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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FBXL5-RTN4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FBXL5-RTN4
FusionPDB ID: 29717
FusionGDB2.0 ID: 29717
HgeneTgene
Gene symbol

FBXL5

RTN4

Gene ID

26234

57142

Gene nameF-box and leucine rich repeat protein 5reticulon 4
SynonymsFBL4|FBL5|FLR1ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

4p15.32

2p16.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 5F-box protein FBL4/FBL5p45SKP2-like proteinreticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2020031320200327
UniProtAcc

Q9UKA1

.
Ensembl transtripts involved in fusion geneENST idsENST00000341285, ENST00000382358, 
ENST00000412094, ENST00000514541, 
ENST00000354474, ENST00000402434, 
ENST00000486085, ENST00000317610, 
ENST00000337526, ENST00000357376, 
ENST00000357732, ENST00000394609, 
ENST00000394611, ENST00000404909, 
ENST00000405240, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 6=33627 X 28 X 9=6804
# samples 1035
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/6804*10)=-4.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FBXL5 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FBXL5(15613888)-RTN4(55214834), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FBXL5-RTN4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXL5

GO:0016567

protein ubiquitination

17532294|19762596|19762597

HgeneFBXL5

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

17532294|19762596|19762597

TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check buttonFusion gene breakpoints across FBXL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer265NFBXL5chr4

15613888

-RTN4chr2

55214834

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341285FBXL5chr415613888-ENST00000394609RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000405240RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000357376RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000317610RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000357732RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000337526RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000394611RTN4chr255214834-36572124532689878
ENST00000341285FBXL5chr415613888-ENST00000404909RTN4chr255214834-36572124532689878
ENST00000412094FBXL5chr415613888-ENST00000394609RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000405240RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000357376RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000317610RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000357732RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000337526RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000394611RTN4chr255214834-35762043232608861
ENST00000412094FBXL5chr415613888-ENST00000404909RTN4chr255214834-35762043232608861

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341285ENST00000394609FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000405240FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000357376FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000317610FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000357732FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000337526FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000394611FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000341285ENST00000404909FBXL5chr415613888-RTN4chr255214834-0.0004530350.99954695
ENST00000412094ENST00000394609FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000405240FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000357376FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000317610FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000357732FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000337526FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000394611FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554
ENST00000412094ENST00000404909FBXL5chr415613888-RTN4chr255214834-0.0003044760.99969554

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29717_29717_1_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_2_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_3_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_4_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_5_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_6_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_7_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_8_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000341285_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=878AA_BP=690
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYII
GLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIA
QHCSQKDTAELLRGLSLWNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWK
HLYPVHWARGDWYSGPATELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLV
LAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKI
TSTAWKNKDITMQSTKQYACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCS
TSGCFSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLS
GCYQITDHGLRVLTLGGGLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVF
SIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL

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>29717_29717_9_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000317610_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

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>29717_29717_10_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000337526_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_11_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000357376_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_12_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000357732_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_13_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000394609_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_14_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000394611_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_15_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000404909_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

--------------------------------------------------------------

>29717_29717_16_FBXL5-RTN4_FBXL5_chr4_15613888_ENST00000412094_RTN4_chr2_55214834_ENST00000405240_length(amino acids)=861AA_BP=673
MPRGEGVYGEAAAAAAEAEAEAVAMAPFPEEVDVFTAPHWRMKQLVGLYCDKSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDN
KLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSL
WNHAEERQKFFKYSVDEKSDKEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDWYSGPA
TELDTEPDDEWVKNRKDESRAFHEWDEDADIDESEESAEESIAISIAQMEKRLLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILE
LCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDVALEKISRALGILTSHQSGFLKTSTSKITSTAWKNKDITMQSTKQ
YACLHDLTNKGIGEEIDNEHPWTKPVSSENFTSPYVWMLDAEDLADIEDTVEWRHRNVESLCVMETASNFSCSTSGCFSKDIVGLRTSVC
WQQHCASPAFAYCGHSFCCTGTALRTMSSLPESSAMCRKAARTRLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRVLTLGG
GLPYLEHLNLSGCLTITGAGLQDLVSACPSLNDEYFYYCDNINVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVT
ISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:15613888/chr2:55214834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FBXL5

Q9UKA1

.
FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011202_248666.3333333333334692.0DomainF-box
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112202_248540.3333333333334566.0DomainF-box
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011202_248649.3333333333334675.0DomainF-box
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-10111_159666.3333333333334692.0RegionNote=Hemerythrin-like
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-11121_159540.3333333333334566.0RegionNote=Hemerythrin-like
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-10111_159649.3333333333334675.0RegionNote=Hemerythrin-like
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011340_364666.3333333333334692.0RepeatNote=LRR 1
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011365_392666.3333333333334692.0RepeatNote=LRR 2
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011393_418666.3333333333334692.0RepeatNote=LRR 3
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011479_508666.3333333333334692.0RepeatNote=LRR 4
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011576_607666.3333333333334692.0RepeatNote=LRR 5
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011608_635666.3333333333334692.0RepeatNote=LRR 6
HgeneFBXL5chr4:15613888chr2:55214834ENST00000341285-1011636_661666.3333333333334692.0RepeatNote=LRR 7
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112340_364540.3333333333334566.0RepeatNote=LRR 1
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112365_392540.3333333333334566.0RepeatNote=LRR 2
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112393_418540.3333333333334566.0RepeatNote=LRR 3
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112479_508540.3333333333334566.0RepeatNote=LRR 4
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011340_364649.3333333333334675.0RepeatNote=LRR 1
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011365_392649.3333333333334675.0RepeatNote=LRR 2
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011393_418649.3333333333334675.0RepeatNote=LRR 3
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011479_508649.3333333333334675.0RepeatNote=LRR 4
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011576_607649.3333333333334675.0RepeatNote=LRR 5
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011608_635649.3333333333334675.0RepeatNote=LRR 6
TgeneRTN4chr4:15613888chr2:55214834ENST0000039460907143_14811.333333333333334200.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003946090730_4711.333333333333334200.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071005_1192185.33333333333334374.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291005_11921004.33333333333341193.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181005_1192204.33333333333334393.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071005_119211.333333333333334200.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291005_1192798.3333333333334987.0DomainReticulon
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071040_1133185.33333333333334374.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071155_1192185.33333333333334374.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291040_11331004.33333333333341193.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291155_11921004.33333333333341193.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181040_1133204.33333333333334393.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181155_1192204.33333333333334393.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071040_113311.333333333333334200.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071155_119211.333333333333334200.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291040_1133798.3333333333334987.0Topological domainLumenal
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291155_1192798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071019_1039185.33333333333334374.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071134_1154185.33333333333334374.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291019_10391004.33333333333341193.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291134_11541004.33333333333341193.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181019_1039204.33333333333334393.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181134_1154204.33333333333334393.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071019_103911.333333333333334200.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071134_115411.333333333333334200.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291134_1154798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291019_1039798.3333333333334987.0TransmembraneHelical
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291134_1154798.3333333333334987.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112576_607540.3333333333334566.0RepeatNote=LRR 5
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112608_635540.3333333333334566.0RepeatNote=LRR 6
HgeneFBXL5chr4:15613888chr2:55214834ENST00000382358-1112636_661540.3333333333334566.0RepeatNote=LRR 7
HgeneFBXL5chr4:15613888chr2:55214834ENST00000412094-1011636_661649.3333333333334675.0RepeatNote=LRR 7
TgeneRTN4chr4:15613888chr2:55214834ENST0000031761007143_148185.33333333333334374.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003176100730_47185.33333333333334374.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000033752629143_1481004.33333333333341193.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003375262930_471004.33333333333341193.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000035737629143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003573762930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000035773218143_148204.33333333333334393.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003577321830_47204.33333333333334393.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000039461129143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000003946112930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000040490929143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000004049092930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST0000040524029143_148798.3333333333334987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:15613888chr2:55214834ENST000004052402930_47798.3333333333334987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:15613888chr2:55214834ENST00000317610071_1018185.33333333333334374.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000337526291_10181004.33333333333341193.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000357376291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000357732181_1018204.33333333333334393.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000394609071_101811.333333333333334200.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000394611291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000404909291_1018798.3333333333334987.0Topological domainCytoplasmic
TgeneRTN4chr4:15613888chr2:55214834ENST00000405240291_1018798.3333333333334987.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FBXL5
RTN4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FBXL5-RTN4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FBXL5-RTN4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource