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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:AGPAT6-ADAM32

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: AGPAT6-ADAM32
	FusionPDB ID: 2970
	FusionGDB2.0 ID: 2970
		Hgene	Tgene
	Gene symbol	AGPAT6	ADAM32
	Gene ID	137964	203102
	Gene name	glycerol-3-phosphate acyltransferase 4	ADAM metallopeptidase domain 32
	Synonyms	1-AGPAT 6\|AGPAT6\|LPAAT-zeta\|LPAATZ\|TSARG7	-
	Cytomap	8p11.21	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	glycerol-3-phosphate acyltransferase 41-AGP acyltransferase 61-acyl-sn-glycerol-3-phosphate acyltransferase zeta1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)glycerol-3-phosphate acyltransferase 6lysophos	disintegrin and metalloproteinase domain-containing protein 32a disintegrin and metalloprotease domain 32a disintegrin and metalloproteinase domain 32metalloproteinase 12-like proteintesticular tissue protein Li 13
	Modification date	20200313	20200313
	UniProtAcc	.	Q8TC27
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000396987, ENST00000520258,	ENST00000524303, ENST00000379907, ENST00000437682, ENST00000519315,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	11 X 12 X 8=1056
	# samples	6	13
	** MAII score	log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/1056*10)=-3.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: AGPAT6 [Title/Abstract] AND ADAM32 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	AGPAT6(41456823)-ADAM32(39079128), # samples:1 AGPAT6(41456823)-ADAM32(39079129), # samples:1 AGPAT6(41456823)-ADAM32(39080559), # samples:1
Anticipated loss of major functional domain due to fusion event.	AGPAT6-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGPAT6-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AGPAT6-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AGPAT6-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AGPAT6	GO:0006637	acyl-CoA metabolic process	18238778
Hgene	AGPAT6	GO:0006656	phosphatidylcholine biosynthetic process	18238778
Hgene	AGPAT6	GO:0019432	triglyceride biosynthetic process	18238778

Fusion gene breakpoints across AGPAT6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BH-A18J-11A	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079128	+
ChimerDB4	Non-Cancer	TCGA-BH-A18J-11A	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079129	+
ChimerDB4	Non-Cancer	TCGA-BH-A18J-11A	AGPAT6	chr8	41456823	+	ADAM32	chr8	39080559	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000437682	ADAM32	chr8	39079128	+	2333	1092	798	2222	474
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000519315	ADAM32	chr8	39079128	+	2177	1092	798	2066	422
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000379907	ADAM32	chr8	39079128	+	2333	1092	798	2222	474
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000437682	ADAM32	chr8	39079129	+	2333	1092	798	2222	474
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000519315	ADAM32	chr8	39079129	+	2177	1092	798	2066	422
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000379907	ADAM32	chr8	39079129	+	2333	1092	798	2222	474
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000437682	ADAM32	chr8	39080559	+	2240	1092	798	2129	443
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000519315	ADAM32	chr8	39080559	+	2084	1092	798	1973	391
ENST00000396987	AGPAT6	chr8	41456823	+	ENST00000379907	ADAM32	chr8	39080559	+	2240	1092	798	2129	443

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396987	ENST00000437682	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079128	+	0.001552927	0.9984471
ENST00000396987	ENST00000519315	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079128	+	0.000964936	0.9990351
ENST00000396987	ENST00000379907	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079128	+	0.001552927	0.9984471
ENST00000396987	ENST00000437682	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079129	+	0.001552927	0.9984471
ENST00000396987	ENST00000519315	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079129	+	0.000964936	0.9990351
ENST00000396987	ENST00000379907	AGPAT6	chr8	41456823	+	ADAM32	chr8	39079129	+	0.001552927	0.9984471
ENST00000396987	ENST00000437682	AGPAT6	chr8	41456823	+	ADAM32	chr8	39080559	+	0.000632383	0.99936765
ENST00000396987	ENST00000519315	AGPAT6	chr8	41456823	+	ADAM32	chr8	39080559	+	0.000354716	0.99964523
ENST00000396987	ENST00000379907	AGPAT6	chr8	41456823	+	ADAM32	chr8	39080559	+	0.000632383	0.99936765

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>2970_2970_1_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079128_ENST00000379907_length(amino acids)=474AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME
RASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKS

--------------------------------------------------------------

>2970_2970_2_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079128_ENST00000437682_length(amino acids)=474AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME
RASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKS

--------------------------------------------------------------

>2970_2970_3_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079128_ENST00000519315_length(amino acids)=422AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME

--------------------------------------------------------------

>2970_2970_4_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079129_ENST00000379907_length(amino acids)=474AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME
RASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKS

--------------------------------------------------------------

>2970_2970_5_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079129_ENST00000437682_length(amino acids)=474AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME
RASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKS

--------------------------------------------------------------

>2970_2970_6_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39079129_ENST00000519315_length(amino acids)=422AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDG
DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD
YKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIME

--------------------------------------------------------------

>2970_2970_7_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39080559_ENST00000379907_length(amino acids)=443AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQ
SDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECV
ESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLAR

--------------------------------------------------------------

>2970_2970_8_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39080559_ENST00000437682_length(amino acids)=443AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQ
SDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECV
ESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLAR

--------------------------------------------------------------

>2970_2970_9_AGPAT6-ADAM32_AGPAT6_chr8_41456823_ENST00000396987_ADAM32_chr8_39080559_ENST00000519315_length(amino acids)=391AA_BP=92
MEWGLLFFGNLLPFPGWCCQEGPSEGCNLFLGRQVLAWPGSSTMFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYM
KSLLKIFAILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQ
SDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECV
ESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLAR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41456823/chr8:39079128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ADAM32 Q8TC27
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

480_502

411.0

788.0

Compositional bias

Note=Cys-rich

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

480_502

411.0

788.0

Compositional bias

Note=Cys-rich

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

480_502

442.0

788.0

Compositional bias

Note=Cys-rich

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

622_654

411.0

788.0

Domain

EGF-like

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

622_654

411.0

788.0

Domain

EGF-like

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

622_654

442.0

788.0

Domain

EGF-like

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

704_787

411.0

788.0

Topological domain

Cytoplasmic

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

704_787

411.0

788.0

Topological domain

Cytoplasmic

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

704_787

442.0

788.0

Topological domain

Cytoplasmic

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

683_703

411.0

788.0

Transmembrane

Helical

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

683_703

411.0

788.0

Transmembrane

Helical

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

683_703

442.0

788.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AGPAT6

chr8:41456823

chr8:39079128

ENST00000396987

248_253

55.0

457.0

Motif

HXXXXD motif

Hgene

AGPAT6

chr8:41456823

chr8:39079129

ENST00000396987

248_253

55.0

457.0

Motif

HXXXXD motif

Hgene

AGPAT6

chr8:41456823

chr8:39080559

ENST00000396987

248_253

55.0

457.0

Motif

HXXXXD motif

Hgene

AGPAT6

chr8:41456823

chr8:39079128

ENST00000396987

156_176

55.0

457.0

Transmembrane

Helical

Hgene

AGPAT6

chr8:41456823

chr8:39079128

ENST00000396987

180_200

55.0

457.0

Transmembrane

Helical

Hgene

AGPAT6

chr8:41456823

chr8:39079129

ENST00000396987

156_176

55.0

457.0

Transmembrane

Helical

Hgene

AGPAT6

chr8:41456823

chr8:39079129

ENST00000396987

180_200

55.0

457.0

Transmembrane

Helical

Hgene

AGPAT6

chr8:41456823

chr8:39080559

ENST00000396987

156_176

55.0

457.0

Transmembrane

Helical

Hgene

AGPAT6

chr8:41456823

chr8:39080559

ENST00000396987

180_200

55.0

457.0

Transmembrane

Helical

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

186_383

411.0

788.0

Domain

Peptidase M12B

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

391_479

411.0

788.0

Domain

Disintegrin

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

186_383

411.0

788.0

Domain

Peptidase M12B

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

391_479

411.0

788.0

Domain

Disintegrin

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

186_383

442.0

788.0

Domain

Peptidase M12B

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

391_479

442.0

788.0

Domain

Disintegrin

Tgene

ADAM32

chr8:41456823

chr8:39079128

ENST00000379907

175_682

411.0

788.0

Topological domain

Extracellular

Tgene

ADAM32

chr8:41456823

chr8:39079129

ENST00000379907

175_682

411.0

788.0

Topological domain

Extracellular

Tgene

ADAM32

chr8:41456823

chr8:39080559

ENST00000379907

175_682

442.0

788.0

Topological domain

Extracellular

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
AGPAT6
ADAM32

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to AGPAT6-ADAM32

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to AGPAT6-ADAM32

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source