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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FGFR1-BCR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FGFR1-BCR
FusionPDB ID: 30240
FusionGDB2.0 ID: 30240
HgeneTgene
Gene symbol

FGFR1

BCR

Gene ID

2260

613

Gene namefibroblast growth factor receptor 1BCR activator of RhoGEF and GTPase
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1ALL|BCR1|CML|D22S11|D22S662|PHL
Cytomap

8p11.23

22q11.23

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrbreakpoint cluster region proteinBCR, RhoGEF and GTPase activating proteinBCR/FGFR1 chimera proteinFGFR1/BCR chimera proteinbreakpoint cluster regionrenal carcinoma antigen NY-REN-26
Modification date2020032920200313
UniProtAcc

Q9NVK5

P11274

Ensembl transtripts involved in fusion geneENST idsENST00000326324, ENST00000335922, 
ENST00000341462, ENST00000356207, 
ENST00000397091, ENST00000397103, 
ENST00000397108, ENST00000397113, 
ENST00000425967, ENST00000447712, 
ENST00000532791, ENST00000496629, 
ENST00000398512, ENST00000436990, 
ENST00000305877, ENST00000359540, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 24 X 9=367215 X 58 X 7=6090
# samples 2061
** MAII scorelog2(20/3672*10)=-4.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/6090*10)=-3.31956108034345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FGFR1 [Title/Abstract] AND BCR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BCR(23603730)-FGFR1(38275904), # samples:2
FGFR1(38277056)-BCR(23610592), # samples:2
Anticipated loss of major functional domain due to fusion event.FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
FGFR1-BCR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851

TgeneBCR

GO:0090630

activation of GTPase activity

7479768


check buttonFusion gene breakpoints across FGFR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BCR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAB742171FGFR1chr8

38277056

-BCRchr22

23610592

+
ChiTaRS5.0N/AAJ298917FGFR1chr8

38277056

-BCRchr22

23610592

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397091FGFR1chr838277056-ENST00000305877BCRchr2223610592+6606202736840901240
ENST00000397091FGFR1chr838277056-ENST00000359540BCRchr2223610592+4387202736839581196
ENST00000447712FGFR1chr838277056-ENST00000305877BCRchr2223610592+6805222656142891242
ENST00000447712FGFR1chr838277056-ENST00000359540BCRchr2223610592+4586222656141571198
ENST00000341462FGFR1chr838277056-ENST00000305877BCRchr2223610592+6805222656142891242
ENST00000341462FGFR1chr838277056-ENST00000359540BCRchr2223610592+4586222656141571198
ENST00000532791FGFR1chr838277056-ENST00000305877BCRchr2223610592+6587200834940711240
ENST00000532791FGFR1chr838277056-ENST00000359540BCRchr2223610592+4368200834939391196
ENST00000397113FGFR1chr838277056-ENST00000305877BCRchr2223610592+6174159513136581175
ENST00000397113FGFR1chr838277056-ENST00000359540BCRchr2223610592+3955159513135261131
ENST00000356207FGFR1chr838277056-ENST00000305877BCRchr2223610592+6320174134338041153
ENST00000356207FGFR1chr838277056-ENST00000359540BCRchr2223610592+4101174134336721109
ENST00000326324FGFR1chr838277056-ENST00000305877BCRchr2223610592+6314173534337981151
ENST00000326324FGFR1chr838277056-ENST00000359540BCRchr2223610592+4095173534336661107
ENST00000397103FGFR1chr838277056-ENST00000305877BCRchr2223610592+565310742731371036
ENST00000397103FGFR1chr838277056-ENST00000359540BCRchr2223610592+34341074273005992

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397091ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0011326220.9988674
ENST00000397091ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0056655870.99433446
ENST00000447712ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0015514640.9984485
ENST00000447712ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0081296680.9918703
ENST00000341462ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.001434170.99856585
ENST00000341462ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0080326970.99196726
ENST00000532791ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0016242740.99837565
ENST00000532791ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0057066980.99429333
ENST00000397113ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0006546340.99934536
ENST00000397113ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0038982130.99610174
ENST00000356207ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0010341580.99896586
ENST00000356207ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0033420840.99665797
ENST00000326324ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.001003590.99899644
ENST00000326324ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0033699420.99663
ENST00000397103ENST00000305877FGFR1chr838277056-BCRchr2223610592+0.0008348850.9991652
ENST00000397103ENST00000359540FGFR1chr838277056-BCRchr2223610592+0.0012431630.9987569

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30240_30240_1_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000326324_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1151AA_BP=464
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN
EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME
VLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ
YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN
GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLY
CTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI
AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK
DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL

--------------------------------------------------------------

>30240_30240_2_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000326324_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1107AA_BP=464
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVEN
EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEME
VLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAV
HKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQ
YDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN
GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLY
CTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRER
SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIAL
SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQ

--------------------------------------------------------------

>30240_30240_3_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000341462_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1242AA_BP=555
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKE
TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD
LLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQ
QYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSR
NGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNL
YCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTV
IAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN
KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMS

--------------------------------------------------------------

>30240_30240_4_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000341462_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1198AA_BP=555
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSVPIDALPSSEDDDDDDDSSSEEKE
TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAE
VLTLFNVTEAQSGEYVCKVSNYIGEANQSAWLTVTRPVLEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD
LLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQ
QYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSR
NGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNL
YCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRE
RSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA
LSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQV

--------------------------------------------------------------

>30240_30240_5_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000356207_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1153AA_BP=466
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE
MEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH
DLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKT
QQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHS
RNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSN
LYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRT
VIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVN
NKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKM

--------------------------------------------------------------

>30240_30240_6_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000356207_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1109AA_BP=466
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETD
NTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIV
ENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKE
MEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM
AVHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH
DLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKT
QQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHS
RNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSN
LYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKR
ERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGI
ALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQ

--------------------------------------------------------------

>30240_30240_7_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397091_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1240AA_BP=553
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
KLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLL
KHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQY
DCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNG
KSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYC
TLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIA
MNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKD
VSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLH

--------------------------------------------------------------

>30240_30240_8_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397091_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1196AA_BP=553
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE
YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV
LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH
KLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLL
KHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQY
DCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNG
KSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYC
TLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERS
KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALS
DPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQV

--------------------------------------------------------------

>30240_30240_9_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397103_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1036AA_BP=349
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGL
PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQS
AWLTVTRPVAKALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTASQLGVYRAFV
DNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFL
SSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPN
IPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQ
KKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAE
PNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPS
RKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFREL
PEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANP

--------------------------------------------------------------

>30240_30240_10_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397103_BCR_chr22_23610592_ENST00000359540_length(amino acids)=992AA_BP=349
MSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAA
KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGL
PANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKHSGINSSDAEVLTLFNVTEAQSGEYVCKVSNYIGEANQS
AWLTVTRPVAKALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTASQLGVYRAFV
DNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFL
SSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPN
IPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQ
KKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAE
PNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIY
RVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTF
LFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFST

--------------------------------------------------------------

>30240_30240_11_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397113_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1175AA_BP=488
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLP
EQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
SDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTK
NSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLR
HVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKK
KLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDES
PGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDR
LMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEV
GIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANL
LTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSIL

--------------------------------------------------------------

>30240_30240_12_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000397113_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1131AA_BP=488
MRPLPALVPPLFPPPNFSSNSRSGAGEAAAAPQVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLP
EQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV
SDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY
ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM
VGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTK
NSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLR
HVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKK
KLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDES
PGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSL
KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKL
YFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK

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>30240_30240_13_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000447712_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1242AA_BP=555
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD
LLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQ
QYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSR
NGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNL
YCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTV
IAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN
KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMS

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>30240_30240_14_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000447712_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1198AA_BP=555
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD
LLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQ
QYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSR
NGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNL
YCTLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRE
RSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA
LSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQV

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>30240_30240_15_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000532791_BCR_chr22_23610592_ENST00000305877_length(amino acids)=1240AA_BP=552
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLL
KHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQY
DCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNG
KSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYC
TLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIA
MNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKD
VSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLH

--------------------------------------------------------------

>30240_30240_16_FGFR1-BCR_FGFR1_chr8_38277056_ENST00000532791_BCR_chr22_23610592_ENST00000359540_length(amino acids)=1196AA_BP=552
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLL
KHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQY
DCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRNG
KSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYC
TLEVDSFGYFVNKAKTRVYRDTAEPNWNELDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERS
KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALS
DPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:23603730/chr22:38275904)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

Q9NVK5

BCR

P11274

FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.FUNCTION: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:1903516, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768, PubMed:23940119). The amino terminus contains an intrinsic kinase activity (PubMed:1657398). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed:17116687). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed:23940119). {ECO:0000250|UniProtKB:Q6PAJ1, ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:17116687, ECO:0000269|PubMed:1903516, ECO:0000269|PubMed:23940119, ECO:0000269|PubMed:7479768}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817158_246337.0732.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-81725_119337.0732.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019158_246418.0813.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019255_357418.0813.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-101925_119418.0813.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817158_246339.0734.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-81725_119339.0734.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918158_246426.0821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918255_357426.0821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-91825_119426.0821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019158_246426.0821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019255_357426.0821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-101925_119426.0821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918158_246426.0821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918255_357426.0821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-91825_119426.0821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019158_246459.0854.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019255_357459.0854.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-101925_119459.0854.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918158_246428.0823.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918255_357428.0823.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-91825_119428.0823.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918158_246426.0821.0DomainNote=Ig-like C2-type 2
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918255_357426.0821.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-91825_119426.0821.0DomainNote=Ig-like C2-type 1
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817160_177337.0732.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019160_177418.0813.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817160_177339.0734.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918160_177426.0821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019160_177426.0821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918160_177426.0821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019160_177459.0854.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918160_177428.0823.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918160_177426.0821.0RegionNote=Heparin-binding
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-101922_376418.0813.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-91822_376426.0821.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-101922_376426.0821.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-91822_376426.0821.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-101922_376459.0854.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-91822_376428.0823.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-91822_376426.0821.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019377_397418.0813.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918377_397426.0821.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019377_397426.0821.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918377_397426.0821.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019377_397459.0854.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918377_397428.0823.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918377_397426.0821.0TransmembraneHelical
TgeneBCRchr8:38277056chr22:23610592ENST00000305877323824_827584.01272.0Compositional biasNote=Poly-Leu
TgeneBCRchr8:38277056chr22:23610592ENST00000359540322824_827584.01228.0Compositional biasNote=Poly-Leu
TgeneBCRchr8:38277056chr22:23610592ENST000003058773231054_1248584.01272.0DomainRho-GAP
TgeneBCRchr8:38277056chr22:23610592ENST00000305877323708_866584.01272.0DomainPH
TgeneBCRchr8:38277056chr22:23610592ENST00000305877323893_1020584.01272.0DomainC2
TgeneBCRchr8:38277056chr22:23610592ENST000003595403221054_1248584.01228.0DomainRho-GAP
TgeneBCRchr8:38277056chr22:23610592ENST00000359540322708_866584.01228.0DomainPH
TgeneBCRchr8:38277056chr22:23610592ENST00000359540322893_1020584.01228.0DomainC2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817255_357337.0732.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817478_767337.0732.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019478_767418.0813.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817255_357339.0734.0DomainNote=Ig-like C2-type 3
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817478_767339.0734.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918478_767426.0821.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019478_767426.0821.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918478_767426.0821.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019478_767459.0854.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918478_767428.0823.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918478_767426.0821.0DomainProtein kinase
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817484_490337.0732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817562_564337.0732.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019484_490418.0813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019562_564418.0813.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817484_490339.0734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817562_564339.0734.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918484_490426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918562_564426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019484_490426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019562_564426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918484_490426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918562_564426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019484_490459.0854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019562_564459.0854.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918484_490428.0823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918562_564428.0823.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918484_490426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918562_564426.0821.0Nucleotide bindingNote=ATP
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-81722_376337.0732.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817398_822337.0732.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000335922-1019398_822418.0813.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-81722_376339.0734.0Topological domainExtracellular
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817398_822339.0734.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397091-918398_822426.0821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397108-1019398_822426.0821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000397113-918398_822426.0821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000425967-1019398_822459.0854.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000447712-918398_822428.0823.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000532791-918398_822426.0821.0Topological domainCytoplasmic
HgeneFGFR1chr8:38277056chr22:23610592ENST00000326324-817377_397337.0732.0TransmembraneHelical
HgeneFGFR1chr8:38277056chr22:23610592ENST00000356207-817377_397339.0734.0TransmembraneHelical
TgeneBCRchr8:38277056chr22:23610592ENST00000305877323498_691584.01272.0DomainDH
TgeneBCRchr8:38277056chr22:23610592ENST00000359540322498_691584.01228.0DomainDH
TgeneBCRchr8:38277056chr22:23610592ENST00000305877323197_385584.01272.0RegionNote=Binding to ABL SH2-domain
TgeneBCRchr8:38277056chr22:23610592ENST000003058773231_426584.01272.0RegionNote=Kinase
TgeneBCRchr8:38277056chr22:23610592ENST00000359540322197_385584.01228.0RegionNote=Binding to ABL SH2-domain
TgeneBCRchr8:38277056chr22:23610592ENST000003595403221_426584.01228.0RegionNote=Kinase


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1957_FGFR1_38277056_BCR_23610592_ranked_0.pdbFGFR13827705638277056ENST00000359540BCRchr2223610592+
MRSGGGGHKVWRPRVADGSPPPAPPPGHQLRLHCSRPGWRRRAPSAAGSRAPAAELLRPRQDPNRARGRRAGAGDAGTRPLAQATADSPE
AEPPRRARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQL
RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDN
TKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE
NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM
EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMA
VHKLAKSIPLRRQVTASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHD
LLKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQ
QYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSR
NGKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNL
YCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTV
IAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN
KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMS
1242


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FGFR1_pLDDT.png
all structure
all structure
BCR_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BCRMLLT4, HCK, PTPN6, FES, RB1, ERCC3, GRB2, ABL1, GAB2, HOXA9, CRKL, KIT, PIK3CG, IGSF21, TP53, UNC119, SOS1, PXN, RAC1, CDC42, RHOA, IL3, WDR48, TSG101, VPS28, INPP5D, MYC, HSP90AA1, HSPA8, HIF1A, CRK, GABRR1, CBL, LNX1, LRRK1, GRK5, UBASH3B, PIK3R2, SHC1, AP2M1, Grasp, CFTR, ERBB2IP, DOK1, PTGES3, HSPA4, HSPD1, UBC, CSNK2A2, STUB1, CCDC183, RSPH9, SEC13, Numb, NTRK1, CEP128, NINL, XPO1, Scai, PIK3R1, PDZK1, COMMD1, TULP3, JPH4, NAGK, USP15, SPAG9, MCM2, MCM4, WEE1, CSNK1A1, MCM6, TRIM25, RAD51, HNRNPL, EGLN3, ESR2, DPF2, RECQL4, EZR, KIAA1429, SCAI, HOOK3, PTPN3, PLK1, PLEKHA4, nsp12, nsp15, nsp2, ARHGEF39, HSCB, SAMD4B, SMG6, BRPF3, CECR2, SP110, TRIM66, AP2A1, CSNK2A1, DDX58, USP1, ACTR1A, ANK3, AP2B1, CEP135, CLTA, CTNNA1, DCTN2, MAPRE3, PFN1, RAB2A, RDX, RHOB, SQSTM1, VASP, ATG7, ATG10, ATG3, MAP4K1, NUDCD2, VPS33A, PSD4, SLA2, AGO4, DDR1, YWHAB, NAA10, YWHAH, YWHAG, SURF6, SYNC, CSNK2B, BACE2, GRAP2,
FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1, RASA1, CDH2, ZMYM2, FGF4, OPCML, SHC1, S100B, AGER, KLB, CDH11, TGFBR3, PTPN1, IL17RD, FBXO7, CRKL, RPN1, STOML2, DDOST, CANX, LMAN2, TMED9, RCN2, HSPA6, CDC37, HSPA2, ACTG1, ACTA1, PARD3, PGRMC1, PHGDH, ATP5B, VDAC1, VDAC2, SLC25A6, RUVBL2, RPA1, PLCG2, RAP1A, PHB, RAB1A, RAB5A, RAB8A, RAB4A, RAB14, RAB15, ARF4, RAB2B, RAB9A, COPA, SEC22B, TMEM109, STX12, CLPTM1, HSPA1L, DNAJC13, DNAJB1, TUBB4A, TUBA4A, AFAP1, TUBA1B, MTCH1, BAX, IMMT, GNB1, RAB7A, RAB11B, GAB1, PTPN11, RXRA, RARA, Nr4a2, H3F3A, Nr4a1, TH, UBC, SHE, Il17rd, PDGFRB, MFHAS1, PDK1, HEXIM1, LARP7, GNAI1, RIN1, ITGB3, KIAA1429, ERBB2, APEX1, ORF3a, ORF3b, CORO1C, HSP90AB3P, HSP90AB1, BAG2, MRPS7, MRPS31, MRPS14, P4HB, CDK1, HPX, ATP5O, LIMA1, TMOD3, CORO1B, ACTB, PLEC, RPL22L1, PPM1B, TBL2, DIMT1, SPATS2L, FARSB, HSD17B10, NUFIP2, TRMT10C, SND1, OBSCN, AIMP2, RARS, SRP19, POLRMT, MRPS2, MRPS26, BOLA2, ARGLU1, PFKFB3, MRPS6, CFL1, MRPS33, RPL22, KCTD5, HSPD1, EGFR, HULC, LDHA, MKRN2, DDX58, MLC1, IL3RA, IL32, AQP9, KCNE3, UGT1A7, GJA8, CLEC4A, AVPR1B, DEFB135, RNF149, C7orf34, EPB41L4A, CRLF2, DEFB109P1B, TBXA2R, NRSN1, OR1M1, IFNAR1, SYT2, CDH16, FBXO2, TSHR, MFI2, BCAN, CSNK1G2, CDHR4, CTSG, C1QTNF9B, PCDHA8, IZUMO1, CD8B, SFTPC, GREM2, DHFRL1, CD83, KCNC3, ANK1, PTPRN2, TMEM59, PCDHB7, P2RX4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FGFR1all structure
BCRall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FGFR1-BCR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FGFR1-BCR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)18CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate6GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0011570Mental Depression5PSYGENET
HgeneFGFR1C0011581Depressive disorder5CTD_human;PSYGENET
HgeneFGFR1C0220658Pfeiffer Syndrome5GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0432283Osteoglophonic dwarfism5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0041696Unipolar Depression4CTD_human;PSYGENET
HgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR1C0005586Bipolar Disorder3PSYGENET
HgeneFGFR1C0795998JACKSON-WEISS SYNDROME3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
HgeneFGFR1C0006142Malignant neoplasm of breast2CGI;CTD_human
HgeneFGFR1C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneFGFR1C0007137Squamous cell carcinoma2CTD_human
HgeneFGFR1C0027022Myeloproliferative disease2CTD_human
HgeneFGFR1C0162809Kallmann Syndrome2CTD_human;ORPHANET
HgeneFGFR1C0432122Interfrontal craniofaciosynostosis2GENOMICS_ENGLAND;UNIPROT
HgeneFGFR1C0678222Breast Carcinoma2CGI;CTD_human
HgeneFGFR1C1257931Mammary Neoplasms, Human2CTD_human
HgeneFGFR1C1458155Mammary Neoplasms2CTD_human
HgeneFGFR1C4704874Mammary Carcinoma, Human2CTD_human
HgeneFGFR1C0004114Astrocytoma1CTD_human
HgeneFGFR1C0008924Cleft upper lip1CTD_human
HgeneFGFR1C0008925Cleft Palate1CTD_human
HgeneFGFR1C0010278Craniosynostosis1CTD_human;GENOMICS_ENGLAND
HgeneFGFR1C0011573Endogenous depression1CTD_human
HgeneFGFR1C0017638Glioma1CTD_human
HgeneFGFR1C0018824Heart valve disease1CTD_human
HgeneFGFR1C0024121Lung Neoplasms1CTD_human
HgeneFGFR1C0025193Melancholia1CTD_human
HgeneFGFR1C0036341Schizophrenia1CTD_human
HgeneFGFR1C0085682Hypophosphatemia1GENOMICS_ENGLAND
HgeneFGFR1C0086133Depressive Syndrome1CTD_human
HgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
HgeneFGFR1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneFGFR1C0206726gliosarcoma1ORPHANET
HgeneFGFR1C0242379Malignant neoplasm of lung1CTD_human
HgeneFGFR1C0259783mixed gliomas1CTD_human
HgeneFGFR1C0265535Trigonocephaly1CTD_human;ORPHANET
HgeneFGFR1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0280785Diffuse Astrocytoma1CTD_human
HgeneFGFR1C0282126Depression, Neurotic1CTD_human
HgeneFGFR1C0334579Anaplastic astrocytoma1CTD_human
HgeneFGFR1C0334580Protoplasmic astrocytoma1CTD_human
HgeneFGFR1C0334581Gemistocytic astrocytoma1CTD_human
HgeneFGFR1C0334582Fibrillary Astrocytoma1CTD_human
HgeneFGFR1C0334583Pilocytic Astrocytoma1CTD_human
HgeneFGFR1C0334588Giant Cell Glioblastoma1ORPHANET
HgeneFGFR1C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0338503Septo-Optic Dysplasia1ORPHANET
HgeneFGFR1C0342384Idiopathic hypogonadotropic hypogonadism1GENOMICS_ENGLAND
HgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
HgeneFGFR1C0431362Lobar Holoprosencephaly1ORPHANET
HgeneFGFR1C0547065Mixed oligoastrocytoma1CTD_human
HgeneFGFR1C0555198Malignant Glioma1CTD_human
HgeneFGFR1C0750935Cerebral Astrocytoma1CTD_human
HgeneFGFR1C0750936Intracranial Astrocytoma1CTD_human
HgeneFGFR1C0751617Semilobar Holoprosencephaly1ORPHANET
HgeneFGFR1C1519086Pilomyxoid astrocytoma1ORPHANET
HgeneFGFR1C1704230Grade I Astrocytoma1CTD_human
HgeneFGFR1C1837218Cleft palate, isolated1CTD_human
HgeneFGFR1C1852406Cutis Gyrata Syndrome of Beare And Stevenson1GENOMICS_ENGLAND
HgeneFGFR1C2931196Craniofacial dysostosis type 11GENOMICS_ENGLAND
HgeneFGFR1C3150773CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME1ORPHANET
TgeneBCRC0005586Bipolar Disorder4PSYGENET
TgeneBCRC0023473Myeloid Leukemia, Chronic3CTD_human;ORPHANET
TgeneBCRC0005699Blast Phase1CTD_human
TgeneBCRC0006413Burkitt Lymphoma1ORPHANET
TgeneBCRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBCRC0027022Myeloproliferative disease1CTD_human
TgeneBCRC0027540Necrosis1CTD_human
TgeneBCRC0027659Neoplasms, Experimental1CTD_human
TgeneBCRC0041696Unipolar Depression1PSYGENET
TgeneBCRC1269683Major Depressive Disorder1PSYGENET
TgeneBCRC1292769Precursor B-cell lymphoblastic leukemia1ORPHANET