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Fusion Protein:ERC1-ZCCHC6 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: ERC1-ZCCHC6 | FusionPDB ID: 27289 | FusionGDB2.0 ID: 27289 | Hgene | Tgene | Gene symbol | ERC1 | ZCCHC6 | Gene ID | 23085 | 79670 |
Gene name | ELKS/RAB6-interacting/CAST family member 1 | terminal uridylyl transferase 7 | |
Synonyms | Cast2|ELKS|ERC-1|RAB6IP2 | PAPD6|TENT3B|ZCCHC6 | |
Cytomap | 12p13.33 | 9q21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | ELKS/Rab6-interacting/CAST family member 1RAB6 interacting protein 2 | terminal uridylyltransferase 7PAP associated domain containing 6TUTase 7zinc finger CCHC domain-containing protein 6zinc finger CCHC-type containing 6zinc finger, CCHC domain containing 6 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8IUD2 | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000355446, ENST00000360905, ENST00000397203, ENST00000543086, ENST00000546231, ENST00000589028, ENST00000536573, | ENST00000375947, ENST00000375948, ENST00000469004, ENST00000375957, ENST00000375960, ENST00000375961, ENST00000375963, ENST00000277141, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 32 X 23 X 16=11776 | 8 X 7 X 6=336 |
# samples | 38 | 9 | |
** MAII score | log2(38/11776*10)=-4.95370634772607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: ERC1 [Title/Abstract] AND ZCCHC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ERC1(1399178)-ZCCHC6(88903659), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ERC1-ZCCHC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ERC1 | GO:0007252 | I-kappaB phosphorylation | 15218148 |
Tgene | ZCCHC6 | GO:0010526 | negative regulation of transposition, RNA-mediated | 30122351 |
Tgene | ZCCHC6 | GO:0010586 | miRNA metabolic process | 25979828 |
Tgene | ZCCHC6 | GO:0031054 | pre-miRNA processing | 25979828 |
Tgene | ZCCHC6 | GO:0031123 | RNA 3'-end processing | 17353264 |
Tgene | ZCCHC6 | GO:0071076 | RNA 3' uridylation | 28671666 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315328 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000543086 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 3979 | 2967 | 271 | 2970 | 899 |
ENST00000546231 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 4332 | 3320 | 528 | 3323 | 931 |
ENST00000397203 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 4198 | 3186 | 406 | 3189 | 927 |
ENST00000360905 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 3973 | 2961 | 181 | 2964 | 927 |
ENST00000589028 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 3949 | 2937 | 157 | 2940 | 927 |
ENST00000355446 | ERC1 | chr12 | 1399178 | + | ENST00000277141 | ZCCHC6 | chr9 | 88903659 | - | 3924 | 2912 | 132 | 2915 | 927 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000543086 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001505239 | 0.99849474 |
ENST00000546231 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001395535 | 0.9986045 |
ENST00000397203 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001632091 | 0.99836797 |
ENST00000360905 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001954992 | 0.99804497 |
ENST00000589028 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001783047 | 0.9982169 |
ENST00000355446 | ENST00000277141 | ERC1 | chr12 | 1399178 | + | ZCCHC6 | chr9 | 88903659 | - | 0.001902311 | 0.9980977 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >27289_27289_1_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000355446_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ -------------------------------------------------------------- >27289_27289_2_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000360905_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ -------------------------------------------------------------- >27289_27289_3_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000397203_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ -------------------------------------------------------------- >27289_27289_4_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000543086_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=899AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRK DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR -------------------------------------------------------------- >27289_27289_5_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000546231_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=931AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKK SAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLS -------------------------------------------------------------- >27289_27289_6_ERC1-ZCCHC6_ERC1_chr12_1399178_ENST00000589028_ZCCHC6_chr9_88903659_ENST00000277141_length(amino acids)=927AA_BP= MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMT LGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:1399178/chr9:88903659) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ERC1 | . |
FUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. {ECO:0000269|PubMed:15218148}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1367_1370 | 373.3333333333333 | 396.0 | Compositional bias | Note=Poly-Arg | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 815_936 | 373.3333333333333 | 396.0 | Compositional bias | Note=Glu-rich | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1367_1370 | 1237.3333333333333 | 1260.0 | Compositional bias | Note=Poly-Arg | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1233_1286 | 373.3333333333333 | 396.0 | Domain | Note=PAP-associated 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 551_600 | 373.3333333333333 | 396.0 | Domain | Note=PAP-associated 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1047_1050 | 373.3333333333333 | 396.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1057_1060 | 373.3333333333333 | 396.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1170_1174 | 373.3333333333333 | 396.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 951_1495 | 373.3333333333333 | 396.0 | Region | Sufficient for monouridylation activity | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1345_1362 | 373.3333333333333 | 396.0 | Zinc finger | CCHC-type 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 1451_1468 | 373.3333333333333 | 396.0 | Zinc finger | CCHC-type 3 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 963_980 | 373.3333333333333 | 396.0 | Zinc finger | CCHC-type 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1345_1362 | 1237.3333333333333 | 1260.0 | Zinc finger | CCHC-type 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1451_1468 | 1237.3333333333333 | 1260.0 | Zinc finger | CCHC-type 3 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1451_1468 | 1435.3333333333333 | 1458.0 | Zinc finger | CCHC-type 3 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000360905 | + | 15 | 19 | 1060_1100 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000360905 | + | 15 | 19 | 144_988 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000397203 | + | 15 | 19 | 1060_1100 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000397203 | + | 15 | 19 | 144_988 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000543086 | + | 14 | 18 | 1060_1100 | 898.6666666666666 | 1089.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000543086 | + | 14 | 18 | 144_988 | 898.6666666666666 | 1089.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000589028 | + | 14 | 18 | 1060_1100 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000589028 | + | 14 | 18 | 144_988 | 926.6666666666666 | 1117.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000360905 | + | 15 | 19 | 1046_1108 | 926.6666666666666 | 1117.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000397203 | + | 15 | 19 | 1046_1108 | 926.6666666666666 | 1117.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000543086 | + | 14 | 18 | 1046_1108 | 898.6666666666666 | 1089.0 | Domain | FIP-RBD |
Hgene | ERC1 | chr12:1399178 | chr9:88903659 | ENST00000589028 | + | 14 | 18 | 1046_1108 | 926.6666666666666 | 1117.0 | Domain | FIP-RBD |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 20_23 | 373.3333333333333 | 396.0 | Compositional bias | Note=Poly-Asp | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 20_23 | 1237.3333333333333 | 1260.0 | Compositional bias | Note=Poly-Asp | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 815_936 | 1237.3333333333333 | 1260.0 | Compositional bias | Note=Glu-rich | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1367_1370 | 1435.3333333333333 | 1458.0 | Compositional bias | Note=Poly-Arg | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 20_23 | 1435.3333333333333 | 1458.0 | Compositional bias | Note=Poly-Asp | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 815_936 | 1435.3333333333333 | 1458.0 | Compositional bias | Note=Glu-rich | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1367_1370 | 1473.3333333333333 | 1496.0 | Compositional bias | Note=Poly-Arg | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 20_23 | 1473.3333333333333 | 1496.0 | Compositional bias | Note=Poly-Asp | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 815_936 | 1473.3333333333333 | 1496.0 | Compositional bias | Note=Glu-rich | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1233_1286 | 1237.3333333333333 | 1260.0 | Domain | Note=PAP-associated 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 551_600 | 1237.3333333333333 | 1260.0 | Domain | Note=PAP-associated 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1233_1286 | 1435.3333333333333 | 1458.0 | Domain | Note=PAP-associated 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 551_600 | 1435.3333333333333 | 1458.0 | Domain | Note=PAP-associated 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1233_1286 | 1473.3333333333333 | 1496.0 | Domain | Note=PAP-associated 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 551_600 | 1473.3333333333333 | 1496.0 | Domain | Note=PAP-associated 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1047_1050 | 1237.3333333333333 | 1260.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1057_1060 | 1237.3333333333333 | 1260.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 1170_1174 | 1237.3333333333333 | 1260.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 951_1495 | 1237.3333333333333 | 1260.0 | Region | Sufficient for monouridylation activity | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1047_1050 | 1435.3333333333333 | 1458.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1057_1060 | 1435.3333333333333 | 1458.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1170_1174 | 1435.3333333333333 | 1458.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 951_1495 | 1435.3333333333333 | 1458.0 | Region | Sufficient for monouridylation activity | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1047_1050 | 1473.3333333333333 | 1496.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1057_1060 | 1473.3333333333333 | 1496.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1170_1174 | 1473.3333333333333 | 1496.0 | Region | UTP binding | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 951_1495 | 1473.3333333333333 | 1496.0 | Region | Sufficient for monouridylation activity | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375957 | 10 | 12 | 244_274 | 373.3333333333333 | 396.0 | Zinc finger | Matrin-type | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 244_274 | 1237.3333333333333 | 1260.0 | Zinc finger | Matrin-type | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375960 | 18 | 20 | 963_980 | 1237.3333333333333 | 1260.0 | Zinc finger | CCHC-type 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 1345_1362 | 1435.3333333333333 | 1458.0 | Zinc finger | CCHC-type 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 244_274 | 1435.3333333333333 | 1458.0 | Zinc finger | Matrin-type | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375961 | 24 | 26 | 963_980 | 1435.3333333333333 | 1458.0 | Zinc finger | CCHC-type 1 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1345_1362 | 1473.3333333333333 | 1496.0 | Zinc finger | CCHC-type 2 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 1451_1468 | 1473.3333333333333 | 1496.0 | Zinc finger | CCHC-type 3 | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 244_274 | 1473.3333333333333 | 1496.0 | Zinc finger | Matrin-type | |
Tgene | ZCCHC6 | chr12:1399178 | chr9:88903659 | ENST00000375963 | 25 | 27 | 963_980 | 1473.3333333333333 | 1496.0 | Zinc finger | CCHC-type 1 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
ERC1 | YWHAG, TWF2, RAB6A, RAB6B, KBTBD7, IKBKB, MAP3K7, IKBKG, XIAP, ITSN2, RAD23A, SH3KBP1, CHUK, NFKBIA, CUL3, APP, ATP6V0D1, NCBP1, WDR4, ERC2, MYC, PAN2, CDK19, MAPK4, CDK20, LATS2, STK4, GFOD1, ADPRHL2, SNX2, MED4, EWSR1, SRPK2, OFD1, PCM1, CEP104, CEP162, CEP152, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, SCLT1, SASS6, DVL2, SLC16A6, KIF23, MAPRE1, RACGAP1, CHST15, PPP1R21, Actb, Cd2ap, Kif4, Myh9, Ckap5, MACROD1, PCGF1, NANOG, POU5F1, NHLRC2, CDH1, EYA4, TSHB, SPERT, TRIM25, BRCA1, LNX1, EFTUD2, MYO6, AGR2, KIAA1429, FLCN, DNAJC5, GBF1, DYNC1I2, BICD1, BICD2, APEX1, DYRK1A, nsp13, LMBR1L, PLEKHA4, CYLD, DUSP1, RASSF8, nsp16, nsp7, CIT, ANLN, KIF14, TRIM33, nsp13ab, nsp16ab, SEC62, ORF6, MKRN3, ACTR3, AGPS, AMOT, ANAPC2, CYP2C9, DCTN2, ERGIC2, GOLGA1, IMPDH2, KDM1A, KRT18, KRT19, KRT8, NDC80, NEFM, PEX14, PFN1, PXN, SEPT10, SYNE3, TMOD1, NAA40, VPS33A, NUP62, FTL, DES, YWHAQ, SERF2, YWHAB, ING1, CEP112, MFAP4, C15orf59, YWHAH, PIPSL, KRT38, KRT37, ATG16L1, TBC1D32, E, ATRX, |
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Gene | STRING network |
ERC1 | ![]() |
ZCCHC6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ERC1-ZCCHC6 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ERC1-ZCCHC6 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ERC1 | C0238463 | Papillary thyroid carcinoma | 1 | ORPHANET |
Hgene | ERC1 | C4749581 | Distal monosomy 12p | 1 | ORPHANET |