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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERBB2IP-ASXL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERBB2IP-ASXL1
	FusionPDB ID: 27153
	FusionGDB2.0 ID: 27153
		Hgene	Tgene
	Gene symbol	ERBB2IP	ASXL1
	Gene ID	55914	171023
	Gene name	erbb2 interacting protein	ASXL transcriptional regulator 1
	Synonyms	ERBB2IP\|HEL-S-78\|LAP2	BOPS\|MDS
	Cytomap	5q12.3	20q11.21
	Type of gene	protein-coding	protein-coding
	Description	erbindensin-180-like proteinepididymis secretory protein Li 78protein LAP2	polycomb group protein ASXL1additional sex combs like 1, transcriptional regulatoradditional sex combs like transcriptional regulator 1putative Polycomb group protein ASXL1
	Modification date	20200322	20200313
	UniProtAcc	.	Q8IXJ9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000284037, ENST00000380935, ENST00000380936, ENST00000380938, ENST00000380939, ENST00000380943, ENST00000506030, ENST00000508515, ENST00000511297, ENST00000416865, ENST00000503913,	ENST00000470145, ENST00000542461, ENST00000306058, ENST00000375689, ENST00000375687,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 4 X 10=560	10 X 7 X 6=420
	# samples	20	10
	** MAII score	log2(20/560*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/420*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERBB2IP [Title/Abstract] AND ASXL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2IP(65350779)-ASXL1(31015931), # samples:1
Anticipated loss of major functional domain due to fusion event.	ERBB2IP-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2IP-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2IP-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERBB2IP-ASXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ASXL1	GO:0035522	monoubiquitinated histone H2A deubiquitination	20436459

Fusion gene breakpoints across ERBB2IP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-50-5944-01A	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000284037	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10377	4022	389	8395	2668
ENST00000380943	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10296	3941	308	8314	2668
ENST00000380935	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10278	3923	290	8296	2668
ENST00000380939	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10278	3923	290	8296	2668
ENST00000380936	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10278	3923	290	8296	2668
ENST00000380938	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10242	3887	254	8260	2668
ENST00000511297	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10113	3758	137	8131	2664
ENST00000506030	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10079	3724	91	8097	2668
ENST00000508515	ERBB2IP	chr5	65350779	-	ENST00000375687	ASXL1	chr20	31015931	+	10047	3692	59	8065	2668

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000284037	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.00091832	0.9990816
ENST00000380943	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000824435	0.9991755
ENST00000380935	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000807242	0.9991928
ENST00000380939	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000807242	0.9991928
ENST00000380936	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000807242	0.9991928
ENST00000380938	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000766601	0.99923337
ENST00000511297	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000679897	0.99932015
ENST00000506030	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000632266	0.9993678
ENST00000508515	ENST00000375687	ERBB2IP	chr5	65350779	-	ASXL1	chr20	31015931	+	0.000613716	0.9993863

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27153_27153_1_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000284037_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_2_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000380935_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_3_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000380936_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_4_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000380938_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_5_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000380939_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_6_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000380943_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_7_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000506030_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_8_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000508515_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2668AA_BP=1211
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALS
NNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENG
NKYPNLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDT
LWHSKQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPS
KRPNARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSN
ASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEV
TQDPAPLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFF
THAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQ
RDGHFKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAE
PDNLARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPW
VVKGQPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACG
HPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALP
LLSSQTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSP
TDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGD
LTAEEGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDE
KPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLP
PAHDDSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSL
HPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKK
LFGSGNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPL
ELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGAS

--------------------------------------------------------------

>27153_27153_9_ERBB2IP-ASXL1_ERBB2IP_chr5_65350779_ENST00000511297_ASXL1_chr20_31015931_ENST00000375687_length(amino acids)=2664AA_BP=1207
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN
LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE
TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDNESFNPSLW
EEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDTSESTTTVKS
KVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKK
DDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKFKAHD
KKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEIMERSKTQDIVLGTSFLSINSKEETEHLENGNKYP
NLESVNKVNGHSEETSQSPNRTEPHDSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVKITSA
VDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRGPTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHS
KQNPQIDHASFPPQLLPRSESTENQSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSVSSTA
SVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPN
ARVGSEHSLLDPPGKSKVPRDWREQVLRHIEAKKLEKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVSGENDVSLDETSSNASCS
TESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVNGAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEVTQDP
APLLRGFRKPATGQMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGLLRLSSSALNNEFFTHAA
QSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQRDGH
FKKRSRPDLRTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDLEGPEFPVESVASRIQAEPDNL
ARASASPDRIPSLPQETVDQEPKDQKRKSFEQAASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVVKG
QPTYQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGGGGGATDEGGGRGSSSGDGGEACGHPEP
RGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAGTAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALPLLSS
QTSVAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQALDSHPTMKDPVNVTPSSTPESSPTDCL
QNRAFDDELGLGGSCPPMRESDTRQENLKTKALVSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGDLTAE
EGLDPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLTEDSSEADTREAAVTKGSSVDKDEKPNW
NQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVCAVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLPPAHD
DSMSESPQVPLTKDQSHGSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLARIEATQAPGAPQKNCKAVPSFDSLHPVT
NPITSSRKLEEMDSKEQFSSFSCEDQKEVRAMSQDSNSNAAPGKSPGDLTTSRTPRFSSPNVISFGPEQTGRALGDQSNVTGQGKKLFGS
GNVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPKPHAFVGSVKNEKTFVGGPLKANAENRKATGHSPLELVG
HLEGMPFVMDLPFWKLPREPGKGLSEPLEPSSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSAS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:65350779/chr20:31015931)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ASXL1 Q8IXJ9
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). {ECO:0000250\|UniProtKB:P59598, ECO:0000269\|PubMed:16606617, ECO:0000269\|PubMed:20436459, ECO:0000269\|PubMed:30982744}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

930_934

1211.0

1413.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

930_934

1211.0

1303.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

930_934

1211.0

1341.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

930_934

1211.0

1347.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

930_934

1211.0

1361.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

930_934

1211.0

1372.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

930_934

1211.0

1420.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

930_934

1211.0

1303.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

930_934

1207.0

1368.0

Compositional bias

Note=Poly-Ser

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

116_137

1211.0

1413.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

139_161

1211.0

1413.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

162_183

1211.0

1413.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

185_206

1211.0

1413.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

208_229

1211.0

1413.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

231_252

1211.0

1413.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

23_44

1211.0

1413.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

254_275

1211.0

1413.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

277_298

1211.0

1413.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

300_321

1211.0

1413.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

323_344

1211.0

1413.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

346_367

1211.0

1413.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

369_391

1211.0

1413.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

392_413

1211.0

1413.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

47_68

1211.0

1413.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

70_91

1211.0

1413.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

93_114

1211.0

1413.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

116_137

1211.0

1303.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

139_161

1211.0

1303.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

162_183

1211.0

1303.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

185_206

1211.0

1303.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

208_229

1211.0

1303.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

231_252

1211.0

1303.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

23_44

1211.0

1303.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

254_275

1211.0

1303.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

277_298

1211.0

1303.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

300_321

1211.0

1303.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

323_344

1211.0

1303.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

346_367

1211.0

1303.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

369_391

1211.0

1303.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

392_413

1211.0

1303.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

47_68

1211.0

1303.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

70_91

1211.0

1303.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

93_114

1211.0

1303.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

116_137

1211.0

1341.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

139_161

1211.0

1341.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

162_183

1211.0

1341.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

185_206

1211.0

1341.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

208_229

1211.0

1341.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

231_252

1211.0

1341.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

23_44

1211.0

1341.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

254_275

1211.0

1341.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

277_298

1211.0

1341.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

300_321

1211.0

1341.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

323_344

1211.0

1341.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

346_367

1211.0

1341.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

369_391

1211.0

1341.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

392_413

1211.0

1341.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

47_68

1211.0

1341.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

70_91

1211.0

1341.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

93_114

1211.0

1341.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

116_137

1211.0

1347.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

139_161

1211.0

1347.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

162_183

1211.0

1347.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

185_206

1211.0

1347.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

208_229

1211.0

1347.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

231_252

1211.0

1347.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

23_44

1211.0

1347.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

254_275

1211.0

1347.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

277_298

1211.0

1347.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

300_321

1211.0

1347.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

323_344

1211.0

1347.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

346_367

1211.0

1347.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

369_391

1211.0

1347.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

392_413

1211.0

1347.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

47_68

1211.0

1347.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

70_91

1211.0

1347.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

93_114

1211.0

1347.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

116_137

1211.0

1361.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

139_161

1211.0

1361.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

162_183

1211.0

1361.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

185_206

1211.0

1361.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

208_229

1211.0

1361.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

231_252

1211.0

1361.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

23_44

1211.0

1361.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

254_275

1211.0

1361.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

277_298

1211.0

1361.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

300_321

1211.0

1361.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

323_344

1211.0

1361.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

346_367

1211.0

1361.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

369_391

1211.0

1361.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

392_413

1211.0

1361.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

47_68

1211.0

1361.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

70_91

1211.0

1361.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

93_114

1211.0

1361.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

116_137

1211.0

1372.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

139_161

1211.0

1372.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

162_183

1211.0

1372.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

185_206

1211.0

1372.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

208_229

1211.0

1372.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

231_252

1211.0

1372.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

23_44

1211.0

1372.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

254_275

1211.0

1372.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

277_298

1211.0

1372.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

300_321

1211.0

1372.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

323_344

1211.0

1372.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

346_367

1211.0

1372.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

369_391

1211.0

1372.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

392_413

1211.0

1372.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

47_68

1211.0

1372.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

70_91

1211.0

1372.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

93_114

1211.0

1372.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

116_137

1211.0

1420.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

139_161

1211.0

1420.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

162_183

1211.0

1420.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

185_206

1211.0

1420.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

208_229

1211.0

1420.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

231_252

1211.0

1420.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

23_44

1211.0

1420.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

254_275

1211.0

1420.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

277_298

1211.0

1420.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

300_321

1211.0

1420.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

323_344

1211.0

1420.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

346_367

1211.0

1420.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

369_391

1211.0

1420.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

392_413

1211.0

1420.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

47_68

1211.0

1420.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

70_91

1211.0

1420.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

93_114

1211.0

1420.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

116_137

1211.0

1303.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

139_161

1211.0

1303.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

162_183

1211.0

1303.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

185_206

1211.0

1303.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

208_229

1211.0

1303.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

231_252

1211.0

1303.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

23_44

1211.0

1303.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

254_275

1211.0

1303.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

277_298

1211.0

1303.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

300_321

1211.0

1303.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

323_344

1211.0

1303.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

346_367

1211.0

1303.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

369_391

1211.0

1303.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

392_413

1211.0

1303.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

47_68

1211.0

1303.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

70_91

1211.0

1303.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

93_114

1211.0

1303.0

Repeat

Note=LRR 4

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

116_137

1207.0

1368.0

Repeat

Note=LRR 5

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

139_161

1207.0

1368.0

Repeat

Note=LRR 6

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

162_183

1207.0

1368.0

Repeat

Note=LRR 7

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

185_206

1207.0

1368.0

Repeat

Note=LRR 8

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

208_229

1207.0

1368.0

Repeat

Note=LRR 9

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

231_252

1207.0

1368.0

Repeat

Note=LRR 10

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

23_44

1207.0

1368.0

Repeat

Note=LRR 1

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

254_275

1207.0

1368.0

Repeat

Note=LRR 11

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

277_298

1207.0

1368.0

Repeat

Note=LRR 12

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

300_321

1207.0

1368.0

Repeat

Note=LRR 13

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

323_344

1207.0

1368.0

Repeat

Note=LRR 14

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

346_367

1207.0

1368.0

Repeat

Note=LRR 15

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

369_391

1207.0

1368.0

Repeat

Note=LRR 16

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

392_413

1207.0

1368.0

Repeat

Note=LRR 17

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

47_68

1207.0

1368.0

Repeat

Note=LRR 2

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

70_91

1207.0

1368.0

Repeat

Note=LRR 3

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

93_114

1207.0

1368.0

Repeat

Note=LRR 4

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

1457_1460

84.0

1542.0

Compositional bias

Note=Poly-Ser

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

199_209

84.0

1542.0

Compositional bias

Note=Poly-Ser

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

641_684

84.0

1542.0

Compositional bias

Note=Gly-rich

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

255_364

84.0

1542.0

Domain

DEUBAD

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

160_164

84.0

1542.0

Motif

Nuclear localization signal 1

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

284_288

84.0

1542.0

Motif

Note=LXXLL motif

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

409_413

84.0

1542.0

Motif

Nuclear localization signal 2

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

1503_1540

84.0

1542.0

Zinc finger

Note=PHD-type%3B atypical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000284037

1321_1410

1211.0

1413.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380935

1321_1410

1211.0

1303.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380936

1321_1410

1211.0

1341.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380938

1321_1410

1211.0

1347.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380939

1321_1410

1211.0

1361.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000380943

1321_1410

1211.0

1372.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000506030

1321_1410

1211.0

1420.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000508515

1321_1410

1211.0

1303.0

Domain

PDZ

Hgene

ERBB2IP

chr5:65350779

chr20:31015931

ENST00000511297

1321_1410

1207.0

1368.0

Domain

PDZ

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

2_9

84.0

1542.0

Compositional bias

Note=Poly-Lys

Tgene

ASXL1

chr5:65350779

chr20:31015931

ENST00000375687

11_86

84.0

1542.0

Domain

HTH HARE-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERBB2IP
ASXL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ERBB2IP-ASXL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ERBB2IP-ASXL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source