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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-EIF1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-EIF1
	FusionPDB ID: 27147
	FusionGDB2.0 ID: 27147
		Hgene	Tgene
	Gene symbol	ERBB2	EIF1
	Gene ID	2064	10209
	Gene name	erb-b2 receptor tyrosine kinase 2	eukaryotic translation initiation factor 1
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	A121\|EIF-1\|EIF1A\|ISO1\|SUI1
	Cytomap	17q12	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	eukaryotic translation initiation factor 1protein translation factor SUI1 homologsui1iso1
	Modification date	20200329	20200313
	UniProtAcc	P04626	O60739
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000584888,	ENST00000310837, ENST00000469257, ENST00000591776,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	16 X 13 X 8=1664
	# samples	73	17
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1664*10)=-3.29104878200339 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND EIF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37868701)-EIF1(39846029), # samples:1 ERBB2(37868300)-EIF1(39846029), # samples:1 ERBB2(37868701)-EIF1(39846030), # samples:1
Anticipated loss of major functional domain due to fusion event.	ERBB2-EIF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-EIF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-EIF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERBB2-EIF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ERBB2-EIF1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ERBB2-EIF1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870
Tgene	EIF1	GO:0006446	regulation of translational initiation	22156057

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EIF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4PE-01A	ERBB2	chr17	37868701	+	EIF1	chr17	39846030	+
ChimerDB4	STAD	TCGA-BR-A4PE	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+
ChimerDB4	STAD	TCGA-BR-A4PE	ERBB2	chr17	37868701	+	EIF1	chr17	39846029	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000584601	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	2342	1728	752	2062	436
ENST00000584601	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3881	1728	752	2038	428
ENST00000406381	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	2055	1441	510	1775	421
ENST00000406381	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3594	1441	510	1751	413
ENST00000541774	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1590	976	0	1310	436
ENST00000541774	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3129	976	0	1286	428
ENST00000445658	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1070	456	50	790	246
ENST00000445658	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	2609	456	50	766	238
ENST00000540147	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1873	1259	25	1593	522
ENST00000540147	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3412	1259	25	1569	514
ENST00000584450	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1850	1236	2	1570	522
ENST00000584450	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3389	1236	2	1546	514
ENST00000269571	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1794	1180	57	1514	485
ENST00000269571	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3333	1180	57	1490	477
ENST00000578199	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	2086	1472	541	1806	421
ENST00000578199	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3625	1472	541	1782	413
ENST00000540042	ERBB2	chr17	37868300	+	ENST00000591776	EIF1	chr17	39846029	+	1711	1097	166	1431	421
ENST00000540042	ERBB2	chr17	37868300	+	ENST00000469257	EIF1	chr17	39846029	+	3250	1097	166	1407	413

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000584601	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.009547677	0.9904523
ENST00000584601	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.004325743	0.9956742
ENST00000406381	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.005476336	0.99452364
ENST00000406381	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.001978484	0.9980215
ENST00000541774	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.012362422	0.9876375
ENST00000541774	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.004036467	0.99596345
ENST00000445658	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.009737628	0.9902624
ENST00000445658	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.009048685	0.9909513
ENST00000540147	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.01854586	0.98145413
ENST00000540147	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.007078851	0.9929212
ENST00000584450	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.019969618	0.98003036
ENST00000584450	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.00733398	0.99266607
ENST00000269571	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.0197575	0.98024255
ENST00000269571	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.007189651	0.99281037
ENST00000578199	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.004093571	0.99590635
ENST00000578199	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.001662781	0.99833715
ENST00000540042	ENST00000591776	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.005486014	0.994514
ENST00000540042	ENST00000469257	ERBB2	chr17	37868300	+	EIF1	chr17	39846029	+	0.001738372	0.99826163

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27147_27147_1_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000269571_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=477AA_BP=374
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQ

--------------------------------------------------------------

>27147_27147_2_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000269571_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=485AA_BP=374
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQ

--------------------------------------------------------------

>27147_27147_3_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000406381_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=413AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

--------------------------------------------------------------

>27147_27147_4_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000406381_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=421AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

--------------------------------------------------------------

>27147_27147_5_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000445658_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=238AA_BP=135
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYD

--------------------------------------------------------------

>27147_27147_6_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000445658_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=246AA_BP=135
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYD

--------------------------------------------------------------

>27147_27147_7_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000540042_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=413AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

--------------------------------------------------------------

>27147_27147_8_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000540042_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=421AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

--------------------------------------------------------------

>27147_27147_9_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000540147_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=514AA_BP=411
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQG

--------------------------------------------------------------

>27147_27147_10_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000540147_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=522AA_BP=411
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQG

--------------------------------------------------------------

>27147_27147_11_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000541774_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=428AA_BP=325
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLT

--------------------------------------------------------------

>27147_27147_12_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000541774_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=436AA_BP=325
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLT

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>27147_27147_13_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000578199_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=413AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

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>27147_27147_14_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000578199_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=421AA_BP=310
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLV

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>27147_27147_15_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000584450_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=514AA_BP=411
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQG

--------------------------------------------------------------

>27147_27147_16_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000584450_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=522AA_BP=411
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQG

--------------------------------------------------------------

>27147_27147_17_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000584601_EIF1_chr17_39846029_ENST00000469257_length(amino acids)=428AA_BP=325
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLT

--------------------------------------------------------------

>27147_27147_18_ERBB2-EIF1_ERBB2_chr17_37868300_ENST00000584601_EIF1_chr17_39846029_ENST00000591776_length(amino acids)=436AA_BP=325
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37868701/chr17:39846029)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	EIF1 O60739
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.	FUNCTION: Probably involved in translation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

720_987

340.3333333333333

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

720_987

325.3333333333333

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

676_689

340.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

676_689

325.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

726_734

340.3333333333333

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

726_734

325.3333333333333

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

23_652

340.3333333333333

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

676_1255

340.3333333333333

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

23_652

325.3333333333333

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

676_1255

325.3333333333333

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000269571

653_675

340.3333333333333

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37868300

chr17:39846029

ENST00000541774

653_675

325.3333333333333

1241.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
EIF1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37868300	chr17:39846029	ENST00000269571	+	8	27	1195_1197	340.3333333333333	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37868300	chr17:39846029	ENST00000541774	+	8	27	1195_1197	325.3333333333333	1241.0	PIK3C2B

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Related Drugs to ERBB2-EIF1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ERBB2-EIF1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source