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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FBXL20-ABCA6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FBXL20-ABCA6
FusionPDB ID: 29626
FusionGDB2.0 ID: 29626
HgeneTgene
Gene symbol

FBXL20

ABCA6

Gene ID

84961

23460

Gene nameF-box and leucine rich repeat protein 20ATP binding cassette subfamily A member 6
SynonymsFbl2|Fbl20EST155051
Cytomap

17q12

17q24.2-q24.3

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2ATP-binding cassette sub-family A member 6ABC transporter ABCA6ATP-binding cassette A6ATP-binding cassette, sub-family A (ABC1), member 6
Modification date2020031320200313
UniProtAcc

Q96IG2

Q8N139

Ensembl transtripts involved in fusion geneENST idsENST00000264658, ENST00000394294, 
ENST00000583610, ENST00000577399, 
ENST00000446604, ENST00000590645, 
ENST00000284425, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score58 X 21 X 16=194884 X 4 X 3=48
# samples 614
** MAII scorelog2(61/19488*10)=-4.99763298545608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FBXL20 [Title/Abstract] AND ABCA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FBXL20(37557614)-ABCA6(67124945), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FBXL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0T1-01AFBXL20chr17

37557614

-ABCA6chr17

67124945

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000583610FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-448829625442161320
ENST00000394294FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-445526322141831320
ENST00000264658FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-449530326142231320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000583610ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.61E-050.9999039
ENST00000394294ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.31E-050.9999069
ENST00000264658ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.51E-050.9999049

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29626_29626_1_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000264658_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

--------------------------------------------------------------

>29626_29626_2_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000394294_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

--------------------------------------------------------------

>29626_29626_3_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000583610_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37557614/chr17:67124945)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL20

Q96IG2

ABCA6

Q8N139

FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:10639163}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391288_1513311.01618.0DomainABC transporter 2
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639478_713311.01618.0DomainABC transporter 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041288_15130186.0DomainABC transporter 2
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504478_7130186.0DomainABC transporter 1
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391320_1327311.01618.0Nucleotide bindingATP 2
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639514_521311.01618.0Nucleotide bindingATP 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041320_13270186.0Nucleotide bindingATP 2
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504514_5210186.0Nucleotide bindingATP 1
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391007_1027311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391062_1082311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391094_1114311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391127_1147311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391150_1170311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391194_1214311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639327_347311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639355_375311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639397_417311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639854_874311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041007_10270186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041062_10820186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041094_11140186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041127_11470186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041150_11700186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041194_12140186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504222_2420186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504268_2880186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504297_3170186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000005906450431_510186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504327_3470186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504355_3750186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504397_4170186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504854_8740186.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-11522_6814.0437.0DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-11422_6814.0405.0DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-11622_6814.0411.6666666666667DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115101_12614.0437.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115127_15214.0437.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115153_17814.0437.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115179_20414.0437.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115205_23014.0437.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115231_25614.0437.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115257_28214.0437.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115283_30814.0437.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115309_33414.0437.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115335_36314.0437.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115364_38814.0437.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115389_41414.0437.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-11574_10014.0437.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114101_12614.0405.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114127_15214.0405.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114153_17814.0405.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114179_20414.0405.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114205_23014.0405.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114231_25614.0405.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114257_28214.0405.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114283_30814.0405.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114309_33414.0405.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114335_36314.0405.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114364_38814.0405.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114389_41414.0405.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-11474_10014.0405.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116101_12614.0411.6666666666667RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116127_15214.0411.6666666666667RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116153_17814.0411.6666666666667RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116179_20414.0411.6666666666667RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116205_23014.0411.6666666666667RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116231_25614.0411.6666666666667RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116257_28214.0411.6666666666667RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116283_30814.0411.6666666666667RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116309_33414.0411.6666666666667RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116335_36314.0411.6666666666667RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116364_38814.0411.6666666666667RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116389_41414.0411.6666666666667RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-11674_10014.0411.6666666666667RepeatNote=LRR 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639222_242311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639268_288311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639297_317311.01618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000028442563931_51311.01618.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FBXL20
ABCA6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FBXL20-ABCA6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FBXL20-ABCA6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource