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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EWSR1-ETV4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EWSR1-ETV4
FusionPDB ID: 27830
FusionGDB2.0 ID: 27830
HgeneTgene
Gene symbol

EWSR1

ETV4

Gene ID

2130

2118

Gene nameEWS RNA binding protein 1ETS variant transcription factor 4
SynonymsEWS|EWS-FLI1|bK984G1.4E1A-F|E1AF|PEA3|PEAS3
Cytomap

22q12.2

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogeneETS translocation variant 4ETS variant 4EWS protein/E1A enhancer binding protein chimeraadenovirus E1A enhancer-binding proteinets variant gene 4 (E1A enhancer-binding protein, E1AF)polyomavirus enhancer activator 3 homolog
Modification date2020032920200313
UniProtAcc

Q01844

P43268

Ensembl transtripts involved in fusion geneENST idsENST00000331029, ENST00000332035, 
ENST00000332050, ENST00000333395, 
ENST00000397938, ENST00000406548, 
ENST00000414183, 		ENST00000586826, 
ENST00000319349, ENST00000393664, 
ENST00000538265, ENST00000545089, 
ENST00000545954, ENST00000591713, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 91 X 16=6406414 X 28 X 6=2352
# samples 9824
** MAII scorelog2(98/64064*10)=-6.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2352*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EWSR1 [Title/Abstract] AND ETV4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EWSR1(29683123)-ETV4(41607549), # samples:2
Anticipated loss of major functional domain due to fusion event.EWSR1-ETV4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ETV4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ETV4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EWSR1-ETV4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETV4

GO:0045944

positive regulation of transcription by RNA polymerase II

24983502


check buttonFusion gene breakpoints across EWSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ewing sarcomaAB005538EWSR1chr22

29684696

ETV4chr17

41609278
ChimerKB3..EWSR1chr22

29678546

+ETV4chr17

13949325

-
ChimerKB3..EWSR1chr22

29683123

+ETV4chr17

41605212

-
ChimerKB3..EWSR1chr22

29683123

+ETV4chr17

41607549

-
ChimerKB3..EWSR1chr22

29684696

+ETV4chr17

41609278

-
ChimerKB4..EWSR1chr22

29683123

+ETV4chr17

41607549

-
ChiTaRS5.0N/AAB005538EWSR1chr22

29684696

+ETV4chr17

41609377

-
ChiTaRS5.0N/AHW906201EWSR1chr22

29683123

+ETV4chr17

41607549

-
ChiTaRS5.0N/AU35622EWSR1chr22

29683123

+ETV4chr17

41607549

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332050EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-244011213281764478
ENST00000332050EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-243811213281764478
ENST00000332050EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-235511213281764478
ENST00000332050EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-200611213281764478
ENST00000332050EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-200411213281764478
ENST00000332050EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-194711213281764478
ENST00000397938EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-243111123191755478
ENST00000397938EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-242911123191755478
ENST00000397938EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-234611123191755478
ENST00000397938EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-199711123191755478
ENST00000397938EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-199511123191755478
ENST00000397938EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-193811123191755478
ENST00000406548EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2176857641500478
ENST00000406548EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2174857641500478
ENST00000406548EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2091857641500478
ENST00000406548EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1742857641500478
ENST00000406548EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1740857641500478
ENST00000406548EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1683857641500478
ENST00000331029EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2158839461482478
ENST00000331029EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2156839461482478
ENST00000331029EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2073839461482478
ENST00000331029EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1724839461482478
ENST00000331029EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1722839461482478
ENST00000331029EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1665839461482478
ENST00000414183EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2151832211475484
ENST00000414183EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2149832211475484
ENST00000414183EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2066832211475484
ENST00000414183EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1717832211475484
ENST00000414183EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1715832211475484
ENST00000414183EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1658832211475484
ENST00000333395EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2131812191455478
ENST00000333395EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2129812191455478
ENST00000333395EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2046812191455478
ENST00000333395EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1697812191455478
ENST00000333395EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1695812191455478
ENST00000333395EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1638812191455478
ENST00000332035EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-1955636111279422
ENST00000332035EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-1953636111279422
ENST00000332035EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-1870636111279422
ENST00000332035EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1521636111279422
ENST00000332035EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1519636111279422
ENST00000332035EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1462636111279422
ENST00000332050EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-244011213281764478
ENST00000332050EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-243811213281764478
ENST00000332050EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-235511213281764478
ENST00000332050EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-200611213281764478
ENST00000332050EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-200411213281764478
ENST00000332050EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-194711213281764478
ENST00000397938EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-243111123191755478
ENST00000397938EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-242911123191755478
ENST00000397938EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-234611123191755478
ENST00000397938EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-199711123191755478
ENST00000397938EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-199511123191755478
ENST00000397938EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-193811123191755478
ENST00000406548EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2176857641500478
ENST00000406548EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2174857641500478
ENST00000406548EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2091857641500478
ENST00000406548EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1742857641500478
ENST00000406548EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1740857641500478
ENST00000406548EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1683857641500478
ENST00000331029EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2158839461482478
ENST00000331029EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2156839461482478
ENST00000331029EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2073839461482478
ENST00000331029EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1724839461482478
ENST00000331029EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1722839461482478
ENST00000331029EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1665839461482478
ENST00000414183EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2151832211475484
ENST00000414183EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2149832211475484
ENST00000414183EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2066832211475484
ENST00000414183EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1717832211475484
ENST00000414183EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1715832211475484
ENST00000414183EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1658832211475484
ENST00000333395EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-2131812191455478
ENST00000333395EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-2129812191455478
ENST00000333395EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-2046812191455478
ENST00000333395EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1697812191455478
ENST00000333395EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1695812191455478
ENST00000333395EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1638812191455478
ENST00000332035EWSR1chr2229683123+ENST00000319349ETV4chr1741607549-1955636111279422
ENST00000332035EWSR1chr2229683123+ENST00000393664ETV4chr1741607549-1953636111279422
ENST00000332035EWSR1chr2229683123+ENST00000538265ETV4chr1741607549-1870636111279422
ENST00000332035EWSR1chr2229683123+ENST00000545954ETV4chr1741607549-1521636111279422
ENST00000332035EWSR1chr2229683123+ENST00000545089ETV4chr1741607549-1519636111279422
ENST00000332035EWSR1chr2229683123+ENST00000591713ETV4chr1741607549-1462636111279422

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332050ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0037664820.9962335
ENST00000332050ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.0037904350.9962096
ENST00000332050ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0044185020.99558145
ENST00000332050ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0070460890.99295396
ENST00000332050ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.0071256310.9928744
ENST00000332050ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.0072872630.9927127
ENST00000397938ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0037220590.99627787
ENST00000397938ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.0037454580.99625456
ENST00000397938ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0043711410.99562883
ENST00000397938ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0069843320.99301565
ENST00000397938ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.007056290.9929437
ENST00000397938ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.007212270.9927878
ENST00000406548ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0040708740.99592906
ENST00000406548ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.004114130.9958859
ENST00000406548ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0049592610.9950407
ENST00000406548ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0085229250.9914771
ENST00000406548ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.0086711190.99132884
ENST00000406548ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.0091883010.9908117
ENST00000331029ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0041746920.9958253
ENST00000331029ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.0042172620.99578273
ENST00000331029ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0051042330.99489576
ENST00000331029ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0089479250.9910521
ENST00000331029ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.0090803170.9909197
ENST00000331029ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.0095549590.990445
ENST00000414183ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0039995920.99600035
ENST00000414183ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.0040279570.995972
ENST00000414183ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0047494980.99525046
ENST00000414183ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0084106430.99158937
ENST00000414183ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.0085302330.9914698
ENST00000414183ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.0088800550.9911199
ENST00000333395ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0041045190.9958955
ENST00000333395ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.004130350.9958696
ENST00000333395ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0049325040.9950675
ENST00000333395ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0086656070.9913344
ENST00000333395ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.008803450.9911965
ENST00000333395ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.009229420.9907706
ENST00000332035ENST00000319349EWSR1chr2229683123+ETV4chr1741607549-0.0038752660.9961247
ENST00000332035ENST00000393664EWSR1chr2229683123+ETV4chr1741607549-0.0039043910.9960956
ENST00000332035ENST00000538265EWSR1chr2229683123+ETV4chr1741607549-0.0046892720.9953107
ENST00000332035ENST00000545954EWSR1chr2229683123+ETV4chr1741607549-0.0087387780.99126124
ENST00000332035ENST00000545089EWSR1chr2229683123+ETV4chr1741607549-0.0088933520.9911067
ENST00000332035ENST00000591713EWSR1chr2229683123+ETV4chr1741607549-0.0092198790.99078006

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27830_27830_1_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_2_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_3_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_4_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_5_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_6_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000331029_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_7_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_8_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_9_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_10_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_11_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_12_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332035_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=422AA_BP=209
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQP
PTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREG
PPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVC

--------------------------------------------------------------

>27830_27830_13_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_14_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_15_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_16_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_17_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_18_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000332050_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_19_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_20_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_21_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_22_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_23_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_24_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000333395_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_25_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_26_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_27_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_28_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_29_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_30_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000397938_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_31_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_32_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

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>27830_27830_33_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

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>27830_27830_34_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

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>27830_27830_35_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

--------------------------------------------------------------

>27830_27830_36_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000406548_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=478AA_BP=265
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPV
QGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYP
MQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQNVTGCA
SMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAWTGRG
MEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL

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>27830_27830_37_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000319349_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

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>27830_27830_38_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000393664_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

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>27830_27830_39_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000538265_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

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>27830_27830_40_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000545089_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

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>27830_27830_41_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000545954_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

--------------------------------------------------------------

>27830_27830_42_EWSR1-ETV4_EWSR1_chr22_29683123_ENST00000414183_ETV4_chr17_41607549_ENST00000591713_length(amino acids)=484AA_BP=271
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDVSYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQ
AYSQPVQGYGTGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQPQSSTGGYNQPSLGYGQSNYSYPQ
VPGSYPMQPVTAPPSYPPTSYSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQQSSSYGQQ
NVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFI
AWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29683123/chr17:41607549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EWSR1

Q01844

ETV4

P43268

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090). {ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:31552090}.; FUNCTION: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. {ECO:0000269|PubMed:8441666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616111_116208.33333333333334601.0RepeatNote=12
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616117_125208.33333333333334601.0RepeatNote=13
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616126_156208.33333333333334601.0RepeatNote=14
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616157_163208.33333333333334601.0RepeatNote=15
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616164_170208.33333333333334601.0RepeatNote=16
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616171_177208.33333333333334601.0RepeatNote=17
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616178_188208.33333333333334601.0RepeatNote=18
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61617_27208.33333333333334601.0RepeatNote=2
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616189_193208.33333333333334601.0RepeatNote=19
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616194_201208.33333333333334601.0RepeatNote=20
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616202_206208.33333333333334601.0RepeatNote=21
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61628_34208.33333333333334601.0RepeatNote=3
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61635_42208.33333333333334601.0RepeatNote=4
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61643_50208.33333333333334601.0RepeatNote=5
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61651_59208.33333333333334601.0RepeatNote=6
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61660_68208.33333333333334601.0RepeatNote=7
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61669_75208.33333333333334601.0RepeatNote=8
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61676_84208.33333333333334601.0RepeatNote=9
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61685_91208.33333333333334601.0RepeatNote=10
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+6168_16208.33333333333334601.0RepeatNote=1
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+61692_110208.33333333333334601.0RepeatNote=11
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79111_116264.3333333333333355.0RepeatNote=12
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79117_125264.3333333333333355.0RepeatNote=13
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79126_156264.3333333333333355.0RepeatNote=14
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79157_163264.3333333333333355.0RepeatNote=15
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79164_170264.3333333333333355.0RepeatNote=16
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79171_177264.3333333333333355.0RepeatNote=17
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79178_188264.3333333333333355.0RepeatNote=18
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7917_27264.3333333333333355.0RepeatNote=2
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79189_193264.3333333333333355.0RepeatNote=19
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79194_201264.3333333333333355.0RepeatNote=20
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79202_206264.3333333333333355.0RepeatNote=21
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79207_212264.3333333333333355.0RepeatNote=22
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79213_218264.3333333333333355.0RepeatNote=23
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79219_224264.3333333333333355.0RepeatNote=24
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79225_230264.3333333333333355.0RepeatNote=25
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79231_238264.3333333333333355.0RepeatNote=26
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79239_245264.3333333333333355.0RepeatNote=27
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79246_252264.3333333333333355.0RepeatNote=28
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79253_259264.3333333333333355.0RepeatNote=29
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7928_34264.3333333333333355.0RepeatNote=3
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7935_42264.3333333333333355.0RepeatNote=4
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7943_50264.3333333333333355.0RepeatNote=5
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7951_59264.3333333333333355.0RepeatNote=6
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7960_68264.3333333333333355.0RepeatNote=7
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7969_75264.3333333333333355.0RepeatNote=8
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7976_84264.3333333333333355.0RepeatNote=9
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7985_91264.3333333333333355.0RepeatNote=10
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+798_16264.3333333333333355.0RepeatNote=1
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+7992_110264.3333333333333355.0RepeatNote=11
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717111_116264.3333333333333657.0RepeatNote=12
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717117_125264.3333333333333657.0RepeatNote=13
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717126_156264.3333333333333657.0RepeatNote=14
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717157_163264.3333333333333657.0RepeatNote=15
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717164_170264.3333333333333657.0RepeatNote=16
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717171_177264.3333333333333657.0RepeatNote=17
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717178_188264.3333333333333657.0RepeatNote=18
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71717_27264.3333333333333657.0RepeatNote=2
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717189_193264.3333333333333657.0RepeatNote=19
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717194_201264.3333333333333657.0RepeatNote=20
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717202_206264.3333333333333657.0RepeatNote=21
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717207_212264.3333333333333657.0RepeatNote=22
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717213_218264.3333333333333657.0RepeatNote=23
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717219_224264.3333333333333657.0RepeatNote=24
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717225_230264.3333333333333657.0RepeatNote=25
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717231_238264.3333333333333657.0RepeatNote=26
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717239_245264.3333333333333657.0RepeatNote=27
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717246_252264.3333333333333657.0RepeatNote=28
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717253_259264.3333333333333657.0RepeatNote=29
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71728_34264.3333333333333657.0RepeatNote=3
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71735_42264.3333333333333657.0RepeatNote=4
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71743_50264.3333333333333657.0RepeatNote=5
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71751_59264.3333333333333657.0RepeatNote=6
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71760_68264.3333333333333657.0RepeatNote=7
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71769_75264.3333333333333657.0RepeatNote=8
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71776_84264.3333333333333657.0RepeatNote=9
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71785_91264.3333333333333657.0RepeatNote=10
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+7178_16264.3333333333333657.0RepeatNote=1
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+71792_110264.3333333333333657.0RepeatNote=11
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717111_116264.3333333333333656.0RepeatNote=12
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717117_125264.3333333333333656.0RepeatNote=13
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717126_156264.3333333333333656.0RepeatNote=14
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717157_163264.3333333333333656.0RepeatNote=15
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717164_170264.3333333333333656.0RepeatNote=16
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717171_177264.3333333333333656.0RepeatNote=17
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717178_188264.3333333333333656.0RepeatNote=18
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71717_27264.3333333333333656.0RepeatNote=2
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717189_193264.3333333333333656.0RepeatNote=19
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717194_201264.3333333333333656.0RepeatNote=20
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717202_206264.3333333333333656.0RepeatNote=21
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717207_212264.3333333333333656.0RepeatNote=22
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717213_218264.3333333333333656.0RepeatNote=23
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717219_224264.3333333333333656.0RepeatNote=24
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717225_230264.3333333333333656.0RepeatNote=25
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717231_238264.3333333333333656.0RepeatNote=26
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717239_245264.3333333333333656.0RepeatNote=27
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717246_252264.3333333333333656.0RepeatNote=28
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717253_259264.3333333333333656.0RepeatNote=29
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71728_34264.3333333333333656.0RepeatNote=3
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71735_42264.3333333333333656.0RepeatNote=4
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71743_50264.3333333333333656.0RepeatNote=5
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71751_59264.3333333333333656.0RepeatNote=6
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71760_68264.3333333333333656.0RepeatNote=7
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71769_75264.3333333333333656.0RepeatNote=8
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71776_84264.3333333333333656.0RepeatNote=9
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71785_91264.3333333333333656.0RepeatNote=10
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+7178_16264.3333333333333656.0RepeatNote=1
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+71792_110264.3333333333333656.0RepeatNote=11
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818111_116270.3333333333333662.0RepeatNote=12
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818117_125270.3333333333333662.0RepeatNote=13
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818126_156270.3333333333333662.0RepeatNote=14
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818157_163270.3333333333333662.0RepeatNote=15
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818164_170270.3333333333333662.0RepeatNote=16
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818171_177270.3333333333333662.0RepeatNote=17
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818178_188270.3333333333333662.0RepeatNote=18
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81817_27270.3333333333333662.0RepeatNote=2
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818189_193270.3333333333333662.0RepeatNote=19
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818194_201270.3333333333333662.0RepeatNote=20
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818202_206270.3333333333333662.0RepeatNote=21
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818207_212270.3333333333333662.0RepeatNote=22
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818213_218270.3333333333333662.0RepeatNote=23
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818219_224270.3333333333333662.0RepeatNote=24
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818225_230270.3333333333333662.0RepeatNote=25
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818231_238270.3333333333333662.0RepeatNote=26
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818239_245270.3333333333333662.0RepeatNote=27
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818246_252270.3333333333333662.0RepeatNote=28
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818253_259270.3333333333333662.0RepeatNote=29
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81828_34270.3333333333333662.0RepeatNote=3
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81835_42270.3333333333333662.0RepeatNote=4
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81843_50270.3333333333333662.0RepeatNote=5
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81851_59270.3333333333333662.0RepeatNote=6
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81860_68270.3333333333333662.0RepeatNote=7
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81869_75270.3333333333333662.0RepeatNote=8
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81876_84270.3333333333333662.0RepeatNote=9
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81885_91270.3333333333333662.0RepeatNote=10
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+8188_16270.3333333333333662.0RepeatNote=1
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+81892_110270.3333333333333662.0RepeatNote=11
TgeneETV4chr22:29683123chr17:41607549ENST00000319349713341_421270.3333333333333485.0DNA bindingETS
TgeneETV4chr22:29683123chr17:41607549ENST00000393664612341_421270.3333333333333485.0DNA bindingETS
TgeneETV4chr22:29683123chr17:41607549ENST00000538265612341_421231.33333333333334446.0DNA bindingETS
TgeneETV4chr22:29683123chr17:41607549ENST00000545954612341_421231.33333333333334446.0DNA bindingETS
TgeneETV4chr22:29683123chr17:41607549ENST00000591713713341_421270.3333333333333485.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616300_340208.33333333333334601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616454_513208.33333333333334601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616559_640208.33333333333334601.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79300_340264.3333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79454_513264.3333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79559_640264.3333333333333355.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717300_340264.3333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717454_513264.3333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717559_640264.3333333333333657.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717300_340264.3333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717454_513264.3333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717559_640264.3333333333333656.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818300_340270.3333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818454_513270.3333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818559_640270.3333333333333662.0Compositional biasNote=Arg/Gly/Pro-rich
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616256_285208.33333333333334601.0DomainNote=IQ
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616361_447208.33333333333334601.0DomainRRM
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79256_285264.3333333333333355.0DomainNote=IQ
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79361_447264.3333333333333355.0DomainRRM
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717256_285264.3333333333333657.0DomainNote=IQ
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717361_447264.3333333333333657.0DomainRRM
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717256_285264.3333333333333656.0DomainNote=IQ
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717361_447264.3333333333333656.0DomainRRM
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818256_285270.3333333333333662.0DomainNote=IQ
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818361_447270.3333333333333662.0DomainRRM
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616639_656208.33333333333334601.0MotifNuclear localization signal
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79639_656264.3333333333333355.0MotifNuclear localization signal
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717639_656264.3333333333333657.0MotifNuclear localization signal
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717639_656264.3333333333333656.0MotifNuclear localization signal
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818639_656270.3333333333333662.0MotifNuclear localization signal
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+6161_285208.33333333333334601.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+6168_285208.33333333333334601.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+791_285264.3333333333333355.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+798_285264.3333333333333355.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+7171_285264.3333333333333657.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+7178_285264.3333333333333657.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+7171_285264.3333333333333656.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+7178_285264.3333333333333656.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+8181_285270.3333333333333662.0RegionNote=EAD (Gln/Pro/Thr-rich)
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+8188_285270.3333333333333662.0RegionNote=31 X approximate tandem repeats
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616207_212208.33333333333334601.0RepeatNote=22
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616213_218208.33333333333334601.0RepeatNote=23
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616219_224208.33333333333334601.0RepeatNote=24
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616225_230208.33333333333334601.0RepeatNote=25
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616231_238208.33333333333334601.0RepeatNote=26
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616239_245208.33333333333334601.0RepeatNote=27
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616246_252208.33333333333334601.0RepeatNote=28
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616253_259208.33333333333334601.0RepeatNote=29
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616260_276208.33333333333334601.0RepeatNote=30
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616277_285208.33333333333334601.0RepeatNote=31
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79260_276264.3333333333333355.0RepeatNote=30
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79277_285264.3333333333333355.0RepeatNote=31
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717260_276264.3333333333333657.0RepeatNote=30
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717277_285264.3333333333333657.0RepeatNote=31
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717260_276264.3333333333333656.0RepeatNote=30
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717277_285264.3333333333333656.0RepeatNote=31
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818260_276270.3333333333333662.0RepeatNote=30
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818277_285270.3333333333333662.0RepeatNote=31
HgeneEWSR1chr22:29683123chr17:41607549ENST00000332035+616518_549208.33333333333334601.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29683123chr17:41607549ENST00000333395+79518_549264.3333333333333355.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29683123chr17:41607549ENST00000397938+717518_549264.3333333333333657.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29683123chr17:41607549ENST00000406548+717518_549264.3333333333333656.0Zinc fingerRanBP2-type
HgeneEWSR1chr22:29683123chr17:41607549ENST00000414183+818518_549270.3333333333333662.0Zinc fingerRanBP2-type
TgeneETV4chr22:29683123chr17:41607549ENST00000319349713148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr22:29683123chr17:41607549ENST0000031934971349_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr22:29683123chr17:41607549ENST00000393664612148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr22:29683123chr17:41607549ENST0000039366461249_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr22:29683123chr17:41607549ENST00000538265612148_244231.33333333333334446.0Compositional biasNote=Gln-rich
TgeneETV4chr22:29683123chr17:41607549ENST0000053826561249_75231.33333333333334446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr22:29683123chr17:41607549ENST00000545954612148_244231.33333333333334446.0Compositional biasNote=Gln-rich
TgeneETV4chr22:29683123chr17:41607549ENST0000054595461249_75231.33333333333334446.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneETV4chr22:29683123chr17:41607549ENST00000591713713148_244270.3333333333333485.0Compositional biasNote=Gln-rich
TgeneETV4chr22:29683123chr17:41607549ENST0000059171371349_75270.3333333333333485.0Compositional biasNote=Asp/Glu-rich (acidic)


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (180) >>>180.pdbFusion protein BP residue: 209
CIF file (180) >>>180.cif		EWSR1chr2229683123+ETV4chr1741607549-
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDV
SYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPVQGYGTGAYDT
TTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTSYSSTQPTSYDQS
SYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQAPSQYSQ
QSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPFPDDVCV
VPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTNAHFIAW
TGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVA
GERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPLSHLDES
422
3D view using mol* of 180 (AA BP:209)
PDB file (260) >>>260.pdbFusion protein BP residue: 265
CIF file (260) >>>260.cif		EWSR1chr2229683123+ETV4chr1741607549-
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDV
SYTQAQTTATYGQTAYATSYGQPPTGYTTPTAPQAYSQPVQGYGTGAYDT
TTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNKPTETSQ
PQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTSYSSTQP
TSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQTGSYSQA
PSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYEKPLRPF
PDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVALLDDPTN
AHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKG
IMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSEEDTVPL
478
3D view using mol* of 260 (AA BP:265)
PDB file (273) >>>273.pdbFusion protein BP residue: 271
CIF file (273) >>>273.cif		EWSR1chr2229683123+ETV4chr1741607549-
MASTDYSTYSQAAAQQGYSAYTAQPTQGYAQTTQAYGQQSYGTYGQPTDV
SYTQAQTTATYGQTAYATSYGQPPTVEGTSTGYTTPTAPQAYSQPVQGYG
TGAYDTTTATVTTTQASYAAQSAYGTQPAYPAYGQQPAATAPTRPQDGNK
PTETSQPQSSTGGYNQPSLGYGQSNYSYPQVPGSYPMQPVTAPPSYPPTS
YSSTQPTSYDQSSYSQQNTYGQPSSYGQQSSYGQQSSYGQQPPTSYPPQT
GSYSQAPSQYSQQSSSYGQQNVTGCASMYLHTEGFSGPSPGDGAMGYGYE
KPLRPFPDDVCVVPEKFEGDIKQEGVGAFREGPPYQRRGALQLWQFLVAL
LDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLR
YYYEKGIMQKVAGERYVYKFVCEPEALFSLAFPDNQRPALKAEFDRPVSE
484
3D view using mol* of 273 (AA BP:271)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EWSR1_pLDDT.png
all structure
all structure
ETV4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EWSR1_ETV4_180_PAE.png (AA BP:209)
all structure
EWSR1_ETV4_180_pLDDT.png (AA BP:209)
all structure
EWSR1_ETV4_180_pLDDT_and_active_sites.png (AA BP:209)
all structure
EWSR1_ETV4_180_violinplot.png (AA BP:209)
all structure
EWSR1_ETV4_260_PAE.png (AA BP:265)
all structure
EWSR1_ETV4_260_pLDDT.png (AA BP:265)
all structure
EWSR1_ETV4_260_pLDDT_and_active_sites.png (AA BP:265)
all structure
EWSR1_ETV4_260_violinplot.png (AA BP:265)
all structure
EWSR1_ETV4_273_pLDDT.png (AA BP:271)
all structure
EWSR1_ETV4_273_pLDDT_and_active_sites.png (AA BP:271)
all structure
EWSR1_ETV4_273_violinplot.png (AA BP:271)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
EWSR1_ETV4_180.png
all structure
EWSR1_ETV4_260.png
all structure
EWSR1_ETV4_273.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
1800.693350.66684.0350.5880.6161.0061.3540.7971.6990.442Chain A: 343,363,366,367,370,371,372,375,376,378
2600.927800.955198.5970.5850.6450.9050.6440.8360.770.792Chain A: 336,337,338,396,399,401,422,423,424,426,4
27,428,431,432,433,434
2730.775580.792100.1560.6420.5450.7350.7320.770.950.728Chain A: 405,425,428,429,432,433,434,437,438,439,4
40

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EWSR1PRTFDC1, ZDHHC3, MSC, SLC22A24, MYO1F, KXD1, KHDRBS2, DNAJB3, FASN, NLE1, MNS1, PRUNE2, WWP2, NDUFB1, BNIP3L, NSUN4, KRR1, WWP1, RMND5B, SLC1A1, RASL11B, DFFA, WDR37, RPS15A, CPSF6, C11orf16, YY1AP1, RNF183, MTCP1, TULP2, RBPMS, KEL, MYOZ2, FAM131C, HMGA1, NPPB, HERPUD1, CD177, RPL31, VPS72, ACTL6A, RAD23A, MAGEA11, CFDP1, DMRTB1, CXADR, ZNF165, SSBP2, TPGS2, RAB37, CETP, NDUFV1, DYNLL2, NBPF3, CEACAM5, GPBP1L1, SERP2, GNPDA1, C19orf57, ELAVL3, ELAVL4, LILRA3, BAD, CCDC7, MRPS18B, CUEDC2, CNST, TSPAN3, CCDC91, TRIM37, NINL, NTNG2, CPSF7, PGLS, EPT1, MYL6, SMAD4, TMSB4Y, TRPV5, MVK, MAPK1IP1L, MDFI, MTMR9, PLSCR1, RALYL, PDHX, C10orf12, RHOXF2, MATK, SALL2, AGT, KCNMB1, SUV39H2, SMNDC1, ARHGDIA, PUF60, GSK3B, ILK, CD2BP2, BARD1, CREBBP, BTK, SF1, SNRPC, ELK1, PTK2B, CALM1, POU4F1, EZH2, IRF3, TONSL, RFX3, HLTF, SUPT4H1, ZNF184, HIST1H2BN, BLZF1, HDAC3, FXR2, HMGN4, POLR3A, ECD, ZBTB1, SCMH1, SUZ12, E2F8, TRIM5, ZNF383, DHX9, SMN1, PCM1, RAD21, NDRG1, CEBPA, ELAVL1, SIRT7, HNRNPA1, TSG101, TP53, POLR2A, YBX1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, KCND3, ATN1, ATXN3, ERCC5, HBP1, HSPA2, PCBP1, USP7, SRSF5, TMEM126A, SAP30BP, GORASP2, MBD3, MRPS9, HAX1, SFXN1, ITGA5, TCIRG1, RNF168, GEMIN5, HAS1, MTCH1, NDUFA5, MCAT, MRPL57, HDAC2, ESR1, FN1, VCAM1, ITGA4, CD81, PRMT1, SF3B4, EP300, PRRC2A, EWSR1, FUS, ITGB5, NONO, TRAF3, HNRNPUL1, EPAS1, CHERP, CDK12, ITCH, WBP4, rev, RPA3, RPA2, RPA1, HSPA5, RIOK2, TRAF1, TRAF2, SEC24D, TFG, SEC24A, SSBP3, PRR13, ATPAF2, PEF1, JUN, CUL7, OBSL1, CCDC8, RNF2, BMI1, EGFR, ABL1, SRPK1, ABCE1, PRMT8, RPS6KB2, ACAA2, ACAT1, EIF4H, ANXA2, HIP1R, PICALM, POR, NTRK1, SCARNA22, NPM1, KRT2, PRDX2, S100A9, YWHAZ, DDX17, PCLO, ANXA6, SEC24C, GIPC1, CSRP2, FHL1, HNRNPA3, CTTN, MARCKSL1, PARP1, SERPINB3, CCDC50, KIF2A, KRT6B, HIST1H1D, STK38, H2AFV, PACSIN2, U2AF1, RSL24D1, XRCC5, ESYT3, RPL29, SDF2L1, LRP1B, MSN, SEC23A, RPL7A, SNX18, PPIL1, RPS27A, IGHM, SUMO3, GTF2I, RUVBL1, KRT16, RBM8A, RPL8, SRSF9, ZC3HAV1L, GAPDH, ETV3, IGF2R, COL5A2, HNRNPD, ANP32B, WAC, TFAP2A, TTN, CBR3, ARGLU1, HNRNPAB, SRRT, ATP1B3, COPS7B, PRR12, ATF3, NOMO3, NOMO1, NOMO2, EYA3, C1orf198, MAZ, U2AF2, SSB, TRA2B, C1orf52, HMGB1, HMGB1P10, RPRD1A, HNRNPH3, EIF5A2, C1orf131, SEC13, MAPRE1, CSTF2T, SRSF3, LENG1, UPF1, HDGFRP2, RPS10P7, RPS10P11, RPS10, RPS10P13, RPS10P4, RPS10P22, DACH1, ANO1, NCOR1, MLX, SUMO1P3, SUMO1, WIZ, PFDN6, ARFIP2, ZHX3, EEF1B2, MBIP, BAG6, DENND2A, PRCC, SRSF1, EIF4ENIF1, SPTAN1, CDCA8, PLS3, API5P1, API5, PSMA4, DNTTIP1, AKAP8, NCOA3, SMTN, FBRS, SMARCE1, ERC1, WBP11, SPTBN1, NFRKB, OLA1, ZNF207, R3HDM1, TRIM33, SAFB, UBFD1, SRSF7, SRSF2, GATA6, VDAC1P1, VDAC1, IL16, GMNN, ILF2, MED4, QKI, VCL, MFAP1, SNAP29, PADI1, BCL9, BCL9L, PKM, GPATCH11, CASC3, PSMC6, CACYBP, RPL12P6, RPL12P32, RPL12P14, RPL12, RPL12P2, RPL12P35, RPL12P19, TPI1, TPI1P1, CHAF1A, MIA3, CIC, SDCBP, CA2, FKBP3, ACE, NKX2-5, CSTF2, PFDN2, UBTF, FAM207A, LOC729774, BRD8, C12orf45, C1orf35, TCF20, SOD1, SPAG7, MED8, ETS2, ALDOC, FKBP4, INCENP, CEP85, CECR2, TFE3, SUPT16HP1, SUPT16H, MAPT, HTATSF1, RPS18P12, RPS18P5, KPNA2, TMX1, CKAP4, HSPE1, COPRS, PTGES3, LAMP2, ERLIN2, CTNNBL1, TOMM22, NRBF2, C9orf78, NCOA6, MED26, RANBP1, LOC389842, LOC727803, HMGB3, CANX, PUS7, RPSAP19, RPSA, RPSAP18, RPSAP58, RPSAP15, RPSAP8, RPSAP9, RPSAP12, RPSAP29, RPSAP61, ARHGAP17, USF1, PSIP1, SNRPEP2, SNRPE, NUDT5, PPM1G, OTUB1, AHCY, COPS3, NSMCE2, SAE1, PROSER1, GRWD1, CREB5, TAF9B, RBM33, EDF1, PGK1, FAM114A2, SRRM1, RAD23B, CIAPIN1, CIAPIN1P, LRRC59, PABPN1, KMT2A, RPRD1B, GPATCH8, CCDC43, DGCR14, PPP1R2, ERICH1, EIF5A, EIF5AL1, BAG3, PCNA, SOX7, PNISR, FAM168A, MED15, SRSF11, SIRT1, RSF1, MAML1, HPRT1, SPDL1, CRTC3, CEP55, CDV3, ALYREF, RNF40, STOML2, DGCR8, NUCKS1, UBN2, PSMD7, WNT10A, HMBS, KHDRBS1, VBP1, NCSTN, CDCA2, SFSWAP, ZRANB2, DDB1, RBBP6, ZEB1, SRSF6, LOC644422, EIF2S1, RFX5, RPS19, RPS19P3, TALDO1, CWC15, CDCA5, LOC645086, C11orf58, TXN, STX12, PHRF1, BSG, TAF4, SH3GL1, LIN37, HRNR, FAM192A, RRBP1, KIAA0907, GOLGB1, PAX9, P4HB, CHMP5, LDHB, CALR, SUMO2P1, SUMO2, PDIA6, AHSA1, EN2, CCDC124, RPLP0P6, RPLP0P2, RPLP0P3, RPLP0, NIPBL, PDLIM4, PRKCSH, C15orf39, HNRNPDL, PDIA4, NUP210, RPLP2P3, RPLP2, PRDX4, DAZAP1, UBE2T, PHAX, AMOT, MARCKS, LOC284685, SMARCC1, BCORL1, RFC4, GLRX3, ANP32E, HYOU1, NPM3, ATF7IP, SARNP, TRA2A, HDGF, STIP1, PELP1, KCTD12, GLO1, PCF11, CLIC1, DNAJC8, RNF114, SLC4A1AP, FAM50A, GTF2A1, PRPF40A, CDC37, PPIAP22, PPIA, SMARCC2, MEGF11, KIAA1143, DENR, LAMP1, MYBL2, PITX1, UBE2MP1, UBE2M, CHTF8, OTX1, NACA, FNBP4, GTF2F2, GLTSCR1, GTF2E1, PQBP1, EMD, RNF113A, GPALPP1, SNRPA, RRP15, RPS25, RPS25P8, GMEB2, LNPEP, DNAJB1, IGBP1P1, IGBP1, HINT1, ARID1A, PPIB, ANXA11, MATR3, Sgol2, PPARGC1A, MCM2, Ksr1, UBASH3B, SFPQ, CAPN13, HEY1, BRCA1, MTCH2, PPIE, TBX3, BMP4, CTNNB1, GSK3A, HNF1B, TCF7L2, TRIP4, YAF2, ZNF217, AAR2, PIH1D1, EFTUD2, TNIP2, CHD3, CHD4, HEXIM1, MEPCE, LARP7, RUNX1, AGR2, RECQL4, REST, CDK9, SMARCA4, DDIT3, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H1, RC3H2, ATG16L1, PHB, DISC1, NR2C2, UBQLN2, ZFYVE21, XRCC6, AGRN, USP19, HIST1H4A, APEX1, DDX5, SNRNP70, SNRPB, SNRPD1, SNRPD2, SNRPD3, RNU1-1, RBMX, HNRNPM, HNRNPA2B1, TAF15, DDX3X, TARDBP, CLINT1, HNRNPL, NUMA1, ZFR, SNRNP200, ZNF326, HNRNPK, SF3B1, TOE1, HSPA8, SNRPB2, DDX20, GOT2, ILF3, PRPF6, ZNF638, HNRNPF, HNRNPH1, HNRNPR, VCP, CAD, CCAR2, DDX23, GEMIN4, HSPA1A, PCMTD1, POTEF, PRMT5, RBM45, SAFB2, SF3B2, SF3B3, SNRPF, SRSF4, THRAP3, TIA1, TTC7A, ZCCHC8, ITFG1, ARAF, BRD7, SOX2, ARIH2, PLEKHA4, NGB, OPTN, ZC3H18, CELF1, MKI67, INS, Apc2, FBP1, N, ZNF768, SYNCRIP, KDM5C, DDX58, OGT, SPOP, UFL1, DDRGK1, WDR5, TPX2, MALL, SOX21, POU3F3, PTP4A3, TRIM8, RCHY1, nsp14, SOX5,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EWSR1all structure
ETV4all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EWSR1-ETV4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EWSR1-ETV4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
EWSR1ETV4Prostate AdenocarcinomaMyCancerGenome
EWSR1ETV4GlioblastomaMyCancerGenome
EWSR1ETV4Multiple MyelomaMyCancerGenome
EWSR1ETV4AstrocytomaMyCancerGenome
EWSR1ETV4Breast Invasive Ductal CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEWSR1C0553580Ewings sarcoma3CTD_human;ORPHANET
HgeneEWSR1C0002736Amyotrophic Lateral Sclerosis1GENOMICS_ENGLAND
HgeneEWSR1C0033578Prostatic Neoplasms1CTD_human
HgeneEWSR1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
HgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human
HgeneEWSR1C0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneEWSR1C0334584Spongioblastoma1CTD_human
HgeneEWSR1C0334596Medulloepithelioma1CTD_human
HgeneEWSR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneEWSR1C0700367Ependymoblastoma1CTD_human
HgeneEWSR1C0751675Cerebral Primitive Neuroectodermal Tumor1CTD_human
HgeneEWSR1C1275278Extraskeletal Myxoid Chondrosarcoma1ORPHANET
TgeneETV4C0033578Prostatic Neoplasms2CTD_human
TgeneETV4C0376358Malignant neoplasm of prostate2CTD_human
TgeneETV4C0006142Malignant neoplasm of breast1CTD_human
TgeneETV4C0027627Neoplasm Metastasis1CTD_human
TgeneETV4C0678222Breast Carcinoma1CTD_human
TgeneETV4C1257931Mammary Neoplasms, Human1CTD_human
TgeneETV4C1458155Mammary Neoplasms1CTD_human
TgeneETV4C4704874Mammary Carcinoma, Human1CTD_human