS SPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEA HIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEV QVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKK GLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGL RMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAE VHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMP MRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQ TDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRV INIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKF	2852
3D view using mol* of 1213 (AA BP:245)


PDB file (1214)	EPS15	chr1	51913717	-	KMT2A	chr11	118354897		MRPLPPPPPRPEPQSARLPSPPLHDGNTMAAAAQLSLTQLSSGNPVYEKY YRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQE FFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPW AVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELS DIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTEKPPP VNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEM GGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPL EDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTK PTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGN FCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLP ESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYR QAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRK MDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMER VFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHT EQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPP PGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDD DGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNC VFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGL EPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKR CVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTA EIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPS AGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMR TGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSS NLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSK SSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEA LSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSII NEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEF MDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQA PRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASEN PGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKR RYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQ VDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKI SQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEK EHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTST PSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALG ESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSS ISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITE KSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQ GHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAV QTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSV METNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHS FPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATP SSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPN HPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAA GTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTL TNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQT PSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTG IHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGG SPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSS SEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVL PEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKK PKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGV NGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSA RAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDL PMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIR SIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCY SRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKC	2855

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EPS15_pLDDT.png

KMT2A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EPS15_KMT2A_1149_pLDDT.png (AA BP:11)

EPS15_KMT2A_1149_pLDDT_and_active_sites.png (AA BP:11)

EPS15_KMT2A_1149_violinplot.png (AA BP:11)

EPS15_KMT2A_1155_pLDDT.png (AA BP:39)

EPS15_KMT2A_1160_pLDDT.png (AA BP:11)

EPS15_KMT2A_1160_pLDDT_and_active_sites.png (AA BP:11)

EPS15_KMT2A_1160_violinplot.png (AA BP:11)

EPS15_KMT2A_1161_pLDDT.png (AA BP:11)

EPS15_KMT2A_1161_pLDDT_and_active_sites.png (AA BP:11)

EPS15_KMT2A_1161_violinplot.png (AA BP:11)

EPS15_KMT2A_1170_pLDDT.png (AA BP:39)

EPS15_KMT2A_1171_pLDDT.png (AA BP:39)

EPS15_KMT2A_1171_pLDDT_and_active_sites.png (AA BP:39)

EPS15_KMT2A_1171_violinplot.png (AA BP:39)

EPS15_KMT2A_1202_pLDDT.png (AA BP:217)

EPS15_KMT2A_1202_pLDDT_and_active_sites.png (AA BP:217)

EPS15_KMT2A_1202_violinplot.png (AA BP:217)

EPS15_KMT2A_1206_pLDDT.png (AA BP:245)

EPS15_KMT2A_1206_pLDDT_and_active_sites.png (AA BP:245)

EPS15_KMT2A_1206_violinplot.png (AA BP:245)

EPS15_KMT2A_1208_pLDDT.png (AA BP:217)

EPS15_KMT2A_1208_pLDDT_and_active_sites.png (AA BP:217)

EPS15_KMT2A_1208_violinplot.png (AA BP:217)

EPS15_KMT2A_1209_pLDDT.png (AA BP:217)

EPS15_KMT2A_1209_pLDDT_and_active_sites.png (AA BP:217)

EPS15_KMT2A_1209_violinplot.png (AA BP:217)

EPS15_KMT2A_1213_pLDDT.png (AA BP:245)

EPS15_KMT2A_1213_pLDDT_and_active_sites.png (AA BP:245)

EPS15_KMT2A_1213_violinplot.png (AA BP:245)

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

EPS15_KMT2A_1149.png

EPS15_KMT2A_1160.png

EPS15_KMT2A_1161.png

EPS15_KMT2A_1171.png

EPS15_KMT2A_1202.png

EPS15_KMT2A_1206.png

EPS15_KMT2A_1208.png

EPS15_KMT2A_1209.png

EPS15_KMT2A_1213.png

Top

Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
1149	1.037	200	1.053	525.133	0.569	0.753	0.996	0.637	1.04	0.613	0.738	Chain A: 1249,1250,1251,1544,1546,2384,2386,2387,2 388,2389,2390,2393,2446,2447,2448,2449,2450,2451,2 452,2469,2487,2490,2491,2492,2493,2494,2495,2496,2 508,2513,2514,2515,2516,2517,2518,2539,2553,2555,2 557,2566,2567,2568,2569,2579
1160	1.044	460	1.061	1450.547	0.495	0.76	0.971	0.693	1.028	0.674	1.002	Chain A: 1282,1283,1284,1285,1286,1287,1288,1289,1 290,1291,1740,1741,1742,2422,2424,2425,2426,2427,2 487,2488,2489,2490,2507,2517,2521,2524,2525,2528,2 529,2530,2531,2532,2533,2534,2535,2541,2545,2546,2 551,2552,2553,2554,2555,2556,2563,2564,2565,2566,2 577,2591,2593,2594,2595,2596,2598,2602,2604,2605,2 606,2607,2608,2617,2618
1161	1.092	155	1.088	232.554	0.351	0.836	1.112	0.907	1.083	0.837	0.802	Chain A: 52,53,54,55,56,58,69,70,72,86,87,88,543,5 44,546,547,574,650,651,653,654,655,656,658,662,673 ,2378,2381,2382
1171	1.115	149	1.096	240.1	0.382	0.87	1.141	1.029	1.123	0.916	0.985	Chain A: 80,82,83,84,86,97,98,100,114,115,571,572, 573,574,575,602,678,679,681,682,683,684,685,686,69 0,701,2406,2409,2410
1202	1.0116	508	1.0348	1408.015	0.5369	0.7058	0.9414	0.7037	1.0084	0.6979	0.8727	Chain A: 823,824,825,826,827,828,830,831,833,836,8 48,2547,2549,2550,2551,2552,2554,2555,2556,2557,25 58,2560,2561,2562,2564,2565,2566,2567,2568,2569,25 70,2582,2583,2584,2585,2586,2587,2588,2589,2590,25 92,2593,2594,2595,2596,2599,2652,2653,2654,2655,26 56,2657,2658,2675,2696,2697,2698,2699,2700,2701,27 02,2703,2714,2719,2720,2721,2722,2723,2724,2745,27 59,2761,2763,2772,2773,2774,2775,2776,2785
1206	1.0626	229	1.1096	551.887	0.5492	0.7277	0.9402	0.7432	0.819	0.9074	0.5531	Chain A: 295,308,309,310,311,312,315,318,319,320,3 22,323,324,325,326,328,333,334,339,340,341,342,344 ,346,347,348,349,363,368,369,370,2552,2553,2554,25 55
1208	0.9936	479	0.9923	1060.213	0.5581	0.6884	0.9224	0.2321	1.1066	0.2097	0.6394	Chain A: 267,270,271,304,305,316,318,319,320,321,3 22,325,327,328,329,330,332,333,334,335,336,338,341 ,342,343,344,345,346,347,349,350,351,352,354,356,3 57,358,359,362,363,371,372,373,378,379,380,2328,23 29,2330,2331,2381,2383,2384,2386,2542,2545,2546,25 49,2550,2553,2554,2556,2557,2562,2563,2564,2565,25 66,2567,2568,2569,2570,2571,2573
1209	1.0187	257	1.0516	791.987	0.6058	0.6968	0.8513	0.3466	0.9402	0.3687	0.9556	Chain A: 710,711,713,714,1593,1594,1595,1596,1597, 1598,1599,1605,1606,1607,1609,1610,1614,1616,1619, 1622,1657,1658,1659,1660,1661,1662,1663,1864,1865, 1866,1867,1868,1872,1873,1874,1875,1876,1878,1879, 1880,2050,2051,2054,2058,2059,2061,2063,2065
1213	1.046	229	1.088	599.564	0.609	0.717	0.919	0.772	0.867	0.89	0.695	Chain A: 298,344,345,346,347,348,349,350,352,353,3 55,356,357,358,360,363,364,366,372,377,378,379,380 ,382,383,384,385,386,387,390,401,406,407,408,2590, 2591,2592,2593

Top

Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
1161	ZINC000000121541	DB00643	Mebendazole	-7.29933	-7.95753
1161	ZINC000000000469	DB00816	Orciprenaline	-7.47712	-7.49152
1161	ZINC000000643046	DB00975	Dipyridamole	-7.43608	-7.43688
1161	ZINC000003830943	DB01362	Iohexol	-7.42868	-7.42868
1161	ZINC000000025958	DB12332	Rucaparib	-7.39136	-7.40636
1161	ZINC000002169830	DB00194	Vidarabine	-7.3961	-7.3961
1161	ZINC000000004166	DB00489	Sotalol	-7.36645	-7.38765
1161	ZINC000002036848	DB00140	Riboflavin	-7.35402	-7.35442
1161	ZINC000043206370	DB11793	Niraparib	-7.28448	-7.28448
1161	ZINC000000007601	DB01001	Salbutamol	-7.24878	-7.24878
1161	ZINC000034220093	DB15058	Flutemetamol	-7.22405	-7.23815
1161	ZINC000003977952	DB00581	Lactulose	-7.18746	-7.18746
1161	ZINC000000056652	DB01064	Isoprenaline	-7.17912	-7.17912
1161	ZINC000030691797	DB08883	Perampanel	-7.15909	-7.15909
1161	ZINC000004214955	DB06769	Bendamustine	-6.67472	-7.11862
1161	Netarsudil	DB06769		-7.09715	-7.10825
1161	ZINC000003830990	DB11868	Etiracetam	-7.07817	-7.07817
1161	ZINC000012414057	DB08167	Methylthioninium	-7.05314	-7.05614
1161	ZINC000000897258	DB00983	Formoterol	-7.03826	-7.05046
1161	ZINC000000034157	DB06707	Levonordefrin	-7.02248	-7.03998

Top

Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000000121541	DB00643	Mebendazole	Small molecule	COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1	Approved\|Vet_approved
ZINC000000000469	DB00816	Orciprenaline	Small molecule	CC(C)NCC(O)C1=CC(O)=CC(O)=C1	Approved
ZINC000000643046	DB00975	Dipyridamole	Small molecule	OCCN(CCO)C1=NC2=C(N=C(N=C2N2CCCCC2)N(CCO)CCO)C(=N1)N1CCCCC1	Approved
ZINC000000025958	DB12332	Rucaparib	Small molecule	CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3	Approved\|Investigational
ZINC000002169830	DB00194	Vidarabine	Small molecule	NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O	Approved\|Investigational
ZINC000002036848	DB00140	Riboflavin	Small molecule	CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1	Approved\|Investigational\|Nutraceutical\|Vet_approved
ZINC000043206370	DB11793	Niraparib	Small molecule	NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1	Approved\|Investigational
ZINC000034220093	DB15058	Flutemetamol	Small molecule	CNC1=C(F)C=C(C=C1)C1=NC2=C(S1)C=C(O)C=C2	Investigational
ZINC000003977952	DB00581	Lactulose	Small molecule	OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O	Approved
ZINC000030691797	DB08883	Perampanel	Small molecule	O=C1N(C=C(C=C1C1=CC=CC=C1C#N)C1=NC=CC=C1)C1=CC=CC=C1	Approved
ZINC000004214955	DB06769	Bendamustine	Small molecule	CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl	Approved\|Investigational
ZINC000003830990	DB11868	Etiracetam	Small molecule	CCC(N1CCCC1=O)C(N)=O	Investigational
ZINC000012414057	DB08167	Methylthioninium	Small molecule	CN(C)C1=CC2=[S+]C3=CC(=CC=C3N=C2C=C1)N(C)C	Experimental\|Investigational
ZINC000000897258	DB00983	Formoterol	Small molecule	COC1=CC=C(CC(C)NCC(O)C2=CC(NC=O)=C(O)C=C2)C=C1	Approved\|Investigational
ZINC000000034157	DB06707	Levonordefrin	Small molecule	C[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1	Approved

Top

Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000000121541	295.297	6.562	576.161	98.468	169.387	308.306	0	957.18	1	5	8.911	3	83.641	0	0
ZINC000000121541	295.297	2.873	577.033	96.773	172.83	307.43	0	959.022	0	3	8.668	3	88.187	0	0
ZINC000000121541	295.297	10.919	575.199	98.469	170.072	306.658	0	956.419	1	5	8.861	3	83.461	0	0
ZINC000000000469	211.26	2.192	479.658	212.457	159.848	107.353	0	782.094	4	4.7	9.205	2	61.391	0	0
ZINC000000000469	211.26	3.668	477.852	212.113	158.053	107.685	0	779.059	4	4.7	8.929	2	61.69	0	0
ZINC000000643046	504.631	1.586	815.307	592.733	195.941	26.633	0	1582.633	4	12.8	7.716	2	52.494	2	0
ZINC000003830943	821.143	2.11	797.152	329.149	341.979	8.796	117.227	1489.14	8	18.2	9.356	1	0	3	1
ZINC000000025958	323.369	9.363	601.398	214.232	112.926	227.819	46.421	1032.273	3	4	8.52	3	85.064	0	0
ZINC000000025958	323.369	9.466	597.964	212.386	112.007	227.152	46.419	1026.229	3	4	8.513	3	85.039	0	0
ZINC000002169830	267.244	3.396	469.36	95.245	259.374	114.741	0	784.03	5	10.8	8.527	2	44.327	0	0
ZINC000000004166	272.362	5.095	568.775	304.129	140.425	123.778	0.442	948.347	3	7.7	9.15	3	65.285	0	0
ZINC000000004166	272.362	6.328	565.576	303.726	137.239	124.569	0.042	941.283	3	7.7	9.164	3	65.814	0	0
ZINC000002036848	376.368	8.767	609.496	261.237	282.582	65.677	0	1115.69	5	12.3	9.092	2	45.86	0	1
ZINC000043206370	320.393	3.754	607.688	185.794	143.417	278.476	0	1055.805	3	5	8.546	3	76.72	0	0
ZINC000000007601	239.314	3.133	507.069	275.176	145.075	86.817	0	875.643	4	5.15	9.068	2	66.522	0	0
ZINC000034220093	274.312	1.949	511.177	89.833	86.339	254.76	80.245	847.322	2	3.25	8.207	3	100	0	0
ZINC000034220093	274.312	1.174	509.609	89.83	84.419	255.176	80.184	844.623	2	3.25	8.146	3	100	0	0
ZINC000003977952	342.299	7.257	545.281	230.326	314.956	0	0	978.368	8	16.8	10.609	1	0	2	2
ZINC000000056652	211.26	3.507	478.577	212.52	152.49	113.567	0	781.059	4	4.7	8.941	2	63.01	0	0
ZINC000030691797	349.391	5.825	656.081	0	102.198	553.883	0	1144.654	0	5.5	8.69	1	100	0	1
ZINC000004214955	358.267	3.446	660.401	298.857	122.78	92.485	146.279	1135.219	1	4.5	8.979	3	95.316	0	1
ZINC000004214955	358.267	5.922	650.52	300.031	115.164	97.2	138.125	1124.979	1	4.5	8.29	3	96.403	0	1
ZINC000003830990	170.211	3.555	386.854	254.13	132.723	0	0	627.855	2	5.5	9.607	2	59.075	0	0
ZINC000000897258	344.41	7.083	674.489	258.736	187.926	227.826	0	1168.666	4	7.2	8.855	2	65.222	0	0
ZINC000000897258	344.41	4.982	586.764	251.201	138.136	197.426	0	1091.391	4	7.2	8.677	3	73.278	0	0
ZINC000000034157	183.207	1.584	399.847	106.772	186.848	106.227	0	646.199	5	4.2	8.948	2	52.109	0	0
ZINC000000034157	183.207	2.284	398.836	105.841	186.106	106.889	0	643.154	5	4.2	8.781	2	52.19	0	0

Top

Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000000121541	COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]1	0.209696342	0.592445172
ZINC000000000469	CC(C)NC[C@@H](O)c1cc(O)cc(O)c1	0.170221255	0.19797014
ZINC000000643046	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	0.137158563	0.379972524
ZINC000003830943	CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I	0.042332243	0.211666342
ZINC000000025958	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	0.204259799	0.179994505
ZINC000002169830	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O	0.079554768	0.347763769
ZINC000000004166	CC(C)NC[C@@H](O)c1ccc(NS(C)(=O)=O)cc1	0.233835874	0.174875168
ZINC000002036848	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)CO)c2cc1C	0.061390494	0.448129596
ZINC000043206370	NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12	0.15810306	0.243905197
ZINC000000007601	CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c1	0.176238455	0.331044881
ZINC000034220093	CNc1ccc(-c2nc3ccc(O)cc3s2)cc1F	0.301158621	0.239116152
ZINC000003977952	OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O	0.029403356	0.491913174
ZINC000000056652	CC(C)NC[C@H](O)c1ccc(O)c(O)c1	0.202150594	0.209218132
ZINC000030691797	N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O	0.292416362	0.331128937
ZINC000004214955	Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21	0.20795331	0.394281261
ZINC000003830990	CC[C@H](C(N)=O)N1CCCC1=O	0.157335861	0.410047131
ZINC000012414057	CN(C)c1ccc2nc3ccc(=[N+](C)C)cc-3sc2c1	0.17581235	0.481215426
ZINC000000897258	COc1ccc(C[C@@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1	0.133863078	0.246482573
ZINC000000034157	C[C@H](N)[C@H](O)c1ccc(O)c(O)c1	0.135079192	0.302260037

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
EPS15	RNF11, SNAP91, AGFG1, NAGPA, STON2, HGS, AP2A2, DNM2, AP2A1, EGFR, CLINT1, EPN1, SCAMP1, STAM2, GRB2, CRK, RAB11FIP2, Synj1, REPS2, UBE2D1, UBE2D2, UBE2D3, UBE2H, UBE2E1, SLC6A3, PARK2, USP8, CD4, EPS15, OCLN, UBQLN1, UBC, NEDD4, GJA1, TGFB1, Zwint, FCHO2, ITSN1, ITSN2, ELAVL1, RAD23A, UBQLN2, EPN3, SH3BP4, AP1B1, NUMB, SPG20, TFAP2A, ABL1, AP2B1, IQGAP1, KRT85, KRT1, KRT10, KRT2, AP2M1, KRT14, KRT86, KRT5, KRT6A, KRT16, KRT9, HSPA8, KRT35, HSPA9, KRT17, KRT33B, KRT83, BMP2K, KRT34, KRT82, NONO, KRT38, KRT75, KRT79, PRDX1, KRT36, KRT32, MAP4, HSPA1L, HSPA1B, KRT37, HSPA5, KRT73, AP2S1, NECAP2, TRAF2, MCCC2, KRT4, ACTB, KRT3, VPRBP, TUBB, HIST4H4, PCCB, KRTAP9-3, NECAP1, VSIG8, CCT3, CRKL, Dab2, FN1, VCAM1, Fcho2, LAPTM5, ITGA4, OPTN, RABL6, EPHA2, CORO7, UBI4, AGFG2, SLC25A41, AURKA, SPC25, Numb, NTRK1, TMEM17, XPO1, CAPZA2, CLTB, CLTC, DBN1, FLNA, GAK, MYH9, PPP1CB, PICALM, PDLIM7, SYNPO, MAPRE1, LIMA1, GTSE1, ANLN, MYO19, Actb, Flot1, Myh9, Myo1c, Tpm1, Lima1, Calml3, Myh10, Sec24c, Flnb, MAPK14, AP1G1, MYO6, SPOPL, SGIP1, FCHO1, CDH1, RUNDC3A, LSR, STAMBPL1, CCDC172, OXCT1, MTNR1A, RNF26, fcho1, HNRNPL, STK40, DYRK1A, PLK1, DVL2, MIB1, ORF7a, ESR1, TRIM56, KIF14, Rnf183, DNAJC5, DDX58, ACBD5, CLTA, VASP, NAA40, RNPS1, MACC1, SYCE1, RARRES1, POLR2J3, EPS15L1, C15orf59, ZCCHC10, SYNC, INO80E, DNAJC6, RUFY4,
KMT2A	PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EPS15
KMT2A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EPS15	chr1:51913717	chr11:118354897	ENST00000371733		9	25	2_330	217.0	897.0	DAB2

Top

Related Drugs to EPS15-KMT2A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EPS15-KMT2A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	KMT2A	C2826025	Mixed phenotype acute leukemia	3	ORPHANET
Tgene	KMT2A	C0023418	leukemia	2	CTD_human
Tgene	KMT2A	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023466	Leukemia, Monocytic, Chronic	2	CTD_human
Tgene	KMT2A	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Tgene	KMT2A	C0023470	Myeloid Leukemia	2	CTD_human
Tgene	KMT2A	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	KMT2A	C1854630	Growth Deficiency and Mental Retardation with Facial Dysmorphism	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	KMT2A	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	KMT2A	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CTD_human
Tgene	KMT2A	C0001418	Adenocarcinoma	1	CTD_human
Tgene	KMT2A	C0004403	Autosome Abnormalities	1	CTD_human
Tgene	KMT2A	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Tgene	KMT2A	C0005695	Bladder Neoplasm	1	CTD_human
Tgene	KMT2A	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Tgene	KMT2A	C0008625	Chromosome Aberrations	1	CTD_human
Tgene	KMT2A	C0023448	Lymphoid leukemia	1	CTD_human
Tgene	KMT2A	C0023465	Acute monocytic leukemia	1	CTD_human
Tgene	KMT2A	C0023479	Acute myelomonocytic leukemia	1	CTD_human
Tgene	KMT2A	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	KMT2A	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	KMT2A	C0036341	Schizophrenia	1	PSYGENET
Tgene	KMT2A	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	KMT2A	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	KMT2A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	KMT2A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	KMT2A	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	KMT2A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	KMT2A	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	KMT2A	C0270972	Cornelia De Lange Syndrome	1	ORPHANET
Tgene	KMT2A	C0280141	Acute Undifferentiated Leukemia	1	ORPHANET
Tgene	KMT2A	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	KMT2A	C0856823	Undifferentiated type acute leukemia	1	ORPHANET
Tgene	KMT2A	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	KMT2A	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	KMT2A	C2239176	Liver carcinoma	1	CTD_human
Tgene	KMT2A	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	KMT2A	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	KMT2A	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	KMT2A	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human