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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FBLN1-PRKAR1B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FBLN1-PRKAR1B
	FusionPDB ID: 29537
	FusionGDB2.0 ID: 29537
		Hgene	Tgene
	Gene symbol	FBLN1	PRKAR1B
	Gene ID	2192	5575
	Gene name	fibulin 1	protein kinase cAMP-dependent type I regulatory subunit beta
	Synonyms	FBLN\|FIBL1	PRKAR1
	Cytomap	22q13.31	7p22.3
	Type of gene	protein-coding	protein-coding
	Description	fibulin-1	cAMP-dependent protein kinase type I-beta regulatory subunitprotein kinase, cAMP-dependent, regulatory subunit type I betaprotein kinase, cAMP-dependent, regulatory, type I, beta
	Modification date	20200313	20200327
	UniProtAcc	P23142	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000327858, ENST00000348697, ENST00000262722, ENST00000340923, ENST00000402984, ENST00000442170, ENST00000476366,	ENST00000488474, ENST00000360274, ENST00000403562, ENST00000406797, ENST00000537384, ENST00000544935,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 14 X 8=1680	14 X 10 X 8=1120
	# samples	17	15
	** MAII score	log2(17/1680*10)=-3.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1120*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FBLN1 [Title/Abstract] AND PRKAR1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FBLN1(45972988)-PRKAR1B(619014), # samples:1
Anticipated loss of major functional domain due to fusion event.	FBLN1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FBLN1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FBLN1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FBLN1-PRKAR1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FBLN1	GO:0001933	negative regulation of protein phosphorylation	11792823
Hgene	FBLN1	GO:0007162	negative regulation of cell adhesion	11792823
Hgene	FBLN1	GO:0007229	integrin-mediated signaling pathway	11792823
Hgene	FBLN1	GO:0070373	negative regulation of ERK1 and ERK2 cascade	11792823
Hgene	FBLN1	GO:0072378	blood coagulation, fibrin clot formation	7642629
Hgene	FBLN1	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	11792823
Hgene	FBLN1	GO:2000146	negative regulation of cell motility	11792823
Hgene	FBLN1	GO:2000647	negative regulation of stem cell proliferation	11238726
Tgene	PRKAR1B	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	21812984

Fusion gene breakpoints across FBLN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRKAR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A486-01A	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000348697	FBLN1	chr22	45972988	+	ENST00000544935	PRKAR1B	chr7	619014	-	3729	2119	45	2495	816
ENST00000348697	FBLN1	chr22	45972988	+	ENST00000537384	PRKAR1B	chr7	619014	-	3729	2119	45	2495	816
ENST00000348697	FBLN1	chr22	45972988	+	ENST00000406797	PRKAR1B	chr7	619014	-	3728	2119	45	2495	816
ENST00000348697	FBLN1	chr22	45972988	+	ENST00000403562	PRKAR1B	chr7	619014	-	3184	2119	45	2495	816
ENST00000348697	FBLN1	chr22	45972988	+	ENST00000360274	PRKAR1B	chr7	619014	-	3176	2119	45	2495	816
ENST00000327858	FBLN1	chr22	45972988	+	ENST00000544935	PRKAR1B	chr7	619014	-	3677	2067	95	2443	782
ENST00000327858	FBLN1	chr22	45972988	+	ENST00000537384	PRKAR1B	chr7	619014	-	3677	2067	95	2443	782
ENST00000327858	FBLN1	chr22	45972988	+	ENST00000406797	PRKAR1B	chr7	619014	-	3676	2067	95	2443	782
ENST00000327858	FBLN1	chr22	45972988	+	ENST00000403562	PRKAR1B	chr7	619014	-	3132	2067	95	2443	782
ENST00000327858	FBLN1	chr22	45972988	+	ENST00000360274	PRKAR1B	chr7	619014	-	3124	2067	95	2443	782

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000348697	ENST00000544935	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.005023714	0.9949763
ENST00000348697	ENST00000537384	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.005023714	0.9949763
ENST00000348697	ENST00000406797	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.005084633	0.99491537
ENST00000348697	ENST00000403562	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.006604168	0.99339586
ENST00000348697	ENST00000360274	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.00647322	0.9935268
ENST00000327858	ENST00000544935	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.004986006	0.995014
ENST00000327858	ENST00000537384	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.004986006	0.995014
ENST00000327858	ENST00000406797	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.005039904	0.99496007
ENST00000327858	ENST00000403562	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.006609567	0.99339044
ENST00000327858	ENST00000360274	FBLN1	chr22	45972988	+	PRKAR1B	chr7	619014	-	0.006474434	0.9935256

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29537_29537_1_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000327858_PRKAR1B_chr7_619014_ENST00000360274_length(amino acids)=782AA_BP=657
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI
HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC
SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQA
NIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLG

--------------------------------------------------------------

>29537_29537_2_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000327858_PRKAR1B_chr7_619014_ENST00000403562_length(amino acids)=782AA_BP=657
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI
HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC
SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQA
NIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLG

--------------------------------------------------------------

>29537_29537_3_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000327858_PRKAR1B_chr7_619014_ENST00000406797_length(amino acids)=782AA_BP=657
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI
HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC
SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQA
NIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLG

--------------------------------------------------------------

>29537_29537_4_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000327858_PRKAR1B_chr7_619014_ENST00000537384_length(amino acids)=782AA_BP=657
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI
HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC
SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQA
NIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLG

--------------------------------------------------------------

>29537_29537_5_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000327858_PRKAR1B_chr7_619014_ENST00000544935_length(amino acids)=782AA_BP=657
MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDR
CATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRC
RGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGI
HNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDEC
APPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPC
SQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINE
TCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQA
NIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLG

--------------------------------------------------------------

>29537_29537_6_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000348697_PRKAR1B_chr7_619014_ENST00000360274_length(amino acids)=816AA_BP=691
MAAEARPERGARAAAPGPRPRLCPPPPTARRPPPMERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYAT
ESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVK
SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI
NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLED
THLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQ
GEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS

--------------------------------------------------------------

>29537_29537_7_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000348697_PRKAR1B_chr7_619014_ENST00000403562_length(amino acids)=816AA_BP=691
MAAEARPERGARAAAPGPRPRLCPPPPTARRPPPMERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYAT
ESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVK
SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI
NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLED
THLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQ
GEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS

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>29537_29537_8_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000348697_PRKAR1B_chr7_619014_ENST00000406797_length(amino acids)=816AA_BP=691
MAAEARPERGARAAAPGPRPRLCPPPPTARRPPPMERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYAT
ESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVK
SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI
NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLED
THLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQ
GEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS

--------------------------------------------------------------

>29537_29537_9_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000348697_PRKAR1B_chr7_619014_ENST00000537384_length(amino acids)=816AA_BP=691
MAAEARPERGARAAAPGPRPRLCPPPPTARRPPPMERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYAT
ESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVK
SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI
NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLED
THLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQ
GEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS

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>29537_29537_10_FBLN1-PRKAR1B_FBLN1_chr22_45972988_ENST00000348697_PRKAR1B_chr7_619014_ENST00000544935_length(amino acids)=816AA_BP=691
MAAEARPERGARAAAPGPRPRLCPPPPTARRPPPMERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYAT
ESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVK
SQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT
VGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCI
NTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCE
NTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLED
THLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVESLEKWERLTVADALEPVQFEDGEKIVVQ
GEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNS

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45972988/chr7:619014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBLN1 P23142	.
FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269\|PubMed:11792823, ECO:0000269\|PubMed:9393974, ECO:0000269\|PubMed:9466671}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

112_144

657.3333333333334

704.0

Domain

Anaphylatoxin-like 3

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

176_215

657.3333333333334

704.0

Domain

EGF-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

216_261

657.3333333333334

704.0

Domain

EGF-like 2%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

262_307

657.3333333333334

704.0

Domain

EGF-like 3%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

308_355

657.3333333333334

704.0

Domain

EGF-like 4%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

356_398

657.3333333333334

704.0

Domain

EGF-like 5%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

36_76

657.3333333333334

704.0

Domain

Anaphylatoxin-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

399_440

657.3333333333334

704.0

Domain

EGF-like 6%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

441_480

657.3333333333334

704.0

Domain

EGF-like 7%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

481_524

657.3333333333334

704.0

Domain

EGF-like 8%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

525_578

657.3333333333334

704.0

Domain

EGF-like 9%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

77_111

657.3333333333334

704.0

Domain

Anaphylatoxin-like 2

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000327858

356_440

657.3333333333334

704.0

Region

Note=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000360274

255_381

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 2

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000403562

255_381

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 2

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000406797

255_381

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 2

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000537384

255_381

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 2

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000544935

255_381

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

112_144

684.0

Domain

Anaphylatoxin-like 3

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

176_215

684.0

Domain

EGF-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

216_261

684.0

Domain

EGF-like 2%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

262_307

684.0

Domain

EGF-like 3%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

308_355

684.0

Domain

EGF-like 4%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

356_398

684.0

Domain

EGF-like 5%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

36_76

684.0

Domain

Anaphylatoxin-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

399_440

684.0

Domain

EGF-like 6%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

441_480

684.0

Domain

EGF-like 7%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

481_524

684.0

Domain

EGF-like 8%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

525_578

684.0

Domain

EGF-like 9%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

77_111

684.0

Domain

Anaphylatoxin-like 2

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

112_144

567.0

Domain

Anaphylatoxin-like 3

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

176_215

567.0

Domain

EGF-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

216_261

567.0

Domain

EGF-like 2%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

262_307

567.0

Domain

EGF-like 3%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

308_355

567.0

Domain

EGF-like 4%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

356_398

567.0

Domain

EGF-like 5%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

36_76

567.0

Domain

Anaphylatoxin-like 1

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

399_440

567.0

Domain

EGF-like 6%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

441_480

567.0

Domain

EGF-like 7%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

481_524

567.0

Domain

EGF-like 8%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

525_578

567.0

Domain

EGF-like 9%3B calcium-binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

77_111

567.0

Domain

Anaphylatoxin-like 2

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000262722

356_440

684.0

Region

Note=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding

Hgene

FBLN1

chr22:45972988

chr7:619014

ENST00000340923

356_440

567.0

Region

Note=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000360274

96_100

256.3333333333333

382.0

Motif

Note=Pseudophosphorylation motif

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000403562

96_100

256.3333333333333

382.0

Motif

Note=Pseudophosphorylation motif

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000406797

96_100

256.3333333333333

382.0

Motif

Note=Pseudophosphorylation motif

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000537384

96_100

256.3333333333333

382.0

Motif

Note=Pseudophosphorylation motif

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000544935

96_100

256.3333333333333

382.0

Motif

Note=Pseudophosphorylation motif

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000360274

137_254

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 1

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000403562

137_254

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 1

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000406797

137_254

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 1

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000537384

137_254

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 1

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000544935

137_254

256.3333333333333

382.0

Nucleotide binding

Note=cAMP 1

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000360274

2_136

256.3333333333333

382.0

Region

Note=Dimerization and phosphorylation

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000403562

2_136

256.3333333333333

382.0

Region

Note=Dimerization and phosphorylation

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000406797

2_136

256.3333333333333

382.0

Region

Note=Dimerization and phosphorylation

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000537384

2_136

256.3333333333333

382.0

Region

Note=Dimerization and phosphorylation

Tgene

PRKAR1B

chr22:45972988

chr7:619014

ENST00000544935

2_136

256.3333333333333

382.0

Region

Note=Dimerization and phosphorylation

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FBLN1
PRKAR1B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FBLN1-PRKAR1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FBLN1-PRKAR1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source