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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EZR-PARP3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EZR-PARP3
FusionPDB ID: 28123
FusionGDB2.0 ID: 28123
HgeneTgene
Gene symbol

EZR

PARP3

Gene ID

7430

10039

Gene nameezrinpoly(ADP-ribose) polymerase family member 3
SynonymsCVIL|CVL|HEL-S-105|VIL2ADPRT3|ADPRTL2|ADPRTL3|ARTD3|IRT1|PADPRT-3
Cytomap

6q25.3

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)protein mono-ADP-ribosyltransferase PARP3ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3ADP-ribosyltransferase diphtheria toxin-like 3ADPRT-3DNA ADP-ribosyltransfera
Modification date2020032220200313
UniProtAcc

P15311

.
Ensembl transtripts involved in fusion geneENST idsENST00000337147, ENST00000367075, 
ENST00000392177, ENST00000476189, 
ENST00000486510, ENST00000398755, 
ENST00000417220, ENST00000431474, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 22 X 10=57202 X 2 X 2=8
# samples 322
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: EZR [Title/Abstract] AND PARP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EZR(159188292)-PARP3(51978793), # samples:1
Anticipated loss of major functional domain due to fusion event.EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-PARP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EZR-PARP3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EZR-PARP3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131

TgenePARP3

GO:0006302

double-strand break repair

21270334

TgenePARP3

GO:0006471

protein ADP-ribosylation

21270334|24598253

TgenePARP3

GO:0030592

DNA ADP-ribosylation

29361132

TgenePARP3

GO:0070213

protein auto-ADP-ribosylation

25043379

TgenePARP3

GO:2001034

positive regulation of double-strand break repair via nonhomologous end joining

24598253


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PARP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0919EZRchr6

159188292

-PARP3chr3

51978793

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337147EZRchr6159188292-ENST00000417220PARP3chr351978793+32131730622830922
ENST00000337147EZRchr6159188292-ENST00000431474PARP3chr351978793+32181730622830922
ENST00000337147EZRchr6159188292-ENST00000398755PARP3chr351978793+32131730622830922
ENST00000392177EZRchr6159188292-ENST00000417220PARP3chr351978793+31231640682740890
ENST00000392177EZRchr6159188292-ENST00000431474PARP3chr351978793+31281640682740890
ENST00000392177EZRchr6159188292-ENST00000398755PARP3chr351978793+31231640682740890

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337147ENST00000417220EZRchr6159188292-PARP3chr351978793+0.0053556630.9946444
ENST00000337147ENST00000431474EZRchr6159188292-PARP3chr351978793+0.0052334740.9947665
ENST00000337147ENST00000398755EZRchr6159188292-PARP3chr351978793+0.0053556630.9946444
ENST00000392177ENST00000417220EZRchr6159188292-PARP3chr351978793+0.0053355860.99466443
ENST00000392177ENST00000431474EZRchr6159188292-PARP3chr351978793+0.0052085130.9947915
ENST00000392177ENST00000398755EZRchr6159188292-PARP3chr351978793+0.0053355860.99466443

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28123_28123_1_EZR-PARP3_EZR_chr6_159188292_ENST00000337147_PARP3_chr3_51978793_ENST00000398755_length(amino acids)=922AA_BP=554
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTA
KIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEK
RITEAEKNERVQRQLLVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALK
GPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDS
GAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSK
SAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFS

--------------------------------------------------------------

>28123_28123_2_EZR-PARP3_EZR_chr6_159188292_ENST00000337147_PARP3_chr3_51978793_ENST00000417220_length(amino acids)=922AA_BP=554
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTA
KIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEK
RITEAEKNERVQRQLLVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALK
GPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDS
GAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSK
SAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFS

--------------------------------------------------------------

>28123_28123_3_EZR-PARP3_EZR_chr6_159188292_ENST00000337147_PARP3_chr3_51978793_ENST00000431474_length(amino acids)=922AA_BP=554
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTA
KIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEK
RITEAEKNERVQRQLLVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALK
GPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDS
GAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSK
SAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFS

--------------------------------------------------------------

>28123_28123_4_EZR-PARP3_EZR_chr6_159188292_ENST00000392177_PARP3_chr3_51978793_ENST00000398755_length(amino acids)=890AA_BP=522
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQ
IQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVK
TKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLVDRGPVRTVTKRVQPC
SLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPI
NSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQ
EGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHIN

--------------------------------------------------------------

>28123_28123_5_EZR-PARP3_EZR_chr6_159188292_ENST00000392177_PARP3_chr3_51978793_ENST00000417220_length(amino acids)=890AA_BP=522
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQ
IQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVK
TKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLVDRGPVRTVTKRVQPC
SLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPI
NSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQ
EGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHIN

--------------------------------------------------------------

>28123_28123_6_EZR-PARP3_EZR_chr6_159188292_ENST00000392177_PARP3_chr3_51978793_ENST00000431474_length(amino acids)=890AA_BP=522
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQ
IQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVK
TKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLVDRGPVRTVTKRVQPC
SLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPI
NSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQ
EGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHIN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159188292/chr3:51978793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

.
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159188292chr3:51978793ENST00000337147-12132_295532.0587.0DomainFERM
HgeneEZRchr6:159188292chr3:51978793ENST00000367075-13142_295532.0587.0DomainFERM
HgeneEZRchr6:159188292chr3:51978793ENST00000337147-1213115_120532.0587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159188292chr3:51978793ENST00000367075-1314115_120532.0587.0Motif[IL]-x-C-x-x-[DE] motif
TgenePARP3chr6:159188292chr3:51978793ENST00000398755311182_300174.0541.0DomainPARP alpha-helical
TgenePARP3chr6:159188292chr3:51978793ENST00000398755311313_533174.0541.0DomainPARP catalytic
TgenePARP3chr6:159188292chr3:51978793ENST00000417220412182_300167.0534.0DomainPARP alpha-helical
TgenePARP3chr6:159188292chr3:51978793ENST00000417220412313_533167.0534.0DomainPARP catalytic
TgenePARP3chr6:159188292chr3:51978793ENST00000431474311182_300167.0534.0DomainPARP alpha-helical
TgenePARP3chr6:159188292chr3:51978793ENST00000431474311313_533167.0534.0DomainPARP catalytic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePARP3chr6:159188292chr3:51978793ENST0000039875531114_20174.0541.0MotifNuclear localization signal
TgenePARP3chr6:159188292chr3:51978793ENST0000041722041214_20167.0534.0MotifNuclear localization signal
TgenePARP3chr6:159188292chr3:51978793ENST0000043147431114_20167.0534.0MotifNuclear localization signal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EZRPRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, Tsc1, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, Cdk1, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, Msn, EGFR, MCM2, Mdm2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, SLC9A1, LASP1, DNM1L, FOXA1, TRIM25, HEY1, PRPF8, AAR2, PIH1D1, EFTUD2, SOCS2, ESR2, RUNX1, AGR2, MME, ZFP36L2, EEF2K, LSM1, MAP3K7, MGEA5, SRGAP2, COBL, IKBKAP, SVIL, MAPT, BCR, CAST, SHC1, NMT1, UTRN, ANK2, ANK3, ABR, GAB1, MTMR1, SNTB1, SEPT6, TAB1, PKN2, COBLL1, C6orf132, MPRIP, KIAA1211, CYFIP1, GPRIN1, R3HCC1L, PARG, SIRT2, PALM2, PHACTR4, ARFGAP1, ENAH, ZC3H15, SEPT8, USP47, DOCK7, ERBB2IP, PPP1R9B, EFHD1, SORBS1, EIF2A, TNKS1BP1, C1orf198, EPB41L1, SH2D4A, LZTFL1, CYLD, SH3GLB2, ARHGAP35, FARSB, PRMT7, ACTR10, DIP2B, ABCF2, SRP68, TRMT112, ASAP1, LIMCH1, AKAP2, WDR45, WASF2, RPA3, RPL32, POLDIP3, MACROD2, CASK, HGS, SEC16A, TIMM44, MYO1B, KIF5C, CTNND1, SRP72, AP2A1, ECD, PAK4, SLC25A5, HSPA1A, DDX6, EPHA2, TIE1, TRAPPC10, NUMB, NUP107, RPS13, OCRL, AKAP12, DST, NOTCH2, TCHH, FCHO2, KIAA0196, HDAC1, SCRIB, GOLGB1, KARS, RABEP1, PCBP2, TBR1, SEL1L2, FAM21A, FTSJ3, ABI1, EHBP1, NDRG1, SYAP1, FERMT2, CCDC124, CYFIP2, AHCYL2, PGAM5, TRAPPC9, FAM129B, TRIOBP, PEAK1, ELP3, PALMD, FAM207A, KLC4, LIN7C, DDX18, LYAR, ABI2, ITSN2, RAI14, FAM135A, ADD3, SWAP70, BAIAP2L1, TNIK, MYH13, MYO6, ICAM5, PACSIN2, SNX6, NCKAP1, TRAPPC1, NUMBL, DSG2, SKA2, EGLN1, PDLIM1, EIF4G3, EPB41, LRBA, AFD1, SNTB2, ITSN1, WDR44, HAUS6, FAM101B, DVL3, BCL11A, PLEKHA1, KIAA1429, ATG16L1, ACTC1, PHB, NEDD4, PODXL, GBF1, KRAS, HADHB, VDAC1, VDAC2, ABCC6, BIRC3, PARK2, PINK1, FANCD2, ORF3a, DUSP6, PTPN12, RAC1, SH2D3C, ERBB3, LRRC6, ZSWIM2, WDR37, S, USP1, CIT, ANLN, AURKB, CHMP4B, KIF14, PRNP, Arhgap28, ARHGEF15, HNRNPH1, SUMO2, NDN, NUPR1, RBM39, LGALS9, PMAIP1, CD274, DDRGK1, TP53, ACTB, SEPT9, ABLIM1, ACTN4, ATP2B1, BASP1, BSG, CCDC18, CDCA3, CORO1C, CTNNAL1, DEPDC1B, DLG5, DTNA, EFNB2, EPB41L5, FLOT2, FRS2, HNRNPA1L2, ITGB1, KIAA1549, KIAA1671, KIDINS220, LIMA1, LMO7, LSR, MARK2, MARK3, MB21D2, MYO5C, NEBL, OCLN, PALM2-AKAP2, PPFIBP1, PPP1R18, PPP1R9A, PPP6R1, PROSER2, PTPN14, RAP1GDS1, RASAL2, SH3D19, SLC12A2, SLC1A5, SLC29A1, SLC38A2, SLC39A14, SLC39A6, SLC3A2, SLC4A7, SLC6A8, SLC7A5, SNAP23, SPTAN1, STK10, VANGL1, VANGL2, YES1, YKT6, ZDHHC5, ANKRD26, ANKRD28, APBB1, APC, ARHGAP21, ARHGEF12, ATP1A1, CALD1, CDC42BPA, CTNNA1, DBN1, DIAPH3, DYNC1I2, DYNC1LI1, EFNB1, GOLGA3, H3F3A, HLA-A, IFT74, INA, IRS2, JMY, KANK2, KIF15, LPP, LUZP1, MACF1, MINK1, NBEA, PI4KA, PLEKHA5, RAPH1, REPS1, RTN1, SDCCAG3, SLAIN2, SLC6A15, STAU2, SYNJ1, TANC1, TDRD3, TJP1, nsp3, E, nsp3ab, SLC26A4-AS1, GOT1, ZNF622, TREML1, nsp11, nsp12, nsp13, nsp14, nsp16, nsp8, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EZRall structure
PARP3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159188292chr3:51978793ENST00000337147-1213244_586532.0587.0SCYL3
HgeneEZRchr6:159188292chr3:51978793ENST00000367075-1314244_586532.0587.0SCYL3


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Related Drugs to EZR-PARP3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EZR-PARP3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEZRC0033578Prostatic Neoplasms3CTD_human
HgeneEZRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEZRC0007097Carcinoma1CTD_human
HgeneEZRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneEZRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEZRC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneEZRC0027627Neoplasm Metastasis1CTD_human
HgeneEZRC0029408Degenerative polyarthritis1CTD_human
HgeneEZRC0086743Osteoarthrosis Deformans1CTD_human
HgeneEZRC0205696Anaplastic carcinoma1CTD_human
HgeneEZRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEZRC0205698Undifferentiated carcinoma1CTD_human
HgeneEZRC0205699Carcinomatosis1CTD_human
HgeneEZRC1257925Mammary Carcinoma, Animal1CTD_human