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Fusion Protein:AGAP1-CIR1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: AGAP1-CIR1 | FusionPDB ID: 2763 | FusionGDB2.0 ID: 2763 | Hgene | Tgene | Gene symbol | AGAP1 | CIR1 | Gene ID | 116987 | 9541 |
Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | corepressor interacting with RBPJ, CIR1 | |
Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | CIR | |
Cytomap | 2q37.2 | 2q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | corepressor interacting with RBPJ 1CBF1 (RBPJ) interacting corepressor 1CBF1-interacting corepressorcorepressor interacting with RBPJ, 1recepin | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UPQ3 | Q86X95 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000304032, ENST00000336665, ENST00000409457, ENST00000409538, ENST00000428334, | ENST00000342016, ENST00000362053, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 49 X 18 X 17=14994 | 11 X 6 X 4=264 |
# samples | 48 | 9 | |
** MAII score | log2(48/14994*10)=-4.96520709119934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/264*10)=-1.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: AGAP1 [Title/Abstract] AND CIR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | AGAP1(236715975)-CIR1(175252507), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | AGAP1-CIR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGAP1-CIR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGAP1-CIR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AGAP1-CIR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CIR1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9874765 |
Tgene | CIR1 | GO:0045892 | negative regulation of transcription, DNA-templated | 9874765 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | COAD | TCGA-AY-5543-01A | AGAP1 | chr2 | 236715975 | - | CIR1 | chr2 | 175252507 | - |
ChimerDB4 | COAD | TCGA-AY-5543-01A | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - |
ChimerDB4 | COAD | TCGA-AY-5543 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000336665 | AGAP1 | chr2 | 236715975 | + | ENST00000342016 | CIR1 | chr2 | 175252507 | - | 3386 | 1630 | 421 | 2910 | 829 |
ENST00000336665 | AGAP1 | chr2 | 236715975 | + | ENST00000362053 | CIR1 | chr2 | 175252507 | - | 3284 | 1630 | 421 | 2166 | 581 |
ENST00000304032 | AGAP1 | chr2 | 236715975 | + | ENST00000342016 | CIR1 | chr2 | 175252507 | - | 3386 | 1630 | 421 | 2910 | 829 |
ENST00000304032 | AGAP1 | chr2 | 236715975 | + | ENST00000362053 | CIR1 | chr2 | 175252507 | - | 3284 | 1630 | 421 | 2166 | 581 |
ENST00000409538 | AGAP1 | chr2 | 236715975 | + | ENST00000342016 | CIR1 | chr2 | 175252507 | - | 4097 | 2341 | 418 | 3621 | 1067 |
ENST00000409538 | AGAP1 | chr2 | 236715975 | + | ENST00000362053 | CIR1 | chr2 | 175252507 | - | 3995 | 2341 | 418 | 2877 | 819 |
ENST00000428334 | AGAP1 | chr2 | 236715975 | + | ENST00000342016 | CIR1 | chr2 | 175252507 | - | 2344 | 588 | 21 | 1868 | 615 |
ENST00000428334 | AGAP1 | chr2 | 236715975 | + | ENST00000362053 | CIR1 | chr2 | 175252507 | - | 2242 | 588 | 21 | 1124 | 367 |
ENST00000409457 | AGAP1 | chr2 | 236715975 | + | ENST00000342016 | CIR1 | chr2 | 175252507 | - | 3404 | 1648 | 439 | 2928 | 829 |
ENST00000409457 | AGAP1 | chr2 | 236715975 | + | ENST00000362053 | CIR1 | chr2 | 175252507 | - | 3302 | 1648 | 439 | 2184 | 581 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000336665 | ENST00000342016 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.000641877 | 0.9993581 |
ENST00000336665 | ENST00000362053 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.001234463 | 0.9987656 |
ENST00000304032 | ENST00000342016 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.000641877 | 0.9993581 |
ENST00000304032 | ENST00000362053 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.001234463 | 0.9987656 |
ENST00000409538 | ENST00000342016 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.001492972 | 0.99850696 |
ENST00000409538 | ENST00000362053 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.001607186 | 0.99839276 |
ENST00000428334 | ENST00000342016 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.002984942 | 0.9970151 |
ENST00000428334 | ENST00000362053 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.002558174 | 0.99744177 |
ENST00000409457 | ENST00000342016 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.000657124 | 0.99934286 |
ENST00000409457 | ENST00000362053 | AGAP1 | chr2 | 236715975 | + | CIR1 | chr2 | 175252507 | - | 0.001272326 | 0.9987276 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >2763_2763_1_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000304032_CIR1_chr2_175252507_ENST00000342016_length(amino acids)=829AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS GPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSK HKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKH ESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRG -------------------------------------------------------------- >2763_2763_2_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000304032_CIR1_chr2_175252507_ENST00000362053_length(amino acids)=581AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS -------------------------------------------------------------- >2763_2763_3_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000336665_CIR1_chr2_175252507_ENST00000342016_length(amino acids)=829AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS GPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSK HKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKH ESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRG -------------------------------------------------------------- >2763_2763_4_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000336665_CIR1_chr2_175252507_ENST00000362053_length(amino acids)=581AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS -------------------------------------------------------------- >2763_2763_5_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000409457_CIR1_chr2_175252507_ENST00000342016_length(amino acids)=829AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS GPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSK HKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKH ESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRG -------------------------------------------------------------- >2763_2763_6_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000409457_CIR1_chr2_175252507_ENST00000362053_length(amino acids)=581AA_BP=403 MLRPRLSSRASSARRRRARLPGGCGAPGSAARGPRGAGRRRRGARGSGRGACTMNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERV EEPVLQNQIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGG PPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLN VERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPV RKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFM YEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGS -------------------------------------------------------------- >2763_2763_7_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000409538_CIR1_chr2_175252507_ENST00000342016_length(amino acids)=1067AA_BP=641 MPSPLGPAPSRPAGSLDAAGPQRAGDMYLLDGSGEPASPPADAMPRGTPPRKTVYRISVTMVRKEQLAAPGSGGPDPRPVRRPRPARSPD APGRLEEEAEEAEGAEEPEGPRPRAWDFRTFRTRSTGQLELGRLRPCARGLEPADLAGSAPAEEEGRGSPASGSPDVEGARAAPLRRSLS FRHWSGPEAPQGRTLGGGRRHSSSGSLAWAPCDEAAAGTTLEPATATQPASEKRNTLDVGEVLSKNDALSDLERWERSKSKNRTLDNSDL QRLERARAAAGAGAASEHRLLRFFSGIFARRDGGPGGGPSPRSGASRPRGYFSLRRAPAEAHSSSAESIDGSPRRDAFVNSQEWTLSRSV PELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYY SRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNS PSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADS IGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAP REKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTAN DPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESN NKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSER -------------------------------------------------------------- >2763_2763_8_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000409538_CIR1_chr2_175252507_ENST00000362053_length(amino acids)=819AA_BP=641 MPSPLGPAPSRPAGSLDAAGPQRAGDMYLLDGSGEPASPPADAMPRGTPPRKTVYRISVTMVRKEQLAAPGSGGPDPRPVRRPRPARSPD APGRLEEEAEEAEGAEEPEGPRPRAWDFRTFRTRSTGQLELGRLRPCARGLEPADLAGSAPAEEEGRGSPASGSPDVEGARAAPLRRSLS FRHWSGPEAPQGRTLGGGRRHSSSGSLAWAPCDEAAAGTTLEPATATQPASEKRNTLDVGEVLSKNDALSDLERWERSKSKNRTLDNSDL QRLERARAAAGAGAASEHRLLRFFSGIFARRDGGPGGGPSPRSGASRPRGYFSLRRAPAEAHSSSAESIDGSPRRDAFVNSQEWTLSRSV PELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYY SRMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNS PSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADS IGSGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAP REKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSDAVLQIEGFWAIDAPLGANSGDEKQWVCTETK -------------------------------------------------------------- >2763_2763_9_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000428334_CIR1_chr2_175252507_ENST00000342016_length(amino acids)=615AA_BP=189 MANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPS HSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIG SGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPRE KYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDP SQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKE -------------------------------------------------------------- >2763_2763_10_AGAP1-CIR1_AGAP1_chr2_236715975_ENST00000428334_CIR1_chr2_175252507_ENST00000362053_length(amino acids)=367AA_BP=189 MANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPS HSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIG SGRAIPIKQVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPRE KYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSDAVLQIEGFWAIDAPLGANSGDEKQWVCTETKCT -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:236715975/chr2:175252507) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
AGAP1 | CIR1 |
FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. | FUNCTION: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 122_126 | 350.0 | 858.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 178_181 | 350.0 | 858.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 78_85 | 350.0 | 858.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 122_126 | 350.0 | 805.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 178_181 | 350.0 | 805.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 78_85 | 350.0 | 805.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 122_126 | 350.0 | 406.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 178_181 | 350.0 | 406.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 78_85 | 350.0 | 406.0 | Nucleotide binding | GTP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 66_276 | 350.0 | 858.0 | Region | Note=Small GTPase-like |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 66_276 | 350.0 | 805.0 | Region | Note=Small GTPase-like |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 66_276 | 350.0 | 406.0 | Region | Note=Small GTPase-like |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | 0 | 10 | 214_368 | 24.0 | 451.0 | Compositional bias | Note=Lys/Ser-rich | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | 0 | 10 | 369_450 | 24.0 | 451.0 | Compositional bias | Note=Arg/Ser-rich (RS domain) | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000362053 | 0 | 11 | 214_368 | 24.0 | 496.3333333333333 | Compositional bias | Note=Lys/Ser-rich | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000362053 | 0 | 11 | 369_450 | 24.0 | 496.3333333333333 | Compositional bias | Note=Arg/Ser-rich (RS domain) | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | 0 | 10 | 235_245 | 24.0 | 451.0 | Motif | Nuclear localization signal | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | 0 | 10 | 291_298 | 24.0 | 451.0 | Motif | Nuclear localization signal | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000362053 | 0 | 11 | 235_245 | 24.0 | 496.3333333333333 | Motif | Nuclear localization signal | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000362053 | 0 | 11 | 291_298 | 24.0 | 496.3333333333333 | Motif | Nuclear localization signal |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 346_588 | 350.0 | 858.0 | Domain | PH |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 609_729 | 350.0 | 858.0 | Domain | Arf-GAP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 346_588 | 350.0 | 805.0 | Domain | PH |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 609_729 | 350.0 | 805.0 | Domain | Arf-GAP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 346_588 | 350.0 | 406.0 | Domain | PH |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 609_729 | 350.0 | 406.0 | Domain | Arf-GAP |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 768_797 | 350.0 | 858.0 | Repeat | Note=ANK 1 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 801_830 | 350.0 | 858.0 | Repeat | Note=ANK 2 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 768_797 | 350.0 | 805.0 | Repeat | Note=ANK 1 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 801_830 | 350.0 | 805.0 | Repeat | Note=ANK 2 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 768_797 | 350.0 | 406.0 | Repeat | Note=ANK 1 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 801_830 | 350.0 | 406.0 | Repeat | Note=ANK 2 |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000304032 | + | 9 | 18 | 624_647 | 350.0 | 858.0 | Zinc finger | C4-type |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000336665 | + | 9 | 17 | 624_647 | 350.0 | 805.0 | Zinc finger | C4-type |
Hgene | AGAP1 | chr2:236715975 | chr2:175252507 | ENST00000409457 | + | 9 | 10 | 624_647 | 350.0 | 406.0 | Zinc finger | C4-type |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
AGAP1_pLDDT.png![]() |
CIR1_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
AGAP1 | |
CIR1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000342016 | 0 | 10 | 1_121 | 24.0 | 451.0 | RBPJ | |
Tgene | CIR1 | chr2:236715975 | chr2:175252507 | ENST00000362053 | 0 | 11 | 1_121 | 24.0 | 496.3333333333333 | RBPJ |
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Related Drugs to AGAP1-CIR1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to AGAP1-CIR1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |