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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERC1-RET

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERC1-RET
	FusionPDB ID: 27278
	FusionGDB2.0 ID: 27278
		Hgene	Tgene
	Gene symbol	ERC1	RET
	Gene ID	23085	5979
	Gene name	ELKS/RAB6-interacting/CAST family member 1	ret proto-oncogene
	Synonyms	Cast2\|ELKS\|ERC-1\|RAB6IP2	CDHF12\|CDHR16\|HSCR1\|MEN2A\|MEN2B\|MTC1\|PTC\|RET-ELE1
	Cytomap	12p13.33	10q11.21
	Type of gene	protein-coding	protein-coding
	Description	ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2	proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
	Modification date	20200313	20200322
	UniProtAcc	Q8IUD2	RTL1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000536573, ENST00000355446, ENST00000360905, ENST00000397203, ENST00000543086, ENST00000546231, ENST00000589028,	ENST00000340058, ENST00000355710,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	32 X 23 X 16=11776	32 X 31 X 11=10912
	# samples	38	48
	** MAII score	log2(38/11776*10)=-4.95370634772607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/10912*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERC1 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERC1(1250953)-RET(43612032), # samples:3 ERC1(1346070)-RET(43612032), # samples:3 ERC1(1553916)-RET(43612032), # samples:3
Anticipated loss of major functional domain due to fusion event.	ERC1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERC1	GO:0007252	I-kappaB phosphorylation	15218148
Tgene	RET	GO:0030155	regulation of cell adhesion	21357690
Tgene	RET	GO:0030335	positive regulation of cell migration	20702524
Tgene	RET	GO:0033619	membrane protein proteolysis	21357690
Tgene	RET	GO:0033630	positive regulation of cell adhesion mediated by integrin	20702524
Tgene	RET	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	28953886
Tgene	RET	GO:0043410	positive regulation of MAPK cascade	28846099

Fusion gene breakpoints across ERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-C8-A1HJ-01A	ERC1	chr12	1250952	+	RET	chr10	43612031	+
ChimerDB4	BRCA	TCGA-C8-A1HJ-01A	ERC1	chr12	1250953	-	RET	chr10	43612032	+
ChimerDB4	BRCA	TCGA-C8-A1HJ-01A	ERC1	chr12	1250953	+	RET	chr10	43612032	+
ChimerDB4	BRCA	TCGA-C8-A1HJ	ERC1	chr12	1250953	+	RET	chr10	43612031	+
ChimerDB4	THCA	TCGA-EL-A3T9-01A	ERC1	chr12	1346070	-	RET	chr10	43612032	+
ChimerDB4	THCA	TCGA-EL-A3T9-01A	ERC1	chr12	1346070	+	RET	chr10	43612032	+
ChimerDB4	THCA	TCGA-EM-A3FQ-01A	ERC1	chr12	1553916	-	RET	chr10	43612032	+
ChimerDB4	THCA	TCGA-EM-A3FQ-01A	ERC1	chr12	1553916	+	RET	chr10	43612032	+
ChimerKB3	.	.	ERC1	chr12	1250953	+	RET	chr10	43612031	+
ChimerKB3	.	.	ERC1	chr12	1292587	+	RET	chr10	43612031	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000543086	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5215	1924	271	3132	953
ENST00000543086	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3757	1924	271	3006	911
ENST00000546231	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5556	2265	528	3473	981
ENST00000546231	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	4098	2265	528	3347	939
ENST00000397203	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5434	2143	406	3351	981
ENST00000397203	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3976	2143	406	3225	939
ENST00000360905	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5209	1918	181	3126	981
ENST00000360905	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3751	1918	181	3000	939
ENST00000589028	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5185	1894	157	3102	981
ENST00000589028	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3727	1894	157	2976	939
ENST00000355446	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5160	1869	132	3077	981
ENST00000355446	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3702	1869	132	2951	939
ENST00000543086	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5635	2344	271	3552	1093
ENST00000543086	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4177	2344	271	3426	1051
ENST00000546231	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5976	2685	528	3893	1121
ENST00000546231	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4518	2685	528	3767	1079
ENST00000397203	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5854	2563	406	3771	1121
ENST00000397203	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4396	2563	406	3645	1079
ENST00000360905	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5629	2338	181	3546	1121
ENST00000360905	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4171	2338	181	3420	1079
ENST00000589028	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5605	2314	157	3522	1121
ENST00000589028	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4147	2314	157	3396	1079
ENST00000355446	ERC1	chr12	1292587	+	ENST00000355710	RET	chr10	43612031	+	5580	2289	132	3497	1121
ENST00000355446	ERC1	chr12	1292587	+	ENST00000340058	RET	chr10	43612031	+	4122	2289	132	3371	1079
ENST00000543086	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5215	1924	271	3132	953
ENST00000543086	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	3757	1924	271	3006	911
ENST00000546231	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5556	2265	528	3473	981
ENST00000546231	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	4098	2265	528	3347	939
ENST00000397203	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5434	2143	406	3351	981
ENST00000397203	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	3976	2143	406	3225	939
ENST00000360905	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5209	1918	181	3126	981
ENST00000360905	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	3751	1918	181	3000	939
ENST00000589028	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5185	1894	157	3102	981
ENST00000589028	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	3727	1894	157	2976	939
ENST00000355446	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612032	+	5160	1869	132	3077	981
ENST00000355446	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612032	+	3702	1869	132	2951	939
ENST00000543086	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	5965	2674	271	3882	1203
ENST00000543086	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4507	2674	271	3756	1161
ENST00000546231	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	6318	3027	528	4235	1235
ENST00000546231	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4860	3027	528	4109	1193
ENST00000397203	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	6184	2893	406	4101	1231
ENST00000397203	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4726	2893	406	3975	1189
ENST00000360905	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	5959	2668	181	3876	1231
ENST00000360905	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4501	2668	181	3750	1189
ENST00000589028	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	5935	2644	157	3852	1231
ENST00000589028	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4477	2644	157	3726	1189
ENST00000355446	ERC1	chr12	1346070	+	ENST00000355710	RET	chr10	43612032	+	5910	2619	132	3827	1231
ENST00000355446	ERC1	chr12	1346070	+	ENST00000340058	RET	chr10	43612032	+	4452	2619	132	3701	1189
ENST00000543086	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	6691	3400	271	4608	1445
ENST00000543086	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5233	3400	271	4482	1403
ENST00000546231	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	7044	3753	528	4961	1477
ENST00000546231	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5586	3753	528	4835	1435
ENST00000397203	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	6910	3619	406	4827	1473
ENST00000397203	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5452	3619	406	4701	1431
ENST00000360905	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	6685	3394	181	4602	1473
ENST00000360905	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5227	3394	181	4476	1431
ENST00000589028	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	6661	3370	157	4578	1473
ENST00000589028	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5203	3370	157	4452	1431
ENST00000355446	ERC1	chr12	1553916	+	ENST00000355710	RET	chr10	43612032	+	6636	3345	132	4553	1473
ENST00000355446	ERC1	chr12	1553916	+	ENST00000340058	RET	chr10	43612032	+	5178	3345	132	4427	1431
ENST00000543086	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5215	1924	271	3132	953
ENST00000543086	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3757	1924	271	3006	911
ENST00000546231	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5556	2265	528	3473	981
ENST00000546231	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	4098	2265	528	3347	939
ENST00000397203	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5434	2143	406	3351	981
ENST00000397203	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3976	2143	406	3225	939
ENST00000360905	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5209	1918	181	3126	981
ENST00000360905	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3751	1918	181	3000	939
ENST00000589028	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5185	1894	157	3102	981
ENST00000589028	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3727	1894	157	2976	939
ENST00000355446	ERC1	chr12	1250953	+	ENST00000355710	RET	chr10	43612031	+	5160	1869	132	3077	981
ENST00000355446	ERC1	chr12	1250953	+	ENST00000340058	RET	chr10	43612031	+	3702	1869	132	2951	939
ENST00000543086	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5215	1924	271	3132	953
ENST00000543086	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	3757	1924	271	3006	911
ENST00000546231	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5556	2265	528	3473	981
ENST00000546231	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	4098	2265	528	3347	939
ENST00000397203	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5434	2143	406	3351	981
ENST00000397203	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	3976	2143	406	3225	939
ENST00000360905	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5209	1918	181	3126	981
ENST00000360905	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	3751	1918	181	3000	939
ENST00000589028	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5185	1894	157	3102	981
ENST00000589028	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	3727	1894	157	2976	939
ENST00000355446	ERC1	chr12	1250952	+	ENST00000355710	RET	chr10	43612031	+	5160	1869	132	3077	981
ENST00000355446	ERC1	chr12	1250952	+	ENST00000340058	RET	chr10	43612031	+	3702	1869	132	2951	939

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543086	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000346184	0.9996538
ENST00000543086	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002294075	0.99770594
ENST00000546231	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000594528	0.9994055
ENST00000546231	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002151648	0.9978484
ENST00000397203	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000510047	0.9994899
ENST00000397203	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002196619	0.9978034
ENST00000360905	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000395236	0.99960476
ENST00000360905	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002273857	0.99772614
ENST00000589028	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000363263	0.99963677
ENST00000589028	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002044815	0.9979552
ENST00000355446	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.000377299	0.9996227
ENST00000355446	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612032	+	0.002159429	0.9978405
ENST00000543086	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.001568467	0.9984315
ENST00000543086	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.004722828	0.99527717
ENST00000546231	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.002257856	0.9977422
ENST00000546231	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.006630394	0.9933696
ENST00000397203	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.001199462	0.9988005
ENST00000397203	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.005690092	0.9943099
ENST00000360905	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.00097826	0.99902177
ENST00000360905	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.004837961	0.99516207
ENST00000589028	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.000888719	0.99911124
ENST00000589028	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.004431854	0.9955681
ENST00000355446	ENST00000355710	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.000899937	0.9991001
ENST00000355446	ENST00000340058	ERC1	chr12	1346070	+	RET	chr10	43612032	+	0.004513457	0.99548656
ENST00000543086	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.001904439	0.9980956
ENST00000543086	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.00463742	0.9953625
ENST00000546231	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.002001273	0.99799865
ENST00000546231	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.004994776	0.9950052
ENST00000397203	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.002219528	0.9977805
ENST00000397203	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.00628728	0.9937127
ENST00000360905	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.001858093	0.9981419
ENST00000360905	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.005681251	0.9943188
ENST00000589028	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.001718538	0.9982815
ENST00000589028	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.005238994	0.99476105
ENST00000355446	ENST00000355710	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.001729428	0.9982705
ENST00000355446	ENST00000340058	ERC1	chr12	1553916	+	RET	chr10	43612032	+	0.00533858	0.9946614
ENST00000543086	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000346184	0.9996538
ENST00000543086	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002294075	0.99770594
ENST00000546231	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000594528	0.9994055
ENST00000546231	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002151648	0.9978484
ENST00000397203	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000510047	0.9994899
ENST00000397203	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002196619	0.9978034
ENST00000360905	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000395236	0.99960476
ENST00000360905	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002273857	0.99772614
ENST00000589028	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000363263	0.99963677
ENST00000589028	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002044815	0.9979552
ENST00000355446	ENST00000355710	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.000377299	0.9996227
ENST00000355446	ENST00000340058	ERC1	chr12	1250953	+	RET	chr10	43612031	+	0.002159429	0.9978405
ENST00000543086	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000346184	0.9996538
ENST00000543086	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002294075	0.99770594
ENST00000546231	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000594528	0.9994055
ENST00000546231	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002151648	0.9978484
ENST00000397203	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000510047	0.9994899
ENST00000397203	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002196619	0.9978034
ENST00000360905	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000395236	0.99960476
ENST00000360905	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002273857	0.99772614
ENST00000589028	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000363263	0.99963677
ENST00000589028	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002044815	0.9979552
ENST00000355446	ENST00000355710	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.000377299	0.9996227
ENST00000355446	ENST00000340058	ERC1	chr12	1250952	+	RET	chr10	43612031	+	0.002159429	0.9978405

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27278_27278_1_ERC1-RET_ERC1_chr12_1250952_ENST00000355446_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_2_ERC1-RET_ERC1_chr12_1250952_ENST00000355446_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_3_ERC1-RET_ERC1_chr12_1250952_ENST00000360905_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_4_ERC1-RET_ERC1_chr12_1250952_ENST00000360905_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_5_ERC1-RET_ERC1_chr12_1250952_ENST00000397203_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_6_ERC1-RET_ERC1_chr12_1250952_ENST00000397203_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_7_ERC1-RET_ERC1_chr12_1250952_ENST00000543086_RET_chr10_43612031_ENST00000340058_length(amino acids)=911AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_8_ERC1-RET_ERC1_chr12_1250952_ENST00000543086_RET_chr10_43612031_ENST00000355710_length(amino acids)=953AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_9_ERC1-RET_ERC1_chr12_1250952_ENST00000546231_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_10_ERC1-RET_ERC1_chr12_1250952_ENST00000546231_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_11_ERC1-RET_ERC1_chr12_1250952_ENST00000589028_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_12_ERC1-RET_ERC1_chr12_1250952_ENST00000589028_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_13_ERC1-RET_ERC1_chr12_1250953_ENST00000355446_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_14_ERC1-RET_ERC1_chr12_1250953_ENST00000355446_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_15_ERC1-RET_ERC1_chr12_1250953_ENST00000355446_RET_chr10_43612032_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_16_ERC1-RET_ERC1_chr12_1250953_ENST00000355446_RET_chr10_43612032_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_17_ERC1-RET_ERC1_chr12_1250953_ENST00000360905_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_18_ERC1-RET_ERC1_chr12_1250953_ENST00000360905_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_19_ERC1-RET_ERC1_chr12_1250953_ENST00000360905_RET_chr10_43612032_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_20_ERC1-RET_ERC1_chr12_1250953_ENST00000360905_RET_chr10_43612032_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_21_ERC1-RET_ERC1_chr12_1250953_ENST00000397203_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_22_ERC1-RET_ERC1_chr12_1250953_ENST00000397203_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_23_ERC1-RET_ERC1_chr12_1250953_ENST00000397203_RET_chr10_43612032_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_24_ERC1-RET_ERC1_chr12_1250953_ENST00000397203_RET_chr10_43612032_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_25_ERC1-RET_ERC1_chr12_1250953_ENST00000543086_RET_chr10_43612031_ENST00000340058_length(amino acids)=911AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_26_ERC1-RET_ERC1_chr12_1250953_ENST00000543086_RET_chr10_43612031_ENST00000355710_length(amino acids)=953AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_27_ERC1-RET_ERC1_chr12_1250953_ENST00000543086_RET_chr10_43612032_ENST00000340058_length(amino acids)=911AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_28_ERC1-RET_ERC1_chr12_1250953_ENST00000543086_RET_chr10_43612032_ENST00000355710_length(amino acids)=953AA_BP=551
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLY
GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL
VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL

--------------------------------------------------------------

>27278_27278_29_ERC1-RET_ERC1_chr12_1250953_ENST00000546231_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_30_ERC1-RET_ERC1_chr12_1250953_ENST00000546231_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_31_ERC1-RET_ERC1_chr12_1250953_ENST00000546231_RET_chr10_43612032_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_32_ERC1-RET_ERC1_chr12_1250953_ENST00000546231_RET_chr10_43612032_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_33_ERC1-RET_ERC1_chr12_1250953_ENST00000589028_RET_chr10_43612031_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_34_ERC1-RET_ERC1_chr12_1250953_ENST00000589028_RET_chr10_43612031_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_35_ERC1-RET_ERC1_chr12_1250953_ENST00000589028_RET_chr10_43612032_ENST00000340058_length(amino acids)=939AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_36_ERC1-RET_ERC1_chr12_1250953_ENST00000589028_RET_chr10_43612032_ENST00000355710_length(amino acids)=981AA_BP=579
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE
IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL

--------------------------------------------------------------

>27278_27278_37_ERC1-RET_ERC1_chr12_1292587_ENST00000355446_RET_chr10_43612031_ENST00000340058_length(amino acids)=1079AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL

--------------------------------------------------------------

>27278_27278_38_ERC1-RET_ERC1_chr12_1292587_ENST00000355446_RET_chr10_43612031_ENST00000355710_length(amino acids)=1121AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL
MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGES

--------------------------------------------------------------

>27278_27278_39_ERC1-RET_ERC1_chr12_1292587_ENST00000360905_RET_chr10_43612031_ENST00000340058_length(amino acids)=1079AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL

--------------------------------------------------------------

>27278_27278_40_ERC1-RET_ERC1_chr12_1292587_ENST00000360905_RET_chr10_43612031_ENST00000355710_length(amino acids)=1121AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL
MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGES

--------------------------------------------------------------

>27278_27278_41_ERC1-RET_ERC1_chr12_1292587_ENST00000397203_RET_chr10_43612031_ENST00000340058_length(amino acids)=1079AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL

--------------------------------------------------------------

>27278_27278_42_ERC1-RET_ERC1_chr12_1292587_ENST00000397203_RET_chr10_43612031_ENST00000355710_length(amino acids)=1121AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL
MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGES

--------------------------------------------------------------

>27278_27278_43_ERC1-RET_ERC1_chr12_1292587_ENST00000543086_RET_chr10_43612031_ENST00000340058_length(amino acids)=1051AA_BP=691
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKA
TAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGG
SRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE
SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK

--------------------------------------------------------------

>27278_27278_44_ERC1-RET_ERC1_chr12_1292587_ENST00000543086_RET_chr10_43612031_ENST00000355710_length(amino acids)=1093AA_BP=691
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKA
TAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGG
SRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE
SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWML

--------------------------------------------------------------

>27278_27278_45_ERC1-RET_ERC1_chr12_1292587_ENST00000546231_RET_chr10_43612031_ENST00000340058_length(amino acids)=1079AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL

--------------------------------------------------------------

>27278_27278_46_ERC1-RET_ERC1_chr12_1292587_ENST00000546231_RET_chr10_43612031_ENST00000355710_length(amino acids)=1121AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL
MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGES

--------------------------------------------------------------

>27278_27278_47_ERC1-RET_ERC1_chr12_1292587_ENST00000589028_RET_chr10_43612031_ENST00000340058_length(amino acids)=1079AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL

--------------------------------------------------------------

>27278_27278_48_ERC1-RET_ERC1_chr12_1292587_ENST00000589028_RET_chr10_43612031_ENST00000355710_length(amino acids)=1121AA_BP=719
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKE
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF
GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL
MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGES

--------------------------------------------------------------

>27278_27278_49_ERC1-RET_ERC1_chr12_1346070_ENST00000355446_RET_chr10_43612032_ENST00000340058_length(amino acids)=1189AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_50_ERC1-RET_ERC1_chr12_1346070_ENST00000355446_RET_chr10_43612032_ENST00000355710_length(amino acids)=1231AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_51_ERC1-RET_ERC1_chr12_1346070_ENST00000360905_RET_chr10_43612032_ENST00000340058_length(amino acids)=1189AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_52_ERC1-RET_ERC1_chr12_1346070_ENST00000360905_RET_chr10_43612032_ENST00000355710_length(amino acids)=1231AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_53_ERC1-RET_ERC1_chr12_1346070_ENST00000397203_RET_chr10_43612032_ENST00000340058_length(amino acids)=1189AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_54_ERC1-RET_ERC1_chr12_1346070_ENST00000397203_RET_chr10_43612032_ENST00000355710_length(amino acids)=1231AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_55_ERC1-RET_ERC1_chr12_1346070_ENST00000543086_RET_chr10_43612032_ENST00000340058_length(amino acids)=1161AA_BP=801
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE

--------------------------------------------------------------

>27278_27278_56_ERC1-RET_ERC1_chr12_1346070_ENST00000543086_RET_chr10_43612032_ENST00000355710_length(amino acids)=1203AA_BP=801
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE
PDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRAD

--------------------------------------------------------------

>27278_27278_57_ERC1-RET_ERC1_chr12_1346070_ENST00000546231_RET_chr10_43612032_ENST00000340058_length(amino acids)=1193AA_BP=833
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL
KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK
LVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLP

--------------------------------------------------------------

>27278_27278_58_ERC1-RET_ERC1_chr12_1346070_ENST00000546231_RET_chr10_43612032_ENST00000355710_length(amino acids)=1235AA_BP=833
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL
KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK
LVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLP

--------------------------------------------------------------

>27278_27278_59_ERC1-RET_ERC1_chr12_1346070_ENST00000589028_RET_chr10_43612032_ENST00000340058_length(amino acids)=1189AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_60_ERC1-RET_ERC1_chr12_1346070_ENST00000589028_RET_chr10_43612032_ENST00000355710_length(amino acids)=1231AA_BP=829
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN
HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR
DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL
LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP

--------------------------------------------------------------

>27278_27278_61_ERC1-RET_ERC1_chr12_1553916_ENST00000355446_RET_chr10_43612032_ENST00000340058_length(amino acids)=1431AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE

--------------------------------------------------------------

>27278_27278_62_ERC1-RET_ERC1_chr12_1553916_ENST00000355446_RET_chr10_43612032_ENST00000355710_length(amino acids)=1473AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE
PDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRAD

--------------------------------------------------------------

>27278_27278_63_ERC1-RET_ERC1_chr12_1553916_ENST00000360905_RET_chr10_43612032_ENST00000340058_length(amino acids)=1431AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE

--------------------------------------------------------------

>27278_27278_64_ERC1-RET_ERC1_chr12_1553916_ENST00000360905_RET_chr10_43612032_ENST00000355710_length(amino acids)=1473AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE
PDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRAD

--------------------------------------------------------------

>27278_27278_65_ERC1-RET_ERC1_chr12_1553916_ENST00000397203_RET_chr10_43612032_ENST00000340058_length(amino acids)=1431AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE

--------------------------------------------------------------

>27278_27278_66_ERC1-RET_ERC1_chr12_1553916_ENST00000397203_RET_chr10_43612032_ENST00000355710_length(amino acids)=1473AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE
PDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRAD

--------------------------------------------------------------

>27278_27278_67_ERC1-RET_ERC1_chr12_1553916_ENST00000543086_RET_chr10_43612032_ENST00000340058_length(amino acids)=1403AA_BP=1043
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR
IEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ
EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQ
NRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGR
AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLD
HPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYT
TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLA

--------------------------------------------------------------

>27278_27278_68_ERC1-RET_ERC1_chr12_1553916_ENST00000543086_RET_chr10_43612032_ENST00000355710_length(amino acids)=1445AA_BP=1043
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR
IEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ
EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQ
NRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGR
AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLD
HPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYT
TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLA
ASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLM

--------------------------------------------------------------

>27278_27278_69_ERC1-RET_ERC1_chr12_1553916_ENST00000546231_RET_chr10_43612032_ENST00000340058_length(amino acids)=1435AA_BP=1075
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS
STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN
YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC

--------------------------------------------------------------

>27278_27278_70_ERC1-RET_ERC1_chr12_1553916_ENST00000546231_RET_chr10_43612032_ENST00000355710_length(amino acids)=1477AA_BP=1075
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS
STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADN
YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKW
EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR
DVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC
WKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPL

--------------------------------------------------------------

>27278_27278_71_ERC1-RET_ERC1_chr12_1553916_ENST00000589028_RET_chr10_43612032_ENST00000340058_length(amino acids)=1431AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE

--------------------------------------------------------------

>27278_27278_72_ERC1-RET_ERC1_chr12_1553916_ENST00000589028_RET_chr10_43612032_ENST00000355710_length(amino acids)=1473AA_BP=1071
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD
HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE
EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE
PDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRAD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1250953/chr10:43612032)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERC1 Q8IUD2	RET RTL1
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269\|PubMed:15218148}.	1358

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000360905

144_988

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000397203

144_988

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000543086

144_988

1043.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000589028

144_988

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

724_1016

712.0

1073.0

Domain

Protein kinase

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

724_1016

712.0

1115.0

Domain

Protein kinase

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

730_738

712.0

1073.0

Nucleotide binding

ATP

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

730_738

712.0

1115.0

Nucleotide binding

ATP

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

805_807

712.0

1073.0

Region

Note=Inhibitors binding

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

805_807

712.0

1115.0

Region

Note=Inhibitors binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000360905

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000360905

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000397203

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000397203

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000543086

1060_1100

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000543086

144_988

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000589028

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000589028

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000360905

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000360905

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000397203

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000397203

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000543086

1060_1100

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000543086

144_988

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000589028

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000589028

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000360905

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000360905

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000397203

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000397203

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000543086

1060_1100

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000543086

144_988

551.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000589028

1060_1100

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000589028

144_988

579.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000360905

1060_1100

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000360905

144_988

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000397203

1060_1100

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000397203

144_988

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000543086

1060_1100

801.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000543086

144_988

801.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000589028

1060_1100

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000589028

144_988

829.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000360905

1060_1100

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000397203

1060_1100

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000543086

1060_1100

1043.0

1089.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000589028

1060_1100

1071.0

1117.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000360905

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000397203

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000543086

1046_1108

551.0

1089.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250952

chr10:43612031

ENST00000589028

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000360905

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000397203

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000543086

1046_1108

551.0

1089.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612031

ENST00000589028

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000360905

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000397203

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000543086

1046_1108

551.0

1089.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1250953

chr10:43612032

ENST00000589028

1046_1108

579.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000360905

1046_1108

829.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000397203

1046_1108

829.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000543086

1046_1108

801.0

1089.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1346070

chr10:43612032

ENST00000589028

1046_1108

829.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000360905

1046_1108

1071.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000397203

1046_1108

1071.0

1117.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000543086

1046_1108

1043.0

1089.0

Domain

FIP-RBD

Hgene

ERC1

chr12:1553916

chr10:43612032

ENST00000589028

1046_1108

1071.0

1117.0

Domain

FIP-RBD

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

168_272

712.0

1073.0

Domain

Cadherin

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

168_272

712.0

1115.0

Domain

Cadherin

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

29_635

712.0

1073.0

Topological domain

Extracellular

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

658_1114

712.0

1073.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

29_635

712.0

1115.0

Topological domain

Extracellular

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

658_1114

712.0

1115.0

Topological domain

Cytoplasmic

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr12:1250952

chr10:43612031

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr12:1250953

chr10:43612031

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr12:1250953

chr10:43612032

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr12:1346070

chr10:43612032

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000340058

636_657

712.0

1073.0

Transmembrane

Helical

Tgene

RET

chr12:1553916

chr10:43612032

ENST00000355710

636_657

712.0

1115.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (708) >>>708.pdbFusion protein BP residue: 551 CIF file (708) >>>708.cif	ERC1	chr12	1250953	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK KEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL	911
3D view using mol* of 708 (AA BP:551)


PDB file (722) >>>722.pdbFusion protein BP residue: 579 CIF file (722) >>>722.cif	ERC1	chr12	1250953	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE EKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEG EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA EGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL	939
3D view using mol* of 722 (AA BP:579)


PDB file (728) >>>728.pdbFusion protein BP residue: 551 CIF file (728) >>>728.cif	ERC1	chr12	1250953	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK KEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL YGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDT	953
3D view using mol* of 728 (AA BP:551)


PDB file (746) >>>746.pdbFusion protein BP residue: 579 CIF file (746) >>>746.cif	ERC1	chr12	1250953	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE EKGTQAGEIHDLKDMLDVKERKVNVLQKKEDPKWEFPRKNLVLGKTLGEG EFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA EGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSD VWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL MLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGL SEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGT	981
3D view using mol* of 746 (AA BP:579)


PDB file (776) >>>776.pdbFusion protein BP residue: 691 CIF file (776) >>>776.cif	ERC1	chr12	1292587	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKEDPKWEFPR KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTR	1051
3D view using mol* of 776 (AA BP:691)


PDB file (792) >>>792.pdbFusion protein BP residue: 719 CIF file (792) >>>792.cif	ERC1	chr12	1292587	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLE IALEQKKEECLKMESQLKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATA FHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGA CSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD KRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDC	1079
3D view using mol* of 792 (AA BP:719)


PDB file (799) >>>799.pdbFusion protein BP residue: 691 CIF file (799) >>>799.cif	ERC1	chr12	1292587	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKEDPKWEFPR KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPG	1093
3D view using mol* of 799 (AA BP:691)


PDB file (812) >>>812.pdbFusion protein BP residue: 719 CIF file (812) >>>812.cif	ERC1	chr12	1292587	+	RET	chr10	43612031	+	MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGS GKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPY GVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNT IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLE IALEQKKEECLKMESQLKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATA FHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGA CSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD KRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDC NNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPND	1121
3D view using mol* of 812 (AA BP:719)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ERC1_pLDDT.png

RET_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ERC1_RET_708_pLDDT.png (AA BP:551)

ERC1_RET_708_pLDDT_and_active_sites.png (AA BP:551)

ERC1_RET_708_violinplot.png (AA BP:551)

ERC1_RET_722_pLDDT.png (AA BP:579)

ERC1_RET_722_pLDDT_and_active_sites.png (AA BP:579)

ERC1_RET_722_violinplot.png (AA BP:579)

ERC1_RET_728_pLDDT.png (AA BP:551)

ERC1_RET_728_pLDDT_and_active_sites.png (AA BP:551)

ERC1_RET_728_violinplot.png (AA BP:551)

ERC1_RET_746_pLDDT.png (AA BP:579)

ERC1_RET_746_pLDDT_and_active_sites.png (AA BP:579)

ERC1_RET_746_violinplot.png (AA BP:579)

ERC1_RET_776_pLDDT.png (AA BP:691)

ERC1_RET_776_pLDDT_and_active_sites.png (AA BP:691)

ERC1_RET_776_violinplot.png (AA BP:691)

ERC1_RET_792_pLDDT.png (AA BP:719)

ERC1_RET_792_pLDDT_and_active_sites.png (AA BP:719)

ERC1_RET_792_violinplot.png (AA BP:719)

ERC1_RET_799_pLDDT.png (AA BP:691)

ERC1_RET_799_pLDDT_and_active_sites.png (AA BP:691)

ERC1_RET_799_violinplot.png (AA BP:691)

ERC1_RET_812_pLDDT.png (AA BP:719)

ERC1_RET_812_pLDDT_and_active_sites.png (AA BP:719)

ERC1_RET_812_violinplot.png (AA BP:719)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

ERC1_RET_708.png

ERC1_RET_722.png

ERC1_RET_728.png

ERC1_RET_746.png

ERC1_RET_776.png

ERC1_RET_799.png

ERC1_RET_812.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
708	1.059	199	1.079	478.828	0.511	0.773	1.027	0.885	0.997	0.888	1.101	Chain A: 573,574,575,597,598,599,606,607,609,610,6 11,614,711,712,713,717,718,731,732,733,734,735,736 ,743,744,745,746,748,750,751,752,753,757,765,767
722	1.074	206	1.112	557.375	0.513	0.758	1.008	1.075	0.867	1.24	0.823	Chain A: 597,598,599,600,601,602,603,605,623,625,6 28,631,632,634,635,638,642,646,655,669,671,672,673 ,674,675,677,678,740,741,745,746,748,758,759,762,7 64,772,774,775,776,778,779,780,781,785,795
728	1.036	434	1.064	1073.933	0.516	0.731	0.95	0.881	0.966	0.912	0.85	Chain A: 569,570,571,572,573,574,575,577,595,597,5 98,599,604,606,607,609,610,611,613,614,616,617,618 ,620,627,641,643,644,645,646,647,649,650,707,709,7 11,712,713,714,717,718,720,730,731,732,733,734,735 ,736,737,740,742,743,744,745,746,747,748,749,750,7 51,752,753,754,756,757,761,762,765,767,775,800
746	1.105	205	1.204	646.212	0.543	0.685	0.914	1.952	0.452	4.315	1.194	Chain A: 260,262,263,266,267,269,270,271,273,274,2 77,278,280,281,284,285,287,288,290,291,292,294,295 ,521,524,527,528,530,531,534,535,537,538,541,544,5 45,548
776	0.9954	533	1.02	1412.131	0.5977	0.682	0.8799	0.7125	1.0097	0.7056	0.9723	Chain A: 685,686,688,689,690,691,692,693,697,709,7 10,712,713,714,715,716,717,735,737,739,740,741,743 ,744,746,747,748,749,750,751,752,753,754,755,756,7 57,758,759,760,767,772,774,775,776,777,778,779,781 ,783,784,785,786,787,789,790,792,847,848,849,850,8 51,852,853,857,858,860,870,871,872,873,874,875,876 ,877,878,879,880,881,882,883,884,885,886,887,888,8 89,890,891,892,893,894,895,896,905,906,907,908,922 ,928,929,930,936
792	1.008	575	1.029	1376.802	0.523	0.707	0.917	0.671	1.029	0.652	0.976	Chain A: 713,714,717,718,719,720,721,725,737,738,7 40,741,742,743,745,763,765,773,774,775,776,777,778 ,779,780,781,782,783,784,785,787,788,795,802,807,8 11,812,813,814,815,817,818,875,877,878,880,881,885 ,886,888,898,899,901,902,903,904,905,906,908,909,9 10,911,912,913,914,915,916,917,918,919,920,921,922 ,923,924,925,930,933,935,936,964
799	1.0877	268	1.1366	717.556	0.5298	0.757	0.9921	1.3282	0.7903	1.6806	1.001	Chain A: 707,709,710,711,712,713,714,715,716,717,7 35,737,739,747,750,751,754,758,767,781,783,784,785 ,786,787,789,851,852,853,857,858,860,870,871,872,8 73,874,875,876,884,885,886,891,892,893,894,895,896 ,897,898,901,902,905,907,911,915,936,940
812	1.0794	148	1.138	376.614	0.5241	0.7281	0.9278	1.5076	0.7328	2.0574	0.9246	Chain A: 737,738,739,740,741,742,743,744,745,763,7 65,782,786,795,809,811,812,813,814,815,816,817,818 ,821,885,886,888,898,899,919,920,921

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
812	ZINC000001530886	DB00966	Telmisartan	-5.52685	-7.68365
812	ZINC000085537017	DB06441	Cangrelor	-5.38858	-7.61488
812	ZINC000013537284	DB00969	Alosetron	-6.49113	-7.39443
812	ZINC000058581064	DB08930	Dolutegravir	-6.99252	-7.27972
812	ZINC000000003876	DB00425	Zolpidem	-6.76782	-7.25452
812	ZINC000000000850	DB00744	Zileuton	-6.99322	-7.01182
812	ZINC000000897089	DB00358	Mefloquine	-6.97579	-6.97829
812	ZINC000000968310	DB00370	Mirtazapine	-6.88015	-6.96825
812	ZINC000000000655	DB01058	Praziquantel	-6.92439	-6.92439
812	ZINC000003874185	DB00358	Mefloquine	-6.91594	-6.91844
812	ZINC000085537014	DB09065	Cobicistat	-6.56496	-6.87656
812	ZINC000150338819	DB09027	Ledipasvir	-6.07835	-6.83615
812	ZINC000022448696	DB00224	Indinavir	-6.44095	-6.83175
812	ZINC000003795819	DB00377	Palonosetron	-6.82536	-6.82606
812	ZINC000004214955	DB06769	Bendamustine	-6.38142	-6.82532
812	ZINC000001530973	DB00639	Butoconazole	-6.43572	-6.81442
812	ZINC000095626706	DB00683	Midazolam	-6.06381	-6.77711
812	ZINC000148723177	DB12267	Brigatinib	-4.51994	-6.76744
812	ZINC000000004448	DB00904	Ondansetron	-5.74788	-6.73108
812	ZINC000034051848	DB09068	Vortioxetine	-6.70654	-6.71304

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000001530886	DB00966	Telmisartan	Small molecule	CCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=O	Approved\|Investigational
ZINC000085537017	DB06441	Cangrelor	Small molecule	CSCCNC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC(F)(F)F)=N1	Approved
ZINC000013537284	DB00969	Alosetron	Small molecule	CN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2	Approved\|Withdrawn
ZINC000058581064	DB08930	Dolutegravir	Small molecule	[H][C@]12CN3C=C(C(=O)NCC4=CC=C(F)C=C4F)C(=O)C(O)=C3C(=O)N1[C@H](C)CCO2	Approved
ZINC000000003876	DB00425	Zolpidem	Small molecule	CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1	Approved
ZINC000085537014	DB09065	Cobicistat	Small molecule	CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1	Approved
ZINC000150338819	DB09027	Ledipasvir	Small molecule	COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1C1=NC(=CN1)C1=CC=C2C3=CC=C(C=C3C(F)(F)C2=C1)C1=CC=C2NC(=NC2=C1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)C	Approved
ZINC000022448696	DB00224	Indinavir	Small molecule	CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[C@H](O)CC2=CC=CC=C12	Approved
ZINC000003795819	DB00377	Palonosetron	Small molecule	[H][C@]12CCCC3=C1C(=CC=C3)C(=O)N(C2)[C@@H]1CN2CCC1CC2	Approved\|Investigational
ZINC000004214955	DB06769	Bendamustine	Small molecule	CN1C(CCCC(O)=O)=NC2=CC(=CC=C12)N(CCCl)CCCl	Approved\|Investigational
ZINC000001530973	DB00639	Butoconazole	Small molecule	ClC1=CC=C(CCC(CN2C=CN=C2)SC2=C(Cl)C=CC=C2Cl)C=C1	Approved
ZINC000095626706	DB00683	Midazolam	Small molecule	CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12	Approved\|Illicit
ZINC000148723177	DB12267	Brigatinib	Small molecule	COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1	Approved\|Investigational
ZINC000034051848	DB09068	Vortioxetine	Small molecule	CC1=CC=C(SC2=CC=CC=C2N2CCNCC2)C(C)=C1	Approved\|Investigational

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000001530886	514.626	7.48	850.985	294.329	111.948	444.709	0	1601.819	1	5	8.498	1	86.979	2	1
ZINC000001530886	514.626	3.392	898.781	323.212	100.491	475.078	0	1648.918	1	5	8.623	1	91.314	2	1
ZINC000001530886	514.626	6.83	830.587	285.837	116.397	428.353	0	1580.24	1	5	8.44	1	85.144	2	1
ZINC000001530886	514.626	8.764	825.335	324.054	51.458	449.823	0	1592.388	1	5	8.537	1	100	2	1
ZINC000085537017	776.353	7.43	927.054	287.655	393.585	54.42	191.394	1783.369	3	20.6	8.462	1	0	3	1
ZINC000085537017	776.353	5.036	918.307	262.294	312.532	51.82	291.661	1775.566	3	20.6	8.603	1	0	3	1
ZINC000013537284	294.355	11.018	558.659	261.639	64.423	232.597	0	975.985	1	4.5	8.467	3	100	0	0
ZINC000013537284	294.355	2.688	556.854	260.966	65.507	230.381	0	971.561	1	4.5	8.221	3	100	0	0
ZINC000013537284	294.355	11.062	555.086	259.102	66.238	229.746	0	970.701	1	4.5	8.471	3	100	0	0
ZINC000058581064	419.384	10.752	671.499	281.937	165.698	150.485	73.379	1193.652	0	8.45	8.755	3	83.672	0	0
ZINC000058581064	419.384	10.808	670.317	276.157	165.522	158.31	70.328	1193.761	0	8.45	8.94	3	83.698	0	0
ZINC000000003876	307.394	6.942	621.454	347.314	41.211	232.929	0	1077.031	0	4.5	8.451	3	100	0	0
ZINC000000003876	307.394	6.932	619.9	347.638	38.881	233.381	0	1080.723	0	4.5	8.438	3	100	0	0
ZINC000000000850	236.288	5.297	457.642	85.783	137.035	198.523	36.3	755.015	3	3.7	8.91	3	75.351	0	0
ZINC000000000850	236.288	5.297	450.837	85.532	135.419	201.893	27.994	746.839	3	3.7	8.57	3	76.555	0	0
ZINC000000897089	378.317	7.024	589.936	192.765	54.441	122.198	220.532	1034.587	2	4.2	9.632	3	100	0	0
ZINC000000968310	265.357	2.146	504.113	215.256	13.985	274.872	0	890.178	0	3.5	8.524	3	100	0	0
ZINC000000968310	265.357	1.467	512.402	223.811	10.787	277.804	0	899.239	0	3.5	8.602	3	100	0	0
ZINC000000968310	265.357	2.159	506.854	212.362	17.71	276.782	0	897.097	0	3.5	8.319	3	100	0	0
ZINC000000968310	265.357	1.212	507.134	222.435	12.709	271.99	0	897.117	0	3.5	8.473	3	100	0	0
ZINC000000000655	312.411	8.136	587.283	357.505	79.355	150.424	0	1051.38	0	6	9.514	3	85.555	0	0
ZINC000003874185	378.317	7.567	591.505	189.633	58.939	124.18	218.753	1037.435	2	4.2	9.501	3	100	0	0
ZINC000085537014	776.023	3.562	1130.896	463.572	119.013	461.565	86.745	2316.712	2.25	12.95	9.035	1	60.052	3	2
ZINC000085537014	776.023	4.572	1189.952	539.169	118.37	441.217	91.196	2383.159	2.25	12.95	9.28	1	63.16	3	2
ZINC000150338819	889.012	4.388	1369.588	772.236	205.681	331.758	59.914	2637.592	2.5	12.5	8.669	1	66.601	3	1
ZINC000150338819	889.012	8.255	1369.279	775.121	203.738	327.37	63.05	2645.271	2.5	12.5	8.582	1	67.426	3	1
ZINC000150338819	889.012	9.619	1351.189	790.212	180.178	319.44	61.36	2612.508	2.5	12.5	8.678	1	71.811	3	1
ZINC000150338819	889.012	3.779	1408.248	811.944	183.707	340.058	72.539	2660.546	2.5	12.5	8.565	1	73.192	3	1
ZINC000150338819	889.012	9.448	1400.543	793.783	195.881	338.356	72.524	2661.746	2.5	12.5	8.543	1	70.182	3	1
ZINC000150338819	889.012	4.839	1395.432	791.3	195.813	335.781	72.538	2661.133	2.5	12.5	8.437	1	70.205	3	1
ZINC000150338819	889.012	7.52	1431.265	780.081	196.772	394.61	59.802	2709.966	2.5	12.5	8.583	1	72.172	3	1
ZINC000150338819	889.012	5.372	1296.949	757.843	185.555	289.14	64.411	2577.205	2.5	12.5	8.658	1	68.626	3	1
ZINC000150338819	889.012	10.969	1383.164	796.537	180.774	333.325	72.528	2658.942	2.5	12.5	8.466	1	74.003	3	1
ZINC000022448696	613.798	6.954	1035.321	444.196	106.92	484.205	0	1983.74	4	13.9	8.672	1	60.656	1	1
ZINC000022448696	613.798	4.692	987.892	420.483	105.118	462.291	0	1950.085	4	13.9	9.459	1	57.593	1	1
ZINC000022448696	613.798	4.883	996.709	456.592	90.226	449.891	0	1954.069	4	13.9	9.026	1	61.724	1	1
ZINC000022448696	613.798	4.038	892.447	367.68	134.761	390.006	0	1866.081	4	13.9	9.424	1	49.06	1	2
ZINC000022448696	613.798	6.203	1015.231	403.285	139.932	472.014	0	1971.466	4	13.9	9.391	1	49.786	1	2
ZINC000003795819	296.411	5.904	535.762	373.788	40.982	120.993	0	976.321	0	5	9.167	3	95.708	0	0
ZINC000004214955	358.267	3.446	660.401	298.857	122.78	92.485	146.279	1135.219	1	4.5	8.979	3	95.316	0	1
ZINC000004214955	358.267	5.922	650.52	300.031	115.164	97.2	138.125	1124.979	1	4.5	8.29	3	96.403	0	1
ZINC000001530973	411.776	1.869	621.561	78.079	23.657	341.675	178.15	1139.921	0	2.5	9.296	1	100	1	1
ZINC000001530973	411.776	7.135	646.647	56.586	31.038	374.101	184.921	1170.512	0	2.5	9.376	1	100	1	1
ZINC000095626706	325.772	4.795	557.909	123.038	39.264	289.258	106.35	972.427	0	2.5	9.21	3	100	0	0
ZINC000095626706	325.772	4.806	560.271	123.473	39.307	291.207	106.284	976.485	0	2.5	9.219	3	100	0	0
ZINC000148723177	584.1	5.166	976.551	585.471	60.71	276.127	54.243	1801.327	1	12.75	7.731	3	78.047	1	1
ZINC000148723177	584.1	5.799	978.721	539.735	84.801	306.938	47.247	1814.982	1	12.75	7.869	2	73.551	1	1
ZINC000000004448	293.368	10.402	542.751	245.654	51.989	245.108	0	972.122	0	3.5	8.593	3	100	0	0
ZINC000000004448	293.368	10.413	540.787	244.769	52.118	243.899	0	968.638	0	3.5	8.593	3	100	0	0
ZINC000034051848	298.445	2.232	547.824	279.015	30.472	216.088	22.249	996.855	1	2.5	8.638	3	100	0	0
ZINC000034051848	298.445	1.26	583.542	324.804	30.075	216.05	12.613	1024.909	1	2.5	8.187	3	100	0	0

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000001530886	CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1	0.217762781	0.303280041
ZINC000085537017	CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)(O)O[P@](=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O	0.017889541	0.259362736
ZINC000013537284	Cc1nc[nH]c1CN1CCc2c(c3ccccc3n2C)C1=O	0.167399199	0.254688426
ZINC000058581064	C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N21	0.07265705	0.3133548
ZINC000000003876	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	0.286065497	0.411420794
ZINC000000000850	C[C@@H](c1cc2ccccc2s1)N(O)C(N)=O	0.136335882	0.223511692
ZINC000000897089	O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	0.082724827	0.290697747
ZINC000000968310	CN1CCN2c3ncccc3Cc3ccccc3[C@H]2C1	0.161648552	0.278705347
ZINC000000000655	O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3[C@@H]2C1	0.180997967	0.220112088
ZINC000003874185	O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	0.082724827	0.290697747
ZINC000085537014	CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1	0.040386906	0.210921474
ZINC000150338819	COC(=O)N[C@H](C(=O)N1CC2(CC2)C[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc([C@@H]6[C@H]7CC[C@H](C7)N6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c5c4)ccc2-3)[nH]1)C(C)C	0.004831095	0.217274953
ZINC000022448696	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	0.045517594	0.324414178
ZINC000003795819	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	0.046476477	0.250202441
ZINC000004214955	Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21	0.20795331	0.394281261
ZINC000001530973	Clc1ccc(CC[C@@H](Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1	0.145833616	0.250445333
ZINC000095626706	Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2	0.208263835	0.399500155
ZINC000148723177	COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1	0.142553556	0.1573686
ZINC000000004448	Cc1nccn1C[C@H]1CCc2c(c3ccccc3n2C)C1=O	0.127456204	0.417082675
ZINC000034051848	Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1	0.30477497	0.391109016

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
ERC1	YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, Actb, Cd2ap, Kif4, Myh9, Ckap5, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1, LNX1, EFTUD2, MYO6, AGR2, KIAA1429, FLCN, DNAJC5, GBF1, DYNC1I2, BICD1, BICD2, APEX1, DYRK1A, nsp13, LMBR1L, PLEKHA4, CYLD, DUSP1, RASSF8, nsp16, nsp7, CIT, ANLN, KIF14, TRIM33, nsp13ab, nsp16ab, SEC62, ORF6, MKRN3, ACTR3, AGPS, AMOT, ANAPC2, CYP2C9, DCTN2, ERGIC2, GOLGA1, IMPDH2, KDM1A, KRT18, KRT19, KRT8, NDC80, NEFM, PEX14, PFN1, PXN, SEPT10, SYNE3, TMOD1, NAA40, VPS33A, NUP62, FTL, DES, YWHAQ, SERF2, YWHAB, ING1, CEP112, MFAP4, C15orf59, YWHAH, PIPSL, KRT38, KRT37, ATG16L1, TBC1D32, E, ATRX,
RET	STAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERC1
RET

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ERC1-RET

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ERC1-RET

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
ERC1	RET	Lung Adenocarcinoma	MyCancerGenome
ERC1	RET	Breast Invasive Ductal Carcinoma	MyCancerGenome
ERC1	RET	Thyroid Gland Papillary Carcinoma	MyCancerGenome
ERC1	RET	Adenocarcinoma Of Unknown Primary	MyCancerGenome
ERC1	RET	Bladder Urothelial Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ERC1	C0238463	Papillary thyroid carcinoma	1	ORPHANET
Hgene	ERC1	C4749581	Distal monosomy 12p	1	ORPHANET
Tgene	RET	C1833921	Familial medullary thyroid carcinoma	23	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C3888239	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	16	GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0025268	Multiple Endocrine Neoplasia Type 2a	15	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C1708353	Hereditary Paraganglioma-Pheochromocytoma Syndrome	12	CLINGEN
Tgene	RET	C0025269	Multiple Endocrine Neoplasia Type 2b	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C0238463	Papillary thyroid carcinoma	3	CTD_human;ORPHANET
Tgene	RET	C1275808	Congenital central hypoventilation	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C1859049	CCHS WITH HIRSCHSPRUNG DISEASE	3	CTD_human;ORPHANET
Tgene	RET	C0009402	Colorectal Carcinoma	2	CTD_human;UNIPROT
Tgene	RET	C0009404	Colorectal Neoplasms	2	CTD_human
Tgene	RET	C0019569	Hirschsprung Disease	2	CTD_human
Tgene	RET	C0027662	Multiple Endocrine Neoplasia	2	CTD_human;GENOMICS_ENGLAND
Tgene	RET	C0085758	Aganglionosis, Colonic	2	CTD_human
Tgene	RET	C0266294	Unilateral agenesis of kidney	2	ORPHANET
Tgene	RET	C1257840	Aganglionosis, Rectosigmoid Colon	2	CTD_human
Tgene	RET	C3661523	Congenital Intestinal Aganglionosis	2	CTD_human
Tgene	RET	C0006413	Burkitt Lymphoma	1	CTD_human
Tgene	RET	C0031511	Pheochromocytoma	1	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0038220	Status Epilepticus	1	CTD_human
Tgene	RET	C0040136	Thyroid Neoplasm	1	CGI;CTD_human
Tgene	RET	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Tgene	RET	C0206693	Medullary carcinoma	1	CTD_human
Tgene	RET	C0238462	Medullary carcinoma of thyroid	1	CGI;CTD_human
Tgene	RET	C0270823	Petit mal status	1	CTD_human
Tgene	RET	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Tgene	RET	C0343640	African Burkitt's lymphoma	1	CTD_human
Tgene	RET	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Tgene	RET	C0549473	Thyroid carcinoma	1	CGI;CTD_human;UNIPROT
Tgene	RET	C0740340	Amyloidosis, Familial	1	CTD_human
Tgene	RET	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Tgene	RET	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Tgene	RET	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Tgene	RET	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Tgene	RET	C1609433	Congenital absence of kidneys syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	RET	C3501843	Nonmedullary Thyroid Carcinoma	1	CTD_human
Tgene	RET	C3501844	Familial Nonmedullary Thyroid Cancer	1	CTD_human
Tgene	RET	C4721444	Burkitt Leukemia	1	CTD_human