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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERC1-ZCCHC6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERC1-ZCCHC6
FusionPDB ID: 27289
FusionGDB2.0 ID: 27289
HgeneTgene
Gene symbol

ERC1

ZCCHC6

Gene ID

23085

79670

Gene nameELKS/RAB6-interacting/CAST family member 1terminal uridylyl transferase 7
SynonymsCast2|ELKS|ERC-1|RAB6IP2PAPD6|TENT3B|ZCCHC6
Cytomap

12p13.33

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2terminal uridylyltransferase 7PAP associated domain containing 6TUTase 7zinc finger CCHC domain-containing protein 6zinc finger CCHC-type containing 6zinc finger, CCHC domain containing 6
Modification date2020031320200313
UniProtAcc

Q8IUD2

.
Ensembl transtripts involved in fusion geneENST idsENST00000355446, ENST00000360905, 
ENST00000397203, ENST00000543086, 
ENST00000546231, ENST00000589028, 
ENST00000536573, 		ENST00000375947, 
ENST00000375948, ENST00000469004, 
ENST00000375957, ENST00000375960, 
ENST00000375961, ENST00000375963, 
ENST00000277141, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score32 X 23 X 16=117768 X 7 X 6=336
# samples 389
** MAII scorelog2(38/11776*10)=-4.95370634772607
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERC1 [Title/Abstract] AND ZCCHC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERC1(1399178)-ZCCHC6(88903659), # samples:1
Anticipated loss of major functional domain due to fusion event.ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ERC1-ZCCHC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERC1

GO:0007252

I-kappaB phosphorylation

15218148

TgeneZCCHC6

GO:0010526

negative regulation of transposition, RNA-mediated

30122351

TgeneZCCHC6

GO:0010586

miRNA metabolic process

25979828

TgeneZCCHC6

GO:0031054

pre-miRNA processing

25979828

TgeneZCCHC6

GO:0031123

RNA 3'-end processing

17353264

TgeneZCCHC6

GO:0071076

RNA 3' uridylation

28671666


check buttonFusion gene breakpoints across ERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZCCHC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315328ERC1chr12

1399178

+ZCCHC6chr9

88903659

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543086ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-397929672712970899
ENST00000546231ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-433233205283323931
ENST00000397203ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-419831864063189927
ENST00000360905ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-397329611812964927
ENST00000589028ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-394929371572940927
ENST00000355446ERC1chr121399178+ENST00000277141ZCCHC6chr988903659-392429121322915927

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543086ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0015052390.99849474
ENST00000546231ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0013955350.9986045
ENST00000397203ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0016320910.99836797
ENST00000360905ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0019549920.99804497
ENST00000589028ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0017830470.9982169
ENST00000355446ENST00000277141ERC1chr121399178+ZCCHC6chr988903659-0.0019023110.9980977

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27289_27289_1_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000355446_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ

--------------------------------------------------------------

>27289_27289_2_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000360905_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ

--------------------------------------------------------------

>27289_27289_3_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000397203_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ

--------------------------------------------------------------

>27289_27289_4_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000543086_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=899AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK
DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV
KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK
EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK
DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR

--------------------------------------------------------------

>27289_27289_5_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000546231_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=931AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK
SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS

--------------------------------------------------------------

>27289_27289_6_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000589028_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP=
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT
LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL
HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE
RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM
LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1399178/chr9:88903659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERC1

Q8IUD2

.
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121367_1370373.3333333333333396.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759571012815_936373.3333333333333396.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201367_13701237.33333333333331260.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121233_1286373.3333333333333396.0DomainNote=PAP-associated 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759571012551_600373.3333333333333396.0DomainNote=PAP-associated 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121047_1050373.3333333333333396.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121057_1060373.3333333333333396.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121170_1174373.3333333333333396.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759571012951_1495373.3333333333333396.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121345_1362373.3333333333333396.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037595710121451_1468373.3333333333333396.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759571012963_980373.3333333333333396.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201345_13621237.33333333333331260.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201451_14681237.33333333333331260.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261451_14681435.33333333333331458.0Zinc fingerCCHC-type 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERC1chr12:1399178chr9:88903659ENST00000360905+15191060_1100926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000360905+1519144_988926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000397203+15191060_1100926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000397203+1519144_988926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000543086+14181060_1100898.66666666666661089.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000543086+1418144_988898.66666666666661089.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000589028+14181060_1100926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000589028+1418144_988926.66666666666661117.0Coiled coilOntology_term=ECO:0000255
HgeneERC1chr12:1399178chr9:88903659ENST00000360905+15191046_1108926.66666666666661117.0DomainFIP-RBD
HgeneERC1chr12:1399178chr9:88903659ENST00000397203+15191046_1108926.66666666666661117.0DomainFIP-RBD
HgeneERC1chr12:1399178chr9:88903659ENST00000543086+14181046_1108898.66666666666661089.0DomainFIP-RBD
HgeneERC1chr12:1399178chr9:88903659ENST00000589028+14181046_1108926.66666666666661117.0DomainFIP-RBD
TgeneZCCHC6chr12:1399178chr9:88903659ENST00000375957101220_23373.3333333333333396.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr12:1399178chr9:88903659ENST00000375960182020_231237.33333333333331260.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759601820815_9361237.33333333333331260.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261367_13701435.33333333333331458.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr12:1399178chr9:88903659ENST00000375961242620_231435.33333333333331458.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759612426815_9361435.33333333333331458.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271367_13701473.33333333333331496.0Compositional biasNote=Poly-Arg
TgeneZCCHC6chr12:1399178chr9:88903659ENST00000375963252720_231473.33333333333331496.0Compositional biasNote=Poly-Asp
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759632527815_9361473.33333333333331496.0Compositional biasNote=Glu-rich
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201233_12861237.33333333333331260.0DomainNote=PAP-associated 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759601820551_6001237.33333333333331260.0DomainNote=PAP-associated 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261233_12861435.33333333333331458.0DomainNote=PAP-associated 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759612426551_6001435.33333333333331458.0DomainNote=PAP-associated 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271233_12861473.33333333333331496.0DomainNote=PAP-associated 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759632527551_6001473.33333333333331496.0DomainNote=PAP-associated 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201047_10501237.33333333333331260.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201057_10601237.33333333333331260.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596018201170_11741237.33333333333331260.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759601820951_14951237.33333333333331260.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261047_10501435.33333333333331458.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261057_10601435.33333333333331458.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261170_11741435.33333333333331458.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759612426951_14951435.33333333333331458.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271047_10501473.33333333333331496.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271057_10601473.33333333333331496.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271170_11741473.33333333333331496.0RegionUTP binding
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759632527951_14951473.33333333333331496.0RegionSufficient for monouridylation activity
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759571012244_274373.3333333333333396.0Zinc fingerMatrin-type
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759601820244_2741237.33333333333331260.0Zinc fingerMatrin-type
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759601820963_9801237.33333333333331260.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596124261345_13621435.33333333333331458.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759612426244_2741435.33333333333331458.0Zinc fingerMatrin-type
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759612426963_9801435.33333333333331458.0Zinc fingerCCHC-type 1
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271345_13621473.33333333333331496.0Zinc fingerCCHC-type 2
TgeneZCCHC6chr12:1399178chr9:88903659ENST0000037596325271451_14681473.33333333333331496.0Zinc fingerCCHC-type 3
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759632527244_2741473.33333333333331496.0Zinc fingerMatrin-type
TgeneZCCHC6chr12:1399178chr9:88903659ENST000003759632527963_9801473.33333333333331496.0Zinc fingerCCHC-type 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERC1YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, Actb, Cd2ap, Kif4, Myh9, Ckap5, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1, LNX1, EFTUD2, MYO6, AGR2, KIAA1429, FLCN, DNAJC5, GBF1, DYNC1I2, BICD1, BICD2, APEX1, DYRK1A, nsp13, LMBR1L, PLEKHA4, CYLD, DUSP1, RASSF8, nsp16, nsp7, CIT, ANLN, KIF14, TRIM33, nsp13ab, nsp16ab, SEC62, ORF6, MKRN3, ACTR3, AGPS, AMOT, ANAPC2, CYP2C9, DCTN2, ERGIC2, GOLGA1, IMPDH2, KDM1A, KRT18, KRT19, KRT8, NDC80, NEFM, PEX14, PFN1, PXN, SEPT10, SYNE3, TMOD1, NAA40, VPS33A, NUP62, FTL, DES, YWHAQ, SERF2, YWHAB, ING1, CEP112, MFAP4, C15orf59, YWHAH, PIPSL, KRT38, KRT37, ATG16L1, TBC1D32, E, ATRX,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERC1all structure
ZCCHC6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERC1-ZCCHC6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERC1-ZCCHC6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERC1C0238463Papillary thyroid carcinoma1ORPHANET
HgeneERC1C4749581Distal monosomy 12p1ORPHANET