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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FDFT1-YWHAZ

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FDFT1-YWHAZ
FusionPDB ID: 30053
FusionGDB2.0 ID: 30053
HgeneTgene
Gene symbol

FDFT1

YWHAZ

Gene ID

2222

7534

Gene namefarnesyl-diphosphate farnesyltransferase 1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
SynonymsDGPT|ERG9|SQS|SQSD|SS14-3-3-zeta|HEL-S-3|HEL-S-93|HEL4|KCIP-1|POPCHAS|YWHAD
Cytomap

8p23.1

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionsqualene synthaseFPP:FPP farnesyltransferasepresqualene-di-diphosphate synthasesqualene synthetase14-3-3 protein zeta/delta14-3-3 delta14-3-3 protein/cytosolic phospholipase A214-3-3 zetaepididymis luminal protein 4epididymis secretory protein Li 3epididymis secretory protein Li 93phospholipase A2protein kinase C inhibitor protein-1tyrosine 3
Modification date2020032020200329
UniProtAcc

P37268

.
Ensembl transtripts involved in fusion geneENST idsENST00000446331, ENST00000220584, 
ENST00000443614, ENST00000525777, 
ENST00000525900, ENST00000528643, 
ENST00000528812, ENST00000530664, 
ENST00000538689, 		ENST00000353245, 
ENST00000395956, ENST00000395957, 
ENST00000395958, ENST00000457309, 
ENST00000522542, ENST00000395948, 
ENST00000395951, ENST00000395953, 
ENST00000419477, ENST00000521309, 
ENST00000522819, ENST00000492736, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 12 X 9=172811 X 10 X 7=770
# samples 2015
** MAII scorelog2(20/1728*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/770*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FDFT1 [Title/Abstract] AND YWHAZ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FDFT1(11683724)-YWHAZ(101937267), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYWHAZ

GO:0070372

regulation of ERK1 and ERK2 cascade

31024343

TgeneYWHAZ

GO:0090128

regulation of synapse maturation

16959763


check buttonFusion gene breakpoints across FDFT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YWHAZ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A43I-01AFDFT1chr8

11683724

+YWHAZchr8

101937267

-
ChimerDB4ESCATCGA-L5-A43IFDFT1chr8

11683724

+YWHAZchr8

101937267

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000538689FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-565410423761485369
ENST00000538689FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-360010423761485369
ENST00000538689FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-360010423761485369
ENST00000538689FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-349610423761485369
ENST00000538689FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-349310423761485369
ENST00000538689FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-235010423761485369
ENST00000220584FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-55369242221367381
ENST00000220584FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-34829242221367381
ENST00000220584FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-34829242221367381
ENST00000220584FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-33789242221367381
ENST00000220584FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-33759242221367381
ENST00000220584FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-22329242221367381
ENST00000443614FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-5279667941110338
ENST00000443614FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-3225667941110338
ENST00000443614FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-3225667941110338
ENST00000443614FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-3121667941110338
ENST00000443614FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-3118667941110338
ENST00000443614FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-1975667941110338
ENST00000525900FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-5360748671191374
ENST00000525900FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-3306748671191374
ENST00000525900FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-3306748671191374
ENST00000525900FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-3202748671191374
ENST00000525900FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-3199748671191374
ENST00000525900FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-2056748671191374
ENST00000528812FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-572211105251553342
ENST00000528812FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-366811105251553342
ENST00000528812FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-366811105251553342
ENST00000528812FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-356411105251553342
ENST00000528812FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-356111105251553342
ENST00000528812FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-241811105251553342
ENST00000530664FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-55909783451421358
ENST00000530664FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-35369783451421358
ENST00000530664FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-35369783451421358
ENST00000530664FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-34329783451421358
ENST00000530664FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-34299783451421358
ENST00000530664FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-22869783451421358
ENST00000528643FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-54648523691295308
ENST00000528643FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-34108523691295308
ENST00000528643FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-34108523691295308
ENST00000528643FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-33068523691295308
ENST00000528643FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-33038523691295308
ENST00000528643FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-21608523691295308
ENST00000525777FDFT1chr811683724+ENST00000395957YWHAZchr8101937267-55289164331359308
ENST00000525777FDFT1chr811683724+ENST00000395958YWHAZchr8101937267-34749164331359308
ENST00000525777FDFT1chr811683724+ENST00000457309YWHAZchr8101937267-34749164331359308
ENST00000525777FDFT1chr811683724+ENST00000395956YWHAZchr8101937267-33709164331359308
ENST00000525777FDFT1chr811683724+ENST00000353245YWHAZchr8101937267-33679164331359308
ENST00000525777FDFT1chr811683724+ENST00000522542YWHAZchr8101937267-22249164331359308

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000538689ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0001017860.9998982
ENST00000538689ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.000104660.99989533
ENST00000538689ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.000104660.99989533
ENST00000538689ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0001013520.9998987
ENST00000538689ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001066730.9998933
ENST00000538689ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0001482910.9998517
ENST00000220584ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0002801860.9997198
ENST00000220584ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0002910730.99970895
ENST00000220584ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0002910730.99970895
ENST00000220584ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0002934710.99970645
ENST00000220584ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0002991910.9997008
ENST00000220584ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0005164390.9994836
ENST00000443614ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0001610070.99983895
ENST00000443614ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0001446910.9998553
ENST00000443614ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0001446910.9998553
ENST00000443614ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0001414810.9998585
ENST00000443614ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001463670.9998536
ENST00000443614ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0002068120.99979323
ENST00000525900ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.000138620.99986136
ENST00000525900ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0001335270.9998665
ENST00000525900ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0001335270.9998665
ENST00000525900ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0001340620.9998659
ENST00000525900ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001372890.9998627
ENST00000525900ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0002144930.9997855
ENST00000528812ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0001026070.99989736
ENST00000528812ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0001030460.9998969
ENST00000528812ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0001030460.9998969
ENST00000528812ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-9.80E-050.999902
ENST00000528812ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001031740.99989676
ENST00000528812ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0001487090.9998512
ENST00000530664ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-9.45E-050.99990547
ENST00000530664ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-9.30E-050.9999069
ENST00000530664ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-9.30E-050.9999069
ENST00000530664ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-9.11E-050.9999088
ENST00000530664ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-9.61E-050.9999039
ENST00000530664ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0001395980.9998604
ENST00000528643ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0001794730.99982053
ENST00000528643ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0001594910.9998405
ENST00000528643ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0001594910.9998405
ENST00000528643ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0001511880.99984884
ENST00000528643ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001632360.9998367
ENST00000528643ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0002042520.99979573
ENST00000525777ENST00000395957FDFT1chr811683724+YWHAZchr8101937267-0.0001600610.9998399
ENST00000525777ENST00000395958FDFT1chr811683724+YWHAZchr8101937267-0.0001391270.9998609
ENST00000525777ENST00000457309FDFT1chr811683724+YWHAZchr8101937267-0.0001391270.9998609
ENST00000525777ENST00000395956FDFT1chr811683724+YWHAZchr8101937267-0.0001358030.9998642
ENST00000525777ENST00000353245FDFT1chr811683724+YWHAZchr8101937267-0.0001460030.99985397
ENST00000525777ENST00000522542FDFT1chr811683724+YWHAZchr8101937267-0.0001925860.9998074

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30053_30053_1_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_2_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_3_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_4_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_5_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_6_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000220584_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=381AA_BP=234
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN

--------------------------------------------------------------

>30053_30053_7_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_8_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_9_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_10_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_11_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_12_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000443614_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=338AA_BP=191
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLED
QQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVF

--------------------------------------------------------------

>30053_30053_13_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_14_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_15_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_16_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_17_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_18_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525777_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_19_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_20_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_21_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_22_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_23_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_24_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000525900_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=374AA_BP=227
MEFVKCLGHPEEFYNLVRFRIGGKRKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLL
HNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLF
SASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGI
VDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSD

--------------------------------------------------------------

>30053_30053_25_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_26_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_27_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_28_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_29_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_30_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528643_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=308AA_BP=161
MVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVT
SEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVF
YLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLS

--------------------------------------------------------------

>30053_30053_31_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_32_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_33_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_34_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_35_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_36_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000528812_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=342AA_BP=195
MKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTIS
LEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRD
YLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALN

--------------------------------------------------------------

>30053_30053_37_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_38_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_39_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_40_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_41_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_42_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000530664_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=358AA_BP=211
MGSLSGQWVLDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFME
SKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTER
ANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK

--------------------------------------------------------------

>30053_30053_43_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000353245_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

--------------------------------------------------------------

>30053_30053_44_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000395956_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

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>30053_30053_45_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000395957_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

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>30053_30053_46_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000395958_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

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>30053_30053_47_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000457309_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

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>30053_30053_48_FDFT1-YWHAZ_FDFT1_chr8_11683724_ENST00000538689_YWHAZ_chr8_101937267_ENST00000522542_length(amino acids)=369AA_BP=222
MKSVRPRTNQFRTHLDSTDSKDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRLFSASEF
EDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQ
QAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11683724/chr8:101937267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FDFT1

P37268

.
FUNCTION: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. {ECO:0000269|PubMed:10896663, ECO:0000269|PubMed:24531458}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFDFT1chr8:11683724chr8:101937267ENST00000220584+58284_304234.0418.0TransmembraneHelical
HgeneFDFT1chr8:11683724chr8:101937267ENST00000220584+58384_404234.0418.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>758_FDFT1_11683724_YWHAZ_101937267_ranked_0.pdbFDFT11168372411683724ENST00000522542YWHAZchr8101937267-
MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISV
EKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQESLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAA
GDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDN
381


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FDFT1_pLDDT.png
all structure
all structure
YWHAZ_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FDFT1
YWHAZ


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FDFT1-YWHAZ


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FDFT1-YWHAZ


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource