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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FARP1-NME1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FARP1-NME1
	FusionPDB ID: 29378
	FusionGDB2.0 ID: 29378
		Hgene	Tgene
	Gene symbol	FARP1	NME1
	Gene ID	10160	6023
	Gene name	FERM, ARH/RhoGEF and pleckstrin domain protein 1	RNA component of mitochondrial RNA processing endoribonuclease
	Synonyms	CDEP\|FARP1-IT1\|PLEKHC2\|PPP1R75	CHH\|NME1\|RMRPR\|RRP2
	Cytomap	13q32.2	9p13.3
	Type of gene	protein-coding	ncRNA
	Description	FERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-li	-
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4F1	P15531
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000319562, ENST00000376581, ENST00000376586, ENST00000595437, ENST00000593990,	ENST00000013034, ENST00000336097, ENST00000393196, ENST00000480143, ENST00000511355,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 10=2470	3 X 4 X 3=36
	# samples	22	4
	** MAII score	log2(22/2470*10)=-3.48893561294738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FARP1 [Title/Abstract] AND NME1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FARP1(98865667)-NME1(49237341), # samples:1 FARP1(98865667)-NME1(49233011), # samples:1 FARP1(98865667)-NME1(49237340), # samples:1
Anticipated loss of major functional domain due to fusion event.	FARP1-NME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FARP1-NME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FARP1	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	NME1	GO:0001172	transcription, RNA-templated	19701182
Tgene	NME1	GO:0030422	production of siRNA involved in RNA interference	19701182

Fusion gene breakpoints across FARP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DB-5275-01A	FARP1	chr13	98865667	+	NME1	chr17	49237341	+
ChimerDB4	LGG	TCGA-DB-5275	FARP1	chr13	98865667	+	NME1	chr17	49233011	+
ChimerDB4	LGG	TCGA-DB-5275	FARP1	chr13	98865667	+	NME1	chr17	49237340	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000595437	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237341	+	1093	410	239	742	167
ENST00000595437	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237341	+	959	410	239	742	167
ENST00000595437	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237341	+	939	410	239	628	129
ENST00000595437	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237341	+	1843	410	785	426	119
ENST00000595437	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237341	+	796	410	239	742	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237341	+	1190	507	336	839	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237341	+	1056	507	336	839	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237341	+	1036	507	336	725	129
ENST00000376586	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237341	+	1940	507	882	523	119
ENST00000376586	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237341	+	893	507	336	839	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237341	+	1119	436	265	768	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237341	+	985	436	265	768	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237341	+	965	436	265	654	129
ENST00000319562	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237341	+	1869	436	811	452	119
ENST00000319562	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237341	+	822	436	265	768	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237341	+	890	207	36	539	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237341	+	756	207	36	539	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237341	+	736	207	36	425	129
ENST00000376581	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237341	+	1640	207	582	223	119
ENST00000376581	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237341	+	593	207	36	539	167
ENST00000595437	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237340	+	1093	410	239	742	167
ENST00000595437	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237340	+	959	410	239	742	167
ENST00000595437	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237340	+	939	410	239	628	129
ENST00000595437	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237340	+	1843	410	785	426	119
ENST00000595437	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237340	+	796	410	239	742	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237340	+	1190	507	336	839	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237340	+	1056	507	336	839	167
ENST00000376586	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237340	+	1036	507	336	725	129
ENST00000376586	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237340	+	1940	507	882	523	119
ENST00000376586	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237340	+	893	507	336	839	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237340	+	1119	436	265	768	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237340	+	985	436	265	768	167
ENST00000319562	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237340	+	965	436	265	654	129
ENST00000319562	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237340	+	1869	436	811	452	119
ENST00000319562	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237340	+	822	436	265	768	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000393196	NME1	chr17	49237340	+	890	207	36	539	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000336097	NME1	chr17	49237340	+	756	207	36	539	167
ENST00000376581	FARP1	chr13	98865667	+	ENST00000480143	NME1	chr17	49237340	+	736	207	36	425	129
ENST00000376581	FARP1	chr13	98865667	+	ENST00000511355	NME1	chr17	49237340	+	1640	207	582	223	119
ENST00000376581	FARP1	chr13	98865667	+	ENST00000013034	NME1	chr17	49237340	+	593	207	36	539	167

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000595437	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.004359138	0.9956409
ENST00000595437	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.003887513	0.9961125
ENST00000595437	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.009027818	0.99097216
ENST00000595437	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.028309105	0.97169095
ENST00000595437	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.002479558	0.9975204
ENST00000376586	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.003445261	0.99655473
ENST00000376586	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.002795132	0.99720484
ENST00000376586	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.007158931	0.9928411
ENST00000376586	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.033667233	0.96633273
ENST00000376586	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.001796898	0.99820304
ENST00000319562	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.004068244	0.9959318
ENST00000319562	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.003785904	0.9962141
ENST00000319562	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.008181249	0.9918188
ENST00000319562	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.016296577	0.98370343
ENST00000319562	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.002571577	0.99742836
ENST00000376581	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.002671913	0.99732804
ENST00000376581	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.002475579	0.99752444
ENST00000376581	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.007428587	0.9925714
ENST00000376581	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.047890197	0.95210975
ENST00000376581	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237341	+	0.001373852	0.9986261
ENST00000595437	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.004359138	0.9956409
ENST00000595437	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.003887513	0.9961125
ENST00000595437	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.009027818	0.99097216
ENST00000595437	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.028309105	0.97169095
ENST00000595437	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.002479558	0.9975204
ENST00000376586	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.003445261	0.99655473
ENST00000376586	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.002795132	0.99720484
ENST00000376586	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.007158931	0.9928411
ENST00000376586	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.033667233	0.96633273
ENST00000376586	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.001796898	0.99820304
ENST00000319562	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.004068244	0.9959318
ENST00000319562	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.003785904	0.9962141
ENST00000319562	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.008181249	0.9918188
ENST00000319562	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.016296577	0.98370343
ENST00000319562	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.002571577	0.99742836
ENST00000376581	ENST00000393196	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.002671913	0.99732804
ENST00000376581	ENST00000336097	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.002475579	0.99752444
ENST00000376581	ENST00000480143	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.007428587	0.9925714
ENST00000376581	ENST00000511355	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.047890197	0.95210975
ENST00000376581	ENST00000013034	FARP1	chr13	98865667	+	NME1	chr17	49237340	+	0.001373852	0.9986261

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29378_29378_1_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237340_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_2_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237340_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_3_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237340_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_4_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237340_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_5_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237340_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_6_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237341_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_7_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237341_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_8_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237341_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_9_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237341_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_10_FARP1-NME1_FARP1_chr13_98865667_ENST00000319562_NME1_chr17_49237341_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_11_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237340_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_12_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237340_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_13_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237340_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_14_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237340_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_15_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237340_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_16_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237341_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_17_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237341_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_18_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237341_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_19_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237341_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_20_FARP1-NME1_FARP1_chr13_98865667_ENST00000376581_NME1_chr17_49237341_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_21_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237340_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_22_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237340_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_23_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237340_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_24_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237340_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_25_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237340_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_26_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237341_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_27_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237341_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_28_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237341_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_29_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237341_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_30_FARP1-NME1_FARP1_chr13_98865667_ENST00000376586_NME1_chr17_49237341_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_31_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237340_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_32_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237340_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_33_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237340_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_34_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237340_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_35_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237340_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

>29378_29378_36_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237341_ENST00000013034_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_37_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237341_ENST00000336097_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_38_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237341_ENST00000393196_length(amino acids)=167AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_39_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237341_ENST00000480143_length(amino acids)=129AA_BP=57
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA

--------------------------------------------------------------

>29378_29378_40_FARP1-NME1_FARP1_chr13_98865667_ENST00000595437_NME1_chr17_49237341_ENST00000511355_length(amino acids)=119AA_BP=
MHMVSCLPPASETQILVATKSDFGKGGKIPKSHLPTCMQKSPRMVPGLESAGLVSPSMTRPVFTTFSPSQTSKDRRRYGQRRKPITAENL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:98865667/chr17:49237341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FARP1 Q9Y4F1	NME1 P15531
FUNCTION: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.	FUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269\|PubMed:12628186, ECO:0000269\|PubMed:16818237, ECO:0000269\|PubMed:8810265}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000319562

449_453

57.0

1046.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000376581

449_453

57.0

130.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000319562

449_453

57.0

1046.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000376581

449_453

57.0

130.0

Compositional bias

Note=Poly-Glu

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000319562

40_320

57.0

1046.0

Domain

FERM

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000319562

540_730

57.0

1046.0

Domain

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000319562

759_856

57.0

1046.0

Domain

PH 1

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000319562

932_1029

57.0

1046.0

Domain

PH 2

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000376581

40_320

57.0

130.0

Domain

FERM

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000376581

540_730

57.0

130.0

Domain

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000376581

759_856

57.0

130.0

Domain

PH 1

Hgene

FARP1

chr13:98865667

chr17:49237340

ENST00000376581

932_1029

57.0

130.0

Domain

PH 2

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000319562

40_320

57.0

1046.0

Domain

FERM

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000319562

540_730

57.0

1046.0

Domain

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000319562

759_856

57.0

1046.0

Domain

PH 1

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000319562

932_1029

57.0

1046.0

Domain

PH 2

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000376581

40_320

57.0

130.0

Domain

FERM

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000376581

540_730

57.0

130.0

Domain

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000376581

759_856

57.0

130.0

Domain

PH 1

Hgene

FARP1

chr13:98865667

chr17:49237341

ENST00000376581

932_1029

57.0

130.0

Domain

PH 2

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FARP1
NME1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FARP1-NME1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FARP1-NME1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source