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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2-FKBP10

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2-FKBP10
	FusionPDB ID: 27148
	FusionGDB2.0 ID: 27148
		Hgene	Tgene
	Gene symbol	ERBB2	FKBP10
	Gene ID	2064	60681
	Gene name	erb-b2 receptor tyrosine kinase 2	FKBP prolyl isomerase 10
	Synonyms	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1	BRKS1\|FKBP65\|OI11\|OI6\|PPIASE\|hFKBP65
	Cytomap	17q12	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2	peptidyl-prolyl cis-trans isomerase FKBP1065 kDa FK506-binding protein65 kDa FKBPFK506 binding protein 10, 65 kDaFK506-binding protein 10FKBP-10FKBP-65PPIase FKBP10immunophilin FKBP65rotamase
	Modification date	20200329	20200313
	UniProtAcc	P04626	Q96AY3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269571, ENST00000445658, ENST00000584450, ENST00000540147, ENST00000406381, ENST00000540042, ENST00000541774, ENST00000578199, ENST00000584601, ENST00000584888,	ENST00000544340, ENST00000321562,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	50 X 44 X 14=30800	8 X 9 X 3=216
	# samples	73	9
	** MAII score	log2(73/30800*10)=-5.39889007670225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2 [Title/Abstract] AND FKBP10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37856564)-FKBP10(39974341), # samples:1 ERBB2(37866734)-FKBP10(39977906), # samples:1 FKBP10(39969531)-ERBB2(37855790), # samples:1
Anticipated loss of major functional domain due to fusion event.	ERBB2-FKBP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-FKBP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-FKBP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2-FKBP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERBB2	GO:0007165	signal transduction	10572067
Hgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Hgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Hgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Hgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Hgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Hgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Hgene	ERBB2	GO:0042060	wound healing	12646923
Hgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Hgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Hgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Hgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FKBP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-RD-A7BT-01A	ERBB2	chr17	37856564	+	FKBP10	chr17	39974341	+
ChimerDB4	STAD	TCGA-RD-A7BT-01A	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000445658	ERBB2	chr17	37856564	+	ENST00000321562	FKBP10	chr17	39974341	+	2499	336	50	1693	547
ENST00000584450	ERBB2	chr17	37856564	+	ENST00000321562	FKBP10	chr17	39974341	+	2451	288	2	1645	547
ENST00000269571	ERBB2	chr17	37856564	+	ENST00000321562	FKBP10	chr17	39974341	+	2395	232	57	1589	510
ENST00000584601	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2763	1608	752	1957	401
ENST00000584601	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2761	1608	752	1957	401
ENST00000406381	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2476	1321	510	1670	386
ENST00000406381	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2474	1321	510	1670	386
ENST00000541774	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2011	856	0	1205	401
ENST00000541774	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2009	856	0	1205	401
ENST00000540147	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2294	1139	25	1488	487
ENST00000540147	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2292	1139	25	1488	487
ENST00000584450	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2271	1116	2	1465	487
ENST00000584450	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2269	1116	2	1465	487
ENST00000269571	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2215	1060	57	1409	450
ENST00000269571	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2213	1060	57	1409	450
ENST00000578199	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2507	1352	541	1701	386
ENST00000578199	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2505	1352	541	1701	386
ENST00000540042	ERBB2	chr17	37866734	+	ENST00000321562	FKBP10	chr17	39977906	+	2132	977	166	1326	386
ENST00000540042	ERBB2	chr17	37866734	+	ENST00000544340	FKBP10	chr17	39977906	+	2130	977	166	1326	386

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000445658	ENST00000321562	ERBB2	chr17	37856564	+	FKBP10	chr17	39974341	+	0.004090909	0.9959091
ENST00000584450	ENST00000321562	ERBB2	chr17	37856564	+	FKBP10	chr17	39974341	+	0.0042603	0.9957397
ENST00000269571	ENST00000321562	ERBB2	chr17	37856564	+	FKBP10	chr17	39974341	+	0.004281864	0.9957182
ENST00000584601	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.014205742	0.98579425
ENST00000584601	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.014090257	0.9859097
ENST00000406381	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.007245237	0.99275476
ENST00000406381	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.007204718	0.9927953
ENST00000541774	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.016335506	0.98366445
ENST00000541774	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.01628267	0.9837173
ENST00000540147	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.018813765	0.9811863
ENST00000540147	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.018728597	0.98127145
ENST00000584450	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.01944338	0.9805566
ENST00000584450	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.019323567	0.9806764
ENST00000269571	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.019612728	0.9803873
ENST00000269571	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.01947517	0.9805249
ENST00000578199	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.006147984	0.993852
ENST00000578199	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.006131643	0.9938684
ENST00000540042	ENST00000321562	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.008025953	0.99197406
ENST00000540042	ENST00000544340	ERBB2	chr17	37866734	+	FKBP10	chr17	39977906	+	0.007992579	0.9920074

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27148_27148_1_ERBB2-FKBP10_ERBB2_chr17_37856564_ENST00000269571_FKBP10_chr17_39974341_ENST00000321562_length(amino acids)=510AA_BP=213
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLL
RPPHCPRMVQDGDFVRYHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMDQGLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASL
VFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRIT
IPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNETTKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQEATLGA
NKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEF

--------------------------------------------------------------

>27148_27148_2_ERBB2-FKBP10_ERBB2_chr17_37856564_ENST00000445658_FKBP10_chr17_39974341_ENST00000321562_length(amino acids)=547AA_BP=250
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMD
QGLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDS
SYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNET
TKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEVELVSR
EDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDE

--------------------------------------------------------------

>27148_27148_3_ERBB2-FKBP10_ERBB2_chr17_37856564_ENST00000584450_FKBP10_chr17_39974341_ENST00000321562_length(amino acids)=547AA_BP=250
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQAGLIPPDATLYFDVVLLDVWNKEDTVQVSTLLRPPHCPRMVQDGDFVRYHYNGTLLDGTSFDTSYSKGGTYDTYVGSGWLIKGMD
QGLLGMCPGERRKIIIPPFLAYGEKGYGTVIPPQASLVFHVLLIDVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDS
SYSRNHTYNTYIGQGYIIPGMDQGLQGACMGERRRITIPPHLAYGENGTGDKIPGSAVLIFNVHVIDFHNPADVVEIRTLSRPSETCNET
TKLGDFVRYHYNCSLLDGTQLFTSHDYGAPQEATLGANKVIEGLDTGLQGMCVGERRQLIVPPHLAHGESGARGVPGSAVLLFEVELVSR
EDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDE

--------------------------------------------------------------

>27148_27148_4_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000269571_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=450AA_BP=333
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTG
YLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL

--------------------------------------------------------------

>27148_27148_5_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000269571_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=450AA_BP=333
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTG
YLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDRNQDGKITVDELKLKSDEDEERVHEEL

--------------------------------------------------------------

>27148_27148_6_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000406381_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_7_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000406381_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_8_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000540042_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_9_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000540042_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_10_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000540147_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=487AA_BP=370
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEK

--------------------------------------------------------------

>27148_27148_11_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000540147_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=487AA_BP=370
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEK

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>27148_27148_12_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000541774_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=401AA_BP=284
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQ

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>27148_27148_13_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000541774_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=401AA_BP=284
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQ

--------------------------------------------------------------

>27148_27148_14_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000578199_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_15_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000578199_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=386AA_BP=269
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
SRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEKTIGDMFQNQDR

--------------------------------------------------------------

>27148_27148_16_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000584450_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=487AA_BP=370
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEK

--------------------------------------------------------------

>27148_27148_17_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000584450_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=487AA_BP=370
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQDPEK

--------------------------------------------------------------

>27148_27148_18_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000584601_FKBP10_chr17_39977906_ENST00000321562_length(amino acids)=401AA_BP=284
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQ

--------------------------------------------------------------

>27148_27148_19_ERBB2-FKBP10_ERBB2_chr17_37866734_ENST00000584601_FKBP10_chr17_39977906_ENST00000544340_length(amino acids)=401AA_BP=284
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPSRGVPGSAVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLMPGQ

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37856564/chr17:39974341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERBB2 P04626	FKBP10 Q96AY3
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.	FUNCTION: PPIases accelerate the folding of proteins during protein synthesis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

510_521

130.33333333333334

583.0

Calcium binding

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

555_566

130.33333333333334

583.0

Calcium binding

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

510_521

466.3333333333333

583.0

Calcium binding

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

555_566

466.3333333333333

583.0

Calcium binding

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

174_262

130.33333333333334

583.0

Domain

PPIase FKBP-type 2

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

286_374

130.33333333333334

583.0

Domain

PPIase FKBP-type 3

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

399_486

130.33333333333334

583.0

Domain

PPIase FKBP-type 4

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

497_532

130.33333333333334

583.0

Domain

EF-hand 1

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

542_577

130.33333333333334

583.0

Domain

EF-hand 2

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

497_532

466.3333333333333

583.0

Domain

EF-hand 1

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

542_577

466.3333333333333

583.0

Domain

EF-hand 2

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

579_582

130.33333333333334

583.0

Motif

Prevents secretion from ER

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

579_582

466.3333333333333

583.0

Motif

Prevents secretion from ER

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

720_987

24.333333333333332

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

720_987

0.0

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

720_987

300.3333333333333

1256.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

720_987

285.3333333333333

1241.0

Domain

Protein kinase

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

676_689

24.333333333333332

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

676_689

0.0

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

676_689

300.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

676_689

285.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

726_734

24.333333333333332

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

726_734

0.0

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

726_734

300.3333333333333

1256.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

726_734

285.3333333333333

1241.0

Nucleotide binding

ATP

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

23_652

24.333333333333332

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

676_1255

24.333333333333332

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

23_652

0.0

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

676_1255

0.0

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

23_652

300.3333333333333

1256.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

676_1255

300.3333333333333

1256.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

23_652

285.3333333333333

1241.0

Topological domain

Extracellular

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

676_1255

285.3333333333333

1241.0

Topological domain

Cytoplasmic

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000269571

653_675

24.333333333333332

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37856564

chr17:39974341

ENST00000541774

653_675

0.0

1241.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000269571

653_675

300.3333333333333

1256.0

Transmembrane

Helical

Hgene

ERBB2

chr17:37866734

chr17:39977906

ENST00000541774

653_675

285.3333333333333

1241.0

Transmembrane

Helical

Tgene

FKBP10

chr17:37856564

chr17:39974341

ENST00000321562

62_150

130.33333333333334

583.0

Domain

PPIase FKBP-type 1

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

174_262

466.3333333333333

583.0

Domain

PPIase FKBP-type 2

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

286_374

466.3333333333333

583.0

Domain

PPIase FKBP-type 3

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

399_486

466.3333333333333

583.0

Domain

PPIase FKBP-type 4

Tgene

FKBP10

chr17:37866734

chr17:39977906

ENST00000321562

62_150

466.3333333333333

583.0

Domain

PPIase FKBP-type 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2
FKBP10

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ERBB2	chr17:37856564	chr17:39974341	ENST00000269571	+	1	27	1195_1197	24.333333333333332	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37856564	chr17:39974341	ENST00000541774	+	1	27	1195_1197	0.0	1241.0	PIK3C2B
Hgene	ERBB2	chr17:37866734	chr17:39977906	ENST00000269571	+	7	27	1195_1197	300.3333333333333	1256.0	PIK3C2B
Hgene	ERBB2	chr17:37866734	chr17:39977906	ENST00000541774	+	7	27	1195_1197	285.3333333333333	1241.0	PIK3C2B

Top

Related Drugs to ERBB2-FKBP10

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERBB2-FKBP10

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source