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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERBB2-TATDN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERBB2-TATDN1
FusionPDB ID: 27198
FusionGDB2.0 ID: 27198
HgeneTgene
Gene symbol

ERBB2

TATDN1

Gene ID

2064

83940

Gene nameerb-b2 receptor tyrosine kinase 2TatD DNase domain containing 1
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1CDA11
Cytomap

17q12

8q24.13

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2putative deoxyribonuclease TATDN1hepatocarcinoma high expression protein
Modification date2020032920200313
UniProtAcc

P04626

.
Ensembl transtripts involved in fusion geneENST idsENST00000269571, ENST00000406381, 
ENST00000445658, ENST00000540042, 
ENST00000540147, ENST00000541774, 
ENST00000578199, ENST00000584450, 
ENST00000584601, ENST00000584888, 
ENST00000521546, ENST00000605953, 
ENST00000276692, ENST00000517678, 
ENST00000519548, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score50 X 44 X 14=308007 X 4 X 5=140
# samples 737
** MAII scorelog2(73/30800*10)=-5.39889007670225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERBB2 [Title/Abstract] AND TATDN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERBB2(37868701)-TATDN1(125507783), # samples:2
Anticipated loss of major functional domain due to fusion event.ERBB2-TATDN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERBB2-TATDN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

HgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

HgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0035556

intracellular signal transduction

19372587

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0046777

protein autophosphorylation

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870


check buttonFusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TATDN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A2I6-01AERBB2chr17

37868701

+TATDN1chr8

125507783

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000584601ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-224218557522155467
ENST00000584601ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-223718557522155467
ENST00000584601ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-206218557522056434
ENST00000406381ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-195515685101868452
ENST00000406381ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-195015685101868452
ENST00000406381ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-177515685101769419
ENST00000541774ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-1490110301403467
ENST00000541774ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-1485110301403467
ENST00000541774ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-1310110301304434
ENST00000445658ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-97058350883277
ENST00000445658ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-96558350883277
ENST00000445658ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-79058350784244
ENST00000540147ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-17731386251686553
ENST00000540147ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-17681386251686553
ENST00000540147ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-15931386251587520
ENST00000584450ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-1750136321663553
ENST00000584450ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-1745136321663553
ENST00000584450ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-1570136321564520
ENST00000269571ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-16941307571607516
ENST00000269571ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-16891307571607516
ENST00000269571ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-15141307571508483
ENST00000578199ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-198615995411899452
ENST00000578199ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-198115995411899452
ENST00000578199ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-180615995411800419
ENST00000540042ERBB2chr1737868701+ENST00000276692TATDN1chr8125507783-161112241661524452
ENST00000540042ERBB2chr1737868701+ENST00000519548TATDN1chr8125507783-160612241661524452
ENST00000540042ERBB2chr1737868701+ENST00000517678TATDN1chr8125507783-143112241661425419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000584601ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0108687110.98913133
ENST00000584601ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0107366460.98926336
ENST00000584601ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0258165780.97418344
ENST00000406381ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0065738620.9934262
ENST00000406381ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0064579590.9935421
ENST00000406381ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0164494960.98355055
ENST00000541774ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0126943870.98730564
ENST00000541774ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0123866380.9876133
ENST00000541774ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.034709390.9652906
ENST00000445658ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0058500110.99415004
ENST00000445658ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0059110690.994089
ENST00000445658ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0454138030.95458627
ENST00000540147ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0230149940.976985
ENST00000540147ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0225518030.97744817
ENST00000540147ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0526653980.9473346
ENST00000584450ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0243920.975608
ENST00000584450ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0238349290.97616506
ENST00000584450ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0556907650.9443093
ENST00000269571ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.023995350.97600466
ENST00000269571ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0234177320.9765822
ENST00000269571ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0552878340.9447122
ENST00000578199ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0049812350.9950187
ENST00000578199ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0049443510.9950557
ENST00000578199ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0121032430.9878968
ENST00000540042ENST00000276692ERBB2chr1737868701+TATDN1chr8125507783-0.0061862350.99381375
ENST00000540042ENST00000519548ERBB2chr1737868701+TATDN1chr8125507783-0.0060715480.99392843
ENST00000540042ENST00000517678ERBB2chr1737868701+TATDN1chr8125507783-0.0169511810.9830488

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27198_27198_1_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000269571_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=516AA_BP=417
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKST

--------------------------------------------------------------

>27198_27198_2_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000269571_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=483AA_BP=417
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKST

--------------------------------------------------------------

>27198_27198_3_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000269571_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=516AA_BP=417
MRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVV
QGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLT
EILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCC
HEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAED
GTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKST

--------------------------------------------------------------

>27198_27198_4_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000406381_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_5_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000406381_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=419AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN

--------------------------------------------------------------

>27198_27198_6_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000406381_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_7_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000445658_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=277AA_BP=178
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSL
KTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTI

--------------------------------------------------------------

>27198_27198_8_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000445658_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=244AA_BP=178
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSL

--------------------------------------------------------------

>27198_27198_9_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000445658_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=277AA_BP=178
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSL
KTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTI

--------------------------------------------------------------

>27198_27198_10_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540042_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_11_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540042_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=419AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN

--------------------------------------------------------------

>27198_27198_12_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540042_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_13_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540147_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=553AA_BP=454
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANT

--------------------------------------------------------------

>27198_27198_14_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540147_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=520AA_BP=454
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE

--------------------------------------------------------------

>27198_27198_15_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000540147_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=553AA_BP=454
MRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANT

--------------------------------------------------------------

>27198_27198_16_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000541774_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=467AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLE

--------------------------------------------------------------

>27198_27198_17_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000541774_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=434AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA

--------------------------------------------------------------

>27198_27198_18_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000541774_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=467AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLE

--------------------------------------------------------------

>27198_27198_19_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000578199_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_20_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000578199_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=419AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN

--------------------------------------------------------------

>27198_27198_21_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000578199_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=452AA_BP=353
MKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSE
DCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGSLKTEAN
LEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFP

--------------------------------------------------------------

>27198_27198_22_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584450_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=553AA_BP=454
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANT

--------------------------------------------------------------

>27198_27198_23_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584450_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=520AA_BP=454
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE

--------------------------------------------------------------

>27198_27198_24_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584450_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=553AA_BP=454
LRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPRGPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPG
AASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFE
DNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMC
KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRY
TFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPE
SFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANT

--------------------------------------------------------------

>27198_27198_25_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584601_TATDN1_chr8_125507783_ENST00000276692_length(amino acids)=467AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLE

--------------------------------------------------------------

>27198_27198_26_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584601_TATDN1_chr8_125507783_ENST00000517678_length(amino acids)=434AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA

--------------------------------------------------------------

>27198_27198_27_ERBB2-TATDN1_ERBB2_chr17_37868701_ENST00000584601_TATDN1_chr8_125507783_ENST00000519548_length(amino acids)=467AA_BP=368
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37868701/chr8:125507783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

P04626

.
FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+927720_987382.66666666666671256.0DomainProtein kinase
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+927720_987367.66666666666671241.0DomainProtein kinase
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+927676_689382.66666666666671256.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+927676_689367.66666666666671241.0MotifNote=Nuclear localization signal
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+927726_734382.66666666666671256.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+927726_734367.66666666666671241.0Nucleotide bindingATP
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+92723_652382.66666666666671256.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+927676_1255382.66666666666671256.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+92723_652367.66666666666671241.0Topological domainExtracellular
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+927676_1255367.66666666666671241.0Topological domainCytoplasmic
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+927653_675382.66666666666671256.0TransmembraneHelical
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+927653_675367.66666666666671241.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERBB2
TATDN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneERBB2chr17:37868701chr8:125507783ENST00000269571+9271195_1197382.66666666666671256.0PIK3C2B
HgeneERBB2chr17:37868701chr8:125507783ENST00000541774+9271195_1197367.66666666666671241.0PIK3C2B


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Related Drugs to ERBB2-TATDN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERBB2-TATDN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource