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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FANCD2-MTMR14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FANCD2-MTMR14
FusionPDB ID: 29328
FusionGDB2.0 ID: 29328
HgeneTgene
Gene symbol

FANCD2

MTMR14

Gene ID

2177

64419

Gene nameFA complementation group D2myotubularin related protein 14
SynonymsFA-D2|FA4|FACD|FAD|FAD2|FANCDC3orf29
Cytomap

3p25.3

3p25.3

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group D2 proteinFanconi anemia complementation group D2myotubularin-related protein 14HCV NS5A-transactivated protein 4 splice variant A-binding protein 1NS5ATP4ABP1egg-derived tyrosine phosphatase homologjumpy
Modification date2020031320200313
UniProtAcc

Q96PS1

Q8NCE2

Ensembl transtripts involved in fusion geneENST idsENST00000287647, ENST00000383806, 
ENST00000383807, ENST00000419585, 
ENST00000431693, ENST00000438741, 
ENST00000296003, ENST00000351233, 
ENST00000420925, ENST00000353332, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 6=3362 X 5 X 3=30
# samples 115
** MAII scorelog2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FANCD2 [Title/Abstract] AND MTMR14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FANCD2(10074656)-MTMR14(9719001), # samples:2
Anticipated loss of major functional domain due to fusion event.FANCD2-MTMR14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FANCD2-MTMR14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FANCD2-MTMR14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FANCD2-MTMR14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FANCD2-MTMR14 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FANCD2-MTMR14 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFANCD2

GO:0010332

response to gamma radiation

12874027


check buttonFusion gene breakpoints across FANCD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MTMR14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JM-01AFANCD2chr3

10070405

+MTMR14chr3

9719001

+
ChimerDB4BRCATCGA-D8-A1JM-01AFANCD2chr3

10074656

-MTMR14chr3

9719001

+
ChimerDB4BRCATCGA-D8-A1JM-01AFANCD2chr3

10074656

+MTMR14chr3

9719001

+
ChimerDB4BRCATCGA-D8-A1JMFANCD2chr3

10074656

+MTMR14chr3

9719000

+
ChimerDB4BRCATCGA-OL-A5D7-01AFANCD2chr3

10085548

+MTMR14chr3

9724862

+
ChimerDB4STADTCGA-BR-8060-01AFANCD2chr3

10094181

-MTMR14chr3

9703951

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287647FANCD2chr310074656+ENST00000353332MTMR14chr39719000+1764298841343419
ENST00000383807FANCD2chr310074656+ENST00000353332MTMR14chr39719000+1749283691328419
ENST00000383806FANCD2chr310074656+ENST00000353332MTMR14chr39719000+1749283691328419
ENST00000419585FANCD2chr310074656+ENST00000353332MTMR14chr39719000+18323661521411419
ENST00000431693FANCD2chr310074656+ENST00000353332MTMR14chr39719000+1709243291288419
ENST00000287647FANCD2chr310074656+ENST00000353332MTMR14chr39719001+1764298841343419
ENST00000383807FANCD2chr310074656+ENST00000353332MTMR14chr39719001+1749283691328419
ENST00000383806FANCD2chr310074656+ENST00000353332MTMR14chr39719001+1749283691328419
ENST00000419585FANCD2chr310074656+ENST00000353332MTMR14chr39719001+18323661521411419
ENST00000431693FANCD2chr310074656+ENST00000353332MTMR14chr39719001+1709243291288419
ENST00000287647FANCD2chr310070405+ENST00000353332MTMR14chr39719001+1623157841202372
ENST00000383807FANCD2chr310070405+ENST00000353332MTMR14chr39719001+1608142691187372
ENST00000383806FANCD2chr310070405+ENST00000353332MTMR14chr39719001+1608142691187372
ENST00000419585FANCD2chr310070405+ENST00000353332MTMR14chr39719001+16912251521270372
ENST00000431693FANCD2chr310070405+ENST00000353332MTMR14chr39719001+1568102291147372
ENST00000287647FANCD2chr310085548+ENST00000353332MTMR14chr39724862+25471227842126680
ENST00000287647FANCD2chr310085548+ENST00000420925MTMR14chr39724862+23611227841946620
ENST00000287647FANCD2chr310085548+ENST00000296003MTMR14chr39724862+27021227842282732
ENST00000287647FANCD2chr310085548+ENST00000351233MTMR14chr39724862+23631227841946620
ENST00000383807FANCD2chr310085548+ENST00000353332MTMR14chr39724862+25321212692111680
ENST00000383807FANCD2chr310085548+ENST00000420925MTMR14chr39724862+23461212691931620
ENST00000383807FANCD2chr310085548+ENST00000296003MTMR14chr39724862+26871212692267732
ENST00000383807FANCD2chr310085548+ENST00000351233MTMR14chr39724862+23481212691931620
ENST00000383806FANCD2chr310085548+ENST00000353332MTMR14chr39724862+25321212692111680
ENST00000383806FANCD2chr310085548+ENST00000420925MTMR14chr39724862+23461212691931620
ENST00000383806FANCD2chr310085548+ENST00000296003MTMR14chr39724862+26871212692267732
ENST00000383806FANCD2chr310085548+ENST00000351233MTMR14chr39724862+23481212691931620
ENST00000419585FANCD2chr310085548+ENST00000353332MTMR14chr39724862+261512951522194680
ENST00000419585FANCD2chr310085548+ENST00000420925MTMR14chr39724862+242912951522014620
ENST00000419585FANCD2chr310085548+ENST00000296003MTMR14chr39724862+277012951522350732
ENST00000419585FANCD2chr310085548+ENST00000351233MTMR14chr39724862+243112951522014620

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287647ENST00000353332FANCD2chr310074656+MTMR14chr39719000+0.0152369410.9847631
ENST00000383807ENST00000353332FANCD2chr310074656+MTMR14chr39719000+0.0150515050.98494846
ENST00000383806ENST00000353332FANCD2chr310074656+MTMR14chr39719000+0.0150515050.98494846
ENST00000419585ENST00000353332FANCD2chr310074656+MTMR14chr39719000+0.0144129140.9855871
ENST00000431693ENST00000353332FANCD2chr310074656+MTMR14chr39719000+0.0158929230.984107
ENST00000287647ENST00000353332FANCD2chr310074656+MTMR14chr39719001+0.0152369410.9847631
ENST00000383807ENST00000353332FANCD2chr310074656+MTMR14chr39719001+0.0150515050.98494846
ENST00000383806ENST00000353332FANCD2chr310074656+MTMR14chr39719001+0.0150515050.98494846
ENST00000419585ENST00000353332FANCD2chr310074656+MTMR14chr39719001+0.0144129140.9855871
ENST00000431693ENST00000353332FANCD2chr310074656+MTMR14chr39719001+0.0158929230.984107
ENST00000287647ENST00000353332FANCD2chr310070405+MTMR14chr39719001+0.0325130860.9674869
ENST00000383807ENST00000353332FANCD2chr310070405+MTMR14chr39719001+0.032531390.9674686
ENST00000383806ENST00000353332FANCD2chr310070405+MTMR14chr39719001+0.032531390.9674686
ENST00000419585ENST00000353332FANCD2chr310070405+MTMR14chr39719001+0.0297671720.97023284
ENST00000431693ENST00000353332FANCD2chr310070405+MTMR14chr39719001+0.03371840.96628153
ENST00000287647ENST00000353332FANCD2chr310085548+MTMR14chr39724862+0.0060223660.99397767
ENST00000287647ENST00000420925FANCD2chr310085548+MTMR14chr39724862+0.0048096780.9951904
ENST00000287647ENST00000296003FANCD2chr310085548+MTMR14chr39724862+0.0069244520.9930755
ENST00000287647ENST00000351233FANCD2chr310085548+MTMR14chr39724862+0.0047203450.99527967
ENST00000383807ENST00000353332FANCD2chr310085548+MTMR14chr39724862+0.0060270260.99397296
ENST00000383807ENST00000420925FANCD2chr310085548+MTMR14chr39724862+0.004800570.99519944
ENST00000383807ENST00000296003FANCD2chr310085548+MTMR14chr39724862+0.0069216290.9930783
ENST00000383807ENST00000351233FANCD2chr310085548+MTMR14chr39724862+0.0047127410.9952872
ENST00000383806ENST00000353332FANCD2chr310085548+MTMR14chr39724862+0.0060270260.99397296
ENST00000383806ENST00000420925FANCD2chr310085548+MTMR14chr39724862+0.004800570.99519944
ENST00000383806ENST00000296003FANCD2chr310085548+MTMR14chr39724862+0.0069216290.9930783
ENST00000383806ENST00000351233FANCD2chr310085548+MTMR14chr39724862+0.0047127410.9952872
ENST00000419585ENST00000353332FANCD2chr310085548+MTMR14chr39724862+0.0057527520.9942472
ENST00000419585ENST00000420925FANCD2chr310085548+MTMR14chr39724862+0.0046370330.995363
ENST00000419585ENST00000296003FANCD2chr310085548+MTMR14chr39724862+0.0064381520.99356186
ENST00000419585ENST00000351233FANCD2chr310085548+MTMR14chr39724862+0.0045541590.99544585

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29328_29328_1_FANCD2-MTMR14_FANCD2_chr3_10070405_ENST00000287647_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=372AA_BP=25
MVKMVSKRRLSKSEDKESLTEDASSCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLS
LVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFS
ALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQP
SEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_2_FANCD2-MTMR14_FANCD2_chr3_10070405_ENST00000383806_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=372AA_BP=25
MVKMVSKRRLSKSEDKESLTEDASSCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLS
LVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFS
ALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQP
SEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_3_FANCD2-MTMR14_FANCD2_chr3_10070405_ENST00000383807_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=372AA_BP=25
MVKMVSKRRLSKSEDKESLTEDASSCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLS
LVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFS
ALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQP
SEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_4_FANCD2-MTMR14_FANCD2_chr3_10070405_ENST00000419585_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=372AA_BP=25
MVKMVSKRRLSKSEDKESLTEDASSCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLS
LVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFS
ALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQP
SEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_5_FANCD2-MTMR14_FANCD2_chr3_10070405_ENST00000431693_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=372AA_BP=25
MVKMVSKRRLSKSEDKESLTEDASSCEFFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLS
LVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFS
ALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQP
SEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_6_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000287647_MTMR14_chr3_9719000_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_7_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000287647_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_8_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000383806_MTMR14_chr3_9719000_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_9_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000383806_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_10_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000383807_MTMR14_chr3_9719000_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_11_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000383807_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_12_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000419585_MTMR14_chr3_9719000_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_13_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000419585_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_14_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000431693_MTMR14_chr3_9719000_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_15_FANCD2-MTMR14_FANCD2_chr3_10074656_ENST00000431693_MTMR14_chr3_9719001_ENST00000353332_length(amino acids)=419AA_BP=71
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLGCEFFKEYKDRDYMAEGLI
FNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLK
PTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLV
MESSPGATGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRL

--------------------------------------------------------------

>29328_29328_16_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000287647_MTMR14_chr3_9724862_ENST00000296003_length(amino acids)=732AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSS
LSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_17_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000287647_MTMR14_chr3_9724862_ENST00000351233_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_18_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000287647_MTMR14_chr3_9724862_ENST00000353332_length(amino acids)=680AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETR

--------------------------------------------------------------

>29328_29328_19_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000287647_MTMR14_chr3_9724862_ENST00000420925_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_20_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383806_MTMR14_chr3_9724862_ENST00000296003_length(amino acids)=732AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSS
LSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_21_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383806_MTMR14_chr3_9724862_ENST00000351233_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_22_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383806_MTMR14_chr3_9724862_ENST00000353332_length(amino acids)=680AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETR

--------------------------------------------------------------

>29328_29328_23_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383806_MTMR14_chr3_9724862_ENST00000420925_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_24_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383807_MTMR14_chr3_9724862_ENST00000296003_length(amino acids)=732AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSS
LSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_25_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383807_MTMR14_chr3_9724862_ENST00000351233_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_26_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383807_MTMR14_chr3_9724862_ENST00000353332_length(amino acids)=680AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETR

--------------------------------------------------------------

>29328_29328_27_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000383807_MTMR14_chr3_9724862_ENST00000420925_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_28_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000419585_MTMR14_chr3_9724862_ENST00000296003_length(amino acids)=732AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRSVDHPLPGSS
LSTDYGSWQMVTGCGSIQERAVLHTDSSLPFSFPDELPNSCLLAALSDRETRLQEVRSAFLAAYSSTVGLRAVAPSPSGAIGGLLEQFAR

--------------------------------------------------------------

>29328_29328_29_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000419585_MTMR14_chr3_9724862_ENST00000351233_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

>29328_29328_30_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000419585_MTMR14_chr3_9724862_ENST00000353332_length(amino acids)=680AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG
SFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSNHSDNFFRMGSSPLEVPKPRLAALSDRETR

--------------------------------------------------------------

>29328_29328_31_FANCD2-MTMR14_FANCD2_chr3_10085548_ENST00000419585_MTMR14_chr3_9724862_ENST00000420925_length(amino acids)=620AA_BP=381
MVKMVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHP
SYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV
SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIENTSLTVPILDVLSSLRLDPNFLLKVRQLVM
DKLSSIRLEDLPVIIKFILHSVTAMDTLEVISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE
KTISEAWIKAIENTASVSEHKCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTV
AYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQRRKSLPARDGGFTLEDICMLRRKDRGSTTSLGSDFSLVMESSPGATG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:10074656/chr3:9719001)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FANCD2

Q96PS1

MTMR14

Q8NCE2

FUNCTION: Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. {ECO:0000269|PubMed:17008356}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMTMR14chr3:10070405chr3:9719001ENST00000296003619512_518250.33333333333334651.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10070405chr3:9719001ENST00000351233617512_518250.33333333333334539.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10070405chr3:9719001ENST00000353332618512_518250.33333333333334599.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719000ENST00000296003619512_518250.33333333333334651.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719000ENST00000351233617512_518250.33333333333334539.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719000ENST00000353332618512_518250.33333333333334599.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719001ENST00000296003619512_518250.33333333333334651.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719001ENST00000351233617512_518250.33333333333334539.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10074656chr3:9719001ENST00000353332618512_518250.33333333333334599.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10085548chr3:9724862ENST00000296003819512_518299.0651.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10085548chr3:9724862ENST00000351233817512_518299.0539.0Compositional biasNote=Poly-Ser
TgeneMTMR14chr3:10085548chr3:9724862ENST00000353332818512_518299.0599.0Compositional biasNote=Poly-Ser

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FANCD2
MTMR14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneFANCD2chr3:10070405chr3:9719001ENST00000287647+243248_35921.3333333333333321472.0BRCA2
HgeneFANCD2chr3:10070405chr3:9719001ENST00000383806+243248_35921.3333333333333321469.6666666666667BRCA2
HgeneFANCD2chr3:10070405chr3:9719001ENST00000383807+244248_35921.3333333333333321452.0BRCA2
HgeneFANCD2chr3:10070405chr3:9719001ENST00000419585+244248_35921.3333333333333321452.0BRCA2
HgeneFANCD2chr3:10070405chr3:9719001ENST00000431693+18248_35921.333333333333332242.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719000ENST00000287647+343248_35968.333333333333331472.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719000ENST00000383806+343248_35968.333333333333331469.6666666666667BRCA2
HgeneFANCD2chr3:10074656chr3:9719000ENST00000383807+344248_35968.333333333333331452.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719000ENST00000419585+344248_35968.333333333333331452.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719000ENST00000431693+28248_35968.33333333333333242.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719001ENST00000287647+343248_35968.333333333333331472.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719001ENST00000383806+343248_35968.333333333333331469.6666666666667BRCA2
HgeneFANCD2chr3:10074656chr3:9719001ENST00000383807+344248_35968.333333333333331452.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719001ENST00000419585+344248_35968.333333333333331452.0BRCA2
HgeneFANCD2chr3:10074656chr3:9719001ENST00000431693+28248_35968.33333333333333242.0BRCA2
HgeneFANCD2chr3:10085548chr3:9724862ENST00000431693+18248_3590242.0BRCA2
HgeneFANCD2chr3:10070405chr3:9719001ENST00000287647+2431_29121.3333333333333321472.0FANCE
HgeneFANCD2chr3:10070405chr3:9719001ENST00000383806+2431_29121.3333333333333321469.6666666666667FANCE
HgeneFANCD2chr3:10070405chr3:9719001ENST00000383807+2441_29121.3333333333333321452.0FANCE
HgeneFANCD2chr3:10070405chr3:9719001ENST00000419585+2441_29121.3333333333333321452.0FANCE
HgeneFANCD2chr3:10070405chr3:9719001ENST00000431693+181_29121.333333333333332242.0FANCE
HgeneFANCD2chr3:10074656chr3:9719000ENST00000287647+3431_29168.333333333333331472.0FANCE
HgeneFANCD2chr3:10074656chr3:9719000ENST00000383806+3431_29168.333333333333331469.6666666666667FANCE
HgeneFANCD2chr3:10074656chr3:9719000ENST00000383807+3441_29168.333333333333331452.0FANCE
HgeneFANCD2chr3:10074656chr3:9719000ENST00000419585+3441_29168.333333333333331452.0FANCE
HgeneFANCD2chr3:10074656chr3:9719000ENST00000431693+281_29168.33333333333333242.0FANCE
HgeneFANCD2chr3:10074656chr3:9719001ENST00000287647+3431_29168.333333333333331472.0FANCE
HgeneFANCD2chr3:10074656chr3:9719001ENST00000383806+3431_29168.333333333333331469.6666666666667FANCE
HgeneFANCD2chr3:10074656chr3:9719001ENST00000383807+3441_29168.333333333333331452.0FANCE
HgeneFANCD2chr3:10074656chr3:9719001ENST00000419585+3441_29168.333333333333331452.0FANCE
HgeneFANCD2chr3:10074656chr3:9719001ENST00000431693+281_29168.33333333333333242.0FANCE
HgeneFANCD2chr3:10085548chr3:9724862ENST00000431693+181_2910242.0FANCE


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Related Drugs to FANCD2-MTMR14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FANCD2-MTMR14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource