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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FBXW11-UIMC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FBXW11-UIMC1
	FusionPDB ID: 29892
	FusionGDB2.0 ID: 29892
		Hgene	Tgene
	Gene symbol	FBXW11	UIMC1
	Gene ID	23291	51720
	Gene name	F-box and WD repeat domain containing 11	ubiquitin interaction motif containing 1
	Synonyms	BTRC2\|BTRCP2\|FBW1B\|FBXW1B\|Fbw11\|Hos	RAP80\|X2HRIP110
	Cytomap	5q35.1	5q35.2
	Type of gene	protein-coding	protein-coding
	Description	F-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homolog	BRCA1-A complex subunit RAP80receptor-associated protein 80retinoid X receptor-interacting protein 110
	Modification date	20200329	20200327
	UniProtAcc	Q9UKB1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265094, ENST00000296933, ENST00000393802, ENST00000425623, ENST00000522891,	ENST00000503273, ENST00000377219, ENST00000377227, ENST00000506128, ENST00000511320,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 6 X 9=702	5 X 5 X 4=100
	# samples	13	5
	** MAII score	log2(13/702*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FBXW11 [Title/Abstract] AND UIMC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FBXW11(171433461)-UIMC1(176402481), # samples:2
Anticipated loss of major functional domain due to fusion event.	FBXW11-UIMC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FBXW11-UIMC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FBXW11-UIMC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FBXW11-UIMC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FBXW11	GO:0000209	protein polyubiquitination	20347421
Hgene	FBXW11	GO:0016567	protein ubiquitination	16885022
Hgene	FBXW11	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	20347421
Hgene	FBXW11	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20347421
Tgene	UIMC1	GO:0045892	negative regulation of transcription, DNA-templated	12080054

Fusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UIMC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-IG-A50L	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000296933	FBXW11	chr5	171433461	-	ENST00000377227	UIMC1	chr5	176402481	-	2706	416	290	2428	712
ENST00000296933	FBXW11	chr5	171433461	-	ENST00000377219	UIMC1	chr5	176402481	-	2706	416	290	2431	713
ENST00000296933	FBXW11	chr5	171433461	-	ENST00000506128	UIMC1	chr5	176402481	-	2163	416	290	1930	546
ENST00000296933	FBXW11	chr5	171433461	-	ENST00000511320	UIMC1	chr5	176402481	-	2661	416	290	2428	712
ENST00000265094	FBXW11	chr5	171433461	-	ENST00000377227	UIMC1	chr5	176402481	-	2473	183	57	2195	712
ENST00000265094	FBXW11	chr5	171433461	-	ENST00000377219	UIMC1	chr5	176402481	-	2473	183	57	2198	713
ENST00000265094	FBXW11	chr5	171433461	-	ENST00000506128	UIMC1	chr5	176402481	-	1930	183	57	1697	546
ENST00000265094	FBXW11	chr5	171433461	-	ENST00000511320	UIMC1	chr5	176402481	-	2428	183	57	2195	712
ENST00000393802	FBXW11	chr5	171433461	-	ENST00000377227	UIMC1	chr5	176402481	-	2483	193	67	2205	712
ENST00000393802	FBXW11	chr5	171433461	-	ENST00000377219	UIMC1	chr5	176402481	-	2483	193	67	2208	713
ENST00000393802	FBXW11	chr5	171433461	-	ENST00000506128	UIMC1	chr5	176402481	-	1940	193	67	1707	546
ENST00000393802	FBXW11	chr5	171433461	-	ENST00000511320	UIMC1	chr5	176402481	-	2438	193	67	2205	712

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000296933	ENST00000377227	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.004729777	0.9952702
ENST00000296933	ENST00000377219	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.004908525	0.99509144
ENST00000296933	ENST00000506128	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.004171712	0.99582833
ENST00000296933	ENST00000511320	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.005970267	0.99402976
ENST00000265094	ENST00000377227	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.004731249	0.99526876
ENST00000265094	ENST00000377219	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.004915446	0.9950846
ENST00000265094	ENST00000506128	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.003679531	0.9963205
ENST00000265094	ENST00000511320	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.006059302	0.9939407
ENST00000393802	ENST00000377227	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.00473257	0.9952675
ENST00000393802	ENST00000377219	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.00493311	0.9950669
ENST00000393802	ENST00000506128	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.003747419	0.99625254
ENST00000393802	ENST00000511320	FBXW11	chr5	171433461	-	UIMC1	chr5	176402481	-	0.006068772	0.9939313

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>29892_29892_1_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000265094_UIMC1_chr5_176402481_ENST00000377219_length(amino acids)=713AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTEVLTRRQKEAKTKSD
SGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKT

--------------------------------------------------------------

>29892_29892_2_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000265094_UIMC1_chr5_176402481_ENST00000377227_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

>29892_29892_3_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000265094_UIMC1_chr5_176402481_ENST00000506128_length(amino acids)=546AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEIT
VCPETQLSSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTV
LTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEG
RLLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSFVSISEATDCLVDFKKQVTVQPGSRTRTKAGR

--------------------------------------------------------------

>29892_29892_4_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000265094_UIMC1_chr5_176402481_ENST00000511320_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

>29892_29892_5_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000296933_UIMC1_chr5_176402481_ENST00000377219_length(amino acids)=713AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTEVLTRRQKEAKTKSD
SGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKT

--------------------------------------------------------------

>29892_29892_6_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000296933_UIMC1_chr5_176402481_ENST00000377227_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

>29892_29892_7_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000296933_UIMC1_chr5_176402481_ENST00000506128_length(amino acids)=546AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEIT
VCPETQLSSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTV
LTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEG
RLLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSFVSISEATDCLVDFKKQVTVQPGSRTRTKAGR

--------------------------------------------------------------

>29892_29892_8_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000296933_UIMC1_chr5_176402481_ENST00000511320_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

>29892_29892_9_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000393802_UIMC1_chr5_176402481_ENST00000377219_length(amino acids)=713AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTEVLTRRQKEAKTKSD
SGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKT

--------------------------------------------------------------

>29892_29892_10_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000393802_UIMC1_chr5_176402481_ENST00000377227_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

>29892_29892_11_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000393802_UIMC1_chr5_176402481_ENST00000506128_length(amino acids)=546AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEIT
VCPETQLSSSETFDLEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTV
LTRRQKEAKTKSDSGTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEG
RLLSFLEQSEHKTSDADIKSSETGAFRVPSPGMEEAGCSREMQSSFTRRDLNESPVKSFVSISEATDCLVDFKKQVTVQPGSRTRTKAGR

--------------------------------------------------------------

>29892_29892_12_FBXW11-UIMC1_FBXW11_chr5_171433461_ENST00000393802_UIMC1_chr5_176402481_ENST00000511320_length(amino acids)=712AA_BP=42
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMEPKEENGLQKTKTKQSNRAKCLAKRKIAQMTEEEQFALALKMSEQEAR
EVNSQEEEEEELLRKAIAESLNSCRPSDASATRSRPLATGPSSQSHQEKTTDSGLTEGIWQLVPPSLFKGSHISQGNEAEEREEPWDHTE
KTEEEPVSGSSGSWDQSSQPVFENVNVKSFDRCTGHSAEHTQCGKPQESTGRGSAFLKAVQGSGDTSRHCLPTLADAKGLQDTGGTVNYF
WGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPPSLIQNECGQGEQASEKNECISEDMGDEDKEERQESRAS
DWHSKTKDFQESSIKSLKEKLLLEEEPTTSHGQSSQGIVEETSEEGNSVPASQSVAALTSKRSLVLMPESSAEEITVCPETQLSSSETFD
LEREVSPGSRDILDGVRIIMADKEVGNKEDAEKEVAISTFSSSNQVSCPLCDQCFPPTKIERHAMYCNGLMEEDTVLTRRQKEAKTKSDS
GTAAQTSLDIDKNEKCYLCKSLVPFREYQCHVDSCLQLAKADQGDGPEGSGRACSTVEGKWQQRLKNPKEKGHSEGRLLSFLEQSEHKTS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433461/chr5:176402481)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FBXW11 Q9UKB1	.
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262). {ECO:0000269\|PubMed:10321728, ECO:0000269\|PubMed:10437795, ECO:0000269\|PubMed:10644755, ECO:0000269\|PubMed:10648623, ECO:0000269\|PubMed:14532120, ECO:0000269\|PubMed:14603323, ECO:0000269\|PubMed:15917222, ECO:0000269\|PubMed:18575781, ECO:0000269\|PubMed:19966869, ECO:0000269\|PubMed:20347421, ECO:0000269\|PubMed:25503564, ECO:0000269\|PubMed:29420262}.; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269\|PubMed:19730691}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

81_108

49.0

720.0

Compositional bias

Note=Glu-rich

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

81_108

49.0

554.0

Compositional bias

Note=Glu-rich

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

81_108

49.0

720.0

Compositional bias

Note=Glu-rich

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

105_124

49.0

720.0

Domain

UIM 2

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

80_99

49.0

720.0

Domain

UIM 1

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

105_124

49.0

554.0

Domain

UIM 2

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

80_99

49.0

554.0

Domain

UIM 1

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

105_124

49.0

720.0

Domain

UIM 2

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

80_99

49.0

720.0

Domain

UIM 1

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

60_78

49.0

720.0

Motif

Note=LR motif

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

60_78

49.0

554.0

Motif

Note=LR motif

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

60_78

49.0

720.0

Motif

Note=LR motif

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

270_400

49.0

720.0

Region

Note=AIR

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

505_582

49.0

720.0

Region

Note=Zinc-finger-like region

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

270_400

49.0

554.0

Region

Note=AIR

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

505_582

49.0

554.0

Region

Note=Zinc-finger-like region

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

270_400

49.0

720.0

Region

Note=AIR

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

505_582

49.0

720.0

Region

Note=Zinc-finger-like region

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

502_529

49.0

720.0

Zinc finger

UBZ4-type

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

502_529

49.0

554.0

Zinc finger

UBZ4-type

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

502_529

49.0

720.0

Zinc finger

UBZ4-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

129_167

15.0

1360.3333333333333

Domain

F-box

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

129_167

15.0

1283.6666666666667

Domain

F-box

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

129_167

15.0

592.0

Domain

F-box

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

67_116

15.0

1360.3333333333333

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

67_116

15.0

1283.6666666666667

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

67_116

15.0

592.0

Region

Homodimerization domain D

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

238_275

15.0

1360.3333333333333

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

278_315

15.0

1360.3333333333333

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

318_355

15.0

1360.3333333333333

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

361_398

15.0

1360.3333333333333

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

401_440

15.0

1360.3333333333333

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

442_478

15.0

1360.3333333333333

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000265094

490_527

15.0

1360.3333333333333

Repeat

Note=WD 7

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

238_275

15.0

1283.6666666666667

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

278_315

15.0

1283.6666666666667

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

318_355

15.0

1283.6666666666667

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

361_398

15.0

1283.6666666666667

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

401_440

15.0

1283.6666666666667

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

442_478

15.0

1283.6666666666667

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000296933

490_527

15.0

1283.6666666666667

Repeat

Note=WD 7

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

238_275

15.0

592.0

Repeat

Note=WD 1

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

278_315

15.0

592.0

Repeat

Note=WD 2

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

318_355

15.0

592.0

Repeat

Note=WD 3

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

361_398

15.0

592.0

Repeat

Note=WD 4

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

401_440

15.0

592.0

Repeat

Note=WD 5

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

442_478

15.0

592.0

Repeat

Note=WD 6

Hgene

FBXW11

chr5:171433461

chr5:176402481

ENST00000393802

490_527

15.0

592.0

Repeat

Note=WD 7

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000377227

1_101

49.0

720.0

Region

Note=Necessary for transcriptional repression

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000506128

1_101

49.0

554.0

Region

Note=Necessary for transcriptional repression

Tgene

UIMC1

chr5:171433461

chr5:176402481

ENST00000511320

1_101

49.0

720.0

Region

Note=Necessary for transcriptional repression

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FBXW11
UIMC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FBXW11-UIMC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FBXW11-UIMC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source