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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EZR-ROS1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EZR-ROS1
FusionPDB ID: 28128
FusionGDB2.0 ID: 28128
HgeneTgene
Gene symbol

EZR

ROS1

Gene ID

7430

6098

Gene nameezrinROS proto-oncogene 1, receptor tyrosine kinase
SynonymsCVIL|CVL|HEL-S-105|VIL2MCF3|ROS|c-ros-1
Cytomap

6q25.3

6q22.1

Type of geneprotein-codingprotein-coding
Descriptionezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
Modification date2020032220200314
UniProtAcc

P15311

P08922

Ensembl transtripts involved in fusion geneENST idsENST00000337147, ENST00000367075, 
ENST00000392177, ENST00000476189, 
ENST00000368507, ENST00000368508, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 22 X 10=572018 X 20 X 5=1800
# samples 3220
** MAII scorelog2(32/5720*10)=-4.15987133677839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1800*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EZR [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]

Long-term progression-free survival in an advanced lung adenocarcinoma patient harboring EZR-ROS1 rearrangement: a case report (pmid: 29361925)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EZR(159191796)-ROS1(117645578), # samples:6
Anticipated loss of major functional domain due to fusion event.EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EZR-ROS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EZR-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EZR-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EZR-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

HgeneEZR

GO:0051017

actin filament bundle assembly

10793131

TgeneROS1

GO:0001558

regulation of cell growth

16885344

TgeneROS1

GO:0006468

protein phosphorylation

16885344

TgeneROS1

GO:0032006

regulation of TOR signaling

16885344


check buttonFusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6986-01AEZRchr6

159191795

-ROS1chr6

117645577

-
ChimerDB4LUADTCGA-55-6986-01AEZRchr6

159191796

-ROS1chr6

117645578

-
ChimerDB4LUADTCGA-55-6986EZRchr6

159191795

-ROS1chr6

117645578

-
ChimerDB4LUADTCGA-NJ-A7XG-01AEZRchr6

159191796

-ROS1chr6

117645578

-
ChimerDB4LUADTCGA-NJ-A7XGEZRchr6

159191796

-ROS1chr6

117645578

-
ChimerKB3..EZRchr6

159190815

-ROS1chr6

117645578

-
ChimerKB3..EZRchr6

159191795

-ROS1chr6

117645578

-
ChiTaRS5.0N/AAB698667EZRchr6

159191796

-ROS1chr6

117645580

-
ChiTaRS5.0N/AAB795246EZRchr6

159191796

-ROS1chr6

117645580

-
ChiTaRS5.0N/AJB625495EZRchr6

159191796

-ROS1chr6

117645580

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337147EZRchr6159191795-ENST00000368508ROS1chr6117645578-29031224622710882
ENST00000337147EZRchr6159191795-ENST00000368507ROS1chr6117645578-29031224622710882
ENST00000392177EZRchr6159191795-ENST00000368508ROS1chr6117645578-28131134682620850
ENST00000392177EZRchr6159191795-ENST00000368507ROS1chr6117645578-28131134682620850
ENST00000337147EZRchr6159191796-ENST00000368508ROS1chr6117645578-29031224622710882
ENST00000337147EZRchr6159191796-ENST00000368507ROS1chr6117645578-29031224622710882
ENST00000392177EZRchr6159191796-ENST00000368508ROS1chr6117645578-28131134682620850
ENST00000392177EZRchr6159191796-ENST00000368507ROS1chr6117645578-28131134682620850
ENST00000337147EZRchr6159191795-ENST00000368508ROS1chr6117645578-29031224622710882
ENST00000337147EZRchr6159191795-ENST00000368507ROS1chr6117645578-29031224622710882
ENST00000392177EZRchr6159191795-ENST00000368508ROS1chr6117645578-28131134682620850
ENST00000392177EZRchr6159191795-ENST00000368507ROS1chr6117645578-28131134682620850
ENST00000337147EZRchr6159191795-ENST00000368508ROS1chr6117645577-29031224622710882
ENST00000337147EZRchr6159191795-ENST00000368507ROS1chr6117645577-29031224622710882
ENST00000392177EZRchr6159191795-ENST00000368508ROS1chr6117645577-28131134682620850
ENST00000392177EZRchr6159191795-ENST00000368507ROS1chr6117645577-28131134682620850
ENST00000337147EZRchr6159191796-ENST00000368508ROS1chr6117645580-29031224622710882
ENST00000337147EZRchr6159191796-ENST00000368507ROS1chr6117645580-29031224622710882
ENST00000392177EZRchr6159191796-ENST00000368508ROS1chr6117645580-28131134682620850
ENST00000392177EZRchr6159191796-ENST00000368507ROS1chr6117645580-28131134682620850

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337147ENST00000368508EZRchr6159191796-ROS1chr6117645578-0.0020581520.9979418
ENST00000337147ENST00000368507EZRchr6159191796-ROS1chr6117645578-0.0020581520.9979418
ENST00000392177ENST00000368508EZRchr6159191796-ROS1chr6117645578-0.0019413050.9980586
ENST00000392177ENST00000368507EZRchr6159191796-ROS1chr6117645578-0.0019413050.9980586
ENST00000337147ENST00000368508EZRchr6159191795-ROS1chr6117645578-0.0020581520.9979418
ENST00000337147ENST00000368507EZRchr6159191795-ROS1chr6117645578-0.0020581520.9979418
ENST00000392177ENST00000368508EZRchr6159191795-ROS1chr6117645578-0.0019413050.9980586
ENST00000392177ENST00000368507EZRchr6159191795-ROS1chr6117645578-0.0019413050.9980586
ENST00000337147ENST00000368508EZRchr6159191795-ROS1chr6117645577-0.0020581520.9979418
ENST00000337147ENST00000368507EZRchr6159191795-ROS1chr6117645577-0.0020581520.9979418
ENST00000392177ENST00000368508EZRchr6159191795-ROS1chr6117645577-0.0019413050.9980586
ENST00000392177ENST00000368507EZRchr6159191795-ROS1chr6117645577-0.0019413050.9980586
ENST00000337147ENST00000368508EZRchr6159191796-ROS1chr6117645580-0.0020581520.9979418
ENST00000337147ENST00000368507EZRchr6159191796-ROS1chr6117645580-0.0020581520.9979418
ENST00000392177ENST00000368508EZRchr6159191796-ROS1chr6117645580-0.0019413050.9980586
ENST00000392177ENST00000368507EZRchr6159191796-ROS1chr6117645580-0.0019413050.9980586

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28128_28128_1_EZR-ROS1_EZR_chr6_159191795_ENST00000337147_ROS1_chr6_117645577_ENST00000368507_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_2_EZR-ROS1_EZR_chr6_159191795_ENST00000337147_ROS1_chr6_117645577_ENST00000368508_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_3_EZR-ROS1_EZR_chr6_159191795_ENST00000337147_ROS1_chr6_117645578_ENST00000368507_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_4_EZR-ROS1_EZR_chr6_159191795_ENST00000337147_ROS1_chr6_117645578_ENST00000368508_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_5_EZR-ROS1_EZR_chr6_159191795_ENST00000392177_ROS1_chr6_117645577_ENST00000368507_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_6_EZR-ROS1_EZR_chr6_159191795_ENST00000392177_ROS1_chr6_117645577_ENST00000368508_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_7_EZR-ROS1_EZR_chr6_159191795_ENST00000392177_ROS1_chr6_117645578_ENST00000368507_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_8_EZR-ROS1_EZR_chr6_159191795_ENST00000392177_ROS1_chr6_117645578_ENST00000368508_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_9_EZR-ROS1_EZR_chr6_159191796_ENST00000337147_ROS1_chr6_117645578_ENST00000368507_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_10_EZR-ROS1_EZR_chr6_159191796_ENST00000337147_ROS1_chr6_117645578_ENST00000368508_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_11_EZR-ROS1_EZR_chr6_159191796_ENST00000337147_ROS1_chr6_117645580_ENST00000368507_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_12_EZR-ROS1_EZR_chr6_159191796_ENST00000337147_ROS1_chr6_117645580_ENST00000368508_length(amino acids)=882AA_BP=387
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVS
AQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQR
VMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIR
NISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVERE
KEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN
HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP
RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRN
CPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYM

--------------------------------------------------------------

>28128_28128_13_EZR-ROS1_EZR_chr6_159191796_ENST00000392177_ROS1_chr6_117645578_ENST00000368507_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_14_EZR-ROS1_EZR_chr6_159191796_ENST00000392177_ROS1_chr6_117645578_ENST00000368508_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_15_EZR-ROS1_EZR_chr6_159191796_ENST00000392177_ROS1_chr6_117645580_ENST00000368507_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

--------------------------------------------------------------

>28128_28128_16_EZR-ROS1_EZR_chr6_159191796_ENST00000392177_ROS1_chr6_117645580_ENST00000368508_length(amino acids)=850AA_BP=355
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDIT
QKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAM
LEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINK
RILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWI
PETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY
LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW
MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL
FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEK

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159191796/chr6:117645578)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EZR

P15311

ROS1

P08922

FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEZRchr6:159191795chr6:117645577ENST00000337147-9132_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191795chr6:117645577ENST00000367075-10142_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191795chr6:117645578ENST00000337147-9132_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191795chr6:117645578ENST00000367075-10142_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191796chr6:117645578ENST00000337147-9132_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191796chr6:117645578ENST00000367075-10142_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191796chr6:117645580ENST00000337147-9132_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191796chr6:117645580ENST00000367075-10142_295363.3333333333333587.0DomainFERM
HgeneEZRchr6:159191795chr6:117645577ENST00000337147-913115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191795chr6:117645577ENST00000367075-1014115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191795chr6:117645578ENST00000337147-913115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191795chr6:117645578ENST00000367075-1014115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191796chr6:117645578ENST00000337147-913115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191796chr6:117645578ENST00000367075-1014115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191796chr6:117645580ENST00000337147-913115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
HgeneEZRchr6:159191796chr6:117645580ENST00000367075-1014115_120363.3333333333333587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431945_22221852.33333333333332348.0DomainProtein kinase
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431945_22221852.33333333333332348.0DomainProtein kinase
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431945_22221852.33333333333332348.0DomainProtein kinase
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431945_22221852.33333333333332348.0DomainProtein kinase
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431951_19591852.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431951_19591852.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431951_19591852.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431951_19591852.33333333333332348.0Nucleotide bindingATP
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431883_23471852.33333333333332348.0Topological domainCytoplasmic
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431883_23471852.33333333333332348.0Topological domainCytoplasmic
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431883_23471852.33333333333332348.0Topological domainCytoplasmic
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431883_23471852.33333333333332348.0Topological domainCytoplasmic
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431860_18821852.33333333333332348.0TransmembraneHelical
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431860_18821852.33333333333332348.0TransmembraneHelical
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431860_18821852.33333333333332348.0TransmembraneHelical
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431860_18821852.33333333333332348.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROS1chr6:159191795chr6:117645577ENST000003685083243101_1961852.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431043_11501852.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431450_15561852.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431557_16561852.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431658_17511852.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr6:159191795chr6:117645577ENST0000036850832431752_18541852.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr6:159191795chr6:117645577ENST000003685083243197_2851852.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr6:159191795chr6:117645577ENST000003685083243557_6711852.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr6:159191795chr6:117645577ENST000003685083243947_10421852.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr6:159191795chr6:117645578ENST000003685083243101_1961852.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431043_11501852.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431450_15561852.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431557_16561852.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431658_17511852.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr6:159191795chr6:117645578ENST0000036850832431752_18541852.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr6:159191795chr6:117645578ENST000003685083243197_2851852.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr6:159191795chr6:117645578ENST000003685083243557_6711852.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr6:159191795chr6:117645578ENST000003685083243947_10421852.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr6:159191796chr6:117645578ENST000003685083243101_1961852.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431043_11501852.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431450_15561852.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431557_16561852.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431658_17511852.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr6:159191796chr6:117645578ENST0000036850832431752_18541852.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr6:159191796chr6:117645578ENST000003685083243197_2851852.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr6:159191796chr6:117645578ENST000003685083243557_6711852.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr6:159191796chr6:117645578ENST000003685083243947_10421852.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr6:159191796chr6:117645580ENST000003685083243101_1961852.33333333333332348.0DomainFibronectin type-III 1
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431043_11501852.33333333333332348.0DomainFibronectin type-III 5
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431450_15561852.33333333333332348.0DomainFibronectin type-III 6
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431557_16561852.33333333333332348.0DomainFibronectin type-III 7
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431658_17511852.33333333333332348.0DomainFibronectin type-III 8
TgeneROS1chr6:159191796chr6:117645580ENST0000036850832431752_18541852.33333333333332348.0DomainFibronectin type-III 9
TgeneROS1chr6:159191796chr6:117645580ENST000003685083243197_2851852.33333333333332348.0DomainFibronectin type-III 2
TgeneROS1chr6:159191796chr6:117645580ENST000003685083243557_6711852.33333333333332348.0DomainFibronectin type-III 3
TgeneROS1chr6:159191796chr6:117645580ENST000003685083243947_10421852.33333333333332348.0DomainFibronectin type-III 4
TgeneROS1chr6:159191795chr6:117645577ENST00000368508324328_18591852.33333333333332348.0Topological domainExtracellular
TgeneROS1chr6:159191795chr6:117645578ENST00000368508324328_18591852.33333333333332348.0Topological domainExtracellular
TgeneROS1chr6:159191796chr6:117645578ENST00000368508324328_18591852.33333333333332348.0Topological domainExtracellular
TgeneROS1chr6:159191796chr6:117645580ENST00000368508324328_18591852.33333333333332348.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (675) >>>675.pdbFusion protein BP residue: 355
CIF file (675) >>>675.cif		EZRchr6159191795-ROS1chr6117645578-
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTG
KQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKE
GILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVM
DQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEI
KNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIK
PIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQ
AREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKT
KKAERDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVT
VLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTL
RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE
AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFY
GPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRI
VKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSF
GILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQC
WAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGED
GDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES
ESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
850
3D view using mol* of 675 (AA BP:355)
PDB file (697)EZRchr6159191795-ROS1chr6117645578-
MGQRLRCCWIVVFSGIEDTHQKPKMPKPINVRVTTMDAELEFAIQPNTTG
KQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPL
QFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLG
SYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWH
AEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLN
IYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRI
NKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETE
KKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERDDFWIPETSFILT
IIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAG
VGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAV
DILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGV
CLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISK
GCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYY
RKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAH
SNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL
QLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALME
TKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDF
882


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EZR_pLDDT.png
all structure
all structure
ROS1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EZR_ROS1_675_pLDDT.png (AA BP:355)
all structure
EZR_ROS1_675_pLDDT_and_active_sites.png (AA BP:355)
all structure
EZR_ROS1_675_violinplot.png (AA BP:355)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
EZR_ROS1_675.png
all structure
EZR_ROS1_697.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
6751.0843311.1411090.3970.5380.7360.9161.2210.741.6490.959Chain A: 1,4,5,7,8,9,10,11,12,13,31,33,35,36,40,42
,44,46,48,49,50,51,52,53,54,57,68,70,71,72,73,74,7
5,76,77,78,79,80,83,84,85,86,87,89,90,93,94,97,214
,279,282,285,286,288,289,290,291,294,297,298
6971.1541821.204377.30.3520.8391.1242.1720.7342.9590.948Chain A: 486,487,488,489,490,491,492,493,494,511,5
13,515,532,536,545,561,562,563,564,565,566,567,568
,571,572,575,612,618,619,621,625,637,638,639,640,6
41,642,644,649

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EZRPRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, Tsc1, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, Cdk1, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, Msn, EGFR, MCM2, Mdm2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, SLC9A1, LASP1, DNM1L, FOXA1, TRIM25, HEY1, PRPF8, AAR2, PIH1D1, EFTUD2, SOCS2, ESR2, RUNX1, AGR2, MME, ZFP36L2, EEF2K, LSM1, MAP3K7, MGEA5, SRGAP2, COBL, IKBKAP, SVIL, MAPT, BCR, CAST, SHC1, NMT1, UTRN, ANK2, ANK3, ABR, GAB1, MTMR1, SNTB1, SEPT6, TAB1, PKN2, COBLL1, C6orf132, MPRIP, KIAA1211, CYFIP1, GPRIN1, R3HCC1L, PARG, SIRT2, PALM2, PHACTR4, ARFGAP1, ENAH, ZC3H15, SEPT8, USP47, DOCK7, ERBB2IP, PPP1R9B, EFHD1, SORBS1, EIF2A, TNKS1BP1, C1orf198, EPB41L1, SH2D4A, LZTFL1, CYLD, SH3GLB2, ARHGAP35, FARSB, PRMT7, ACTR10, DIP2B, ABCF2, SRP68, TRMT112, ASAP1, LIMCH1, AKAP2, WDR45, WASF2, RPA3, RPL32, POLDIP3, MACROD2, CASK, HGS, SEC16A, TIMM44, MYO1B, KIF5C, CTNND1, SRP72, AP2A1, ECD, PAK4, SLC25A5, HSPA1A, DDX6, EPHA2, TIE1, TRAPPC10, NUMB, NUP107, RPS13, OCRL, AKAP12, DST, NOTCH2, TCHH, FCHO2, KIAA0196, HDAC1, SCRIB, GOLGB1, KARS, RABEP1, PCBP2, TBR1, SEL1L2, FAM21A, FTSJ3, ABI1, EHBP1, NDRG1, SYAP1, FERMT2, CCDC124, CYFIP2, AHCYL2, PGAM5, TRAPPC9, FAM129B, TRIOBP, PEAK1, ELP3, PALMD, FAM207A, KLC4, LIN7C, DDX18, LYAR, ABI2, ITSN2, RAI14, FAM135A, ADD3, SWAP70, BAIAP2L1, TNIK, MYH13, MYO6, ICAM5, PACSIN2, SNX6, NCKAP1, TRAPPC1, NUMBL, DSG2, SKA2, EGLN1, PDLIM1, EIF4G3, EPB41, LRBA, AFD1, SNTB2, ITSN1, WDR44, HAUS6, FAM101B, DVL3, BCL11A, PLEKHA1, KIAA1429, ATG16L1, ACTC1, PHB, NEDD4, PODXL, GBF1, KRAS, HADHB, VDAC1, VDAC2, ABCC6, BIRC3, PARK2, PINK1, FANCD2, ORF3a, DUSP6, PTPN12, RAC1, SH2D3C, ERBB3, LRRC6, ZSWIM2, WDR37, S, USP1, CIT, ANLN, AURKB, CHMP4B, KIF14, PRNP, Arhgap28, ARHGEF15, HNRNPH1, SUMO2, NDN, NUPR1, RBM39, LGALS9, PMAIP1, CD274, DDRGK1, TP53, ACTB, SEPT9, ABLIM1, ACTN4, ATP2B1, BASP1, BSG, CCDC18, CDCA3, CORO1C, CTNNAL1, DEPDC1B, DLG5, DTNA, EFNB2, EPB41L5, FLOT2, FRS2, HNRNPA1L2, ITGB1, KIAA1549, KIAA1671, KIDINS220, LIMA1, LMO7, LSR, MARK2, MARK3, MB21D2, MYO5C, NEBL, OCLN, PALM2-AKAP2, PPFIBP1, PPP1R18, PPP1R9A, PPP6R1, PROSER2, PTPN14, RAP1GDS1, RASAL2, SH3D19, SLC12A2, SLC1A5, SLC29A1, SLC38A2, SLC39A14, SLC39A6, SLC3A2, SLC4A7, SLC6A8, SLC7A5, SNAP23, SPTAN1, STK10, VANGL1, VANGL2, YES1, YKT6, ZDHHC5, ANKRD26, ANKRD28, APBB1, APC, ARHGAP21, ARHGEF12, ATP1A1, CALD1, CDC42BPA, CTNNA1, DBN1, DIAPH3, DYNC1I2, DYNC1LI1, EFNB1, GOLGA3, H3F3A, HLA-A, IFT74, INA, IRS2, JMY, KANK2, KIF15, LPP, LUZP1, MACF1, MINK1, NBEA, PI4KA, PLEKHA5, RAPH1, REPS1, RTN1, SDCCAG3, SLAIN2, SLC6A15, STAU2, SYNJ1, TANC1, TDRD3, TJP1, nsp3, E, nsp3ab, SLC26A4-AS1, GOT1, ZNF622, TREML1, nsp11, nsp12, nsp13, nsp14, nsp16, nsp8, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EZRall structure
ROS1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEZRchr6:159191795chr6:117645577ENST00000337147-913244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191795chr6:117645577ENST00000367075-1014244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191795chr6:117645578ENST00000337147-913244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191795chr6:117645578ENST00000367075-1014244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191796chr6:117645578ENST00000337147-913244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191796chr6:117645578ENST00000367075-1014244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191796chr6:117645580ENST00000337147-913244_586363.3333333333333587.0SCYL3
HgeneEZRchr6:159191796chr6:117645580ENST00000367075-1014244_586363.3333333333333587.0SCYL3


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Related Drugs to EZR-ROS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
EZRROS1CrizotinibPubMed25230898

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Related Diseases to EZR-ROS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
EZRROS1Metastatic Mediastinum Lymph NodePubMed25230898
EZRROS1Lung Adenocarcinoma Having The Greatest PrevalenceMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEZRC0033578Prostatic Neoplasms3CTD_human
HgeneEZRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEZRC0007097Carcinoma1CTD_human
HgeneEZRC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneEZRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEZRC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneEZRC0027627Neoplasm Metastasis1CTD_human
HgeneEZRC0029408Degenerative polyarthritis1CTD_human
HgeneEZRC0086743Osteoarthrosis Deformans1CTD_human
HgeneEZRC0205696Anaplastic carcinoma1CTD_human
HgeneEZRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEZRC0205698Undifferentiated carcinoma1CTD_human
HgeneEZRC0205699Carcinomatosis1CTD_human
HgeneEZRC1257925Mammary Carcinoma, Animal1CTD_human
TgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneROS1C0017638Glioma1CTD_human
TgeneROS1C0025202melanoma1CTD_human
TgeneROS1C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
TgeneROS1C0259783mixed gliomas1CTD_human
TgeneROS1C0555198Malignant Glioma1CTD_human