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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FGFR3-AES

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FGFR3-AES
FusionPDB ID: 30299
FusionGDB2.0 ID: 30299
HgeneTgene
Gene symbol

FGFR3

AES

Gene ID

2261

166

Gene namefibroblast growth factor receptor 3TLE family member 5, transcriptional modulator
SynonymsACH|CD333|CEK2|HSFGFR3EX|JTK4AES|AES-1|AES-2|ESP1|GRG|GRG5|Grg-5
Cytomap

4p16.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3 variant 4fibroblast growth factor receptor 3-Shydroxyaryl-protein kinasetyrosine kinase JTK4TLE family member 5amino-terminal enhancer of splitgp130-associated protein GAMgroucho-related protein 5
Modification date2020031320200327
UniProtAcc

P22607

.
Ensembl transtripts involved in fusion geneENST idsENST00000260795, ENST00000340107, 
ENST00000352904, ENST00000412135, 
ENST00000440486, ENST00000481110, 
ENST00000474521, 		ENST00000586839, 
ENST00000592330, ENST00000221561, 
ENST00000327141, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 22 X 14=308010 X 12 X 6=720
# samples 3313
** MAII scorelog2(33/3080*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FGFR3 [Title/Abstract] AND AES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FGFR3(1808661)-AES(3061255), # samples:5
Anticipated loss of major functional domain due to fusion event.FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
FGFR3-AES seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR3

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR3

GO:0018108

peptidyl-tyrosine phosphorylation

11294897

HgeneFGFR3

GO:0046777

protein autophosphorylation

11294897

TgeneAES

GO:0032091

negative regulation of protein binding

15489227

TgeneAES

GO:0045892

negative regulation of transcription, DNA-templated

19460168

TgeneAES

GO:0070555

response to interleukin-1

15489227

TgeneAES

GO:0090090

negative regulation of canonical Wnt signaling pathway

19460168


check buttonFusion gene breakpoints across FGFR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808660

+AESchr19

3061254

-
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808661

-AESchr19

3061255

-
ChimerDB4PRADTCGA-EJ-A7NM-01AFGFR3chr4

1808661

+AESchr19

3061255

-
ChimerDB4PRADTCGA-EJ-A7NMFGFR3chr4

1808661

+AESchr19

3061255

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440486FGFR3chr41808661+ENST00000221561AESchr193061255-400625302233096957
ENST00000440486FGFR3chr41808661+ENST00000327141AESchr193061255-375425302233096957
ENST00000412135FGFR3chr41808661+ENST00000221561AESchr193061255-367021942232760845
ENST00000412135FGFR3chr41808661+ENST00000327141AESchr193061255-341821942232760845
ENST00000340107FGFR3chr41808661+ENST00000221561AESchr193061255-401225362233102959
ENST00000340107FGFR3chr41808661+ENST00000327141AESchr193061255-376025362233102959
ENST00000260795FGFR3chr41808661+ENST00000221561AESchr193061255-38522376692942957
ENST00000260795FGFR3chr41808661+ENST00000327141AESchr193061255-36002376692942957
ENST00000352904FGFR3chr41808661+ENST00000221561AESchr193061255-3453197762543845
ENST00000352904FGFR3chr41808661+ENST00000327141AESchr193061255-3201197762543845
ENST00000440486FGFR3chr41808660+ENST00000221561AESchr193061254-400625302233096957
ENST00000440486FGFR3chr41808660+ENST00000327141AESchr193061254-375425302233096957
ENST00000412135FGFR3chr41808660+ENST00000221561AESchr193061254-367021942232760845
ENST00000412135FGFR3chr41808660+ENST00000327141AESchr193061254-341821942232760845
ENST00000340107FGFR3chr41808660+ENST00000221561AESchr193061254-401225362233102959
ENST00000340107FGFR3chr41808660+ENST00000327141AESchr193061254-376025362233102959
ENST00000260795FGFR3chr41808660+ENST00000221561AESchr193061254-38522376692942957
ENST00000260795FGFR3chr41808660+ENST00000327141AESchr193061254-36002376692942957
ENST00000352904FGFR3chr41808660+ENST00000221561AESchr193061254-3453197762543845
ENST00000352904FGFR3chr41808660+ENST00000327141AESchr193061254-3201197762543845

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440486ENST00000221561FGFR3chr41808661+AESchr193061255-0.0011429210.99885714
ENST00000440486ENST00000327141FGFR3chr41808661+AESchr193061255-0.0020051870.9979948
ENST00000412135ENST00000221561FGFR3chr41808661+AESchr193061255-0.0025371650.99746287
ENST00000412135ENST00000327141FGFR3chr41808661+AESchr193061255-0.0045722470.9954277
ENST00000340107ENST00000221561FGFR3chr41808661+AESchr193061255-0.0012532850.99874663
ENST00000340107ENST00000327141FGFR3chr41808661+AESchr193061255-0.0021560610.997844
ENST00000260795ENST00000221561FGFR3chr41808661+AESchr193061255-0.0011089410.99889106
ENST00000260795ENST00000327141FGFR3chr41808661+AESchr193061255-0.0019780680.99802196
ENST00000352904ENST00000221561FGFR3chr41808661+AESchr193061255-0.002323910.9976761
ENST00000352904ENST00000327141FGFR3chr41808661+AESchr193061255-0.0043884160.9956116
ENST00000440486ENST00000221561FGFR3chr41808660+AESchr193061254-0.0011429210.99885714
ENST00000440486ENST00000327141FGFR3chr41808660+AESchr193061254-0.0020051870.9979948
ENST00000412135ENST00000221561FGFR3chr41808660+AESchr193061254-0.0025371650.99746287
ENST00000412135ENST00000327141FGFR3chr41808660+AESchr193061254-0.0045722470.9954277
ENST00000340107ENST00000221561FGFR3chr41808660+AESchr193061254-0.0012532850.99874663
ENST00000340107ENST00000327141FGFR3chr41808660+AESchr193061254-0.0021560610.997844
ENST00000260795ENST00000221561FGFR3chr41808660+AESchr193061254-0.0011089410.99889106
ENST00000260795ENST00000327141FGFR3chr41808660+AESchr193061254-0.0019780680.99802196
ENST00000352904ENST00000221561FGFR3chr41808660+AESchr193061254-0.002323910.9976761
ENST00000352904ENST00000327141FGFR3chr41808660+AESchr193061254-0.0043884160.9956116

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30299_30299_1_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_2_FGFR3-AES_FGFR3_chr4_1808660_ENST00000260795_AES_chr19_3061254_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_3_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000221561_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL

--------------------------------------------------------------

>30299_30299_4_FGFR3-AES_FGFR3_chr4_1808660_ENST00000340107_AES_chr19_3061254_ENST00000327141_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL

--------------------------------------------------------------

>30299_30299_5_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_6_FGFR3-AES_FGFR3_chr4_1808660_ENST00000352904_AES_chr19_3061254_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_7_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_8_FGFR3-AES_FGFR3_chr4_1808660_ENST00000412135_AES_chr19_3061254_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_9_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_10_FGFR3-AES_FGFR3_chr4_1808660_ENST00000440486_AES_chr19_3061254_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_11_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_12_FGFR3-AES_FGFR3_chr4_1808661_ENST00000260795_AES_chr19_3061255_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_13_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000221561_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL

--------------------------------------------------------------

>30299_30299_14_FGFR3-AES_FGFR3_chr4_1808661_ENST00000340107_AES_chr19_3061255_ENST00000327141_length(amino acids)=959AA_BP=613
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL

--------------------------------------------------------------

>30299_30299_15_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

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>30299_30299_16_FGFR3-AES_FGFR3_chr4_1808661_ENST00000352904_AES_chr19_3061255_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_17_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000221561_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_18_FGFR3-AES_FGFR3_chr4_1808661_ENST00000412135_AES_chr19_3061255_ENST00000327141_length(amino acids)=845AA_BP=499
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPA
DPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL
YVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD
VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECW
HAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLN
IEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTG

--------------------------------------------------------------

>30299_30299_19_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000221561_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

--------------------------------------------------------------

>30299_30299_20_FGFR3-AES_FGFR3_chr4_1808661_ENST00000440486_AES_chr19_3061255_ENST00000327141_length(amino acids)=957AA_BP=611
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKL
ASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALAL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1808661/chr19:3061255)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR3

P22607

.
FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617151_244758.0807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+161724_126758.0807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617253_355758.0807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617472_761758.0807.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718151_244760.0809.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+171824_126760.0809.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718253_355760.0809.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718472_761760.0809.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415151_244646.0695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+141524_126646.0695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415253_355646.0695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516151_244646.0695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+151624_126646.0695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516253_355646.0695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718151_244758.0807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+171824_126758.0807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718253_355758.0807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718472_761758.0807.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617151_244758.0807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+161724_126758.0807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617253_355758.0807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617472_761758.0807.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718151_244760.0809.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+171824_126760.0809.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718253_355760.0809.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718472_761760.0809.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415151_244646.0695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+141524_126646.0695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415253_355646.0695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516151_244646.0695.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+151624_126646.0695.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516253_355646.0695.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718151_244758.0807.0DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+171824_126758.0807.0DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718253_355758.0807.0DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718472_761758.0807.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617478_486758.0807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718478_486760.0809.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415478_486646.0695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516478_486646.0695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718478_486758.0807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617478_486758.0807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718478_486760.0809.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415478_486646.0695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516478_486646.0695.0Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718478_486758.0807.0Nucleotide bindingATP
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+161723_375758.0807.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+171823_375760.0809.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+141523_375646.0695.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+151623_375646.0695.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+171823_375758.0807.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+161723_375758.0807.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+171823_375760.0809.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+141523_375646.0695.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+151623_375646.0695.0Topological domainExtracellular
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+171823_375758.0807.0Topological domainExtracellular
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617376_396758.0807.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718376_396760.0809.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415376_396646.0695.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516376_396646.0695.0TransmembraneHelical
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718376_396758.0807.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617376_396758.0807.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718376_396760.0809.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415376_396646.0695.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516376_396646.0695.0TransmembraneHelical
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718376_396758.0807.0TransmembraneHelical
TgeneAESchr4:1808660chr19:3061254ENST0000022156107132_16576.0265.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808660chr19:3061254ENST0000032714107132_1659.0198.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808661chr19:3061255ENST0000022156107132_16576.0265.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808661chr19:3061255ENST0000032714107132_1659.0198.0Compositional biasNote=Gly/Pro-rich (GP domain)
TgeneAESchr4:1808660chr19:3061254ENST0000022156107166_19776.0265.0RegionNote=CCN domain
TgeneAESchr4:1808660chr19:3061254ENST0000032714107166_1979.0198.0RegionNote=CCN domain
TgeneAESchr4:1808661chr19:3061255ENST0000022156107166_19776.0265.0RegionNote=CCN domain
TgeneAESchr4:1808661chr19:3061255ENST0000032714107166_1979.0198.0RegionNote=CCN domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415472_761646.0695.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516472_761646.0695.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415472_761646.0695.0DomainProtein kinase
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516472_761646.0695.0DomainProtein kinase
HgeneFGFR3chr4:1808660chr19:3061254ENST00000260795+1617397_806758.0807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000340107+1718397_806760.0809.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000352904+1415397_806646.0695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000412135+1516397_806646.0695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808660chr19:3061254ENST00000440486+1718397_806758.0807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000260795+1617397_806758.0807.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000340107+1718397_806760.0809.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000352904+1415397_806646.0695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000412135+1516397_806646.0695.0Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr19:3061255ENST00000440486+1718397_806758.0807.0Topological domainCytoplasmic
TgeneAESchr4:1808660chr19:3061254ENST00000221561071_13176.0265.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808660chr19:3061254ENST00000327141071_1319.0198.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808661chr19:3061255ENST00000221561071_13176.0265.0Compositional biasNote=Gln-rich (Q domain)
TgeneAESchr4:1808661chr19:3061255ENST00000327141071_1319.0198.0Compositional biasNote=Gln-rich (Q domain)


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1759_FGFR3_1808661_AES_3061255_ranked_0.pdbFGFR318086601808661ENST00000327141AESchr193061255-
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEK
AFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPL
VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEME
MMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD
LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLL
KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECD
KLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQAL
959


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FGFR3_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FGFR3C6orf47, SMG7, BORA, CCDC17, HBZ, HNRNPL, NDUFS6, RNF130, ATF3, ARAP1, CHGB, CTSK, RADIL, GTF3C1, KRT8, POLA2, KIAA1377, RPL8, SLC25A6, Sh2b1, SH2B1, FGF9, FGF1, GRB2, FGF8, HSP90AA1, HSP90AB1, HSPA1B, HSPA8, CDC37, HSPA4, SOCS1, SOCS3, FGFR3, SNX11, TMEM231, ILKAP, SRPK2, PVRL1, BRD4, VHL, FNTA, CDK6, FGFR2, TMEM30B, ARRDC3, SDC2, EPHA4, KAL1, RPS6KA3, fgf3, KLB, CSPG4, HEXIM1, LARP7, MAP3K4, CDC25A, DCXR, ERBB2, BRD2, OXT, PRKAR1A, POMC, CUL4B, ATG5, MKRN2, ABCA2, CTLA4, POTEI, TNFRSF10A, MPDZ, SDC4, CLEC4A, CRLF2, FBXO2, ALG6, TM2D3, KLK1, PI15, FSTL4, PRG2, TMEM87A, PDGFRA, LY86, MFAP4, FHL3, DNASE1L1, CELA2B, FBXO6, SIRPD, CBLN4, KLK3, EDN3, PRTN3, ELSPBP1, LYPD4, GGH, GPIHBP1, IL5RA, DNAJB9, TCTN1, UQCC1, LIPG, FCGR3B, SDF2L1, EPDR1, ADAMTS12, IGLL5, CFC1, C1QB,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FGFR3all structure
AES


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FGFR3-AES


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FGFR3-AES


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR3C0001080Achondroplasia13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0410529Hypochondroplasia (disorder)10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C1864436Muenke Syndrome9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C1868678THANATOPHORIC DYSPLASIA, TYPE I (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C2677099CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)7CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C0005684Malignant neoplasm of urinary bladder6CGI;CTD_human;UNIPROT
HgeneFGFR3C0005695Bladder Neoplasm4CGI;CTD_human
HgeneFGFR3C1300257Thanatophoric dysplasia, type 24CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR3C1864852CATSHL syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C2674173Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0265269Lacrimoauriculodentodigital syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR3C0007138Carcinoma, Transitional Cell1CTD_human
HgeneFGFR3C0008924Cleft upper lip1CTD_human
HgeneFGFR3C0008925Cleft Palate1CTD_human
HgeneFGFR3C0014544Epilepsy1GENOMICS_ENGLAND
HgeneFGFR3C0014547Epilepsies, Partial1GENOMICS_ENGLAND
HgeneFGFR3C0022603Seborrheic keratosis1UNIPROT
HgeneFGFR3C0026764Multiple Myeloma1CGI;CTD_human
HgeneFGFR3C0036631Seminoma1CTD_human
HgeneFGFR3C0039743Thanatophoric Dysplasia1CTD_human
HgeneFGFR3C0152423Congenital small ears1GENOMICS_ENGLAND
HgeneFGFR3C0206726gliosarcoma1ORPHANET
HgeneFGFR3C0221356Brachycephaly1ORPHANET
HgeneFGFR3C0265529Plagiocephaly1ORPHANET
HgeneFGFR3C0334082NEVUS, EPIDERMAL (disorder)1CTD_human;UNIPROT
HgeneFGFR3C0334588Giant Cell Glioblastoma1ORPHANET
HgeneFGFR3C0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
HgeneFGFR3C1336708Testicular Germ Cell Tumor1CTD_human;UNIPROT
HgeneFGFR3C1837218Cleft palate, isolated1CTD_human
HgeneFGFR3C4048328cervical cancer1CTD_human;UNIPROT